LOCUS       NM_001303473            1883 bp    mRNA    linear   PRI 13-NOV-2024
DEFINITION  Homo sapiens G protein-coupled receptor 146 (GPR146), transcript
            variant 3, mRNA.
ACCESSION   NM_001303473
VERSION     NM_001303473.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1883)
  AUTHORS   Ryk,A., Marcinkiewicz,A., Chrzanowski,J., Michalak,A.M., Drozdz,I.,
            Burzynski,J., Krejca,M. and Fendler,W.
  TITLE     Cholesin receptor signalling is active in cardiovascular
            system-associated adipose tissue and correlates with SGLT2i
            treatment in patients with diabetes
  JOURNAL   Cardiovasc Diabetol 23 (1), 211 (2024)
   PUBMED   38902687
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1883)
  AUTHORS   Tharehalli,U. and Rimbert,A.
  TITLE     G protein-coupled receptor 146: new insights from genetics and
            model systems
  JOURNAL   Curr Opin Lipidol 35 (3), 162-169 (2024)
   PUBMED   38465903
  REMARK    GeneRIF: G protein-coupled receptor 146: new insights from genetics
            and model systems.
            Review article
REFERENCE   3  (bases 1 to 1883)
  AUTHORS   Hu,X., Chen,F., Jia,L., Long,A., Peng,Y., Li,X., Huang,J., Wei,X.,
            Fang,X., Gao,Z., Zhang,M., Liu,X., Chen,Y.G., Wang,Y., Zhang,H. and
            Wang,Y.
  TITLE     A gut-derived hormone regulates cholesterol metabolism
  JOURNAL   Cell 187 (7), 1685-1700 (2024)
   PUBMED   38503280
REFERENCE   4  (bases 1 to 1883)
  AUTHORS   Huang,J., Xie,Y., Chen,B., Xia,Y., Jiang,Y., Sun,Z. and Liu,Y.
  TITLE     GPR146 regulates pulmonary vascular remodeling by promoting
            pulmonary artery smooth muscle cell proliferation through
            5-lipoxygenase
  JOURNAL   Eur J Pharmacol 961, 176123 (2023)
   PUBMED   37926274
  REMARK    GeneRIF: GPR146 regulates pulmonary vascular remodeling by
            promoting pulmonary artery smooth muscle cell proliferation through
            5-lipoxygenase.
REFERENCE   5  (bases 1 to 1883)
  AUTHORS   Rimbert,A., Yeung,M.W., Dalila,N., Thio,C.H.L., Yu,H., Loaiza,N.,
            Oldoni,F., van der Graaf,A., Wang,S., Said,M.A., Blauw,L.L.,
            Girardeau,A., Bray,L., Caillaud,A., Bloks,V.W., Marrec,M.,
            Moulin,P., Rensen,P.C.N., van de Sluis,B., Snieder,H., Di
            Filippo,M., van der Harst,P., Tybjaerg-Hansen,A., Zimmerman,P.,
            Cariou,B. and Kuivenhoven,J.A.
  TITLE     Variants in the GPR146 Gene Are Associated With a Favorable
            Cardiometabolic Risk Profile
  JOURNAL   Arterioscler Thromb Vasc Biol 42 (10), 1262-1271 (2022)
   PUBMED   36047410
  REMARK    GeneRIF: Variants in the GPR146 Gene Are Associated With a
            Favorable Cardiometabolic Risk Profile.
REFERENCE   6  (bases 1 to 1883)
  AUTHORS   Yosten,G.L., Kolar,G.R., Redlinger,L.J. and Samson,W.K.
  TITLE     Evidence for an interaction between proinsulin C-peptide and GPR146
  JOURNAL   J Endocrinol 218 (2), B1-B8 (2013)
   PUBMED   23759446
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1883)
  AUTHORS   Yosten,G.L., Kolar,G.R., Redlinger,L.J. and Samson,W.K.
  TITLE     Evidence for an interaction between proinsulin C-peptide and GPR146
  JOURNAL   J Endocrinol 218 (2), B1-B8 (2013)
   PUBMED   23980258
  REMARK    GeneRIF: Knockdown of GPR146 blocked C-peptide-induced cFos
            expression in KATOIII cells.
REFERENCE   8  (bases 1 to 1883)
  AUTHORS   Gloriam,D.E., Schioth,H.B. and Fredriksson,R.
  TITLE     Nine new human Rhodopsin family G-protein coupled receptors:
            identification, sequence characterisation and evolutionary
            relationship
  JOURNAL   Biochim Biophys Acta 1722 (3), 235-246 (2005)
   PUBMED   15777626
REFERENCE   9  (bases 1 to 1883)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 1883)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073957.7, BI910046.1, CD676083.1, BC014241.2 and AK300166.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001303473.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.952765.1,
                                           SRR3476690.1049433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444847.2/ ENSP00000410743.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC073957.7         165606-165632
            28-30               BI910046.1         5-7
            31-639              CD676083.1         1-609
            640-1389            BC014241.2         514-1263
            1390-1390           AK300166.1         1069-1069
            1391-1883           BC014241.2         1265-1757
FEATURES             Location/Qualifiers
     source          1..1883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..1883
                     /gene="GPR146"
                     /gene_synonym="PGR8"
                     /note="G protein-coupled receptor 146"
                     /db_xref="GeneID:115330"
                     /db_xref="HGNC:HGNC:21718"
     exon            1..113
                     /gene="GPR146"
                     /gene_synonym="PGR8"
                     /inference="alignment:Splign:2.1.0"
     exon            114..1883
                     /gene="GPR146"
                     /gene_synonym="PGR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1139
                     /gene="GPR146"
                     /gene_synonym="PGR8"
                     /note="G-protein coupled receptor PGR8"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 146"
                     /protein_id="NP_001290402.1"
                     /db_xref="CCDS:CCDS5321.1"
                     /db_xref="GeneID:115330"
                     /db_xref="HGNC:HGNC:21718"
                     /translation="MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCY
                     NALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVH
                     VALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSF
                     SSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDT
                     PLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHF
                     VKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA"
     regulatory      1859..1864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR146"
                     /gene_synonym="PGR8"
                     /note="hexamer: AATATA"
     regulatory      1865..1870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR146"
                     /gene_synonym="PGR8"
                     /note="hexamer: AATAAA"
     polyA_site      1875
                     /gene="GPR146"
                     /gene_synonym="PGR8"
     polyA_site      1883
                     /gene="GPR146"
                     /gene_synonym="PGR8"
                     /note="major polyA site"
ORIGIN      
        1 ggtcacgtgt gtacacaggg cccgggcggc gtgcgcgccg tgagccccgc cgcctccgcc
       61 agcccgagct gcccgcccgg cggcgactgc gccggccgcc gcccagcaag ccgggtcgcg
      121 gagcctcgcc ggccgccatg tggagctgca gctggttcaa cggcacaggg ctggtggagg
      181 agctgcctgc ctgccaggac ctgcagctgg ggctgtcact gttgtcgctg ctgggcctgg
      241 tggtgggcgt gccagtgggc ctgtgctaca acgccctgct ggtgctggcc aacctacaca
      301 gcaaggccag catgaccatg ccggacgtgt actttgtcaa catggcagtg gcaggcctgg
      361 tgctcagcgc cctggcccct gtgcacctgc tcggcccccc gagctcccgg tgggcgctgt
      421 ggagtgtggg cggcgaagtc cacgtggcac tgcagatccc cttcaatgtg tcctcactgg
      481 tggccatgta ctccaccgcc ctgctgagcc tcgaccacta catcgagcgt gcactgccgc
      541 ggacctacat ggccagcgtg tacaacacgc ggcacgtgtg cggcttcgtg tggggtggcg
      601 cgctgctgac cagcttctcc tcgctgctct tctacatctg cagccatgtg tccacccgcg
      661 cgctagagtg cgccaagatg cagaacgcag aagctgccga cgccacgctg gtgttcatcg
      721 gctacgtggt gccagcactg gccaccctct acgcgctggt gctactctcc cgcgtccgca
      781 gggaggacac gcccctggac cgggacacgg gccggctgga gccctcggca cacaggctgc
      841 tggtggccac cgtgtgcacg cagtttgggc tctggacgcc acactatctg atcctgctgg
      901 ggcacacggt catcatctcg cgagggaagc ccgtggacgc acactacctg gggctactgc
      961 actttgtgaa ggatttctcc aaactcctgg ccttctccag cagctttgtg acaccacttc
     1021 tctaccgcta catgaaccag agcttcccca gcaagctcca acggctgatg aaaaagctgc
     1081 cctgcgggga ccggcactgc tccccggacc acatgggggt gcagcaggtg ctggcgtagg
     1141 cggcccagcc ctcctgggga gacgtgactc tggtggacgc agagcactta gttaccctgg
     1201 acgctcccca catccttcca gaaggagacg agctgctgga agagaagcag gaggggtgtt
     1261 tttcttgaag tttccttttt cccacaaatg ccactcttgg gccaaggctg tggtccccgt
     1321 ggctggcatc tggcttgagt ctccccgagg cctgtgcgtc tcccaaacac gcagctcaag
     1381 gtccacatcc gcaaaagcct cctcgccttc agcctcctca gcattcagtt tgtcaatgaa
     1441 gtgatgaaag cttagagcca gtatttatac tttgtggtta aaatacttga ttcccccttg
     1501 tttgttttac aaaaacagat gtttcctaga aaaatgacaa atagtaaaat gaacaaaacc
     1561 ctacgaaaga atggcaacag ccagggtggc cgggccctgc cagtgggcgg cgtgtgctag
     1621 caaggcctgc cgggtgtgcc gcagtcacca cagggttctg agaacatttc acagaagtgc
     1681 ctgagacgcg gagacatggc tggtgttaaa tggagctatt caatagcagt gacgcgctct
     1741 cctcagccac caaatgtccc tgacaccctc cccagccccc acagataaca tcagctgagg
     1801 tttttttcag tatgaacctg tcctaaatca attcctcaaa gtgtgcacaa aactaaagaa
     1861 tataaataaa caaaagaaag gtg
//
