LOCUS       NM_022571               4622 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens G protein-coupled receptor 135 (GPR135), mRNA.
ACCESSION   NM_022571
VERSION     NM_022571.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4622)
  AUTHORS   Kettunen,E., Hernandez-Vargas,H., Cros,M.P., Durand,G., Le
            Calvez-Kelm,F., Stuopelyte,K., Jarmalaite,S., Salmenkivi,K.,
            Anttila,S., Wolff,H., Herceg,Z. and Husgafvel-Pursiainen,K.
  TITLE     Asbestos-associated genome-wide DNA methylation changes in lung
            cancer
  JOURNAL   Int J Cancer 141 (10), 2014-2029 (2017)
   PUBMED   28722770
  REMARK    GeneRIF: GPR135 hypermethylation is associated with lung cancer.
REFERENCE   2  (bases 1 to 4622)
  AUTHORS   Oishi,A., Karamitri,A., Gerbier,R., Lahuna,O., Ahmad,R. and
            Jockers,R.
  TITLE     Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2
            receptor reciprocally modulate their signaling functions
  JOURNAL   Sci Rep 7 (1), 8990 (2017)
   PUBMED   28827538
  REMARK    GeneRIF: Collectively, these data show that GPR61, GPR62 and GPR135
            are unable to bind melatonin, but show a reciprocal regulatory
            interaction with MT2 receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4622)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4622)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   5  (bases 1 to 4622)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL159140.4, BC032831.2, AY288418.1 and BX094623.1.
            
            On Jun 2, 2019 this sequence version replaced NM_022571.5.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY288418.1, SRR7346977.2843554.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395116.2/ ENSP00000378548.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AL159140.4         129100-129138       c
            40-154              BC032831.2         1-115
            155-1639            AY288418.1         1-1485
            1640-1859           BX094623.1         480-699
            1860-4622           AL159140.4         124517-127279       c
FEATURES             Location/Qualifiers
     source          1..4622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..4622
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /note="G protein-coupled receptor 135"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
     exon            1..4622
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1639
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /note="probable G-protein coupled receptor 135"
                     /codon_start=1
                     /product="G-protein coupled receptor 135"
                     /protein_id="NP_072093.2"
                     /db_xref="CCDS:CCDS9738.1"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
                     /translation="MEEPQPPRPPASMALLGSQHSGAPSAAGPPGGTSSAATAAVLSF
                     STVATAALGNLSDASGGGTAAAPGGGGLGGSGAAREAGAAVRRPLGPEAAPLLSHGAA
                     VAAQALVLLLIFLLSSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAA
                     FLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPR
                     EKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAA
                     FSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVL
                     IMIVFVICCWGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNP
                     NISMLLGRNREEGYRTRNVDAFLPSQGPGLQARSRSRLRNRYANRLGACNRMSSSNPA
                     SGVAGDVAMWARKNPVVLFCREGPPEPVTAVTKQPKSEAGDTSL"
     regulatory      1838..1843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /note="hexamer: ATTAAA"
     polyA_site      1859
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /note="major polyA site"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /note="hexamer: AATATA"
     polyA_site      3331
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /note="major polyA site"
     regulatory      4594..4599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /note="hexamer: ATTAAA"
     polyA_site      4622
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
ORIGIN      
        1 aaaggctccg ccaggtcccc agcgaccgcc acccctccgg ccgagcccag ctccccgcgg
       61 cggccgctag cccccggccc cgagccacca ctccgaccta gcggccgccg cccccggtgc
      121 gggatgagga gatccgcggc cgccactggg ccccatggag gagccgcagc cgccccgccc
      181 accagcgagc atggccttac tgggcagcca gcactccggc gccccctccg cggccggccc
      241 acctggcggg acttcctccg cggccacggc ggccgtgctc tccttcagca ccgtggcgac
      301 cgcggcgctg gggaacctga gcgacgcaag cggaggcggc acagctgccg ctcccggtgg
      361 cggcggcctt ggcgggtccg gggcagcgcg ggaggcgggg gcggcggtga ggcggccgct
      421 aggcccggag gcggcgccgc tgctgtcgca cggagctgca gtggcggccc aggcgctcgt
      481 cctcctgctc atcttcctgc tgtctagcct tggcaactgc gcggtgatgg gggtgattgt
      541 gaagcaccgg cagctccgca ccgtcaccaa cgccttcatc ctgtcgctgt ccctatcgga
      601 tctgctcacg gcgctgctct gcctgcccgc cgccttcctg gacctcttca ctccgcccgg
      661 gggttcggcg cctgccgccg ccgcggggcc ctggcgcggc ttctgcgccg ccagccgctt
      721 cttcagctcg tgcttcggca tcgtgtccac gctcagcgtg gcgctcatct cgttggaccg
      781 ttactgcgct atcgtgcggc cgccgcggga gaagatcggc cgccgccgcg cgctgcagct
      841 gctggcgggc gcctggctga cggccctggg cttctccttg ccctgggagc tgctcggggc
      901 gccccgggaa ctcgcggcgg cgcagagctt ccacggctgc ctctaccgga cctccccgga
      961 ccccgcgcag ctgggcgcgg ccttcagcgt ggggctggtg gtggcctgct acctgctgcc
     1021 cttcctgctc atgtgcttct gccactacca catctgcaag acggtgcgcc tgtcggacgt
     1081 gcgcgtgcgg ccggtgaaca cctacgcgcg cgtgctgcgc ttcttcagcg aggtgcgcac
     1141 ggccaccacc gtcctcatca tgatcgtctt cgtcatctgc tgctgggggc cctactgctt
     1201 cctggtgctg ctggccgccg cccggcaggc ccagaccatg caggccccct cgctcctcag
     1261 cgtggtggcc gtctggctga cctgggccaa tggggccatc aaccctgtca tctacgccat
     1321 ccgcaatccc aacatttcga tgctcctagg gcgcaaccgc gaggagggct accggactag
     1381 gaatgtggac gctttcctgc ccagccaggg cccgggtctg caagccagaa gccgcagtcg
     1441 ccttcgaaac cgctatgcca accggctggg ggcctgcaac aggatgtcct cttccaaccc
     1501 ggccagcgga gtggcagggg acgtggccat gtgggcccgc aaaaatccag ttgtactttt
     1561 ctgccgagag ggaccaccag agccggtgac ggcagtgacc aaacagccta aatccgaagc
     1621 tggggatacc agcctctaag acggttggaa tggccagctt atgaaggcaa atttccactc
     1681 gcattattta atgatggaag attctggggg agagttgtgg atttcataaa gccaaacatt
     1741 taaagctaga gacgggggag gcttaccact ttccccaaac aacataaaag acaatgtccc
     1801 ttcttcaaaa gtgccaaaag gaatgtaaaa tgcaaaaatt aaaacaatct taaaccacat
     1861 aaccaagcat tgtgaactgt aagtgccaaa aatgacaaaa ataacattca ctataactga
     1921 aaagctcata ttataggacc acactgtgaa acaaacaaaa cattgaatgc aaccagtatt
     1981 gttcaactac acagaatttc aggaatgaat ggagaccttc agagctgctt gaaagcccct
     2041 ctaaatcgct accatccaac aaaactttag cttctagagc ttgcacctct gacatgcttt
     2101 gggtgcttag attgcaagtg gaaaagtctt atccttacac acattggtgc acctcctcac
     2161 cccaccccct aataaccttt gtggaaaatt tttaattcat aacccattta aaatcatttt
     2221 aggattttga aaagctggtt attattagat aaaattcaac catctgaagg acaaatagaa
     2281 gtatgaacat aaagaaatgt gtcttttaaa tgttttccaa gattatatgt aaaaattaac
     2341 attccttcca cccgcgtcat acctccaaaa tgatcttcct tggaaaactt tgaagtttta
     2401 tccttactct aacctgttac ttttatttct gataaatttt ggaatgctgc tctcagaatg
     2461 ctttcacatt taaaaaaata ttttcattgt agaaaatttt tgtcttttga ggtaaatttg
     2521 atttttggat atagccaaaa atgtaatttg aagtcaagtt gattgaataa ggtgagtgat
     2581 gccactttat ttaaattttt attatttttt aaaatgagac ctctataaaa caacaaggtt
     2641 gggtttccta cgtggctttt agctaactga aaacgattcc aaagagaaat tctaaaacta
     2701 ttttgagaag cagcctcttg gaattagcgt agacttttcc aaatagatca taccctccta
     2761 catttagaaa tttggtatat tttgtatttt ttaaaatagc tgatggttgc tttatagcta
     2821 tgacttgtcg aagataatgt atttattaaa gggagaatag gtgtgggact atatgtaacg
     2881 gtattaaaac acaggcataa agttggagaa gaacttcaag caaactgaaa atatctttag
     2941 aaatatgcaa atcaaagatg ctttttaaat ttctatctta gcagaaaaga tggttttaca
     3001 ataattcaaa agcgtatgtg aactttctaa tgttaaatac gactatacac agaatcattt
     3061 actcagaatt tttttaaata ttatttttcc ctttcttttc ctccatcctg ccccttttct
     3121 tcagtatttc atagccttaa ttgaacaagt tatttacagt agatatgaaa agacattagc
     3181 tgtcgtatga agatttcaat gtgaaatagc cagcattttc ttcctgtaaa gtatttaaat
     3241 atgtttttaa gtatttcttt gtttgacagg tgggtacatg tcattatttt gtaatcaaag
     3301 gtggaaatat atgagtcatg tcagagctaa agatgtttta attttttctg cttctcaggg
     3361 tatcatcaca aatcagaagt ttgtaaattg tatatatttt gctacactca atgtagtaca
     3421 aagtagatga gataatccct cccctctagc ccttatttta taaagcatat acagacttca
     3481 tgcagctgga ctaacaaaaa caggtgtctg cggtatttgc ctgttaaagg caaaaaattg
     3541 tgtatttttt ggcaccgagt cacttttggg atttagagag aaatgataaa gtcttcaatt
     3601 ataaaagaca tcatagaata gaagtacagt tgtgaataaa gggcagaggg ttagagatct
     3661 tagagtaagg aggtgagcgt gttgcaaaat agtgtgttgc ctgagaagaa gaattgaagg
     3721 aaggcattga aaaataaatg tgatatagaa taaacctacc tggtgagtga agggaaaatc
     3781 tgagagattg gaagtgacaa ggtgatggca tgaaggactt taaggaagaa aaggaattcc
     3841 agccctacct tttcggtggc aggaagtttt aggaaaggca tggcttgtga aagaggccat
     3901 tctgttagtg gctccgagag tcatggtagg caagaattgg aggggaaaaa gagaaaattg
     3961 ttcataaatt actgaacaat ttacaatgct ctaaattgtt tgtttttaat ccaaggctat
     4021 ccaactattt agtggtagaa ctaggatttg aactgcagtc tgtttggcct cagaactcca
     4081 tgtttgtttc tctctatccc cacagaagtc tacaggtaag gaaatcaatc atgatcaatt
     4141 atggtactgt catcattatc atcatcgtga tcatcatcta ccatttttgt ttcctacttt
     4201 atataagggc aacttcctgg gagctaaggc tactaaaagg tagaagccac agtactcatc
     4261 tgcagagggc ttacagcctc agcaaggacc ttgtggcttt gtaacaacaa tcagccataa
     4321 caagtttact tgtggaaaag aaaaggtgta gcactttcag aagaggctat caaagaaaag
     4381 agatgaactt ggaagcaaga gatacgcagg tataagtcag ccacccattt gacccagtgt
     4441 aaatacttag acaatcaata cctcaaaagg tgaagaaaga atgattctca aaataatcta
     4501 agacttcgac ctttcgttgt gcttactatg agtatgcaat tatagtgact tcatgggaaa
     4561 acgagaaaga aaagctatga aatattggaa tggattaaat attgagtact atgtaaaggc
     4621 ca
//
