LOCUS       NM_001170880            2166 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens G protein-coupled receptor 137 (GPR137), transcript
            variant 2, mRNA.
ACCESSION   NM_001170880
VERSION     NM_001170880.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2166)
  AUTHORS   Li,L., Tang,J., Cao,B., Xu,Q., Xu,S., Lin,C. and Tang,C.
  TITLE     GPR137 inactivates Hippo signaling to promote gastric cancer cell
            malignancy
  JOURNAL   Biol Direct 19 (1), 3 (2024)
   PUBMED   38163861
  REMARK    GeneRIF: GPR137 inactivates Hippo signaling to promote gastric
            cancer cell malignancy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2166)
  AUTHORS   Li,L., Zhu,C., Xu,Q., Xu,S., Ye,J., Xu,D., Wang,L., Gan,S., Liu,B.
            and Tang,C.
  TITLE     ALKBH1 contributes to renal cell carcinoma progression by reducing
            N6-methyladenine of GPR137
  JOURNAL   Eur J Clin Invest 53 (7), e13986 (2023)
   PUBMED   36920340
  REMARK    GeneRIF: ALKBH1 contributes to renal cell carcinoma progression by
            reducing N6-methyladenine of GPR137.
REFERENCE   3  (bases 1 to 2166)
  AUTHORS   Lu,J., Zhong,F., Sun,B. and Wang,C.
  TITLE     GPR137 is a promising novel bio-marker for the prognosis of bladder
            cancer patients
  JOURNAL   Medicine (Baltimore) 98 (35), e16576 (2019)
   PUBMED   31464892
  REMARK    GeneRIF: Results show the expression of GPR137 in patients with
            bladder cancer was significantly higher than that in normal tissues
            at both mRNA and protein levels. The expression of GPR137 was
            associated with tumor size and low survival rate.
REFERENCE   4  (bases 1 to 2166)
  AUTHORS   Gan,L., Seki,A., Shen,K., Iyer,H., Han,K., Hayer,A., Wollman,R.,
            Ge,X., Lin,J.R., Dey,G., Talbot,W.S. and Meyer,T.
  TITLE     The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1
            localization and activity
  JOURNAL   Nat Cell Biol 21 (5), 614-626 (2019)
   PUBMED   31036939
REFERENCE   5  (bases 1 to 2166)
  AUTHORS   Zhang,L.Q., Yang,S.Q., Qu,X.D., Chen,X.J., Lu,H.S. and Wang,Y.
  TITLE     GRP137 promotes cell proliferation and metastasis through
            regulation of the PI3K/AKT pathway in human ovarian cancer
  JOURNAL   Tumori 104 (5), 330-337 (2018)
   PUBMED   29739299
  REMARK    GeneRIF: High GRP137 expression is associated with metastasis in
            ovarian cancer.
REFERENCE   6  (bases 1 to 2166)
  AUTHORS   Du,Y., Bi,W., Zhang,F., Wu,W., Xia,S. and Liu,H.
  TITLE     G-protein-coupled receptor 137 accelerates proliferation of urinary
            bladder cancer cells in vitro
  JOURNAL   Biotechnol Appl Biochem 62 (6), 855-860 (2015)
   PUBMED   25496438
  REMARK    GeneRIF: GPR137 as an essential player in urinary bladder cancer
            cell growth
            Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi:
            10.1002/bab.2499.. PMID: 37559496]
REFERENCE   7  (bases 1 to 2166)
  AUTHORS   Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X.
  TITLE     Down-regulation of G protein-coupled receptor 137 by RNA
            interference inhibits cell growth of two hepatoma cell lines
  JOURNAL   Cell Biol Int 39 (4), 418-426 (2015)
   PUBMED   25490967
  REMARK    GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle
            arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis,
            as determined by flow cytometry analysis, which contributed to cell
            growth inhibition.
REFERENCE   8  (bases 1 to 2166)
  AUTHORS   Zong,G., Wang,H., Li,J., Xie,Y., Bian,E. and Zhao,B.
  TITLE     Inhibition of GPR137 expression reduces the proliferation and
            colony formation of malignant glioma cells
  JOURNAL   Neurol Sci 35 (11), 1707-1714 (2014)
   PUBMED   24870220
  REMARK    GeneRIF: Our results indicated that GPR137 is involved in the
            progression of human glioma
REFERENCE   9  (bases 1 to 2166)
  AUTHORS   Fischer,A., Schmid,B., Ellinghaus,D., Nothnagel,M., Gaede,K.I.,
            Schurmann,M., Lipinski,S., Rosenstiel,P., Zissel,G., Hohne,K.,
            Petrek,M., Kolek,V., Pabst,S., Grohe,C., Grunewald,J.,
            Ronninger,M., Eklund,A., Padyukov,L., Gieger,C., Wichmann,H.E.,
            Nebel,A., Franke,A., Muller-Quernheim,J., Hofmann,S. and
            Schreiber,S.
  TITLE     A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1
  JOURNAL   Am J Respir Crit Care Med 186 (9), 877-885 (2012)
   PUBMED   22837380
REFERENCE   10 (bases 1 to 2166)
  AUTHORS   O'Brien,K.P., Tapia-Paez,I., Stahle-Backdahl,M., Kedra,D. and
            Dumanski,J.P.
  TITLE     Characterization of five novel human genes in the 11q13-q22 region
  JOURNAL   Biochem Biophys Res Commun 273 (1), 90-94 (2000)
   PUBMED   10873569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001453.6, AJ250392.1, BX119209.1, BC033920.1 and BU730610.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001170880.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            contains an alternate in-frame exon in the central coding region
            compared to variant 1. The encoded protein (isoform 2) is longer,
            compared to isoform 1. Variants 2 and 8-12 all encode the same
            isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1150760.1,
                                           SRR3476690.837147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438980.7/ ENSP00000415698.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AP001453.6         58030-58291
            263-300             AJ250392.1         1-38
            301-482             BX119209.1         6-187
            483-530             AP001453.6         58512-58559
            531-570             BX119209.1         235-274
            571-2164            BC033920.1         1-1594
            2165-2166           BU730610.1         25-26               c
FEATURES             Location/Qualifiers
     source          1..2166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2166
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /note="G protein-coupled receptor 137"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
     exon            1..1034
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             678..1868
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     integral membrane protein GPR137; transmembrane 7
                     superfamily member 1-like 1 protein"
                     /codon_start=1
                     /product="integral membrane protein GPR137 isoform 2"
                     /protein_id="NP_001164351.1"
                     /db_xref="CCDS:CCDS53656.1"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
                     /translation="MESNLSGLVPAAGLVPALPPAVTLGLTAAYTTLYALLFFSVYAQ
                     LWLVLLYGHKRLSYQTVFLALCLLWAALRTTLFSFYFRDTPRANRLGPLPFWLLYCCP
                     VCLQFFTLTLMNLYFAQVVFKAKVKRRPEMSRGLLAVRGAFVGASLLFLLVNVLCAVL
                     SHRRRAQPWALLLVRVLVSDSLFVICALSLAACLCLVARRAPSTSIYLEAKGTSVCQA
                     AAMGGAMVLLYASRACYNLTALALAPQSRLDTFDYDWYNVSDQADLVNDLGNKGYLVF
                     GLILFVWELLPTTLLVGFFRVHRPPQDLSTSHILNGQVFASRSYFFDRAGHCEDEGCS
                     WEHSRGESTSMSGSLGSGSWYGAIGREPGWYGGSQTKTTPLLFSQVPGPGGHHHSLYS
                     TPQT"
     exon            1035..1084
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1310
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1460
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1589
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1708
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..2166
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /note="hexamer: AATAAA"
     polyA_site      2166
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /note="major polyA site"
ORIGIN      
        1 ggagcagcgg gagccgggga gccggagccc cgggtcccca cgacctgagc cggctctccc
       61 atcagcggcc tgaggacctg gcgtccgcct cctccctccc cttgaggctg gagcgtggac
      121 gcggtggggg agggtggggc gggggcagct ttcgagaatt acgaggacag gaggcagagg
      181 ccctccccat ccgcattatt ggaggagaga gagcctcccc cagcttgggg agggggagag
      241 cggggcattg ggcgcccctc gcagcggccg ctgccctgac ccgacgggta tcagccggct
      301 ctccccctcc acccaggacg acatgaacga ccgaggccag ggagtcctct ccttgggcct
      361 ctgcatcccc ccatccttgg ctctggggta ggcccaggga ggagacaccc ccaaccccta
      421 tccggtctgt cctggagaaa agagactgcc cttccatgcc cctgagtgag gggcctgggg
      481 cccaggctgc ctgtgttccc caagggcaag ggtctctctg ttgaggagga ggggcctgtc
      541 agccacaact tctttcctcc tgagcgcccc atctccctct ctgcaccctg caattcccac
      601 ccctccgtat ttatttccct ggtcccgccg acagtccctc cttgtctgtc tccgggattc
      661 aggcctccct ccctgacatg gagagtaacc tgtctggcct ggtgcctgct gccgggctgg
      721 tgcctgcgct gccacctgct gtgaccctgg ggctgacagc tgcctacacc accctgtatg
      781 ccctgctctt cttctccgtc tatgcccagc tctggctggt gcttctgtat gggcacaagc
      841 gtctcagcta tcagacggtg ttcctggccc tctgtctgct ctgggccgcc ttgcgtacca
      901 ccctcttctc cttctacttc cgagatactc cccgcgccaa ccgcctgggg cccttgccct
      961 tctggcttct ctactgctgc cccgtctgcc tgcagttctt caccttgacg cttatgaacc
     1021 tctactttgc ccaggtggtg ttcaaggcca aggtgaagcg tcggccggag atgagccgag
     1081 gcttgctcgc tgtccgaggg gcctttgtgg gggcctcgct gctctttctg ctggtgaacg
     1141 tgctgtgtgc tgtgctctcc catcggcgcc gggcacagcc ctgggccctg ctgcttgtcc
     1201 gcgtcctggt gagcgactcc ctgttcgtca tctgcgcgct gtctcttgct gcctgcctct
     1261 gcctcgtcgc caggcgggcg ccctccacta gcatctacct ggaggccaag gggaccagtg
     1321 tgtgccaggc ggccgcgatg ggtggcgcca tggtcctgct ctatgccagc cgggcctgct
     1381 acaacctgac agcactggcc ttggcccccc agagccggct ggacaccttc gattacgact
     1441 ggtacaatgt gtctgaccag gcggacctgg tgaatgacct ggggaacaaa ggctacctgg
     1501 tatttggcct catcctcttc gtgtgggagc tactgcccac caccctgctg gtgggcttct
     1561 tccgggtgca ccggccccca caggacctga gcaccagcca catcctcaat gggcaggtct
     1621 ttgcctctcg gtcctacttc tttgaccggg ctgggcactg tgaagatgag ggctgctcct
     1681 gggagcacag ccggggtgag agcaccagta tgtcgggcag tctaggctct gggagctggt
     1741 atggtgccat cgggcgtgag ccgggctggt atgggggcag ccagacgaag accactcctc
     1801 tgctcttctc ccaggtgcca ggaccaggcg gccaccacca cagtctctac tccaccccac
     1861 agacgtgatc cccctccctc ccccacagaa tacccaggcc ccagtccccc tcaccctagg
     1921 cccctgtgcc aagtttgtct gccgcttctt gcccaggatc ctgggggtcg tggctacccc
     1981 ctcctctggc cggctccttg ctgctcctgt catagtgagc ttgtgccgtc cccctaggat
     2041 ggggggcatg gccctggctg ccagatgccc acagcaccct ggcatgacct gccacctctg
     2101 cttccacacc ggagccagct acctctcctg tgcctgccac tcaataaaca gtgtctgcgc
     2161 cccaca
//
