LOCUS       NM_178471               4342 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 119 (GPR119), mRNA.
ACCESSION   NM_178471
VERSION     NM_178471.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4342)
  AUTHORS   Zheng,T., Sun,M., Liu,L., Lan,Y., Wang,L. and Lin,F.
  TITLE     GPR116 overexpression correlates with poor prognosis in gastric
            cancer
  JOURNAL   Medicine (Baltimore) 100 (48), e28059 (2021)
   PUBMED   35049225
  REMARK    GeneRIF: GPR116 overexpression correlates with poor prognosis in
            gastric cancer.
REFERENCE   2  (bases 1 to 4342)
  AUTHORS   Jia,J., Chen,Y., Xu,L., Yang,Y., Xu,X., Ding,H., Jia,C., Gao,H.,
            Guo,P. and Hu,R.
  TITLE     Screening for bacterial enzymes synthesizing GPR119 agonist in
            cAMP-responsive cells
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (1), 121-123 (2021)
   PUBMED   33242325
  REMARK    GeneRIF: Screening for bacterial enzymes synthesizing GPR119
            agonist in cAMP-responsive cells.
REFERENCE   3  (bases 1 to 4342)
  AUTHORS   Markovics,A., Angyal,A., Toth,K.F., Adam,D., Penzes,Z., Magi,J.,
            Por,A., Kovacs,I., Torocsik,D., Zouboulis,C.C., Biro,T. and Olah,A.
  TITLE     GPR119 Is a Potent Regulator of Human Sebocyte Biology
  JOURNAL   J Invest Dermatol 140 (10), 1909-1918 (2020)
   PUBMED   32142797
  REMARK    GeneRIF: GPR119 Is a Potent Regulator of Human Sebocyte Biology.
REFERENCE   4  (bases 1 to 4342)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4342)
  AUTHORS   Arifin,S.A., Paternoster,S., Carlessi,R., Casari,I., Ekberg,J.H.,
            Maffucci,T., Newsholme,P., Rosenkilde,M.M. and Falasca,M.
  TITLE     Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1
            secretion from enteroendocrine L-cells through GPR119
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (9), 1132-1141
            (2018)
   PUBMED   29883799
  REMARK    GeneRIF: GPR119 is the oleoyl-lysophosphatidylinositol receptor
            that is required for GLP-1 secretion in enteroendocrine cells.
REFERENCE   6  (bases 1 to 4342)
  AUTHORS   Overton,H.A., Fyfe,M.C. and Reynet,C.
  TITLE     GPR119, a novel G protein-coupled receptor target for the treatment
            of type 2 diabetes and obesity
  JOURNAL   Br J Pharmacol 153 Suppl 1 (Suppl 1), S76-S81 (2008)
   PUBMED   18037923
  REMARK    Review article
REFERENCE   7  (bases 1 to 4342)
  AUTHORS   Winzell,M.S. and Ahren,B.
  TITLE     G-protein-coupled receptors and islet function-implications for
            treatment of type 2 diabetes
  JOURNAL   Pharmacol Ther 116 (3), 437-448 (2007)
   PUBMED   17900700
  REMARK    Review article
REFERENCE   8  (bases 1 to 4342)
  AUTHORS   Overton,H.A., Babbs,A.J., Doel,S.M., Fyfe,M.C., Gardner,L.S.,
            Griffin,G., Jackson,H.C., Procter,M.J., Rasamison,C.M.,
            Tang-Christensen,M., Widdowson,P.S., Williams,G.M. and Reynet,C.
  TITLE     Deorphanization of a G protein-coupled receptor for
            oleoylethanolamide and its use in the discovery of small-molecule
            hypophagic agents
  JOURNAL   Cell Metab 3 (3), 167-175 (2006)
   PUBMED   16517404
  REMARK    GeneRIF: GPR119 therefore represents a novel and attractive
            potential target for the therapy of obesity and related metabolic
            disorders.
REFERENCE   9  (bases 1 to 4342)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   10 (bases 1 to 4342)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035423.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 22, 2020 this sequence version replaced NM_178471.2.
            
            Summary: This gene encodes a member of the rhodopsin subfamily of
            G-protein-coupled receptors that is expressed in the pancreas and
            gastrointestinal tract. The encoded protein is activated by lipid
            amides including lysophosphatidylcholine and oleoylethanolamide and
            may be involved in glucose homeostasis. This protein is a potential
            drug target in the treatment of type 2 diabetes.[provided by
            RefSeq, Jan 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142348,
                              SAMEA2142586 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682440.1/ ENSP00000508182.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1239              AL035423.4         81001-82239         c
            1240-4342           AL035423.4         76014-79116         c
FEATURES             Location/Qualifiers
     source          1..4342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.1"
     gene            1..4342
                     /gene="GPR119"
                     /gene_synonym="GPCR2"
                     /note="G protein-coupled receptor 119"
                     /db_xref="GeneID:139760"
                     /db_xref="HGNC:HGNC:19060"
                     /db_xref="MIM:300513"
     exon            1..1239
                     /gene="GPR119"
                     /gene_synonym="GPCR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1235
                     /gene="GPR119"
                     /gene_synonym="GPCR2"
                     /note="G-protein coupled receptor 2"
                     /codon_start=1
                     /product="glucose-dependent insulinotropic receptor"
                     /protein_id="NP_848566.1"
                     /db_xref="CCDS:CCDS14625.1"
                     /db_xref="GeneID:139760"
                     /db_xref="HGNC:HGNC:19060"
                     /db_xref="MIM:300513"
                     /translation="MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFT
                     LNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFD
                     RYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAV
                     FHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTP
                     SDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNP
                     LIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFD
                     G"
     exon            1240..4342
                     /gene="GPR119"
                     /gene_synonym="GPCR2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttagag agctggagag gcaggaggct gaggactgaa aagagagggt gagtaattct
       61 tcatgacctg taggatccca aagatggcga cctgccagcc tggactgcca gcgaaggcca
      121 gaatcgtgct gtagctctga acccacagct cctctgcccc tggcccatga gaatttcagc
      181 tggagagata gcatgccctg gtaagtgaag tcctgccact tcgagacatg gaatcatctt
      241 tctcatttgg agtgatcctt gctgtcctgg cctccctcat cattgctact aacacactag
      301 tggctgtggc tgtgctgctg ttgatccaca agaatgatgg tgtcagtctc tgcttcacct
      361 tgaatctggc tgtggctgac accttgattg gtgtggccat ctctggccta ctcacagacc
      421 agctctccag cccttctcgg cccacacaga agaccctgtg cagcctgcgg atggcatttg
      481 tcacttcctc cgcagctgcc tctgtcctca cggtcatgct gatcaccttt gacaggtacc
      541 ttgccatcaa gcagcccttc cgctacttga agatcatgag tgggttcgtg gccggggcct
      601 gcattgccgg gctgtggtta gtgtcttacc tcattggctt cctcccactc ggaatcccca
      661 tgttccagca gactgcctac aaagggcagt gcagcttctt tgctgtattt caccctcact
      721 tcgtgctgac cctctcctgc gttggcttct tcccagccat gctcctcttt gtcttcttct
      781 actgcgacat gctcaagatt gcctccatgc acagccagca gattcgaaag atggaacatg
      841 caggagccat ggctggaggt tatcgatccc cacggactcc cagcgacttc aaagctctcc
      901 gtactgtgtc tgttctcatt gggagctttg ctctatcctg gacccccttc cttatcactg
      961 gcattgtgca ggtggcctgc caggagtgtc acctctacct agtgctggaa cggtacctgt
     1021 ggctgctcgg cgtgggcaac tccctgctca acccactcat ctatgcctat tggcagaagg
     1081 aggtgcgact gcagctctac cacatggccc taggagtgaa gaaggtgctc acctcattcc
     1141 tcctctttct ctcggccagg aattgtggcc cagagaggcc cagggaaagt tcctgtcaca
     1201 tcgtcactat ctccagctca gagtttgatg gctaagacgt cgctttgctt accagtctgg
     1261 cccagaggag aaacatgctt gctttcacca tagcaagcat cgtgttccta caactgaaga
     1321 actttttgac tctcaagtgg acgatggaac ccaatatgcc ttgaaatgct gagcatccag
     1381 caagtaccag gccagcaata aggcacattc ttggattgta ttgtgagtta ctgggaacta
     1441 ggtaaaatac gaataactgg attttggaca aaattgaaag caggctcaaa ccaatgccct
     1501 ccttactggt ggttcaaagc ttaaatcctg gccttgctac aaaggactga tcttgccaag
     1561 ataatataag caaagtggaa tgaaaattaa agttaattct gaagccaagg tccttttaga
     1621 aaaaaaaaag taaattagcc tgatttaatc attccacatt ttaaacatat atcaacatca
     1681 cattgtaccc cacgtaatat atacaattat ttgtcaatta aaaataaaaa atatatatat
     1741 ttttaagtac agaaaagcag gaggggagga gaggccaggt gatcagtgtg ttattaggtt
     1801 caatctaaga aactctgcta cccctgggag tcagtatgtg caatggaaaa atcacaggtc
     1861 ttgaaatcca acagaccagt gttcaaatga taattcagtc atttaaattc tcaaactaga
     1921 tctcgcattc atcaaaccgg ggtaataatg cctactttac atggttatat tgaagattaa
     1981 ctcagataat gtatatgtaa atatctagta aactacagca cattgttagt gctcaaaaat
     2041 gtcagttctc ttcctcttct ttaaacaccc tggactaaac agtcagttga cccatttaag
     2101 ggagtccctc atattcagat attatgacat ataggacaag gacaattgga ctcagaactg
     2161 taaattcctc aacctctgaa taagattttt aaaaatgagt gatgagaggt gattcaggtt
     2221 gaaaaagaca aacaataaat ctaatacctt agcagtatca agacagagcg gatacaaaca
     2281 aggcactggc actagtatgg taattggatt taagagtaat cacaattaaa aacactgtgt
     2341 ttggccaggc atggtggctc acgcctgtaa tcccagcatg ttgggaggct gaggcaggtg
     2401 gatcacgagg tcaggggttc aagaccagcc tgaccaatat ggtgaaaagc tgtctctact
     2461 aaaaatacaa aaattagctg ggcacgatgg caggcgcctg taatcccagc tactcaagag
     2521 gctaaggcag gaaaatcgct tgaacctggg cggcagaggt tgcagtgagc caaggtcgcg
     2581 ccactgcact ccagcctggg caacagagtg agactccgtc tcaaaaaaac aaacaaacaa
     2641 acaaaaaaaa aaacagcaac aacactgtgt ttaataagcc accaagagca gagctacagg
     2701 atgctacaca aaagtctaat ggctttcttt gatgcaagct ccttcacaga taagggaatg
     2761 taccggaaac gtttagattt cattcataca tctgatgttg tttcctgata ggcttaccaa
     2821 gaaaccagat tcagttcagc aaggtgatca aaacatccca gatattaata ccttgtagga
     2881 tgcaatgtag gccaatcagt cccatttatt atttccatga acagcttact gtgaatttgt
     2941 ggtgtttttg ttttaagaga cagggtctcg ctcatcaccc aggctggagt gcagtggtgc
     3001 gatcatagct cactgtagct tcaacttccc agactcaagc aatcttccca cctcagcttc
     3061 ctgagtaact gggaccacag gcacatgcca ccatgcccag ctaatttatt tatattttgt
     3121 agagacaggg tctccctatg ttgttcatga tagtcttgag tgatgctccc acctcagcct
     3181 ttcaatgtgc tgtgattaca ggaggaagcc actgcaccag gctgaatttg taattaaaat
     3241 tgtaacatga ctaagtttta tattaattcc ttaggtagga aaggttatac atatcaacac
     3301 ctcaatttca gaggactatt ctcaaagaac ataaggacac tgtaggcctc tgtacagagg
     3361 tgttttaagt ggtttcacaa gtgttagagg caggttaccc tgaccaacac actcctgctt
     3421 gtccatatgt ccagtgtcag ccagagatag ccttgggata tcttctccct agaaggagaa
     3481 gtgttaactg gttcaaatgg gaattgaact catgaccttg atttcattcc caccatgctc
     3541 agtcactggc caaactgaat agagaccagt gaaaacagca ggcacaagat acttaaggac
     3601 acacatagaa tcagcaaaaa caagaatagc aatggaccca atgacagacc acaactcctc
     3661 agctactgtc agccactcaa ttctgtggct ccttcagtat tttccacgtc atccttcaaa
     3721 ctgctgacag gtctggaatt ttctcctttt aattaaaaaa tcttcacttg ttatttctgc
     3781 aatcttataa attcaatgat ggtgcctaca aatgccaatc gtcattcatt catccgtctg
     3841 tccacttacc tatctcacaa acattgagag ctatgtgcta aaattgcccc agctttgctg
     3901 ggatatcttc taggggtata gattgatata taaatgatgt ttactatttc ttttacgatt
     3961 ataaaaacaa cttttgttca ttaaaaaaat tttgcaaaca taggaaatca caaagtaccc
     4021 ataattatac tatccagaga tgaccactgt tattctcctt catctgtttt tttcacttaa
     4081 cattatattg tgtatatttt cctatgtcgt ctttttcaaa aacacaactt gtaatggttg
     4141 catgcttttt caacaaatgg tataatactt taactatttc cctatagctg tgctaaaact
     4201 taggttattt ctaatttctg ttataatagc atgataaata tccctgtgta taaatcattg
     4261 gcatgtctct gtcccattcc ttaggataaa ttcaccaagc agtattacta gatcaaggag
     4321 cattaaatat ttataagtat tt
//
