LOCUS       NM_001038705            5527 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 149 (GPR149), mRNA.
ACCESSION   NM_001038705 XM_293580 XM_941192
VERSION     NM_001038705.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5527)
  AUTHORS   Kim,Y.J., Jang,W., Piao,X.M., Yoon,H.Y., Byun,Y.J., Kim,J.S.,
            Kim,S.M., Lee,S.K., Seo,S.P., Kang,H.W., Kim,W.T., Yun,S.J.,
            Shon,H.S., Ryu,K.H., Kim,S.W., Ha,Y.S., Yoon,G.S., Lee,S.C.,
            Kwon,T.G. and Kim,W.J.
  TITLE     ZNF492 and GPR149 methylation patterns as prognostic markers for
            clear cell renal cell carcinoma: Array-based DNA methylation
            profiling
  JOURNAL   Oncol Rep 42 (1), 453-460 (2019)
   PUBMED   31115548
  REMARK    GeneRIF: Data revealed that hypermethylation of ZNF492 and GPR149
            was significantly associated with shorter timetoprogression of
            patients with clear cell renal cell carcinoma (ccRCC).
            Hypermethylation of ZNF492 and GPR149 may be independent predictors
            of tumor progression. Similarly, the methylation status of these
            two genes was significantly associated with poor outcomes in the
            independent external validation cohort.
REFERENCE   2  (bases 1 to 5527)
  AUTHORS   Kakarala,K.K. and Jamil,K.
  TITLE     Sequence-structure based phylogeny of GPCR Class A Rhodopsin
            receptors
  JOURNAL   Mol Phylogenet Evol 74, 66-96 (2014)
   PUBMED   24503482
  REMARK    Erratum:[Mol Phylogenet Evol. 2014 Jul;76:293-7]
REFERENCE   3  (bases 1 to 5527)
  AUTHORS   Katritch,V., Cherezov,V. and Stevens,R.C.
  TITLE     Structure-function of the G protein-coupled receptor superfamily
  JOURNAL   Annu Rev Pharmacol Toxicol 53, 531-556 (2013)
   PUBMED   23140243
  REMARK    Review article
REFERENCE   4  (bases 1 to 5527)
  AUTHORS   Civelli,O., Reinscheid,R.K., Zhang,Y., Wang,Z., Fredriksson,R. and
            Schioth,H.B.
  TITLE     G protein-coupled receptor deorphanizations
  JOURNAL   Annu Rev Pharmacol Toxicol 53, 127-146 (2013)
   PUBMED   23020293
  REMARK    Review article
REFERENCE   5  (bases 1 to 5527)
  AUTHORS   Katritch,V., Cherezov,V. and Stevens,R.C.
  TITLE     Diversity and modularity of G protein-coupled receptor structures
  JOURNAL   Trends Pharmacol Sci 33 (1), 17-27 (2012)
   PUBMED   22032986
  REMARK    Review article
REFERENCE   6  (bases 1 to 5527)
  AUTHORS   Edson,M.A., Lin,Y.N. and Matzuk,M.M.
  TITLE     Deletion of the novel oocyte-enriched gene, Gpr149, leads to
            increased fertility in mice
  JOURNAL   Endocrinology 151 (1), 358-368 (2010)
   PUBMED   19887567
REFERENCE   7  (bases 1 to 5527)
  AUTHORS   Schoneberg,T., Hofreiter,M., Schulz,A. and Rompler,H.
  TITLE     Learning from the past: evolution of GPCR functions
  JOURNAL   Trends Pharmacol Sci 28 (3), 117-121 (2007)
   PUBMED   17280721
  REMARK    Review article
REFERENCE   8  (bases 1 to 5527)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   9  (bases 1 to 5527)
  AUTHORS   Friedel,R.H., Stubbusch,J., Barde,Y.A. and Schnurch,H.
  TITLE     A novel 7-transmembrane receptor expressed in nerve growth
            factor-dependent sensory neurons
  JOURNAL   Mol Cell Neurosci 17 (1), 31-40 (2001)
   PUBMED   11161467
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092946.7, DQ318360.1,
            AC134026.2 and BU743000.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001038705.2.
            
            Summary: This gene encodes a seven-transmembrane G protein coupled
            receptor (GPCR) class A family member. Although categorized as a
            class A GPCR, the encoded protein lacks the first two charged amino
            acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the
            third transmembrane helix of class A receptors which is important
            for efficient G protein-coupled signal transduction. Mice with a
            knockout of the orthologous gene are viable and have normal
            maturation of the ovarian follicle, but show enhanced fertility and
            ovulation. All GPCRs have a common structural architecture
            consisting of seven transmembrane alpha-helices interconnected by
            three extracellular and three intracellular loops. A general
            feature of GPCR signaling is agonist-induced conformational changes
            in the receptor, leading to activation of the heterotrimeric G
            proteins, which consist of the guanine nucleotide-binding G-alpha
            subunit and the dimeric G-beta-gamma subunits. The activated G
            proteins then bind to and activate numerous downstream effector
            proteins, which generate second messengers that mediate a broad
            range of cellular and physiological processes. [provided by RefSeq,
            Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ318360.1, AY255534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMN03267754
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389740.3/ ENSP00000374390.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-475               AC092946.7         95067-95541         c
            476-2798            DQ318360.1         1-2323
            2799-3819           AC092946.7         2002-3022           c
            3820-5525           AC134026.2         54909-56614         c
            5526-5526           BU743000.1         18-18               c
            5527-5527           AC134026.2         54907-54907         c
FEATURES             Location/Qualifiers
     source          1..5527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.2"
     gene            1..5527
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /note="G protein-coupled receptor 149"
                     /db_xref="GeneID:344758"
                     /db_xref="HGNC:HGNC:23627"
     exon            1..1556
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /inference="alignment:Splign:2.1.0"
     CDS             576..2771
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /note="G protein-coupled receptor PGR10"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 149"
                     /protein_id="NP_001033794.1"
                     /db_xref="CCDS:CCDS43162.1"
                     /db_xref="GeneID:344758"
                     /db_xref="HGNC:HGNC:23627"
                     /translation="MSLFLSNLSTNDSSLWKENHNSTDLLNPPGTLNIYLFCLTCLMT
                     FAALVGSIYSLISLLKMQNRTVVSMLVASWSVDDLMSVLSVTIFMFLQWPNEVPGYFQ
                     FLCTTSALMYLCQGLSSNLKATLLVSYNFYTMHRGVGSQTASRRSGQVLGVVLTVWAA
                     SLLLSALPLCGWGAFVRTPWGCLVDCSSSYVLFLSIVYALAFGLLVGLSVPLTHRLLC
                     SEEPPRLHSNYQEISRGASIPGTPPTAGRVVSLSPEDAPGPSLRRSGGCSPSSDTVFG
                     PGAPAAAGAEACRRENRGTLYGTRSFTVSVAQKRFALILALTKVVLWLPMMMHMVVQN
                     VVGFQSLPLETFSFLLTLLATTVTPVFVLSKRWTHLPCGCIINCRQNAYAVASDGKKI
                     KRKGFEFNLSFQKSYGIYKIAHEDYYDDDENSIFYHNLMNSECETTKDPQRDNRNIFN
                     AIKVEISTTPSLDSSTQRGINKCTNTDITEAKQDSNNKKDAFSDKTGGDINYEETTFS
                     EGPERRLSHEESQKPDLSDWEWCRSKSERTPRQRSGYALAIPLCAFQGTVSLHAPTGK
                     TLSLSTYEVSAEGQKITPASKKIEVYRSKSVGHEPNSEDSSSTFVDTSVKIHLEVLEI
                     CDNEEALDTVSIISNISQSSTQVRSPSLRYSRKENRFVSCDLGETASYSLFLPTSNPD
                     GDINISIPDTVEAHRQNSKRQHQERDGYQEEIQLLNKAYRKREEESKGS"
     exon            1557..1749
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2198
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..5527
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5258..5263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /note="hexamer: AATAAA"
     polyA_site      5279
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
     regulatory      5333..5338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /note="hexamer: AATAAA"
     polyA_site      5352
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
     regulatory      5504..5509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /note="hexamer: AATAAA"
     polyA_site      5526
                     /gene="GPR149"
                     /gene_synonym="IEDA; PGR10; R35"
                     /note="major polyA site"
ORIGIN      
        1 gcacaagctc cctctgactg gctcgcgctc gccctctctc tctctctctc tgtctctctc
       61 tctctctcca ccttcaaagc tgaaacctac ctgacaatct cctgcctttg aatccagctc
      121 tggaaccaaa tgcatcattt tactgctctt aaaagtgaac agagtttgat tatctcaagc
      181 tacaagctgc tttgctccat aagaaggacc ccaaaggatc cagacatcat tggtttttaa
      241 tgtacctgaa gagttttgtt ttgtttattt ttttggcttt cttccctgaa acttgatggt
      301 gggaaggagt ttttgctttg tttttaattg gaatgttgaa aagttatctg ttcgggtttt
      361 ttttttttta tgcttgaaat ggaacctaat ttttaaatat agcttgagtc agatctaaag
      421 gagacatggc tgaccatttt ctgcaggact gacaaggaga acatctagag gggaacttgg
      481 taggaggaat gaaatctgat ttgcagcagc cggtctttct tttgagaaaa ttatcagact
      541 cattgataag ggaaattaaa tattgaccaa ggacaatgtc tttatttctc agtaacttat
      601 caacaaatga ctctagcctg tggaaagaga atcataattc tacggacctt ttaaatccgc
      661 caggaaccct gaatatctat cttttttgct tgacatgtct catgactttt gcagccttgg
      721 tgggcagcat ttattcacta atttccctgc tgaaaatgca gaacagaact gttgtgtcca
      781 tgcttgtggc ttcctggtct gtggatgatc tcatgagcgt cctgtcggtg accatcttca
      841 tgtttttgca gtggccaaac gaggtccccg gttacttcca atttctgtgc accacctctg
      901 ccttaatgta tttatgccag ggcctctcta gcaacttgaa ggcgactctc ctagtctctt
      961 acaactttta tacgatgcac agaggtgtgg ggagccagac agcctccaga agatcgggcc
     1021 aggtgctcgg cgtggtgctg accgtgtggg cagccagtct gctgctctcg gcgctcccgc
     1081 tgtgcggctg gggcgccttc gtgcgcacgc cctggggctg cctggtggac tgctccagct
     1141 cctacgtact attcctctct atcgtgtacg ctttggcctt cggactcctc gtgggcctct
     1201 cagtcccact cactcaccga ttgctgtgtt cggaggagcc gccgagactc cactccaact
     1261 accaggaaat ttcccgtgga gcttcaattc ctgggacccc tcctactgcg gggagagtgg
     1321 tttccctgtc cccagaggat gctccaggcc cgagtctgcg gcgctctggg ggatgctctc
     1381 cgagctccga caccgtgttc ggaccgggtg cgcccgctgc cgctggggct gaagcctgca
     1441 ggcgtgagaa ccgggggact ctctatggca ccaggagctt caccgtgagc gtagcgcaga
     1501 agcgcttcgc tttgatccta gcgcttacaa aagtcgtcct ttggctgccc atgatgatgc
     1561 acatggtggt ccagaacgtc gtggggtttc agagccttcc cttggagaca ttcagctttc
     1621 tacttaccct gctggccacc actgtaaccc cagtgtttgt cttgtccaaa cgctggaccc
     1681 acttgccctg tggctgcatc atcaactgca ggcagaacgc atatgcagtg gcgtccgatg
     1741 ggaaaaaaat caagagaaaa ggctttgaat tcaatctatc attccaaaaa agttatggga
     1801 tttataaaat agcacatgaa gattactatg atgatgatga aaattccata ttctatcaca
     1861 acctgatgaa ctctgagtgt gaaactacaa aagaccctca gagagacaac cgtaacatct
     1921 tcaatgctat aaaagtagaa atcagcacca cgccctctct ggacagctcc acacaaagag
     1981 gcatcaacaa atgcacaaat actgatatta cagaagctaa acaggattcc aacaacaaaa
     2041 aggatgcgtt ttctgacaaa acaggaggtg atattaacta tgaagaaact accttttctg
     2101 aagggccaga aagaagactg tctcatgaag agagtcagaa accagatctt tcagactggg
     2161 agtggtgtag gagtaaatca gaaagaaccc ctcgtcagcg ttccggttat gcccttgcca
     2221 ttcccttgtg tgcattccag gggactgtgt ctctccatgc acctacaggg aaaaccctat
     2281 ctctttctac ctatgaggta agcgcagaag ggcaaaaaat aactccagcc tctaagaaaa
     2341 tagaagtcta tcgatccaaa agtgttggcc atgaaccaaa ctcagaagat tcttcatcca
     2401 cgtttgtgga caccagtgtg aaaatacact tggaggttct tgaaatttgt gataatgaag
     2461 aggccttgga cactgtgtca atcattagta acatcagtca gtcctccaca caagtcagat
     2521 ctccatccct acgttactcc aggaaagaaa acagatttgt ttcatgtgac ctaggggaaa
     2581 cagcctcata ctccctcttt ttgcccacca gtaatcctga tggtgatatt aatatctcca
     2641 ttccagacac agtagaagca cacaggcaga acagtaaaag gcagcatcaa gagagggatg
     2701 gctaccagga ggaaatccag ttgttaaata aagcttacag aaaaagagag gaagaaagca
     2761 agggtagtta gtgggtattt ggtctaacag gagcaagaat ggatctgcaa cgtcaactgt
     2821 gaaactaaca cctttgttat gagactgatt tccttttatt tgttggctta cattagtttt
     2881 actgatttaa tagttaattt ttttgtggga acaactggaa ctagtgtaaa cacttaagtg
     2941 catttgatgt gttacctaaa gatcacacac tgtggtaatg aaaagatttt acttcttatc
     3001 tgacttctaa aaaatatttt ctaaatcaaa tcttggccta gtttaccaat gtttttgctt
     3061 gtcaacttcc tagtaaacag aaaattgtat aaactcagtg aatatactgt tccatgcata
     3121 tgtttctata tacaatgttg gcctttactg caaaggggaa aaaagaggaa ttctgggaat
     3181 ggaagaaatg taacaaaacc ccaaattata tttgaaggaa cttgcctaaa tgtggctagc
     3241 aaaacaagct tattacactt actgctttag ctttacattc ttctgtaaaa tgaaaaatta
     3301 gcttccaact gagaaacacg caggttccta gtctataaat agttgtttcc ttcatttcta
     3361 ccaaatataa attgtttact gttttttctt tttttcttac ctataacagt tttcctttca
     3421 tcttttcagt atgtcaagac tgtcccataa aacaaatata ttgtgtgtta gaggtggaat
     3481 tagaagtatc tttaactcaa acattattgg aaaaaagttg taattgtgta attgtatact
     3541 ttatcctaaa attgtttttt tttttaactt gagtggaaat tgggagaaaa tactggcaga
     3601 ttcagttatg agaggtacat ccaaacatgg taggcttctg gatacagcag agcaaaatcc
     3661 tctaagtcta aaacaaaagt atctgttttt aaagctgagg attgggcaac ctttcttagt
     3721 cattcttgaa atagaaaagt ttacttcaaa tattatatca agtttagctg cttttttgtt
     3781 tcttctctaa agacgtgttg tctcaaagaa acagttgaac ctattttatt aagtgattgt
     3841 aaggtataca tttcaagata attctagaat gcattacatt gcaaaaatgc aggaatcacc
     3901 ttggcagaat aatagtaaga tgtatttcaa aaattataaa gtgattttcc ttcaaattgc
     3961 tttattctaa ccttcctgta aacatatatg aaatgtatta cctaaaagtt tattttccaa
     4021 agttactgag ttgacacttt acatagtctt agactttgtg cccctcacat cactcacata
     4081 ctttatttat ttatttacag attgaatgaa ttgtgtttta gaatgattta ttttggtttc
     4141 tgttttatta ggttgaatta gaattcaaaa ttacttgaca tcggctttca gaatgtttca
     4201 tcttttgttg ccacaagcat gagtcatttt caaaataatt atctcaatgg actttctcaa
     4261 tctttaactt ctcaatatct agttatctaa atttgggaaa catatgtatt accactaata
     4321 atgtttgtaa agcaagcctc aaataatgtg taacatataa attcaaagtc aaatgtattc
     4381 tcgttacaaa tatattttat tttaaaagac tgtatcacca atattaacag ctattttaac
     4441 acagtgacaa atggacagat aaatcagata ttataaatca gtagcattaa atgtctttat
     4501 aaaagaaaaa ttgaattgaa tattctcata atgctttgta gaagataggc tttgatatct
     4561 taaacttaga tgtataattt tctgaaagag aaaggtgata ttgctgcttt aaaatgcaat
     4621 ttcaggcaaa aaggaaatta gacacaggat cataataaag ctgaagaaaa tagcaaagat
     4681 ttgaaggcaa acaaattctt tataactgca cagcaatttg aatgggatgg agattataac
     4741 agaaatcaag gtttaaagag cattaagaaa tagatagaag acaataatac ccattttccg
     4801 tctcatttta ttttaactgg acaagggctt aaactggggg aattggaaaa ataattagga
     4861 tattcccatt taattgccct tggttgttga attaactgta taatggatgc acataaaaat
     4921 tctgctgcat tgaaacaaca ccagtattat ttagcccaaa gtcttagttt gaaaggctaa
     4981 tcagcaccat attactaacc tgtaacactt caaactccaa gccaacaata gctgaatata
     5041 caagaaaaat ctactagagc tgtgcctaag catgaatgac gctccaaatc cttgttaagg
     5101 gaggagaagg ttaaactaca taagtttact taagtctgct tactctttag agtgattgat
     5161 tataaaagtg tgtttctagt agaggaaata cctttctaga tatcttgtga tatagccaaa
     5221 taccttaccc ttgtatagtt atattgttct tcttattaat aaatactata ttttgtatag
     5281 ttttctcttt tctctataaa ttgatgtatc tgaaggcaaa aacttattac ctaataaaaa
     5341 tatcaccatc tggtggtgac tcctataaac tgcaaacacg taatccccga gactcccaaa
     5401 tagtataaac acctaatata taatccctaa gacttctgag agttgtgact gacagaggca
     5461 actctttgaa gatagcaaat ggcacaatat tacttaaaaa tataataaaa gagtcttagt
     5521 tatgcat
//
