LOCUS       NM_207370               4198 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 153 (GPR153), mRNA.
ACCESSION   NM_207370
VERSION     NM_207370.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4198)
  AUTHORS   Ambalavanan,A., Girard,S.L., Ahn,K., Zhou,S., Dionne-Laporte,A.,
            Spiegelman,D., Bourassa,C.V., Gauthier,J., Hamdan,F.F., Xiong,L.,
            Dion,P.A., Joober,R., Rapoport,J. and Rouleau,G.A.
  TITLE     De novo variants in sporadic cases of childhood onset schizophrenia
  JOURNAL   Eur J Hum Genet 24 (6), 944-948 (2016)
   PUBMED   26508570
REFERENCE   2  (bases 1 to 4198)
  AUTHORS   Krishnan,A. and Schioth,H.B.
  TITLE     The role of G protein-coupled receptors in the early evolution of
            neurotransmission and the nervous system
  JOURNAL   J Exp Biol 218 (Pt 4), 562-571 (2015)
   PUBMED   25696819
  REMARK    Review article
REFERENCE   3  (bases 1 to 4198)
  AUTHORS   Kakarala,K.K. and Jamil,K.
  TITLE     Sequence-structure based phylogeny of GPCR Class A Rhodopsin
            receptors
  JOURNAL   Mol Phylogenet Evol 74, 66-96 (2014)
   PUBMED   24503482
  REMARK    Erratum:[Mol Phylogenet Evol. 2014 Jul;76:293-7]
REFERENCE   4  (bases 1 to 4198)
  AUTHORS   Sreedharan,S., Almen,M.S., Carlini,V.P., Haitina,T.,
            Stephansson,O., Sommer,W.H., Heilig,M., de Barioglio,S.R.,
            Fredriksson,R. and Schioth,H.B.
  TITLE     The G protein coupled receptor Gpr153 shares common evolutionary
            origin with Gpr162 and is highly expressed in central regions
            including the thalamus, cerebellum and the arcuate nucleus
  JOURNAL   FEBS J 278 (24), 4881-4894 (2011)
   PUBMED   21981325
REFERENCE   5  (bases 1 to 4198)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4198)
  AUTHORS   Gloriam,D.E., Schioth,H.B. and Fredriksson,R.
  TITLE     Nine new human Rhodopsin family G-protein coupled receptors:
            identification, sequence characterisation and evolutionary
            relationship
  JOURNAL   Biochim Biophys Acta 1722 (3), 235-246 (2005)
   PUBMED   15777626
REFERENCE   7  (bases 1 to 4198)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031847.17, BC068275.1 and
            BQ575651.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_207370.3.
            
            Summary: This gene encodes an integral membrane protein that
            belongs to the Class A rhodopsin superfamily of G protein coupled
            receptors. The encoded protein is expressed primarily in the
            central nervous system. A knockdown of the orthologous gene in rat
            is associated with a significant reduction in food intake and
            impaired decision making ability. Mutations in this gene are
            associated with schizophrenia, autism, and other neuropsychiatric
            disorders. The expression of this gene is activated by the
            glioma-associated oncogene homolog 1 transcription factor which, in
            turn, is activated by sonic hedgehog in normal and tumorigenic
            cells. [provided by RefSeq, Feb 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068275.1, DRR138525.71039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377893.3/ ENSP00000367125.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL031847.17        48765-48887
            124-526             BC068275.1         1-403
            527-527             AL031847.17        55101-55101
            528-1008            BC068275.1         405-885
            1009-1009           AL031847.17        55985-55985
            1010-2291           BC068275.1         887-2168
            2292-4197           AL031847.17        60604-62509
            4198-4198           BQ575651.1         25-25               c
FEATURES             Location/Qualifiers
     source          1..4198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..4198
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /note="G protein-coupled receptor 153"
                     /db_xref="GeneID:387509"
                     /db_xref="HGNC:HGNC:23618"
                     /db_xref="MIM:614269"
     exon            1..274
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..739
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..2213
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /note="G-protein coupled receptor PGR1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 153"
                     /protein_id="NP_997253.2"
                     /db_xref="CCDS:CCDS64.1"
                     /db_xref="GeneID:387509"
                     /db_xref="HGNC:HGNC:23618"
                     /db_xref="MIM:614269"
                     /translation="MSDERRLPGSAVGWLVCGGLSLLANAWGILSVGAKQKKWKPLEF
                     LLCTLAATHMLNVAVPIATYSVVQLRRQRPDFEWNEGLCKVFVSTFYTLTLATCFSVT
                     SLSYHRMWMVCWPVNYRLSNAKKQAVHTVMGIWMVSFILSALPAVGWHDTSERFYTHG
                     CRFIVAEIGLGFGVCFLLLVGGSVAMGVICTAIALFQTLAVQVGRQADRRAFTVPTIV
                     VEDAQGKRRSSIDGSEPAKTSLQTTGLVTTIVFIYDCLMGFPVLVVSFSSLRADASAP
                     WMALCVLWCSVAQALLLPVFLWACDRYRADLKAVREKCMALMANDEESDDETSLEGGI
                     SPDLVLERSLDYGYGGDFVALDRMAKYEISALEGGLPQLYPLRPLQEDKMQYLQVPPT
                     RRFSHDDADVWAAVPLPAFLPRWGSGEDLAALAHLVLPAGPERRRASLLAFAEDAPPS
                     RARRRSAESLLSLRPSALDSGPRGARDSPPGSPRRRPGPGPRSASASLLPDAFALTAF
                     ECEPQALRRPPGPFPAAPAAPDGADPGEAPTPPSSAQRSPGPRPSAHSHAGSLRPGLS
                     ASWGEPGGLRAAGGGGSTSSFLSSPSESSGYATLHSDSLGSAS"
     exon            740..1169
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1362
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1547
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..4198
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4174..4179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /note="hexamer: AATAAA"
     polyA_site      4198
                     /gene="GPR153"
                     /gene_synonym="PGR1"
                     /note="major polyA site"
ORIGIN      
        1 ggccgcccgg cgcagcagcg gagcggcggg agctgagcga agcgcggcgg cggcggcggc
       61 gcctagggga gggaggggcg gcggggccga gcccacctag cggagcgcgc cggccgccgg
      121 tggccgccgc cagcatgccc cggcccgcgg gccgctccgc cgccagccac ccccgcggcc
      181 ctcggcggcc tgcgctcggc ccgggggcgc gggaaccgca gccggagccg gaggcgggag
      241 cagcgagccg gagccccggg cgctcgaatg caggatgctc gtggtcccca gcatccttga
      301 gccaccagga gtgagggctg ctgctccctg agacctggct ccaaggagga tgccacagcc
      361 gcctgccagc tccggtctgc accatgagtg atgagcggcg gctgcctggc agtgcagtgg
      421 gctggctggt atgtgggggc ctctccctgc tggccaatgc ctggggcatc ctcagcgttg
      481 gcgccaagca gaagaagtgg aagcccttgg agttcctgct gtgtacactc gcggccaccc
      541 acatgctaaa tgtggccgtg cccatcgcca cctactccgt ggtgcagctg cggcggcagc
      601 gccccgactt cgagtggaat gagggtctct gcaaggtctt cgtgtccacc ttctacaccc
      661 tcaccctggc cacctgtttc tctgtcacct ccctctccta ccaccgcatg tggatggtct
      721 gctggcctgt caactaccgg ctgagcaatg ccaagaagca ggcggtgcac acagtcatgg
      781 gtatctggat ggtgtccttc atcctgtcgg ccctgcctgc cgttggctgg cacgacacca
      841 gcgagcgctt ctacacccat ggctgccgct tcatcgtggc tgagatcggc ctgggctttg
      901 gcgtctgctt cctgctgctg gtgggcggca gcgtggccat gggcgtgatc tgcacagcca
      961 tcgccctctt ccagacgctg gccgtgcagg tggggcgcca ggccgaccgc cgcgccttca
     1021 ccgtgcccac catcgtggtg gaggacgcgc agggcaagcg gcgctcctcc atcgatggct
     1081 cggagcccgc caaaacctct ctgcagacca cgggcctcgt gaccaccata gtcttcatct
     1141 acgactgcct catgggcttc cctgtgctgg tggtgagctt cagcagcctg cgggccgacg
     1201 cctcagcgcc ctggatggca ctctgcgtgc tgtggtgctc cgtggcccag gccctgctgc
     1261 tgcctgtgtt cctctgggcc tgcgaccgct accgggctga cctcaaagct gtccgggaga
     1321 agtgcatggc cctcatggcc aacgacgagg agtcagacga tgagaccagc ctggaaggtg
     1381 gcatctcccc ggacctggtg ttggagcgct ccctggacta tggctatgga ggtgattttg
     1441 tggccctaga taggatggcc aagtatgaga tctccgccct ggaggggggc ctgccccagc
     1501 tctacccact gcggcccttg caggaggaca agatgcaata cctgcaggtc ccgcccacgc
     1561 ggcgcttctc ccacgacgat gcggacgtgt gggccgccgt cccgctgccc gccttcctgc
     1621 cgcgctgggg ctccggcgag gacctggccg ccctggcgca cctggtgctg cctgccgggc
     1681 ccgagcggcg ccgcgccagc ctcctggcct tcgcggagga cgcaccaccg tcccgcgcgc
     1741 gccgccgctc ggccgagagc ctgctgtcgc tgcggccctc ggccctggat agcggcccgc
     1801 ggggagcccg cgactcgccc cccggcagcc cgcgccgccg ccccgggccc ggcccccgct
     1861 ccgcctcggc ctcgctgctg cccgacgcct tcgccctgac cgccttcgag tgcgagccac
     1921 aggccctgcg ccgcccgccc gggcccttcc ccgctgcgcc cgccgccccc gacggcgcag
     1981 atcccggaga ggccccgacg cccccaagca gcgcccagcg gagcccaggg ccacgcccct
     2041 ctgcgcactc gcacgccggc tctctgcgcc ccggcctgag cgcgtcgtgg ggcgagcccg
     2101 gggggctgcg cgcggcgggc ggcggcggca gcaccagcag cttcctgagt tccccctccg
     2161 agtcctcggg ctacgccacg ctgcactcgg actcgctggg ctccgcgtcc taggaccgcc
     2221 ggcgcctccc cacggacgcc aggcaggcca ggccgctctc cggggccgca gcaccaaaga
     2281 cgcccgcctc cgccccgcgc gcagacatgc gccacccctc ccaggggtga gggggcgttg
     2341 gcctcagcgt ttgtcttccg gctcctccca gctggccttg tcccaggggc gacggctgcc
     2401 ccggacgact gcgctgggca ccgcatgtcc cgggccgagt gaggtcgggc ctggggagct
     2461 gagtgacatc ccaagcttgg gcttgggtag tgagtgacat gtgcacacgt ccagctgcgc
     2521 catcaccagc cctgcgcaac aggacgtcgg gagcagggaa cctgagacag ggccactgcg
     2581 ggatcggaca aagccccgct ttggagaggc tgagctggag ccattggcct ccccaggggc
     2641 tttccaccca cactgcacca taaccgccac acccttcggg gggggggagg gtacagaggg
     2701 tctctaagca caggggtgtt cagagcccga acaagctttg atcaggtttc cctgcttccg
     2761 acctgtcctg cctcagtttc cccatctgtg atgagcaggt gaccacgtta actctcaggg
     2821 ctgtttgaag tctcttggtt gtaggccctc gccactgagt ggcccaggtg tgagaggtag
     2881 tctagagccc tctgcggcct ttgtggaggt ccgttttcag catgtggcct ggtgtggctc
     2941 cctaggcctg aggcctccca ctctcagtgc cccctgcccc cttgggaacc cacactccac
     3001 cccagctaag cacaacactg tggaccacca ccaatggcac ctgagccacc ttgaccacca
     3061 ttagtgtccc caccctcatt actctgccgt cgttgcctgt ccccaccaca tcatctccct
     3121 ccatggctcc caccatgacg ctggcaggtg caagcggaga gcacgagggc agcagggcct
     3181 ggccttccgt gtccctgcgt catccccagc ctcactcccc acccgtgcag gcctggccag
     3241 gaagggatcc tggcaggggc ttccaggttc tcagctcaag gcctggtccc gggcaggcgt
     3301 ccaacccctg ggagcaatgt atttctttgc cttccatcct gggcagaccc cttacaggcc
     3361 tgggcattgc catgggccct gggtcttccc aggctaagga gaaccaggaa cagctataac
     3421 cttgagctag tgaaataggg tagatgagaa ggctgtctcc tccagacccc tacccctaca
     3481 cagtggcccc acaatatgaa gacctggggt aattccaagg tgagcataga gcctgcctgt
     3541 gcccagttcc ttctggccct caggtggcca agcccatctc ttcatccttc agatagggtc
     3601 ccactcccag aagaagctgc tggggtgggg gtgggaggct gcctaagcct gtctgtgctt
     3661 cagaggcccc tccagtccct ggctgtgggg taactggggg tatgagctgt ggccacaggt
     3721 gagcaaggca gggaactgca atccagccct ggccgcggga ggggccatct ctggccaatg
     3781 ctgctgtgcc ttcaaggact gacaagttac gtaggggcag aggtcgccag ctagccagtg
     3841 tctcctccat ctggggggcg tctgtccact tgtcacctta ggttttcact catttgtcac
     3901 cttggggttt tgctctgtgt gtttcatatc caacggcaat acttgcaggg ggacagagtc
     3961 ctctaaatac tccaatcctg cggtttttac aaacataaag ggggagaccc caagtggagg
     4021 accctgggcc tggagctccc tcccaaactt tgtccagcat ccagcctgtt ccctgggctc
     4081 actggggagg gagttgtctt catagcacac ccagagccag ggatcccttt gtagtttttt
     4141 gacaacggag catttctctt ctgtacagga cccaataaaa acttccttat gatttgca
//
