LOCUS       NM_194251               3047 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA.
ACCESSION   NM_194251 XM_068829
VERSION     NM_194251.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3047)
  AUTHORS   Gurtan,A., Dominy,J., Khalid,S., Vong,L., Caplan,S., Currie,T.,
            Richards,S., Lamarche,L., Denning,D., Shpektor,D., Gurinovich,A.,
            Rasheed,A., Hameed,S., Saeed,S., Saleem,I., Jalal,A., Abbas,S.,
            Sultana,R., Rasheed,S.Z., Memon,F.U., Shah,N., Ishaq,M.,
            Khera,A.V., Danesh,J., Frossard,P. and Saleheen,D.
  TITLE     Analyzing human knockouts to validate GPR151 as a therapeutic
            target for reduction of body mass index
  JOURNAL   PLoS Genet 18 (4), e1010093 (2022)
   PUBMED   35381001
  REMARK    GeneRIF: Analyzing human knockouts to validate GPR151 as a
            therapeutic target for reduction of body mass index.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3047)
  AUTHORS   Forch,A., Wallner,S., Zeman,F., Ettl,T., Brochhausen,C. and
            Schreml,S.
  TITLE     Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in
            Common Skin Tumors
  JOURNAL   Cells 11 (1), 27 (2021)
   PUBMED   35011589
  REMARK    GeneRIF: Expression of Proton-Sensitive GPR31, GPR151, TASK1 and
            TASK3 in Common Skin Tumors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3047)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3047)
  AUTHORS   Antolin-Fontes,B., Li,K., Ables,J.L., Riad,M.H., Gorlich,A.,
            Williams,M., Wang,C., Lipford,S.M., Dao,M., Liu,J., Molina,H.,
            Heintz,N., Kenny,P.J. and Ibanez-Tallon,I.
  TITLE     The habenular G-protein-coupled receptor 151 regulates synaptic
            plasticity and nicotine intake
  JOURNAL   Proc Natl Acad Sci U S A 117 (10), 5502-5509 (2020)
   PUBMED   32098843
  REMARK    GeneRIF: These data identify GPR151 as a critical modulator of
            habenular function that controls nicotine addiction vulnerability
REFERENCE   5  (bases 1 to 3047)
  AUTHORS   Mashiko,M., Kurosawa,A., Tani,Y., Tsuji,T. and Takeda,S.
  TITLE     GPR31 and GPR151 are activated under acidic conditions
  JOURNAL   J Biochem 166 (4), 317-322 (2019)
   PUBMED   31119277
REFERENCE   6  (bases 1 to 3047)
  AUTHORS   Ignatov,A., Hermans-Borgmeyer,I. and Schaller,H.C.
  TITLE     Cloning and characterization of a novel G-protein-coupled receptor
            with homology to galanin receptors
  JOURNAL   Neuropharmacology 46 (8), 1114-1120 (2004)
   PUBMED   15111018
  REMARK    GeneRIF: Northern blot analysis reveals expression of
            galanin-receptor like (GalRL) in the central nervous system with
            minor levels in peripheral organs and tissues, such as testis,
            liver, kidney and stomach.
REFERENCE   7  (bases 1 to 3047)
  AUTHORS   Berthold,M., Collin,M., Sejlitz,T., Meister,B. and Lind,P.
  TITLE     Cloning of a novel orphan G protein-coupled receptor (GPCR-2037):
            in situ hybridization reveals high mRNA expression in rat brain
            restricted to neurons of the habenular complex
  JOURNAL   Brain Res Mol Brain Res 120 (1), 22-29 (2003)
   PUBMED   14667573
REFERENCE   8  (bases 1 to 3047)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   9  (bases 1 to 3047)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   10 (bases 1 to 3047)
  AUTHORS   Howard,A.D., McAllister,G., Feighner,S.D., Liu,Q., Nargund,R.P.,
            Van der Ploeg,L.H. and Patchett,A.A.
  TITLE     Orphan G-protein-coupled receptors and natural ligand discovery
  JOURNAL   Trends Pharmacol Sci 22 (3), 132-140 (2001)
   PUBMED   11239576
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011375.5.
            
            On Dec 12, 2019 this sequence version replaced NM_194251.2.
            
            Summary: This gene encodes an orphan member of the class A
            rhodopsin-like family of G-protein-coupled receptors (GPCRs).
            Within the rhodopsin-like family, this gene is a member of the SOG
            subfamily that includes somatostatin, opioid, galanin, and
            kisspeptin receptors. The orthologous mouse gene has a restricted
            pattern of neuronal expression which is induced following nerve
            injury. All GPCRs have a transmembrane domain that includes seven
            transmembrane alpha-helices. A general feature of GPCR signaling is
            the agonist-induced conformational change in the receptor, leading
            to activation of the heterotrimeric G protein. The activated G
            protein then binds to and activates numerous downstream effector
            proteins, which generate second messengers that mediate a broad
            range of cellular and physiological processes. [provided by RefSeq,
            Jul 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY351676.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311104.3/ ENSP00000308733.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3047              AC011375.5         4874-7920
FEATURES             Location/Qualifiers
     source          1..3047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..3047
                     /gene="GPR151"
                     /gene_synonym="GALR4; GALRL; GPCR; GPCR-2037; PGR7"
                     /note="G protein-coupled receptor 151"
                     /db_xref="GeneID:134391"
                     /db_xref="HGNC:HGNC:23624"
                     /db_xref="MIM:618487"
     exon            1..3047
                     /gene="GPR151"
                     /gene_synonym="GALR4; GALRL; GPCR; GPCR-2037; PGR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1337
                     /gene="GPR151"
                     /gene_synonym="GALR4; GALRL; GPCR; GPCR-2037; PGR7"
                     /note="galanin receptor 4; G-protein coupled receptor
                     PGR7; galanin-receptor-like protein"
                     /codon_start=1
                     /product="G-protein coupled receptor 151"
                     /protein_id="NP_919227.2"
                     /db_xref="CCDS:CCDS34266.1"
                     /db_xref="GeneID:134391"
                     /db_xref="HGNC:HGNC:23624"
                     /db_xref="MIM:618487"
                     /translation="MLAAAFADSNSSSMNVSFAHLHFAGGYLPSDSQDWRTIIPALLV
                     AVCLVGFVGNLCVIGILLHNAWKGKPSMIHSLILNLSLADLSLLLFSAPIRATAYSKS
                     VWDLGWFVCKSSDWFIHTCMAAKSLTIVVVAKVCFMYASDPAKQVSIHNYTIWSVLVA
                     IWTVASLLPLPEWFFSTIRHHEGVEMCLVDVPAVAEEFMSMFGKLYPLLAFGLPLFFA
                     SFYFWRAYDQCKKRGTKTQNLRNQIRSKQVTVMLLSIAIISALLWLPEWVAWLWVWHL
                     KAAGPAPPQGFIALSQVLMFSISSANPLIFLVMSEEFREGLKGVWKWMITKKPPTVSE
                     SQETPAGNSEGLPDKVPSPESPASIPEKEKPSSPSSGKGKTEKAEIPILPDVEQFWHE
                     RDTVPSVQDNDPIPWEHEDQETGEGVK"
ORIGIN      
        1 tttcctatgc aaaagagccc aggcagaaag acaaacctaa ataagaatct aacttctgta
       61 agaagctgtg aagagtgatg ctggcagctg cctttgcaga ctctaactcc agcagcatga
      121 atgtgtcctt tgctcacctc cactttgccg gagggtacct gccctctgat tcccaggact
      181 ggagaaccat catcccggct ctcttggtgg ctgtctgcct ggtgggcttc gtgggaaacc
      241 tgtgtgtgat tggcatcctc cttcacaatg cttggaaagg aaagccatcc atgatccact
      301 ccctgattct gaatctcagc ctggctgatc tctccctcct gctgttttct gcacctatcc
      361 gagctacggc gtactccaaa agtgtttggg atctaggctg gtttgtctgc aagtcctctg
      421 actggtttat ccacacatgc atggcagcca agagcctgac aatcgttgtg gtggccaaag
      481 tatgcttcat gtatgcaagt gacccagcca agcaagtgag tatccacaac tacaccatct
      541 ggtcagtgct ggtggccatc tggactgtgg ctagcctgtt acccctgccg gaatggttct
      601 ttagcaccat caggcatcat gaaggtgtgg aaatgtgcct cgtggatgta ccagctgtgg
      661 ctgaagagtt tatgtcgatg tttggtaagc tctacccact cctggcattt ggccttccat
      721 tattttttgc cagcttttat ttctggagag cttatgacca atgtaaaaaa cgaggaacta
      781 agactcaaaa tcttagaaac cagatacgct caaagcaagt cacagtgatg ctgctgagca
      841 ttgccatcat ctctgctctc ttgtggctcc ccgaatgggt agcttggctg tgggtatggc
      901 atctgaaggc tgcaggcccg gccccaccac aaggtttcat agccctgtct caagtcttga
      961 tgttttccat ctcttcagca aatcctctca tttttcttgt gatgtcggaa gagttcaggg
     1021 aaggcttgaa aggtgtatgg aaatggatga taaccaaaaa acctccaact gtctcagagt
     1081 ctcaggaaac accagctggc aactcagagg gtcttcctga caaggttcca tctccagaat
     1141 ccccagcatc cataccagaa aaagagaaac ccagctctcc ctcctctggc aaagggaaaa
     1201 ctgagaaggc agagattccc atccttcctg acgtagagca gttttggcat gagagggaca
     1261 cagtcccttc tgtacaggac aatgacccta tcccctggga acatgaagat caagagacag
     1321 gggaaggtgt taaatagatt taagtttcaa agcaaaacaa actgtgatta ttgtatttac
     1381 ttgtactgct gcttatcaat attgctgact ttacaaactg atataattat taccattagg
     1441 aattataaaa atatttcaca atctacactt tccaaatgtg caatgtggta agtagagaac
     1501 catgttagaa gtaataattg tttcagaatt agaacttggc ttcccaaaca atttaagtgt
     1561 tgtgtaaaga tgttgctgtc aaagtgatta gacagcctgg ctattctgtc atttgttcac
     1621 agtggtttta ctgggtaccc cctaggacca gccctgtagt ggaccggctg gagcctgcag
     1681 tagaggttct gtcaaagctg agccccttta ccttcagttt cacccaggac ctgctagtcc
     1741 taattttacc tactaaattg tatttcacat aaccaaagct caaaatctac tttcacttga
     1801 gatttttaac acattaatga taaattttaa tgcgttcttc atttacttaa taagtgttaa
     1861 tttacttgat gaaaagtccg tatcataatg ttcatgactg aaggtcaaag aaaaagaaac
     1921 agcaccttat tccaattctg gactcatttc aagccatggc tggttctggc caagtttaaa
     1981 taaattcaaa cttaaactaa agcctgcttc agtgaacttt ttaaagctac ctgaatgagt
     2041 cttcagtttc taagtctaag aattgtagca gctttccaat gacattcagt agtctgatat
     2101 gggggaaaaa atacttaaaa aaatgtcctc tcttcacttc caaaatgtgg gaaagttatt
     2161 tttctataag cagaaatgtg ttcctcctaa tatctccttt ctcccaagat aaaccatggt
     2221 taatgatata ggtatagatt actcctcaaa tacaaataga agatggagat ggtgatcttt
     2281 cttgttaatg gtactaaact tacccttact cagaacattg aacttgaacc ctactcaact
     2341 tttaaaatac tataggctaa gttataaaaa taatctagca acctgagaaa gagattaata
     2401 tcaaaaagag aaaattcaac aaaccaagac agaatttggt taagaataca aaataaaaag
     2461 cataagggca atgcagaaag cagtaaaact gtgtacccag acatacggta aaatctgagt
     2521 aacaggcaat aaccattcat tttatagcaa ggtaaaacat acccaataaa acatgattat
     2581 gatatatttc tgcccctttt aagtataatg acattcaccc atgattcttg attactttgt
     2641 tatggaactc gggtattttc actgaaagtt tccctcagaa tagaaatgcc tttagggcaa
     2701 accaagccat ggagaatctg aaatataaag gatatgttat ggaaaaaaaa agattttgct
     2761 ttttgtctat gggtttccgg attctttgct ttttcataag tggtcatagt ttgcttttta
     2821 acacaggagg tagggctgta ttctttttac atccttcatt acaaatttta tttgaagctc
     2881 atgtattcaa ataaagtaaa atttaaccca agaatccaaa atattgtctt gtgatatggt
     2941 agttataaaa aggattatca ttgtctgtga ttatttgaat aaataatttt tatgttcatt
     3001 atatgtagta aatttaggat gtaagcttcc agggtttgac actttaa
//
