LOCUS       NM_005290               2704 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens G protein-coupled receptor 15 (GPR15), mRNA.
ACCESSION   NM_005290
VERSION     NM_005290.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Schramm,S., Liu,L.J., Saad,M., Dietz,L., Dedden,M., Muller,T.M.,
            Atreya,I., Voskens,C.J., Atreya,R., Neurath,M.F. and Zundler,S.
  TITLE     Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in
            Vivo
  JOURNAL   J Crohns Colitis 18 (7), 1162-1172 (2024)
   PUBMED   38243565
  REMARK    GeneRIF: Blocking GPR15 Counteracts Integrin-dependent T Cell Gut
            Homing in Vivo.
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Liu,C., Lan,Q., Cao,S., Zheng,F., Liang,Y., Shen,J., Wang,Y.,
            Ikezoe,T., Xu,K. and Pan,B.
  TITLE     Thrombin receptor activating peptide-6 decreases acute
            graft-versus-host disease through activating GPR15
  JOURNAL   Leukemia 38 (6), 1390-1402 (2024)
   PUBMED   38459169
  REMARK    GeneRIF: Thrombin receptor activating peptide-6 decreases acute
            graft-versus-host disease through activating GPR15.
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Okamoto,Y. and Shikano,S.
  TITLE     Emerging roles of a chemoattractant receptor GPR15 and ligands in
            pathophysiology
  JOURNAL   Front Immunol 14, 1179456 (2023)
   PUBMED   37457732
  REMARK    GeneRIF: Emerging roles of a chemoattractant receptor GPR15 and
            ligands in pathophysiology.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Zhao,J., Liu,X., Xu,J., Fang,Y., Du,P., Gao,C., Cai,T., Gu,Z.,
            Qin,Q. and Zhang,J.
  TITLE     Elevated Expression and Activation of GPR15 in Immune Cells in
            Graves' Disease
  JOURNAL   Biomolecules 12 (12), 1899 (2022)
   PUBMED   36551327
  REMARK    GeneRIF: Elevated Expression and Activation of GPR15 in Immune
            Cells in Graves' Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Fernandez-Ruiz,J.C., Ochoa-Gonzalez,F.L., Zapata-Zuniga,M.,
            Mondragon-Marin,E., Lara-Ramirez,E.E., Ruiz-Carrillo,J.L.,
            DelaCruz-Flores,P.A., Layseca-Espinosa,E., Enciso-Moreno,J.A. and
            Castaneda-Delgado,J.E.
  TITLE     GPR15 expressed in T lymphocytes from RA patients is involved in
            leukocyte chemotaxis to the synovium
  JOURNAL   J Leukoc Biol 112 (5), 1209-1221 (2022)
   PUBMED   36164808
  REMARK    GeneRIF: GPR15 expressed in T lymphocytes from RA patients is
            involved in leukocyte chemotaxis to the synovium.
REFERENCE   6  (bases 1 to 2704)
  AUTHORS   Clayton,F., Kotler,D.P., Kuwada,S.K., Morgan,T., Stepan,C.,
            Kuang,J., Le,J. and Fantini,J.
  TITLE     Gp120-induced Bob/GPR15 activation: a possible cause of human
            immunodeficiency virus enteropathy
  JOURNAL   Am J Pathol 159 (5), 1933-1939 (2001)
   PUBMED   11696454
REFERENCE   7  (bases 1 to 2704)
  AUTHORS   Cunningham,A.L., Li,S., Juarez,J., Lynch,G., Alali,M. and Naif,H.
  TITLE     The level of HIV infection of macrophages is determined by
            interaction of viral and host cell genotypes
  JOURNAL   J Leukoc Biol 68 (3), 311-317 (2000)
   PUBMED   10985245
  REMARK    Review article
REFERENCE   8  (bases 1 to 2704)
  AUTHORS   Farzan,M., Choe,H., Martin,K., Marcon,L., Hofmann,W., Karlsson,G.,
            Sun,Y., Barrett,P., Marchand,N., Sullivan,N., Gerard,N., Gerard,C.
            and Sodroski,J.
  TITLE     Two orphan seven-transmembrane segment receptors which are
            expressed in CD4-positive cells support simian immunodeficiency
            virus infection
  JOURNAL   J Exp Med 186 (3), 405-411 (1997)
   PUBMED   9236192
REFERENCE   9  (bases 1 to 2704)
  AUTHORS   Deng,H.K., Unutmaz,D., KewalRamani,V.N. and Littman,D.R.
  TITLE     Expression cloning of new receptors used by simian and human
            immunodeficiency viruses
  JOURNAL   Nature 388 (6639), 296-300 (1997)
   PUBMED   9230441
REFERENCE   10 (bases 1 to 2704)
  AUTHORS   Heiber,M., Marchese,A., Nguyen,T., Heng,H.H., George,S.R. and
            O'Dowd,B.F.
  TITLE     A novel human gene encoding a G-protein-coupled receptor (GPR15) is
            located on chromosome 3
  JOURNAL   Genomics 32 (3), 462-465 (1996)
   PUBMED   8838812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313375.1, BC101779.1,
            AC021660.16 and AA687817.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005290.3.
            
            Summary: This gene encodes a G protein-coupled receptor that acts
            as a chemokine receptor for human immunodeficiency virus type 1 and
            2. The encoded protein localizes to the cell membrane. [provided by
            RefSeq, Nov 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1163658.566298.1,
                                        SRR1163655.549051.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284311.5/ ENSP00000284311.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK313375.1         80-109
            31-230              BC101779.1         1-200
            231-1139            AK313375.1         310-1218
            1140-1173           BC101779.1         1110-1143
            1174-2226           AC021660.16        108016-109068       c
            2227-2702           AA687817.1         1-476               c
            2703-2704           AC021660.16        107538-107539       c
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q11.2"
     gene            1..2704
                     /gene="GPR15"
                     /gene_synonym="BOB"
                     /note="G protein-coupled receptor 15"
                     /db_xref="GeneID:2838"
                     /db_xref="HGNC:HGNC:4469"
                     /db_xref="MIM:601166"
     exon            1..2704
                     /gene="GPR15"
                     /gene_synonym="BOB"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1139
                     /gene="GPR15"
                     /gene_synonym="BOB"
                     /note="brother of Bonzo"
                     /codon_start=1
                     /product="G-protein coupled receptor 15"
                     /protein_id="NP_005281.1"
                     /db_xref="CCDS:CCDS2931.1"
                     /db_xref="GeneID:2838"
                     /db_xref="HGNC:HGNC:4469"
                     /db_xref="MIM:601166"
                     /translation="MDPEETSVYLDYYYATSPNSDIRETHSHVPYTSVFLPVFYTAVF
                     LTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTG
                     SFLCKGSSYMISVNMHCSVLLLTCMSVDRYLAIVWPVVSRKFRRTDCAYVVCASIWFI
                     SCLLGLPTLLSRELTLIDDKPYCAEKKATPIKLIWSLVALIFTFFVPLLSIVTCYCCI
                     ARKLCAHYQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKFLAIVSGLRQEHYLP
                     SAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETSD
                     SHLTKALSTFIHAEDFARRRKRSVSL"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR15"
                     /gene_synonym="BOB"
                     /note="hexamer: AATAAA"
     regulatory      2685..2690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR15"
                     /gene_synonym="BOB"
                     /note="hexamer: AATATA"
     polyA_site      2701
                     /gene="GPR15"
                     /gene_synonym="BOB"
     polyA_site      2704
                     /gene="GPR15"
                     /gene_synonym="BOB"
                     /note="major polyA site"
ORIGIN      
        1 atacaaaaac atcatatgta agtaaactca ccagatttgg catctgctct ttggtgatgg
       61 acccagaaga aacttcagtt tatttggatt attactatgc tacgagccca aactctgaca
      121 tcagggagac ccactcccat gttccttaca cctctgtctt ccttccagtc ttttacacag
      181 ctgtgttcct gactggagtg ctggggaacc ttgttctcat gggagcgttg catttcaaac
      241 ccggcagccg aagactgatc gacatcttta tcatcaatct ggctgcctct gacttcattt
      301 ttcttgtcac attgcctctc tgggtggata aagaagcatc tctaggactg tggaggacgg
      361 gctccttcct gtgcaaaggg agctcctaca tgatctccgt caatatgcac tgcagtgtcc
      421 tcctgctcac ttgcatgagt gttgaccgct acctggccat tgtgtggcca gtcgtatcca
      481 ggaaattcag aaggacagac tgtgcatatg tagtctgtgc cagcatctgg tttatctcct
      541 gcctgctggg gttgcctact cttctgtcca gggagctcac gctgattgat gataagccat
      601 actgtgcaga gaaaaaggca actccaatta aactcatatg gtccctggtg gccttaattt
      661 tcaccttttt tgtccctttg ttgagcattg tgacctgcta ctgttgcatt gcaaggaagc
      721 tgtgtgccca ttaccagcaa tcaggaaagc acaacaaaaa gctgaagaaa tctataaaga
      781 tcatctttat tgtcgtggca gcctttcttg tctcctggct gcccttcaat actttcaagt
      841 tcctggccat tgtctctggg ttgcggcaag aacactattt accctcagct attcttcagc
      901 ttggtatgga ggtgagtgga cccttggcat ttgccaacag ctgtgtcaac cctttcattt
      961 actatatctt cgacagctac atccgccggg ccattgtcca ctgcttgtgc ccttgcctga
     1021 aaaactatga ctttgggagt agcactgaga catcagatag tcacctcact aaggctctct
     1081 ccaccttcat tcatgcagaa gattttgcca ggaggaggaa gaggtctgtg tcactctaaa
     1141 gggaactgtg acatttcaag ctctgttggt gggtttagga gttaattttt gtcagcaaca
     1201 aagaaggaag tgttaatgat aggattcaca ttgcttcata gatgcaagga agagttcatt
     1261 tttaaagaga ggactgaaaa atccctgtgt tgtggatata attaggccat gtgctgtttt
     1321 ctcagctaag cagccttctt cgacccttgc caatcaagtc caccagacaa aatccaattc
     1381 ccatctgtcc ttgaactcct ggataaaggc tcctgcttga accagtccct ttcttcatga
     1441 ttgttaatgc acatttgggc ctttcctctc tcaaaaacca tggtaccttc atccccacca
     1501 cccttcatac tgggctctaa attggactac atttaaatga ttctgcctac tttcatctga
     1561 tgagaaatgc agtaacaatg caggtaacaa aaatataata tacctgcact gtgcaattaa
     1621 ttgtttctga gttactaagc tagattctga cctcaatctt taaagctttg tatcgtgatt
     1681 cttcatcatc ttccaacatt gtgcttcatc ctatgcctat tcacaatggc tttggactgg
     1741 caaaaaaaaa ctcatgggga ttttgtattg tgtttatgat ttgggactta ctttatcata
     1801 tggtcttcta gtattttaat acataagcat atggcaggat tcaacatcta tttgctttat
     1861 aagatattga taaaaatgta tctcattcat aatggtgtag caactacttt ttaatggggt
     1921 tttactatgc tcttttgttt ccattggctt tataaattag gatttgactt tgctttaatt
     1981 acatgttttt aattacccag ttatctagtt atcaaatgaa aatgttatta ctaatataat
     2041 tggaactcat aaaatgctta gctgtacccc gatgcagatt atcattttgt attttaatta
     2101 aaatgttagt gctacacatt ccctatagta tcatttgctt ggtgcctata atttcaagat
     2161 aagatccagt aatataggga gacaggctgc tctgtattca gccaaagtag aaaatctcta
     2221 acaaagatct cactagtatt ttatatatat tttttccata cccagaaacc ttcttgaatt
     2281 cctttaccca ataaatattt attgagtcaa tttgtaccta tattcctttt gaagactttg
     2341 atgtgaaaaa catgtaatta gtggcaacca caaaagactc tgcagcagca agcatgctat
     2401 tgtaaacatc ttttgattca agggaaagcg ggttatgttt ttacctccac tgttgacttg
     2461 aatgaattac cattttactt ctaaatatta gatttgaaaa tcagaaaaaa cttagaatcc
     2521 tttcaaagac tagccaattt aatttcatct catgtatctt tcacatgaag agaaacctca
     2581 aatatcggac atctccttgt agcctaatta gaagctgaaa atacagtttt tggttttata
     2641 aattggctaa cttgttaatt tttcttaaac tgttattaaa taaaaatata atttccttac
     2701 ataa
//
