LOCUS       NM_001080452            2034 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens G protein-coupled receptor 108 (GPR108), transcript
            variant 1, mRNA.
ACCESSION   NM_001080452 XM_290854
VERSION     NM_001080452.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2034)
  AUTHORS   Zhao,M., Zhang,Y., Qiang,L., Lu,Z., Zhao,Z., Fu,Y., Wu,B., Chai,Q.,
            Ge,P., Lei,Z., Zhang,X., Li,B., Wang,J., Zhang,L. and Liu,C.H.
  TITLE     A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1
            to suppress antiviral innate immunity
  JOURNAL   Cell Rep 42 (6), 112655 (2023)
   PUBMED   37330913
  REMARK    GeneRIF: A Golgi-resident GPR108 cooperates with E3 ubiquitin
            ligase Smurf1 to suppress antiviral innate immunity.
REFERENCE   2  (bases 1 to 2034)
  AUTHORS   Lyu,S., Zhang,X., Tu,Z., Zhou,H., Ke,X. and Qu,Y.
  TITLE     GPR108 is required for gambogic acid inhibiting NF-kappaB signaling
            in cancer
  JOURNAL   Pharmacol Res 182, 106279 (2022)
   PUBMED   35659621
  REMARK    GeneRIF: GPR108 is required for gambogic acid inhibiting NF-kappaB
            signaling in cancer.
REFERENCE   3  (bases 1 to 2034)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2034)
  AUTHORS   Meisen,W.H., Nejad,Z.B., Hardy,M., Zhao,H., Oliverio,O., Wang,S.,
            Hale,C., Ollmann,M.M. and Collins,P.J.
  TITLE     Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors
            Critical for AAV Transduction
  JOURNAL   Mol Ther Methods Clin Dev 17, 601-611 (2020)
   PUBMED   32280726
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2034)
  AUTHORS   Dudek,A.M., Zabaleta,N., Zinn,E., Pillay,S., Zengel,J., Porter,C.,
            Franceschini,J.S., Estelien,R., Carette,J.E., Zhou,G.L. and
            Vandenberghe,L.H.
  TITLE     GPR108 Is a Highly Conserved AAV Entry Factor
  JOURNAL   Mol Ther 28 (2), 367-381 (2020)
   PUBMED   31784416
REFERENCE   6  (bases 1 to 2034)
  AUTHORS   Dong,D., Zhou,H., Na,S.Y., Niedra,R., Peng,Y., Wang,H., Seed,B. and
            Zhou,G.L.
  TITLE     GPR108, an NF-kappaB activator suppressed by TIRAP, negatively
            regulates TLR-triggered immune responses
  JOURNAL   PLoS One 13 (10), e0205303 (2018)
   PUBMED   30332431
  REMARK    GeneRIF: GPR108, an NF-kappaB activator suppressed by TIRAP,
            negatively regulates TLR-triggered immune responses.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2034)
  AUTHORS   Han,S., Lan,Q., Park,A.K., Lee,K.M., Park,S.K., Ahn,H.S.,
            Shin,H.Y., Kang,H.J., Koo,H.H., Seo,J.J., Choi,J.E., Ahn,Y.O.,
            Chanock,S.J., Kim,H., Rothman,N. and Kang,D.
  TITLE     Polymorphisms in innate immunity genes and risk of childhood
            leukemia
  JOURNAL   Hum Immunol 71 (7), 727-730 (2010)
   PUBMED   20438785
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 2034)
  AUTHORS   Rajaraman,P., Brenner,A.V., Neta,G., Pfeiffer,R., Wang,S.S.,
            Yeager,M., Thomas,G., Fine,H.A., Linet,M.S., Rothman,N.,
            Chanock,S.J. and Inskip,P.D.
  TITLE     Risk of meningioma and common variation in genes related to innate
            immunity
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (5), 1356-1361 (2010)
   PUBMED   20406964
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2034)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2034)
  AUTHORS   Edgar,A.J.
  TITLE     Human GPR107 and murine Gpr108 are members of the LUSTR family of
            proteins found in both plants and animals, having similar topology
            to G-protein coupled receptors
  JOURNAL   DNA Seq 18 (3), 235-241 (2007)
   PUBMED   17454009
  REMARK    GeneRIF: The 18-exon human GPR107 gene is located at 9q34.2-3 and
            spans 86.4 kb and the cDNA encodes a 552 residue protein; murine
            Gpr108 cDNA encodes a 562 residue protein that has 49% identity to
            human GPR107.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008760.7.
            
            On May 3, 2021 this sequence version replaced NM_001080452.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291968.1, AL365404.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264080.12/ ENSP00000264080.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC008760.7         173143-173266       c
            125-244             AC008760.7         172278-172397       c
            245-295             AC008760.7         171594-171644       c
            296-378             AC008760.7         171308-171390       c
            379-503             AC008760.7         169869-169993       c
            504-553             AC008760.7         169691-169740       c
            554-622             AC008760.7         169531-169599       c
            623-727             AC008760.7         169256-169360       c
            728-861             AC008760.7         168854-168987       c
            862-937             AC008760.7         168673-168748       c
            938-1011            AC008760.7         168162-168235       c
            1012-1129           AC008760.7         167949-168066       c
            1130-1260           AC008760.7         167711-167841       c
            1261-1304           AC008760.7         167577-167620       c
            1305-1354           AC008760.7         167159-167208       c
            1355-1438           AC008760.7         166885-166968       c
            1439-1563           AC008760.7         166673-166797       c
            1564-2034           AC008760.7         165600-166070       c
FEATURES             Location/Qualifiers
     source          1..2034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2034
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /note="G protein-coupled receptor 108"
                     /db_xref="GeneID:56927"
                     /db_xref="HGNC:HGNC:17829"
                     /db_xref="MIM:618491"
     exon            1..124
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1636
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein GPR108; lung seven transmembrane
                     receptor 2"
                     /codon_start=1
                     /product="protein GPR108 isoform 1 precursor"
                     /protein_id="NP_001073921.1"
                     /db_xref="CCDS:CCDS42479.1"
                     /db_xref="GeneID:56927"
                     /db_xref="HGNC:HGNC:17829"
                     /db_xref="MIM:618491"
                     /translation="MAVSERRGLGRGSPAEWGQRLLLVLLLGGCSGRIHQLALTGEKR
                     ADIQLNSFGFYTNGSLEVELSVLRLGLREAEEKSLLVGFSLSRVRSGRVRSYSTRDFQ
                     DCPLQKNSSSFLVLFLINTKDLQVQVRKYGEQKTLFIFPGLLPEAPSKPGLPKPQATV
                     PRKVDGGGTSAASKPKSTPAVIQGPSGKDKDLVLGLSHLNNSYNFSFHVVIGSQAEEG
                     QYSLNFHNCNNSVPGKEHPFDITVMIREKNPDGFLSAAEMPLFKLYMVMSACFLAAGI
                     FWVSILCRNTYSVFKIHWLMAALAFTKSISLLFHSINYYFINSQGHPIEGLAVMYYIA
                     HLLKGALLFITIALIGSGWAFIKYVLSDKEKKVFGIVIPMQVLANVAYIIIESREEGA
                     SDYVLWKEILFLVDLICCGAILFPVVWSIRHLQDASGTDGKVAVNLAKLKLFRHYYVM
                     VICYVYFTRIIAILLQVAVPFQWQWLYQLLVEGSTLAFFVLTGYKFQPTGNNPYLQLP
                     QEDEEDVQMEQVMTDSGFREGLSKVNKTASGRELL"
     exon            125..244
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            245..295
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..378
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            379..503
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..553
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..622
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..727
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..861
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..937
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1011
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1129
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1260
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1304
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1354
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1438
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1563
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..2034
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /note="hexamer: AATAAT"
     polyA_site      1893
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /note="major polyA site"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
                     /note="hexamer: AATAAA"
     polyA_site      2034
                     /gene="GPR108"
                     /gene_synonym="LUSTR2"
ORIGIN      
        1 agagatggca gtgagcgaga ggagggggct cggccgcggg agccccgcgg agtgggggca
       61 gcggctactt ctggtgctgc tgctgggtgg ctgctccggg cgcatccacc agctggcgct
      121 gacgggggag aagcgagcgg acatccagct gaacagcttc ggtttctaca ccaatggctc
      181 tctggaggtg gagttgagcg tcctgcggct gggcctccgg gaggcagaag agaagtccct
      241 gctggtgggg ttcagtctca gccgggttcg gtctggcaga gttcgctcct attcaacccg
      301 ggatttccag gactgccctc tccagaaaaa cagtagcagt ttcctggtcc tgttcctcat
      361 caacaccaag gatctgcagg tccaggtgcg gaagtatgga gagcagaaga cgttgtttat
      421 ctttcccggg ctcctcccgg aagcaccctc caaaccaggg ctcccgaagc cacaggccac
      481 agtcccccgc aaggtggatg gcggagggac ctctgcagcc agcaagccca agtcaacacc
      541 cgcagtgatt cagggtccta gtgggaagga caaggacctg gtgttgggcc tgagccacct
      601 caacaactcc tacaacttca gtttccacgt ggtgatcggc tctcaggcgg aagaaggcca
      661 gtacagcctg aacttccaca actgcaacaa ttcagtgcca ggaaaggagc atccattcga
      721 catcacggtg atgatccggg agaagaaccc cgatggcttc ctgtcggcag cggagatgcc
      781 ccttttcaag ctctacatgg tcatgtccgc ctgcttcctg gccgctggca tcttctgggt
      841 gtccatcctc tgcaggaaca cgtacagcgt cttcaagatc cactggctca tggcggcctt
      901 ggccttcacc aagagcatct ctctcctctt ccacagcatc aactactact tcatcaacag
      961 ccagggccac cccatcgaag gccttgccgt catgtactac atcgcacacc tgctgaaggg
     1021 cgccctcctc ttcatcacca tcgccctgat tggctcaggc tgggccttca tcaagtacgt
     1081 cctgtcggat aaggagaaga aggtctttgg gatcgtgatc cccatgcagg tcctggccaa
     1141 cgtggcctac atcatcatcg agtcccgcga ggaaggcgcc agcgactacg tgctgtggaa
     1201 ggagattttg ttcctggtgg acctcatctg ctgtggtgcc atcctgttcc ccgtagtctg
     1261 gtccatccgg catctccagg atgcgtctgg cacagacggg aaggtggcag tgaacctggc
     1321 caagctgaag ctgttccggc attactatgt catggtcatc tgctacgtct acttcacccg
     1381 catcatcgcc atcctgctgc aggtggctgt gccctttcag tggcagtggc tgtaccagct
     1441 cttggtggag ggctccaccc tggccttctt cgtgctcacg ggctacaagt tccagcccac
     1501 aggaaacaac ccgtacctgc agctgcccca ggaggacgag gaggatgttc agatggagca
     1561 agtaatgacg gactctgggt tccgggaagg cctctccaaa gtcaacaaaa cagccagcgg
     1621 gcgggaactg ttatgatcac ctccacatct cagaccaaag ggtcgtcctc ccccagcatt
     1681 tctcactcct gcccttcttc cacagcgtat gtggggaggt ggagggggtc catgtggacc
     1741 aggcgcccag ctccccggga ccccggttcc cggacaagcc catttggaag aagagtccct
     1801 tcctcccccc aaatattggg cagccctgtc cttaccccgg gaccacccct cccttccagc
     1861 tatgtgtaca ataatgacca atctgtttgg ctacgccgtt gtcttgcctt tttgggggtt
     1921 ggggtctaca cggaggttgt gtttacaatg tagaaacctg ttttcgctgt gtgtggcggg
     1981 ggcgcgggca cagggtccgt gtctttgtat attcaataaa tattcattca gtaa
//
