LOCUS       NM_001099652            4200 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 137C (GPR137C), transcript
            variant 2, mRNA.
ACCESSION   NM_001099652 XM_290615 XM_941182
VERSION     NM_001099652.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4200)
  AUTHORS   Gan,L., Seki,A., Shen,K., Iyer,H., Han,K., Hayer,A., Wollman,R.,
            Ge,X., Lin,J.R., Dey,G., Talbot,W.S. and Meyer,T.
  TITLE     The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1
            localization and activity
  JOURNAL   Nat Cell Biol 21 (5), 614-626 (2019)
   PUBMED   31036939
REFERENCE   2  (bases 1 to 4200)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   3  (bases 1 to 4200)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   4  (bases 1 to 4200)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157971.4, AW470753.1, AK123953.1, BX647179.1, AL133453.3 and
            BM842962.1.
            
            On Aug 7, 2018 this sequence version replaced NM_001099652.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.231411.1,
                                           SRR1803616.32931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321662.11/ ENSP00000315106.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               AL157971.4         33713-34085         c
            374-416             AW470753.1         1-43
            417-2630            AK123953.1         1-2214
            2631-3324           BX647179.1         3840-4533
            3325-3325           AL133453.3         99990-99990
            3326-3763           BM842962.1         106-543
            3764-4200           BX647179.1         4973-5409
FEATURES             Location/Qualifiers
     source          1..4200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..4200
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /note="G protein-coupled receptor 137C"
                     /db_xref="GeneID:283554"
                     /db_xref="HGNC:HGNC:25445"
     exon            1..756
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1602
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     integral membrane protein GPR137C; G protein-coupled
                     receptor TM7SF1L2; transmembrane 7 superfamily member
                     1-like 2 protein"
                     /codon_start=1
                     /product="integral membrane protein GPR137C isoform 2"
                     /protein_id="NP_001093122.1"
                     /db_xref="CCDS:CCDS45106.1"
                     /db_xref="GeneID:283554"
                     /db_xref="HGNC:HGNC:25445"
                     /translation="MRVSVPGPAAAAAPAAGREPSTPGGGSGGGGAVAAASGAAVPGS
                     VQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLLWAALRTTLFSA
                     AFSLSGSLPLLRPPAHLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELD
                     RHKILLHLGFIMASLLFLVVNLTCAMLVHGDVPENQLKWTVFVRALINDSLFILCAIS
                     LVCYICKITKMSSANVYLESKGMSLCQTVVVGSVVILLYSSRACYNLVVVTISQDTLE
                     SPFNYGWDNLSDKAHVEDISGEEYIVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPA
                     GMINSHSYSSRAYFFDNPRRYDSDDDLPRLGSSREGSLPNSQSLGWYGTMTGCGSSSY
                     TVTPHLNGPMTDTAPLLFTCSNLDLNNHHSLYVTPQN"
     exon            757..800
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1029
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1179
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1305
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1424
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..4200
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /note="hexamer: AATAAA"
     polyA_site      3217
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /note="major polyA site"
     regulatory      4179..4184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /note="hexamer: AATAAA"
     polyA_site      4200
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggagc gagcgcctca aatgctcggg tttctcagct gattgtctcc agccgagagt
       61 tgttttttgc agctacggag ccgagccgca gcaggaggag ccgagacccc cggggggtgg
      121 ggggaaagag gaggcggggt ccgggggagc cgcggctgct ttgcgctgga ctccgggtcc
      181 cgtcacggcg cttcctgggg ttagaggctg gggtgggtgg ggggtaaggg ggcagtcctt
      241 ctccccttcg acggcggctc cgagtccagc cccttccttc ccgcgctcgc tcgcccggcc
      301 cccagccccc tcatgagggt gtccgtgccg ggtccggcgg ccgctgccgc ccccgcagcc
      361 ggccgcgagc cctccacgcc cggcgggggc agcggaggcg gaggcgccgt cgctgcagcc
      421 tcaggcgccg cggtgccggg ctccgtgcag ttggcgctga gcgtcctgca cgccctgctc
      481 tacgccgcgc tgttcgcctt tgcctacctg cagctgtggc ggctgctcct gtaccgcgag
      541 cggcggctga gttaccagag cctctgcctc ttcctctgtc tcctgtgggc agcgctcagg
      601 accaccctct tctccgccgc cttctcgctc agcggctccc tgcccttgct ccggccgccc
      661 gctcacctgc acttcttccc ccactggctg ctctactgct tcccctcctg tctccagttc
      721 tccacgctct gtctcctcaa cctctacctg gcggaggtta tatgtaaagt cagatgtgcc
      781 actgaacttg acagacacaa aattctactg catttgggct ttataatggc aagcctgctc
      841 tttttagtgg tgaacttgac ttgcgcaatg ctagttcatg gagatgtccc agaaaatcag
      901 ttgaagtgga ctgtgtttgt tcgagcatta attaatgata gcctgtttat tctttgtgcc
      961 atctctttag tgtgttacat atgcaaaatt acaaaaatgt catcagctaa tgtctacctc
     1021 gaatcaaagg gtatgtctct gtgccagact gtcgtcgtgg gctctgtagt cattcttctg
     1081 tactcttcca gagcttgtta taatttggtg gtggtcacca tatctcagga tacattagaa
     1141 agtccattta attatggctg ggataatctt tcagataagg ctcatgtaga agacataagt
     1201 ggagaagagt atatagtatt tggaatggtc ctctttctgt gggaacatgt gccagcatgg
     1261 tcggtggtac tgtttttccg ggcacagaga ttaaaccaga atttggcacc tgctggcatg
     1321 ataaatagtc acagttatag ttccagagct tactttttcg acaatccaag acgatatgat
     1381 agtgatgatg acctgccaag actgggaagt tcaagagaag gaagtttacc aaattcgcaa
     1441 agtttgggct ggtatggcac catgactggg tgtggcagca gcagttacac agtcactccc
     1501 cacctgaatg gacctatgac agatactgct cctttgctct ttacttgtag taatttagat
     1561 ttgaacaatc atcatagctt atatgtgaca ccacaaaact gacagcatca ccaagtcatg
     1621 attcttgagt tgtttttcat aaatgtgtat attcaatgtg tttaaattcc atctacataa
     1681 acattccatt atctgttgca actgaaaaca aaatctggaa gtgtggctgt gtttggtaaa
     1741 taacacagct attatttttg acctcttcat agtaaaatga agtaaaatgg aaagtttgga
     1801 gtaggagaaa agagagatta gatcttaagg cacttgatgg cctccaaaaa tcctgacttt
     1861 ggaacatcaa atgcatatgt gcacttttat ctttgttctg agtcactgca gtccccaaag
     1921 tcatatgcca atgttcacac tgaaatactg tattgtacac caaactggaa ggcaattttc
     1981 ctatgaaaat caaagccggt atattcattg gtatgctcta tacagatatc ttaataaaaa
     2041 ttttatagtg tgaacagtgc acagagttaa ggcataaaaa tgtatcattc tttataaaaa
     2101 tctactgaaa atgtgtaatc attgaagaca gttcttttaa gcatgatttt aaaatagcaa
     2161 ctgaaattca atcattttaa acaaatgatg gtagtaatcc attagttatg gccagcagtg
     2221 ttctttggag agccacaata atttcaagag gaaaatatac cagtgaaaat tgtgtggcta
     2281 ttttgagtag aattggtcag ttgattattt tgtgtaattg agatatatgt agtagtttaa
     2341 gcatgattct tgaagaaagc aatagtgact tttgcatagg gagattttgg tagaaacttc
     2401 ttgggactaa acaagtttag agatgcattt aagaattatt cacaaaatgt gtaattctaa
     2461 attaaaacat aaatatattt tcaaaagcat ttgatttctc tgaagcatga tatagctggt
     2521 cttacctagt gaatcaggat tgtcctcagg taaatgaaat catgatacat tattgcagtg
     2581 aactcaagtg caatactttg taagacatat aattcctatg attttcacat ttttatatct
     2641 tatatatggg aaaagccaaa ttaaattgaa ttcagattaa ttccagcatt agactaaatg
     2701 agcaaactta agtaaatgta caaactaggt aagtataaaa ccacaggtta acaatattgg
     2761 agtactttta gaattacatt aaaactgtct taaatgtcct atcccaaatc taaaaaaaaa
     2821 gaaaatggca ggctgagata atacagaatt ttaaaatgca ctttgtacca gtgtctatat
     2881 ggaaagaagt agatgctgaa tacctcaaga tgccaaggga acaagcaaca ttgggaagtt
     2941 gtcacaacat gctcaaagac aaactacaat tgtctgctag ctatttcttc agaactggaa
     3001 ctaatacgac tatccttttc tgttttatac tttgattaga atgttatttc ctcgcttact
     3061 taaaatgtac ttcaactttt taacaactga tacaataact tcataaaagt ataacactag
     3121 gttgaaacct taaggaaaaa ttgaaattgt taatgctttc gatcttttgg gaggccagta
     3181 cacagacaaa taaatttctt ctttttatga tacaaaatga ctttgtattc aatcagaagc
     3241 atatacttat gttattttgg gtttgtttat aattctctca ttgtaaccaa attattttaa
     3301 aatgtatagt ataaaaagtt acccgtggta ttaagtgaca aaagcgtact tttattacaa
     3361 ctccagttgt tagattgctt ctcagaatgc taactgttta ttttgctaat aatgttaggc
     3421 atctaatcat ctagagctgt ccaaaaagat atgttgtctt tgttaatcct tggggttcaa
     3481 ggtgataaag tttttctagt aaggctcccc tcgataatgt tcctatttga ccaaactaac
     3541 aaagattact ttttaaaaat ttttcagata aaataacttg gttctttctg ctgcattagt
     3601 tgattgttcc aaatttgagg tttgtaagtt tattcttatc actgactagg gtacccaaat
     3661 tcttgcattt gtctccttat acacatctaa catatcacca aagacaaata aagatacact
     3721 ctggcccaat ctttgcttaa aaattccaaa gcactaggag cactttaagt ttggtctcga
     3781 aaggagttgt ttataaaatc aaagggctac cgattccctg ttcatcctgc actgaagcac
     3841 atgatgacag tatcaaacct tcatttttgt tcattaaaaa gtgaatttca ttacttaagt
     3901 gtgtaattct atagtgatta gcagtatttg ttttcatcat ttcacttggg tggccattaa
     3961 ttttgaaacc tttaccactc attgtagttg gttgtagttt tatggaaaat gtaatttata
     4021 gctaaagtgg cttttttatg catagctgcc ttttttattg tttaacagtg tttctcagct
     4081 atataatcag tttcaaactg gttgtaaaag tatagctgtg gccaatgaat gtatttattt
     4141 gttgtttcac taaattgtaa caaaacacta ctattaaaaa taaaagtgtt tgtgctttta
//
