LOCUS       NM_199243               2056 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 150 (GPR150), mRNA.
ACCESSION   NM_199243 XM_209675
VERSION     NM_199243.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Martin,A.L., Steurer,M.A. and Aronstam,R.S.
  TITLE     Constitutive Activity among Orphan Class-A G Protein Coupled
            Receptors
  JOURNAL   PLoS One 10 (9), e0138463 (2015)
   PUBMED   26384023
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Kakarala,K.K. and Jamil,K.
  TITLE     Sequence-structure based phylogeny of GPCR Class A Rhodopsin
            receptors
  JOURNAL   Mol Phylogenet Evol 74, 66-96 (2014)
   PUBMED   24503482
  REMARK    Erratum:[Mol Phylogenet Evol. 2014 Jul;76:293-7]
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Cai,L.Y., Abe,M., Izumi,S., Imura,M., Yasugi,T. and Ushijima,T.
  TITLE     Identification of PRTFDC1 silencing and aberrant promoter
            methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers
  JOURNAL   Life Sci 80 (16), 1458-1465 (2007)
   PUBMED   17303177
REFERENCE   4  (bases 1 to 2056)
  AUTHORS   Gloriam,D.E., Schioth,H.B. and Fredriksson,R.
  TITLE     Nine new human Rhodopsin family G-protein coupled receptors:
            identification, sequence characterisation and evolutionary
            relationship
  JOURNAL   Biochim Biophys Acta 1722 (3), 235-246 (2005)
   PUBMED   15777626
REFERENCE   5  (bases 1 to 2056)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030197.1, BK005422.1,
            AC008547.6 and CR744504.1.
            
            On Nov 22, 2018 this sequence version replaced NM_199243.2.
            
            Summary: This gene encodes an orphan member of the class A
            rhodopsin-like family of G-protein-coupled receptors (GPCRs).
            Within the rhodopsin-like family, this gene is a member of the
            vasopressin-like subfamily that also includes vasopressin and
            oxytocin receptors. The silencing of this gene, due to promoter
            methylation, is associated with ovarian cancer progression. All
            GPCRs have a transmembrane domain that includes seven transmembrane
            alpha-helices. A general feature of GPCR signaling is the
            agonist-induced conformational change in the receptor, leading to
            activation of the heterotrimeric G protein. The activated G protein
            then binds to and activates numerous downstream effector proteins,
            which generate second messengers that mediate a broad range of
            cellular and physiological processes. [provided by RefSeq, Jul
            2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BK005422.1, JF810884.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380007.3/ ENSP00000369344.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               BC030197.1         10-198
            190-1494            BK005422.1         1-1305
            1495-1632           AC008547.6         66405-66542
            1633-2056           CR744504.1         6-429               c
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..2056
                     /gene="GPR150"
                     /gene_synonym="PGR11"
                     /note="G protein-coupled receptor 150"
                     /db_xref="GeneID:285601"
                     /db_xref="HGNC:HGNC:23628"
     exon            1..2056
                     /gene="GPR150"
                     /gene_synonym="PGR11"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1494
                     /gene="GPR150"
                     /gene_synonym="PGR11"
                     /note="seven transmembrane helix receptor"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 150"
                     /protein_id="NP_954713.1"
                     /db_xref="CCDS:CCDS4074.1"
                     /db_xref="GeneID:285601"
                     /db_xref="HGNC:HGNC:23628"
                     /translation="MEDLFSPSILPPAPNISVPILLGWGLNLTLGQGAPASGPPSRRV
                     RLVFLGVILVVAVAGNTTVLCRLCGGGGPWAGPKRRKMDFLLVQLALADLYACGGTAL
                     SQLAWELLGEPRAATGDLACRFLQLLQASGRGASAHLVVLIALERRRAVRLPHGRPLP
                     ARALAALGWLLALLLALPPAFVVRGDSPSPLPPPPPPTSLQPGAPPAARAWPGERRCH
                     GIFAPLPRWHLQVYAFYEAVAGFVAPVTVLGVACGHLLSVWWRHRPQAPAAAAPWSAS
                     PGRAPAPSALPRAKVQSLKMSLLLALLFVGCELPYFAARLAAAWSSGPAGDWEGEGLS
                     AALRVVAMANSALNPFVYLFFQAGDCRLRRQLRKRLGSLCCAPQGGAEDEEGPRGHQA
                     LYRQRWPHPHYHHARREPLDEGGLRPPPPRPRPLPCSCESAF"
     regulatory      2036..2041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR150"
                     /gene_synonym="PGR11"
                     /note="hexamer: AATAAA"
     polyA_site      2056
                     /gene="GPR150"
                     /gene_synonym="PGR11"
                     /note="major polyA site"
ORIGIN      
        1 aggacaatcg acaaaaacaa ctaagcgcaa agccgcccga atccatctcc ctctctgtgc
       61 gtgtgccttt tcaactaact ttgggaactc gtatagaccc agcgtcgctc cccgcgccgc
      121 ctcgcctcca ctttggtttc ccgcgtcctg cccgccctct tcggtgcctc ctcttcctcc
      181 gggacaagga tggaggatct ctttagcccc tcaattctgc cgccggcgcc caacatttcc
      241 gtgcccatct tgctgggctg gggtctcaac ctgaccttgg ggcaaggagc ccctgcctct
      301 gggccgccca gccgccgcgt ccgcctggtg ttcctggggg tcatcctggt ggtggcggtg
      361 gcaggcaaca ccacagtgct gtgccgcctg tgcggcggcg gcgggccctg ggcgggcccc
      421 aagcgtcgca agatggactt cctgctggtg cagctggccc tggcggacct gtacgcgtgc
      481 gggggcacgg cgctgtcaca gctggcctgg gaactgctgg gcgagccccg cgcggccacg
      541 ggggacctgg cgtgccgctt cctgcagctg ctgcaggcat ccgggcgggg cgcctcggcc
      601 cacctcgtgg tgctcatcgc cctcgagcgc cggcgcgcgg tgcgtcttcc gcacggccgg
      661 ccgctgcccg cgcgtgccct cgccgccctg ggctggctgc tggcactgct gctggcgctg
      721 cccccggcct tcgtggtgcg cggggactcc ccctcgccgc tgccgccgcc gccgccgcca
      781 acgtccctgc agccaggcgc gcccccggcc gcccgcgcct ggccggggga gcgtcgctgc
      841 cacgggatct tcgcgcccct gccgcgctgg cacctgcagg tctacgcgtt ctacgaggcc
      901 gtcgcgggct tcgtcgcgcc tgttacggtc ctgggcgtcg cttgcggcca cctactctcc
      961 gtctggtggc ggcaccggcc gcaggccccc gcggctgcag cgccctggtc ggcgagccca
     1021 ggtcgagccc ctgcgcccag cgcgctgccc cgcgccaagg tgcagagcct gaagatgagc
     1081 ctgctgctgg cgctgctgtt cgtgggctgc gagctgccct actttgccgc ccggctggcg
     1141 gccgcgtggt cgtccgggcc cgcgggagac tgggagggag agggcctgtc ggcggcgctg
     1201 cgcgtggtgg cgatggccaa cagcgctctc aatcccttcg tctacctctt cttccaggcg
     1261 ggcgactgcc ggctccggcg acagctgcgg aagcggctgg gctctctgtg ctgcgcgccg
     1321 cagggaggcg cggaggacga ggaggggccc cggggccacc aggcgctcta ccgccaacgc
     1381 tggccccacc ctcattatca ccatgctcgg cgggaaccgc tggacgaggg cggcttgcgc
     1441 ccaccccctc cgcgccccag acccctgcct tgctcctgcg aaagtgcctt ctaggtgctt
     1501 ggtggtcaga gacgggtcat ctgtcgctaa ggcgcaacct ccagggaact cgaggcctgc
     1561 cagggtctgt ccagatcaca aggggcagga gagtctgtga gagagtgaca ctgaagttgt
     1621 ccccttcctc cactctccta ttcccttctc atgtttacat ttccctatgc tcttccagtt
     1681 tctcttcttc cctacagttc ctctcatatc tccccatttg gagacagtga gccactggaa
     1741 agttgtaaaa acaaaaacag ttatttttgc agttttcttt cacgcattta tagtgctctg
     1801 gataatgcca tttatttttg ctgattaccc aactttcagt atttgctgtg ttatcatctg
     1861 tatttactta ttttgaatcg tgcttaaatc aaatgtacct tcagcacctg caagtttgcc
     1921 ttttctttcc aggaggaaaa tccccacgtt gctctccctg gggagtctga gaattatacc
     1981 agtgctgtca gaaatgtaat catgctgtca tttcagagcc acagagtatt tataaaataa
     2041 aaacctttcc cacgga
//
