LOCUS       NM_001002911            4832 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens G protein-coupled receptor 139 (GPR139), transcript
            variant 1, mRNA.
ACCESSION   NM_001002911 XM_064062
VERSION     NM_001002911.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4832)
  AUTHORS   Pallareti,L., Rath,T.F., Trapkov,B., Tsonkov,T., Nielsen,A.T.,
            Harpsoe,K., Gentry,P.R., Brauner-Osborne,H., Gloriam,D.E. and
            Foster,S.R.
  TITLE     Pharmacological characterization of novel small molecule agonists
            and antagonists for the orphan receptor GPR139
  JOURNAL   Eur J Pharmacol 943, 175553 (2023)
   PUBMED   36736525
REFERENCE   2  (bases 1 to 4832)
  AUTHORS   Liu,C., Bonaventure,P., Lee,G., Nepomuceno,D., Kuei,C., Wu,J.,
            Li,Q., Joseph,V., Sutton,S.W., Eckert,W., Yao,X., Yieh,L.,
            Dvorak,C., Carruthers,N., Coate,H., Yun,S., Dugovic,C.,
            Harrington,A. and Lovenberg,T.W.
  TITLE     GPR139, an Orphan Receptor Highly Enriched in the Habenula and
            Septum, Is Activated by the Essential Amino Acids L-Tryptophan and
            L-Phenylalanine
  JOURNAL   Mol Pharmacol 88 (5), 911-925 (2015)
   PUBMED   26349500
REFERENCE   3  (bases 1 to 4832)
  AUTHORS   Dvorak,C.A., Coate,H., Nepomuceno,D., Wennerholm,M., Kuei,C.,
            Lord,B., Woody,D., Bonaventure,P., Liu,C., Lovenberg,T. and
            Carruthers,N.I.
  TITLE     Identification and SAR of Glycine Benzamides as Potent Agonists for
            the GPR139 Receptor
  JOURNAL   ACS Med Chem Lett 6 (9), 1015-1018 (2015)
   PUBMED   26396690
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4832)
  AUTHORS   Isberg,V., Andersen,K.B., Bisig,C., Dietz,G.P., Brauner-Osborne,H.
            and Gloriam,D.E.
  TITLE     Computer-aided discovery of aromatic l-alpha-amino acids as
            agonists of the orphan G protein-coupled receptor GPR139
  JOURNAL   J Chem Inf Model 54 (6), 1553-1557 (2014)
   PUBMED   24826842
REFERENCE   5  (bases 1 to 4832)
  AUTHORS   Castellani,C.A., Awamleh,Z., Melka,M.G., O'Reilly,R.L. and
            Singh,S.M.
  TITLE     Copy number variation distribution in six monozygotic twin pairs
            discordant for schizophrenia
  JOURNAL   Twin Res Hum Genet 17 (2), 108-120 (2014)
   PUBMED   24556202
REFERENCE   6  (bases 1 to 4832)
  AUTHORS   Matsuo,A., Matsumoto,S., Nagano,M., Masumoto,K.H., Takasaki,J.,
            Matsumoto,M., Kobori,M., Katoh,M. and Shigeyoshi,Y.
  TITLE     Molecular cloning and characterization of a novel Gq-coupled orphan
            receptor GPRg1 exclusively expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 331 (1), 363-369 (2005)
   PUBMED   15845401
  REMARK    GeneRIF: Molecular cloning of GPRg1, a Gq-coupled orphan receptor
            that is expressed in the brain.
REFERENCE   7  (bases 1 to 4832)
  AUTHORS   Gloriam,D.E., Schioth,H.B. and Fredriksson,R.
  TITLE     Nine new human Rhodopsin family G-protein coupled receptors:
            identification, sequence characterisation and evolutionary
            relationship
  JOURNAL   Biochim Biophys Acta 1722 (3), 235-246 (2005)
   PUBMED   15777626
REFERENCE   8  (bases 1 to 4832)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   9  (bases 1 to 4832)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   10 (bases 1 to 4832)
  AUTHORS   Ottolenghi,C., Fellous,M., Barbieri,M. and McElreavey,K.
  TITLE     Novel paralogy relations among human chromosomes support a link
            between the phylogeny of doublesex-related genes and the evolution
            of sex determination
  JOURNAL   Genomics 79 (3), 333-343 (2002)
   PUBMED   11863363
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291384.1, BC137237.1 and
            AC021089.8.
            
            On Nov 27, 2019 this sequence version replaced NM_001002911.3.
            
            Summary: This gene encodes a member of the rhodopsin family of
            G-protein-coupled receptors. The encoded protein is almost
            exclusively expressed in the central nervous system. L-tryptophan
            and L-phenylalanine may act as the physiologic ligands of the
            encoded protein. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2016].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291384.1, SRR14038193.2314684.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156099, SAMN03267763
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000570682.2/ ENSP00000458791.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AK291384.1         28-209
            183-1404            BC137237.1         60-1281
            1405-1586           AK291384.1         1432-1613
            1587-4832           AC021089.8         14738-17983         c
FEATURES             Location/Qualifiers
     source          1..4832
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..4832
                     /gene="GPR139"
                     /gene_synonym="GPRg1; PGR3"
                     /note="G protein-coupled receptor 139"
                     /db_xref="GeneID:124274"
                     /db_xref="HGNC:HGNC:19995"
                     /db_xref="MIM:618448"
     exon            1..401
                     /gene="GPR139"
                     /gene_synonym="GPRg1; PGR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1336
                     /gene="GPR139"
                     /gene_synonym="GPRg1; PGR3"
                     /note="isoform 1 is encoded by transcript variant 1; G
                     protein-coupled receptor PGR3; probable G-protein coupled
                     receptor 139; g(q)-coupled orphan receptor GPRg1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 139 isoform
                     1"
                     /protein_id="NP_001002911.1"
                     /db_xref="CCDS:CCDS32398.1"
                     /db_xref="GeneID:124274"
                     /db_xref="HGNC:HGNC:19995"
                     /db_xref="MIM:618448"
                     /translation="MEHTHAHLAANSSLSWWSPGSACGLGFVPVVYYSLLLCLGLPAN
                     ILTVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILNMQMPQVPDK
                     IIEVLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTS
                     IPYYWWPNIWTEDYISTSVHHVLIWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRL
                     RGYSTGKTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALL
                     NTAINFFLYCFISKRFRTMAAATLKAFFKCQKQPVQFYTNHNFSITSSPWISPANSHC
                     IKMLVYQYDKNGKPIKVSP"
     exon            402..4832
                     /gene="GPR139"
                     /gene_synonym="GPRg1; PGR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4643..4648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR139"
                     /gene_synonym="GPRg1; PGR3"
                     /note="hexamer: AATAAA"
     polyA_site      4665
                     /gene="GPR139"
                     /gene_synonym="GPRg1; PGR3"
                     /note="major polyA site"
     regulatory      4809..4814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR139"
                     /gene_synonym="GPRg1; PGR3"
                     /note="hexamer: ATTAAA"
     polyA_site      4832
                     /gene="GPR139"
                     /gene_synonym="GPRg1; PGR3"
                     /note="major polyA site"
ORIGIN      
        1 acagacgggc tccgggagcc cctcccgagg ccccgcgcag cgcgccccgc accctgcgcc
       61 ccgcgccctg cgggagggct gagccaagac tccaggcggg caggtgcgga gcgagcagag
      121 gggatcacgg ccaagggtag gagccagtcc tgcggggaga gaggcgctgc tgctccagct
      181 gccgctgcct ccgccgccgc caccaccgag ccggcgacca gagtcgggct ggcaggccgg
      241 gcgcgaagcg gcaaggggag cgaggggcgc gctcatggag cacacgcacg cccacctcgc
      301 agccaacagc tcgctgtctt ggtggtcccc cggctcggcc tgcggcttgg gtttcgtgcc
      361 cgtggtctac tacagcctct tgctgtgcct cggtttacca gcaaatatct tgacagtgat
      421 catcctctcc cagctggtgg caagaagaca gaagtcctcc tacaactatc tcttggcact
      481 cgctgctgcc gacatcttgg tcctcttttt catagtgttt gtggacttcc tgttggaaga
      541 tttcatcttg aacatgcaga tgcctcaggt ccccgacaag atcatagaag tgctggaatt
      601 ctcatccatc cacacctcca tatggattac tgtaccgtta accattgaca ggtatatcgc
      661 tgtctgccac ccgctcaagt accacacggt ctcataccca gcccgcaccc ggaaagtcat
      721 tgtaagtgtt tacatcacct gcttcctgac cagcatcccc tattactggt ggcccaacat
      781 ctggactgaa gactacatca gcacctctgt gcatcacgtc ctcatctgga tccactgctt
      841 caccgtctac ctggtgccct gctccatctt cttcatcttg aactcaatca ttgtgtacaa
      901 gctcaggagg aagagcaatt ttcgtctccg tggctactcc acggggaaga ccaccgccat
      961 cttgttcacc attacctcca tctttgccac actttgggcc ccccgcatca tcatgattct
     1021 ttaccacctc tatggggcgc ccatccagaa ccgctggctg gtacacatca tgtccgacat
     1081 tgccaacatg ctagcccttc tgaacacagc catcaacttc ttcctctact gcttcatcag
     1141 caagcggttc cgcaccatgg cagccgccac gctcaaggct ttcttcaagt gccagaagca
     1201 acctgtacag ttctacacca atcataactt ttccataaca agtagcccct ggatctcgcc
     1261 ggcaaactca cactgcatca agatgctggt gtaccagtat gacaaaaatg gaaaacctat
     1321 aaaagtatcc ccgtgattcc ataggtgtgg caactactgc ctctgtctaa tccatttcca
     1381 gatgggaagg tgtcccatcc tatggctgag cagctctcct taagagtgct aatccgattt
     1441 cctgtctccc gcagactggg caattctcag actggtagat gagaagagat ggaagagaag
     1501 aaaggagagc atgaagcttg tttttactta tgcatttatt tccacagagt cgtaatgaca
     1561 gcaaaagctc ctaccagttt gaagatgcca ttggagcttg tgtcatcatc ctgtgaccag
     1621 ttaggacaca aagtagagaa gtagtctgtg atttcgccct ggtaccatcc acagtcactg
     1681 ggaacccttc atttatggga cttaccaagc cccagtagca catagctgag cctgcactct
     1741 tcttccgaga gctgaggtca ttcatcactt ccctctgctg ttcccaggag ctaacaataa
     1801 tgactatttc aggatttttt tcaaggtgcc ctttgtccta gagagggttg tggtcttgaa
     1861 ttggctctgg cactcctagc ttcagaatga cactgtggga atagaagagt attggatccc
     1921 atccaaactg tggccagagc ttcttcagga aatctccaaa cccgcatagc tgtgacctca
     1981 aacctggggt ctaaaaggca gttttctatt tatcattatg tatagatttt ctctatctcc
     2041 tccaaaacaa agaccctgcc tggtgcgcag ggggaaagga ggaattctcg agcccagaaa
     2101 aacaaaaaaa taagcccaca cttgccattg tttcaaccca tccctgtgtc agctgcatac
     2161 gatcccgtta ctcaaaattg cttcttgtta tggtatcact ccagcttcct agagaagcct
     2221 ttttacgtgt caagttgcca accctgcctc cttgcttgct gaggccctca ccaaattgtt
     2281 ttatttgaag tgacttccga actgaattta atattcaagg gtcaggaact gcagctctgc
     2341 gggtatgaga ggaggtgttc tcagctctgt ctcacagccc agctggcgct gccatttcgc
     2401 cacaaacgca gacacaaaag gtgcccatgc tgacgcctcg tctgcccttt gacgcacatg
     2461 gctcaaaagg gggtgccagt tcttggtaaa gctatttaac ccagatcctt tgtaaaatga
     2521 taaaatataa gtgtgtttat ttattctacc cttgcctgtc caaggcaaga acatttctag
     2581 gatgtaatga ataggggcat ccctggaaat tgctacttat gtgtgcagca cacacacaca
     2641 catgattata ttcgtcttat ttagtgtttc ttttttcttc tttttttttt aacttctccc
     2701 tcagattccc agtattcgaa ttcatccctg ttttggaata aatttgccaa actgactttg
     2761 aaattgcatg acatttttgg tgaccaaaaa acggcagaca gtccacctgg aatatttagt
     2821 tcctcaggct ggatttttac tgcattttgt ccctaagttg gaagacatgt ctatcttttt
     2881 taagggaatt tgcaataaat gaatgggata agaaaaggcc ccatggcaac acaaacccta
     2941 aacttcagcc aatgctctca atactaactc aatacaaact taggtcatat tagtcctgat
     3001 gatcctaatt cttacccctt ttaaaggatc gcaatagaat ctcatcagag ccaaggatta
     3061 gattctaaag tcagtgcaaa agataaaacc ttacagagcc aaagttacct ttgcaaaaga
     3121 tcctcaaaaa agagccatgt tggagattat attccattgc tttcaaaacc taacacagct
     3181 aagtttttct ctagcattgg aacaagttgc tgtttctctg gttgatgaca agacagaatt
     3241 ggctctcatt tagggaccat attgtgtgat tctaatgtat ctgagaacat taggaccacc
     3301 ctggtgcatc aagatgcttc cactcaaaga agttcatgga agtcgtctga ctgagggaca
     3361 gatctcccat ctcccacgct ccccagggcg tatgctcatt gagtggaatg gtaagcagat
     3421 tccctcacct cccttaaatt gcatttctct ctgtctcttt tttgccaagc acgtgtaatt
     3481 gaacatgtgt tcattaaatg tgtgtgtgat gcaacgccac tacaccccct tatgaatgga
     3541 cattgaccaa aggctaccta tactgaatat atatatatat atatatttat ttatttattt
     3601 tttaaacatg tagctctgaa aaatgctagt ttgagctaca catgaatgag tcaaagtgca
     3661 atatctacaa aggttaagca attccttttt gagaatgtat ataagatgga aaatatgtat
     3721 gtgactctcc atgctctctg ctccatattt ttaattgtgt gtaacaatta attgttgatg
     3781 tttaaaaact gggtgtgcat tgggaacatt ttcctcagac actttaattt attacttctc
     3841 gatgatagag gctctaccac gtggtattgt gatctctttt cctccgaata tattttatat
     3901 tttgctacat gatatttaaa agaggtccaa ttcttgaagg cactgtagtg aattgctgtc
     3961 ttctgcttaa aatgcaaatg aatgcccatt gggttaggtt gattcatatc tcttaaaatt
     4021 tatttcaaac tatctaagga cttttattat tatttatagt aataattatg gacatcatga
     4081 aatgggtttt ttttaacttt aaaactttaa aaacttgtaa gccttttctt tcaggccagt
     4141 tttgacaata aagccttgaa ctttgaagcc tgtcatgtaa atggctgctg ctggtggcac
     4201 taaagcaatt gccttatcgt gggtttttgt ggtgcctctt tcaaagacag ttaactagct
     4261 tctctcttgc tatatgattt gtgtccttgg ttggacattg caatgatgat acgcaccacc
     4321 atgctgtgtc tttttattga acaacttgac ggctgaaatg tctcatgggg aaggaaatga
     4381 ggggaatgac agacaaacca taaaagacag accggagtgg gcacgaactt gtgtgttgca
     4441 aacaccctgc tattggaaaa gatcactttg cacatttggt acctcctggt tcaacatggg
     4501 gagcctaccc gaagtgaata aaagactcta atgttggcta ttccagttca gagaatggaa
     4561 tagaaagtta ccatagaaaa aaagcaaatg ttcatatttt cttaattaga ttatatattg
     4621 tgtttggact tgtttgtatt ataataaatt ctaatatggt gcacacttgg tgtttggtat
     4681 ttgcatctat gttcaagcaa ttgcagtatg ctgattttta ttactattat ttttaattga
     4741 taaatcataa ttgtatacat ttatgggata caatgtgatg ttttgatata tgtatacaat
     4801 gtggaataat taaatcaagc taaattaaca ca
//
