LOCUS       NM_003272               2033 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 137B (GPR137B), mRNA.
ACCESSION   NM_003272
VERSION     NM_003272.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Gan,L., Seki,A., Shen,K., Iyer,H., Han,K., Hayer,A., Wollman,R.,
            Ge,X., Lin,J.R., Dey,G., Talbot,W.S. and Meyer,T.
  TITLE     The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1
            localization and activity
  JOURNAL   Nat Cell Biol 21 (5), 614-626 (2019)
   PUBMED   31036939
  REMARK    GeneRIF: PR137B-knockout cells exhibited defective autophagy and an
            expanded lysosome compartment, similar to Rag-knockout cells. Like
            zebrafish RagA mutants, GPR137B-mutant zebrafish had upregulated
            TFEB target gene expression and an expanded lysosome compartment in
            microglia.
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Bukszar,J., Khachane,A.N.,
            Keefe,R.S., Perkins,D.O., McEvoy,J.P., Stroup,T.S., Vann,R.E.,
            Beardsley,P.M., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genome-wide pharmacogenomic study of neurocognition as an indicator
            of antipsychotic treatment response in schizophrenia
  JOURNAL   Neuropsychopharmacology 36 (3), 616-626 (2011)
   PUBMED   21107309
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Bommel,H., Xie,G., Rossoll,W., Wiese,S., Jablonka,S., Boehm,T. and
            Sendtner,M.
  TITLE     Missense mutation in the tubulin-specific chaperone E (Tbce) gene
            in the mouse mutant progressive motor neuronopathy, a model of
            human motoneuron disease
  JOURNAL   J Cell Biol 159 (4), 563-569 (2002)
   PUBMED   12446740
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Spangenberg,C., Winterpacht,A., Zabel,B.U. and Lobbert,R.W.
  TITLE     Cloning and characterization of a novel gene (TM7SF1) encoding a
            putative seven-pass transmembrane protein that is upregulated
            during kidney development
  JOURNAL   Genomics 48 (2), 178-185 (1998)
   PUBMED   9521871
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012100.1 and AI634648.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003272.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.790449.1,
                                           SRR1660807.65880.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366592.8/ ENSP00000355551.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1680              BC012100.1         8-1687
            1681-2033           AI634648.1         7-359               c
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3"
     gene            1..2033
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /note="G protein-coupled receptor 137B"
                     /db_xref="GeneID:7107"
                     /db_xref="HGNC:HGNC:11862"
                     /db_xref="MIM:604658"
     exon            1..498
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1284
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /note="transmembrane 7 superfamily member 1 (upregulated
                     in kidney); transmembrane 7 superfamily member 1 protein"
                     /codon_start=1
                     /product="integral membrane protein GPR137B"
                     /protein_id="NP_003263.1"
                     /db_xref="CCDS:CCDS1609.1"
                     /db_xref="GeneID:7107"
                     /db_xref="HGNC:HGNC:11862"
                     /db_xref="MIM:604658"
                     /translation="MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLG
                     LTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFKD
                     FVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYL
                     ASLFISLVFLLVNLTCAVLVKTGNWERKVIVSVRVAINDTLFVLCAVSLSICLYKISK
                     MSLANIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQNKSVHSFDYDWYNV
                     SDQADLKNQLGDAGYVLFGVVLFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFS
                     PRSYFFDNPRRYDSDDDLAWNIAPQGLQGGFAPDYYDWGQQTNSFLAQAGTLQDSTLD
                     PDKPSLG"
     exon            499..548
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..771
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..921
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1050
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1175
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..2033
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1983..1988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /note="hexamer: ATTAAA"
     polyA_site      2033
                     /gene="GPR137B"
                     /gene_synonym="TM7SF1"
                     /note="major polyA site"
ORIGIN      
        1 gttttctttc ctccagtctc ggggctgcag gctgagcgcg atgcgcggag acccccgcgg
       61 gggcggcggc ggccgtgagc cccgatgagg cccgagcgtc cccggccgcg cggcagcgcc
      121 cccggcccga tggagacccc gccgtgggac ccagcccgca acgactcgct gccgcccacg
      181 ctgaccccgg ccgtgccccc ctacgtgaag cttggcctca ccgtcgtcta caccgtgttc
      241 tacgcgctgc tcttcgtgtt catctacgtg cagctctggc tggtgctgcg ttaccgccac
      301 aagcggctca gctaccagag cgtcttcctc tttctctgcc tcttctgggc ctccctgcgg
      361 accgtcctct tctccttcta cttcaaagac ttcgtggcgg ccaattcgct cagccccttc
      421 gtcttctggc tgctctactg cttccctgtg tgcctgcagt ttttcaccct cacgctgatg
      481 aacttgtact tcacgcaggt gattttcaaa gccaagtcaa aatattctcc agaattactc
      541 aaataccggt tgcccctcta cctggcctcc ctcttcatca gccttgtttt cctgttggtg
      601 aatttaacct gtgctgtgct ggtaaagacg ggaaattggg agaggaaggt tatcgtctct
      661 gtgcgagtgg ccattaatga cacgctcttc gtgctgtgtg ccgtctctct ctccatctgt
      721 ctctacaaaa tctctaagat gtccttagcc aacatttact tggagtccaa gggctcctcc
      781 gtgtgtcaag tgactgccat cggtgtcacc gtgatactgc tttacacctc tcgggcctgc
      841 tacaacctgt tcatcctgtc attttctcag aacaagagcg tccattcctt tgattatgac
      901 tggtacaatg tatcagacca ggcagatttg aagaatcagc tgggagatgc tggatacgta
      961 ttatttggag tggtgttatt tgtttgggaa ctcttaccta ccaccttagt cgtttatttc
     1021 ttccgagtta gaaatcctac aaaggacctt accaaccctg gaatggtccc cagccatgga
     1081 ttcagtccca gatcttattt ctttgacaac cctcgaagat atgacagtga tgatgacctt
     1141 gcctggaaca ttgcccctca gggacttcag ggaggttttg ctccagatta ctatgattgg
     1201 ggacaacaaa ctaacagctt cctggcacaa gcaggaactt tgcaagactc aactttggat
     1261 cctgacaaac caagccttgg gtagcatcag ttaacagttt tatggacgat tcctcagatg
     1321 aaaagcttca gaaaagcata gtgacagctg aatttttagg gcacttttcc ttaagaaata
     1381 gaacttgatt tttatttgtt acaggtttcc aatggcccca taggaataag caataatgta
     1441 gactgataaa cccttatttt agtactaaag agggagcctt gctatttcag tgggtataat
     1501 ttaaactttt taaagaaaat ctgtactttt ataaagatgt attttgtata acttaaataa
     1561 taatgctaaa gtatactagg gttttttttt cttgagaatg ttactgcaat catgttgtag
     1621 tttgcacaga cttttatgca taattcactt taaaaatata gaatatatgg tctaatagtt
     1681 ttttaaagct tttggactaa agtattccac aaatcttacc tctttaggtc actgatggtc
     1741 actccgattc tgagtgccac attggtagac tcctaaaata cagttgacaa cttagccaat
     1801 tgcaactcca gtgttgataa ttaaaatgaa atggtaaagc agcagactgt aaggtcttta
     1861 gagatttttt ttttaaggtt caggccgtag gttcctcaag gaatctctta agttttgccc
     1921 aaagactggt acttcctttc agtagggcgc taatgtatac acattaatga taagttgata
     1981 acattaaaaa tgtagctgac ttatcctatt aaacctcctc tgctatgttc aca
//
