LOCUS       NM_001381946            3718 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 141 (GPR141), transcript
            variant 4, mRNA.
ACCESSION   NM_001381946
VERSION     NM_001381946.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3718)
  AUTHORS   Parija,M., Adhya,A.K. and Mishra,S.K.
  TITLE     G-protein-coupled receptor 141 mediates breast cancer proliferation
            and metastasis by regulating oncogenic mediators and the p-mTOR/p53
            axis
  JOURNAL   Oncotarget 14, 466-480 (2023)
   PUBMED   37204251
  REMARK    GeneRIF: G-protein-coupled receptor 141 mediates breast cancer
            proliferation and metastasis by regulating oncogenic mediators and
            the p-mTOR/p53 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3718)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3718)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   4  (bases 1 to 3718)
  AUTHORS   Shimizu,S., Momozawa,Y., Takahashi,A., Nagasawa,T., Ashikawa,K.,
            Terada,Y., Izumi,Y., Kobayashi,H., Tsuji,M., Kubo,M. and
            Furuichi,Y.
  TITLE     A genome-wide association study of periodontitis in a Japanese
            population
  JOURNAL   J Dent Res 94 (4), 555-561 (2015)
   PUBMED   25672891
  REMARK    GeneRIF: GPR141-NME8 locus had strong genetic effect on
            susceptibility to generalized periodontitis in Japanese individuals
            with history of smoking. identified suggestive loci for
            periodontitis in Japanese population.
REFERENCE   5  (bases 1 to 3718)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   6  (bases 1 to 3718)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083860.2 and AC083865.2.
            
            Summary: GPR141 is a member of the rhodopsin family of G
            protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed
            14623098]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3087308.1,
                                           DRR138517.916051.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334425.2/ ENSP00000334540.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC083860.2         120689-120826
            139-262             AC083860.2         122383-122506
            263-3718            AC083865.2         133109-136564
FEATURES             Location/Qualifiers
     source          1..3718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..3718
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /note="G protein-coupled receptor 141"
                     /db_xref="GeneID:353345"
                     /db_xref="HGNC:HGNC:19997"
                     /db_xref="MIM:609045"
     exon            1..138
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /inference="alignment:Splign:2.1.0"
     exon            139..262
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /inference="alignment:Splign:2.1.0"
     exon            263..3718
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1194
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /note="G-protein coupled receptor PGR13"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 141"
                     /protein_id="NP_001368875.1"
                     /db_xref="CCDS:CCDS5451.1"
                     /db_xref="GeneID:353345"
                     /db_xref="HGNC:HGNC:19997"
                     /db_xref="MIM:609045"
                     /translation="MPGHNTSRNSSCDPIVTPHLISLYFIVLIGGLVGVISILFLLVK
                     MNTRSVTTMAVINLVVVHSVFLLTVPFRLTYLIKKTWMFGLPFCKFVSAMLHIHMYLT
                     FLFYVVILVTRYLIFFKCKDKVEFYRKLHAVAASAGMWTLVIVIVVPLVVSRYGIHEE
                     YNEEHCFKFHKELAYTYVKIINYMIVIFVIAVAVILLVFQVFIIMLMVQKLRHSLLSH
                     QEFWAQLKNLFFIGVILVCFLPYQFFRIYYLNVVTHSNACNSKVAFYNEIFLSVTAIS
                     CYDLLLFVFGGSHWFKQKIIGLWNCVLCR"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /note="hexamer: AATAAA"
     polyA_site      2759
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /note="major polyA site"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /note="hexamer: AATAAA"
     polyA_site      3718
                     /gene="GPR141"
                     /gene_synonym="PGR13"
                     /note="major polyA site"
ORIGIN      
        1 gagctgtcca gagcctttgc aaatgcatgc agagcatgga aatgacccag ctgccctgct
       61 gttgaaacag aatcctattt ggaaggcaga catgtggccc atctctgtag ccatcactga
      121 gaaatctgga ttttcaaggg cctttctctc tgttgcccag gctggagttt agcgactcaa
      181 tcatggctca ctgactgcag catcgacctc cggggctcaa gtgatccttt catctcagcc
      241 tcctcagtag ctgagactac aggtgacttc ccaagtatgc ctggccacaa tacctccagg
      301 aattcctctt gcgatcctat agtgacaccc cacttaatca gcctctactt catagtgctt
      361 attggcgggc tggtgggtgt catttccatt cttttcctcc tggtgaaaat gaacacccgg
      421 tcagtgacca ccatggcggt cattaacttg gtggtggtcc acagcgtttt tctgctgaca
      481 gtgccatttc gcttgaccta cctcatcaag aagacttgga tgtttgggct gcccttctgc
      541 aaatttgtga gtgccatgct gcacatccac atgtacctca cgttcctatt ctatgtggtg
      601 atcctggtca ccagatacct catcttcttc aagtgcaaag acaaagtgga attctacaga
      661 aaactgcatg ctgtggctgc cagtgctggc atgtggacgc tggtgattgt cattgtggta
      721 cccctggttg tctcccggta tggaatccat gaggaataca atgaggagca ctgttttaaa
      781 tttcacaaag agcttgctta cacatatgtg aaaatcatca actatatgat agtcattttt
      841 gtcatagccg ttgctgtgat tctgttggtc ttccaggtct tcatcattat gttgatggtg
      901 cagaagctac gccactcttt actatcccac caggagttct gggctcagct gaaaaaccta
      961 ttttttatag gggtcatcct tgtttgtttc cttccctacc agttctttag gatctattac
     1021 ttgaatgttg tgacgcattc caatgcctgt aacagcaagg ttgcatttta taacgaaatc
     1081 ttcttgagtg taacagcaat tagctgctat gatttgcttc tctttgtctt tgggggaagc
     1141 cattggttta agcaaaagat aattggctta tggaattgtg ttttgtgccg ttagccacaa
     1201 actacagtat tcatatttgc ttcctttata ttgggaataa aaatgggtat aggggaggta
     1261 agaatggtat ttcattactt gatcaaaacc atgccttgat gtacccaaaa caaaaggact
     1321 ataaaatgca agagccctca ttgtagtcct tatgggatcc ctcccatctc tgagtgatgg
     1381 ccgtacaaag accagtgttg ttgaatccac ctggagttgc aatattacat tattttccag
     1441 tacagaatgt ctgtgtggcc catgaaagca acataggttt taagagtttt agagtttcat
     1501 tagctcattc taagttcctc tgtttgaagc atggtctctt aggttttgga ctgaactcag
     1561 acctttagtt cttttcatcc cacttcacct taggtaagta aattctggcc accacccagc
     1621 tccaaagaca caaactctcc ttcgctaacc aggttagatg tcccattcat ctcatgccct
     1681 gataaaaact gataagggga gagaatagtt aaaaattttt ctagggtatc ataactctgg
     1741 taggaagtca tctgtctaga aatcaagaga aaaagaacgt gtggcctcct gttataacaa
     1801 gggtttctag atttgtcctg tgaaaggtcg tttaaggact tggggatcaa cttcctcaat
     1861 tatcaccaat tgcactgttg ctccaaaaat catttaaaag cttactggac atatctacat
     1921 aatggtgaaa ctgtaattta gagactatcc ctgactaatg tgctggtagg cattaaaatg
     1981 agttcccaag ggaagtgatt aaaatttttt tctcttctgt tttttgagag aatttctaga
     2041 tgtcctgggc cacagttaat taagattttt aggggggaca gaaagttata ctgaaatctt
     2101 tagagctccc ttccgccgtt aaaattatat atatatatat ttaaattata ccttaagttc
     2161 tggggtacat gtgcagaatg tgcaggtttg ttacataggt atacacgtgc catggtggtt
     2221 tgcggcacct gtcaacccat ctacattagg tatttctcct aatgctctcc ctcccctagc
     2281 cccccacccc tggacaggcc ccattgtgtg atgttcccct ccctgtgtcc atgtgttttc
     2341 attgttcaac tcccacttct aagtgagaac atgcggtgtt tggttttctg ttcctgtgtt
     2401 agtttgctga gaatgatggt ttccaggtta aaattatata tttttaaata aatgaaaact
     2461 gtgtttttaa aagaggactt ttgagaagta tatagaaaaa ccattaattt agactctgtg
     2521 agattaggtt gcatgaagaa ggttttctga atatttgaag agtggataaa taaatgtccc
     2581 ccaaagcaat aaaatcataa tcctttaaaa tataggaaaa ataactaatg ggaactaggc
     2641 ttaatactcg ggatgaaata atctgtacaa caaactccca tgacacatgt ttacctatgt
     2701 aacaaacctg cacatgtacc cctgaactta aaataaaatt taaagtaata ataataaaat
     2761 aatatggatt ttctttccaa attcggaatt actttttgta aaattgtatt aataacttgt
     2821 ggcatgtggc acgttaaact gattttattt caagaacttc tgttactggc taggttgata
     2881 cataggcttg tgggtttttg ctttttgggt tttttttgct cctgcccata cttccagtgt
     2941 cttcagtgtt ttatcttaaa attttcccag gatctgatcc agtttcatat ttaatgctgc
     3001 agaaaacctg aagtgattag taacatgaat agaataacag aatgaattaa gggaactttt
     3061 tttttcatca aggtatatct tcgggattta aaagtttttc ataatttatt atcactgtgg
     3121 atccacaaat tcctcagatg aataagaaat acctctgtga atttctgtga ccactaaaat
     3181 tactgagcca cagaaattaa ttctgaggaa gcagaagtag caacatagtt caaacatgac
     3241 ttgtttccat atattttctg ttttatatat tcttttaaat atccttttaa acaagtaata
     3301 tttcttttct ttcttgcctt ttttcccatt tattttttac attttttctt tctcattttg
     3361 aaccataaaa tttgtaagac cgttactaag acccctgata gttttaagaa aatttataat
     3421 acctataaat atgtaaaaaa aatttagaaa aatatttaaa ttaaaagtat tcatgagaat
     3481 ttcattacct tgtagattat gtcatactct tttccagatt ttagatatgt tgaggtcagg
     3541 caattcaaaa gaattaatct ctgtattaat ctgttataat gttaacataa cactatgtta
     3601 ttttcatata ttataataac aggcttatta gaaatgttct caaaagatag aaatgcaata
     3661 tttcataata taaaatatct ttttcatcag tatttatgga ataaatagaa aaatttta
//
