LOCUS       NM_013345               3654 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 132 (GPR132), transcript
            variant 2, mRNA.
ACCESSION   NM_013345
VERSION     NM_013345.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3654)
  AUTHORS   Yi,C., He,J., Huang,D., Zhao,Y., Zhang,C., Ye,X., Huang,Y.,
            Nussinov,R., Zheng,J., Liu,M. and Lu,W.
  TITLE     Activation of orphan receptor GPR132 induces cell differentiation
            in acute myeloid leukemia
  JOURNAL   Cell Death Dis 13 (11), 1004 (2022)
   PUBMED   36437247
  REMARK    GeneRIF: Activation of orphan receptor GPR132 induces cell
            differentiation in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3654)
  AUTHORS   Li,Q., Feng,C., Li,L., Xu,G., Gu,H., Li,S., Li,D., Liu,M., Han,S.
            and Zheng,B.
  TITLE     Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in
            Inflammatory Response by Promoting Classical Macrophage Activation
  JOURNAL   J Immunol 206 (10), 2338-2352 (2021)
   PUBMED   33941654
  REMARK    GeneRIF: Lipid Receptor G2A-Mediated Signal Pathway Plays a
            Critical Role in Inflammatory Response by Promoting Classical
            Macrophage Activation.
REFERENCE   3  (bases 1 to 3654)
  AUTHORS   Klatt,W., Wallner,S., Brochhausen,C., Stolwijk,J.A. and Schreml,S.
  TITLE     Expression profiles of proton-sensing G-protein coupled receptors
            in common skin tumors
  JOURNAL   Sci Rep 10 (1), 15327 (2020)
   PUBMED   32948783
  REMARK    GeneRIF: Expression profiles of proton-sensing G-protein coupled
            receptors in common skin tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3654)
  AUTHORS   Lahvic,J.L., Ammerman,M., Li,P., Blair,M.C., Stillman,E.R.,
            Fast,E.M., Robertson,A.L., Christodoulou,C., Perlin,J.R., Yang,S.,
            Chiang,N., Norris,P.C., Daily,M.L., Redfield,S.E., Chan,I.T.,
            Chatrizeh,M., Chase,M.E., Weis,O., Zhou,Y., Serhan,C.N. and
            Zon,L.I.
  TITLE     Specific oxylipins enhance vertebrate hematopoiesis via the
            receptor GPR132
  JOURNAL   Proc Natl Acad Sci U S A 115 (37), 9252-9257 (2018)
   PUBMED   30139917
REFERENCE   5  (bases 1 to 3654)
  AUTHORS   Ogawa,A., Obinata,H., Hattori,T., Kishi,M., Tatei,K., Ishikawa,O.
            and Izumi,T.
  TITLE     Identification and analysis of two splice variants of human G2A
            generated by alternative splicing
  JOURNAL   J Pharmacol Exp Ther 332 (2), 469-478 (2010)
   PUBMED   19855098
  REMARK    GeneRIF: we found an additional novel G2A variant (G2A-b) that is
            the major transcript with functional response to ligand stimulation
            as well as G2A-a, and succeeded in discriminating proton-sensing
            and oxidized fatty acid-sensing activities of G2A.
REFERENCE   6  (bases 1 to 3654)
  AUTHORS   Obinata,H., Hattori,T., Nakane,S., Tatei,K. and Izumi,T.
  TITLE     Identification of 9-hydroxyoctadecadienoic acid and other oxidized
            free fatty acids as ligands of the G protein-coupled receptor G2A
  JOURNAL   J Biol Chem 280 (49), 40676-40683 (2005)
   PUBMED   16236715
  REMARK    GeneRIF: results indicate that G protein-coupled receptor G2A is a
            receptor for 9-hydroxyoctadecadienoic acid (9-HODE) and other
            oxidized free fatty acids and is activated by oxidized free fatty
            acids
REFERENCE   7  (bases 1 to 3654)
  AUTHORS   Murakami,N., Yokomizo,T., Okuno,T. and Shimizu,T.
  TITLE     G2A is a proton-sensing G-protein-coupled receptor antagonized by
            lysophosphatidylcholine
  JOURNAL   J Biol Chem 279 (41), 42484-42491 (2004)
   PUBMED   15280385
  REMARK    GeneRIF: G2A is a proton-sensing G-protein-coupled receptor
            antagonized by lysophosphatidylcholine
REFERENCE   8  (bases 1 to 3654)
  AUTHORS   Rikitake,Y., Hirata,K., Yamashita,T., Iwai,K., Kobayashi,S.,
            Itoh,H., Ozaki,M., Ejiri,J., Shiomi,M., Inoue,N., Kawashima,S. and
            Yokoyama,M.
  TITLE     Expression of G2A, a receptor for lysophosphatidylcholine, by
            macrophages in murine, rabbit, and human atherosclerotic plaques
  JOURNAL   Arterioscler Thromb Vasc Biol 22 (12), 2049-2053 (2002)
   PUBMED   12482833
  REMARK    GeneRIF: In atherosclerotic plaques of human coronary arterial
            specimens, G2A is expressed by macrophages within the lipid-rich
            plaques, whereas no immunoreactivity of G2A is observed in fibrous
            plaques where macrophages do not exist.
REFERENCE   9  (bases 1 to 3654)
  AUTHORS   Le,L.Q., Kabarowski,J.H., Wong,S., Nguyen,K., Gambhir,S.S. and
            Witte,O.N.
  TITLE     Positron emission tomography imaging analysis of G2A as a negative
            modifier of lymphoid leukemogenesis initiated by the BCR-ABL
            oncogene
  JOURNAL   Cancer Cell 1 (4), 381-391 (2002)
   PUBMED   12086852
  REMARK    GeneRIF: G2A is a negative modifier of lymphoid leukemogenesis
            initiated by the BCR-ABL oncogene
REFERENCE   10 (bases 1 to 3654)
  AUTHORS   Weng,Z., Fluckiger,A.C., Nisitani,S., Wahl,M.I., Le,L.Q.,
            Hunter,C.A., Fernal,A.A., Le Beau,M.M. and Witte,O.N.
  TITLE     A DNA damage and stress inducible G protein-coupled receptor blocks
            cells in G2/M
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12334-12339 (1998)
   PUBMED   9770487
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB465599.1 and AA714520.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013345.3.
            
            Summary: This gene encodes a member of the guanine
            nucleotide-binding protein (G protein)-coupled receptor (GPCR)
            superfamily. The receptors are seven-pass transmembrane proteins
            that respond to extracellular cues and activate intracellular
            signal transduction pathways. This protein was reported to be a
            receptor for lysophosphatidylcholine action, but PubMedID: 15653487
            retracts this finding and instead suggests this protein to be an
            effector of lysophosphatidylcholine action. This protein may have
            proton-sensing activity and may be a receptor for oxidized free
            fatty acids. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB465599.1, AF083955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329797.8/ ENSP00000328818.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3649              AB465599.1         1-3649
            3650-3654           AA714520.1         15-19               c
FEATURES             Location/Qualifiers
     source          1..3654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..3654
                     /gene="GPR132"
                     /gene_synonym="G2A"
                     /note="G protein-coupled receptor 132"
                     /db_xref="GeneID:29933"
                     /db_xref="HGNC:HGNC:17482"
                     /db_xref="MIM:606167"
     exon            1..52
                     /gene="GPR132"
                     /gene_synonym="G2A"
                     /inference="alignment:Splign:2.1.0"
     exon            53..166
                     /gene="GPR132"
                     /gene_synonym="G2A"
                     /inference="alignment:Splign:2.1.0"
     exon            167..946
                     /gene="GPR132"
                     /gene_synonym="G2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             913..2055
                     /gene="GPR132"
                     /gene_synonym="G2A"
                     /note="isoform 1 is encoded by transcript variant 2; G2
                     accumulation protein; probable G-protein coupled receptor
                     132"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 132 isoform
                     1"
                     /protein_id="NP_037477.1"
                     /db_xref="CCDS:CCDS9997.1"
                     /db_xref="GeneID:29933"
                     /db_xref="HGNC:HGNC:17482"
                     /db_xref="MIM:606167"
                     /translation="MCPMLLKNGYNGNATPVTTTAPWASLGLSAKTCNNVSFEESRIV
                     LVVVYSAVCTLGVPANCLTAWLALLQVLQGNVLAVYLLCLALCELLYTGTLPLWVIYI
                     RNQHRWTLGLLACKVTAYIFFCNIYVSILFLCCISCDRFVAVVYALESRGRRRRRTAI
                     LISACIFILVGIVHYPVFQTEDKETCFDMLQMDSRIAGYYYARFTVGFAIPLSIIAFT
                     NHRIFRSIKQSMGLSAAQKAKVKHSAIAVVVIFLVCFAPYHLVLLVKAAAFSYYRGDR
                     NAMCGLEERLYTASVVFLCLSTVNGVADPIIYVLATDHSRQEVSRIHKGWKEWSMKTD
                     VTRLTHSRDTEELQSPVALADHYTFSRPVHPPGSPCPAKRLIEESC"
     exon            947..3654
                     /gene="GPR132"
                     /gene_synonym="G2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3636..3641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR132"
                     /gene_synonym="G2A"
                     /note="hexamer: AAGAAA"
     polyA_site      3654
                     /gene="GPR132"
                     /gene_synonym="G2A"
                     /note="major polyA site"
ORIGIN      
        1 agctaggact gcagggaggg gtgcgaggct agccacgcag gcggggccct gggtcatttt
       61 aaactctcag agtgaacgtc ttgataggac cgacaagacg catgacatgt acttagaaag
      121 cttatcttag agccacactg agattggaac ccgcaaaata tgccagggag gaaggtgagc
      181 aagggacacg acactcaccc ggagaaaccc agcaagcgca gcgaggctgt ggggagaccg
      241 gagccctgca caccgccggg ggaaggtggg ccagcgccac caccgtggag aacagcgcgg
      301 aggcacccca cgagatgaga cggaactgcc gtgagatcca gcaatgccaa ctgtgggtct
      361 gacccaggag aacggaaagc agggacgtga acagccctcc tcatgttctt gacaccgtca
      421 ttctcagcag ctcagctaag gcacagaggc agccgagcgt ctgtcagcgg agtcgtggct
      481 gagcagaaca cgccacacgc cacacgccac acgccacacg tgcaggattg ctcaagatgg
      541 aagggcacag tggaatatat atatatattt atatttttgg cgagaccctg gaggacacac
      601 tgaatacaat ggaataccat cccgcctttg aaaggaaggg aaatcctggc acacgctgca
      661 acaggaggga gcttgaggac actgtggtga gtggagcacg tgagacacgg aaggacacac
      721 gctgaagaca cgcagagatg cccacccacg tggggaggtg acaggggagc ccagcgcaca
      781 gagacaaagt ggaatggagg cctgggggct gggagcaaat gcggagcgag tgcttcctgg
      841 ggcagagtct ccgtttggga agatgagaag gttctgccga cggatgctgg cgatggttgc
      901 agaagaatgt gaatgtgccc aatgctactg aaaaacggtt acaatggaaa cgccacccca
      961 gtgaccacca ctgccccgtg ggcctccctg ggcctctccg ccaagacctg caacaacgtg
     1021 tccttcgaag agagcaggat agtcctggtc gtggtgtaca gcgcggtgtg cacgctgggg
     1081 gtgccggcca actgcctgac tgcgtggctg gcgctgctgc aggtactgca gggcaacgtg
     1141 ctggccgtct acctgctctg cctggcactc tgcgagctgc tgtacacagg cacgctgcca
     1201 ctctgggtca tctatatccg caaccagcac cgctggaccc taggcctgct ggcctgcaag
     1261 gtgaccgcct acatcttctt ctgcaacatc tacgtcagca tcctcttcct gtgctgcatc
     1321 tcctgcgacc gcttcgtggc cgtggtgtac gcgctggaga gtcggggccg ccgccgccgg
     1381 aggaccgcca tcctcatctc cgcctgcatc ttcatcctcg tcgggatcgt tcactacccg
     1441 gtgttccaga cggaagacaa ggagacctgc tttgacatgc tgcagatgga cagcaggatt
     1501 gccgggtact actacgccag gttcaccgtt ggctttgcca tccctctctc catcatcgcc
     1561 ttcaccaacc accggatttt caggagcatc aagcagagca tgggcttaag cgctgcccag
     1621 aaggccaagg tgaagcactc ggccatcgcg gtggttgtca tcttcctagt ctgcttcgcc
     1681 ccgtaccacc tggttctcct cgtcaaagcc gctgcctttt cctactacag aggagacagg
     1741 aacgccatgt gcggcttgga ggaaaggctg tacacagcct ctgtggtgtt tctgtgcctg
     1801 tccacggtga acggcgtggc tgaccccatt atctacgtgc tggccacgga ccattcccgc
     1861 caagaagtgt ccagaatcca taaggggtgg aaagagtggt ccatgaagac agacgtcacc
     1921 aggctcaccc acagcaggga caccgaggag ctgcagtcgc ccgtggccct tgcagaccac
     1981 tacaccttct ccaggcccgt gcacccacca gggtcaccat gccctgcaaa gaggctgatt
     2041 gaggagtcct gctgagccca ctgtgtggca gggggatggc aggttggggg tcctggggcc
     2101 agcaatgtgg ttcctgtgca ctgagcccac cagccacagt gcccatgtcc cctctggaag
     2161 acaaactacc aatttctcgt tcctgaagcc actccctccg tgaccactgg ccccaggctt
     2221 tcccacatgg aaggtggctg catgccaagg ggaggagcga cacctccagg cttccgggag
     2281 cccagagagc atgtggcagg cagtggggcc tcttcatcag cagcctgcct ggctggctcc
     2341 cttggctgtg ggcaggtagc acgcctgctg gcagaggtac ctggtggctg ccctgttcgc
     2401 atcagtggcg atgactttat ttgcggagca tttctgcaag cgttgcctgg atgcggtggt
     2461 gcattgtggg ccctctgggc tcctgcctca gaatgtcagt gagcaccatg ctggaggtca
     2521 cccagcactg tggcagcgcc caggagggca tagggcagcc taccacctcc aagggggcag
     2581 gcgccctcat ctggggttgg gtctgtgctg agctggaggg cctctaggga accgtggggc
     2641 agggtggcca gctgctggct cccagagcgc agcccaggcg tcctcaacgg ggagccccaa
     2701 atgtccacgc ccagaacaac agttggcagg acaggtgtga cacagccaca gcagaggcaa
     2761 ggggtgccag gagtccccag cggcatcctc ggggagatgc tggtgagggg tccgtacagg
     2821 gtggggtccc cacccctagc cccttactga ggggggagtg cagcagttgg cctgcttgtc
     2881 tggcggagaa agccagctcc ctgcaccctc ggggctgagt cagatctggg tctgccgcaa
     2941 aggccttgcc tagaccaggt cacactgatg ccctggtttc cctatctgta aaatggggcc
     3001 aatgacacct acctcactgg gtcaccatcg agatcaatcc tcctccctgc cccgacacct
     3061 cgggcacatc gcatgcactc agagcacaga gccgggcaga cgcagcacct gcatggggag
     3121 cccagtgccc ggcacagcac aggggcttcc agggaggccg cgcagggccg tggggctgag
     3181 ccacgctctc gttttgtcag gcagctatgc agttgctctt ccttgttttt gttttgtttt
     3241 tgtttttgtt tttaatattt atttttttag agacagggcc ttgctctgtt gcctgggctg
     3301 gagaacagtg gcaccatcat agctcactgc agcctcaaac tcctgggctc aagcgatcct
     3361 ccccgctcag cctcctgagt agctgggact acaggtgtgc accaccacac ccagccaaaa
     3421 cagccatcct ccccttgaga gtcatcagaa aaatacatta ggaaaatgtg tttagaaata
     3481 aaagcacaag gcagggcagt gctcacgcct gtcatcccag cactttggga ggccgagacg
     3541 ggaggatcag ttgaggtcag gagtttgaga ccagcctcgg caacatggca aaatcttgtc
     3601 tctttttttt ggtattaaaa aaatcataaa aataaaagaa ataatgcaat ttaa
//
