LOCUS       NM_054021               8032 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens G protein-coupled receptor 101 (GPR101), mRNA.
ACCESSION   NM_054021
VERSION     NM_054021.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8032)
  AUTHORS   Costanzi,S., Stahr,L.G., Trivellin,G. and Stratakis,C.A.
  TITLE     GPR101: Modeling a constitutively active receptor linked to
            X-linked acrogigantism
  JOURNAL   J Mol Graph Model 127, 108676 (2024)
   PUBMED   38006624
  REMARK    GeneRIF: GPR101: Modeling a constitutively active receptor linked
            to X-linked acrogigantism.
REFERENCE   2  (bases 1 to 8032)
  AUTHORS   Abboud,D., Daly,A.F., Dupuis,N., Bahri,M.A., Inoue,A., Chevigne,A.,
            Ectors,F., Plenevaux,A., Pirotte,B., Beckers,A. and Hanson,J.
  TITLE     GPR101 drives growth hormone hypersecretion and gigantism in mice
            via constitutive activation of Gs and Gq/11
  JOURNAL   Nat Commun 11 (1), 4752 (2020)
   PUBMED   32958754
  REMARK    GeneRIF: GPR101 drives growth hormone hypersecretion and gigantism
            in mice via constitutive activation of Gs and Gq/11.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8032)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 8032)
  AUTHORS   Flak,M.B., Koenis,D.S., Sobrino,A., Smith,J., Pistorius,K.,
            Palmas,F. and Dalli,J.
  TITLE     GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in
            arthritis and infections
  JOURNAL   J Clin Invest 130 (1), 359-373 (2020)
   PUBMED   31793912
  REMARK    GeneRIF: findings demonstrate a fundamental role for GPR101 in
            mediating the leukocyte-directed actions of RvD5n-3 DPA.
REFERENCE   5  (bases 1 to 8032)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   6  (bases 1 to 8032)
  AUTHORS   Kober,P., Bujko,M., Oledzki,J., Tysarowski,A. and Siedlecki,J.A.
  TITLE     Methyl-CpG binding column-based identification of nine genes
            hypermethylated in colorectal cancer
  JOURNAL   Mol Carcinog 50 (11), 846-856 (2011)
   PUBMED   21438024
REFERENCE   7  (bases 1 to 8032)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
REFERENCE   8  (bases 1 to 8032)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   9  (bases 1 to 8032)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
REFERENCE   10 (bases 1 to 8032)
  AUTHORS   Iacovazzo,D. and Korbonits,M.
  TITLE     X-Linked Acrogigantism
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29389097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390879.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 18, 2020 this sequence version replaced NM_054021.1.
            
            Summary: The protein encoded by this gene is an orphan G
            protein-coupled receptor of unknown function. The encoded protein
            is a member of a family of proteins that contain seven
            transmembrane domains and transduce extracellular signals through
            heterotrimeric G proteins. [provided by RefSeq, Sep 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.112496.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651716.2/ ENSP00000498972.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AL390879.20        113694-113887       c
            195-8032            AL390879.20        103821-111658       c
FEATURES             Location/Qualifiers
     source          1..8032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..8032
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /note="G protein-coupled receptor 101"
                     /db_xref="GeneID:83550"
                     /db_xref="HGNC:HGNC:14963"
                     /db_xref="MIM:300393"
     exon            1..194
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..8032
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1813
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 101"
                     /protein_id="NP_473362.1"
                     /db_xref="CCDS:CCDS14662.1"
                     /db_xref="GeneID:83550"
                     /db_xref="HGNC:HGNC:14963"
                     /db_xref="MIM:300393"
                     /translation="MTSTCTNSTRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAA
                     SFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSH
                     FCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAI
                     LQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCA
                     ARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEEFQDESEFRRQHEGEVKAKEGR
                     MEAKDGSLKAKEGSTGTSESSVEARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKA
                     DKGRTEVNQCSIDLGEDDMEFGEDDINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRC
                     YQCKAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIH
                     PYVYGYMHKTIKKEIQDMLKKFFCKEKPPKEDSHPDLPGTEGGTEGKIVPSYDSATFP
                     "
     regulatory      3529..3534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /note="hexamer: AATAAA"
     polyA_site      3549
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /note="major polyA site"
     regulatory      7513..7518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /note="hexamer: AATAAA"
     polyA_site      7539
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /note="major polyA site"
     regulatory      8008..8013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
                     /note="hexamer: AATAAA"
     polyA_site      8032
                     /gene="GPR101"
                     /gene_synonym="GPCR6; PAGH2; PITA2"
ORIGIN      
        1 agagcttgca gcgcggcgcg ctggccggac gtgcgggcac agacgctgtg ccccgctcct
       61 gccgcgcccg cagcgcccgc tgccccgtgc cagctcgcag ccgcccgagc cccgagaggc
      121 ggccgggacg agcgcgagga gccccgaagg acctgcacgc ggcgcccgcg acgccacgtc
      181 tgcagcagca acagcatagg cactgagtgc ggtctgtgca cccctttgcc acccaccggt
      241 gccggcactg agcctgcaac ctgtctcacg ccctctggct gttgccatga cgtccacctg
      301 caccaacagc acgcgcgaga gtaacagcag ccacacgtgc atgcccctct ccaaaatgcc
      361 catcagcctg gcccacggca tcatccgctc aaccgtgctg gttatcttcc tcgccgcctc
      421 tttcgtcggc aacatagtgc tggcgctagt gttgcagcgc aagccgcagc tgctgcaggt
      481 gaccaaccgt tttatcttta acctcctcgt caccgacctg ctgcagattt cgctcgtggc
      541 cccctgggtg gtggccacct ctgtgcctct cttctggccc ctcaacagcc acttctgcac
      601 ggccctggtt agcctcaccc acctgttcgc cttcgccagc gtcaacacca ttgtcgtggt
      661 gtcagtggat cgctacttgt ccatcatcca ccctctctcc tacccgtcca agatgaccca
      721 gcgccgcggt tacctgctcc tctatggcac ctggattgtg gccatcctgc agagcactcc
      781 tccactctac ggctggggcc aggctgcctt tgatgagcgc aatgctctct gctccatgat
      841 ctggggggcc agccccagct acactattct cagcgtggtg tccttcatcg tcattccact
      901 gattgtcatg attgcctgct actccgtggt gttctgtgca gcccggaggc agcatgctct
      961 gctgtacaat gtcaagagac acagcttgga agtgcgagtc aaggactgtg tggagaatga
     1021 ggatgaagag ggagcagaga agaaggagga gttccaggat gagagtgagt ttcgccgcca
     1081 gcatgaaggt gaggtcaagg ccaaggaggg cagaatggaa gccaaggacg gcagcctgaa
     1141 ggccaaggaa ggaagcacgg ggaccagtga gagtagtgta gaggccaggg gcagcgagga
     1201 ggtcagagag agcagcacgg tggccagcga cggcagcatg gagggtaagg aaggcagcac
     1261 caaagttgag gagaacagca tgaaggcaga caagggtcgc acagaggtca accagtgcag
     1321 cattgacttg ggtgaagatg acatggagtt tggtgaagac gacatcaatt tcagtgagga
     1381 tgacgtcgag gcagtgaaca tcccggagag cctcccaccc agtcgtcgta acagcaacag
     1441 caaccctcct ctgcccaggt gctaccagtg caaagctgct aaagtgatct tcatcatcat
     1501 tttctcctat gtgctatccc tggggcccta ctgcttttta gcagtcctgg ccgtgtgggt
     1561 ggatgtcgaa acccaggtac cccagtgggt gatcaccata atcatctggc ttttcttcct
     1621 gcagtgctgc atccacccct atgtctatgg ctacatgcac aagaccatta agaaggaaat
     1681 ccaggacatg ctgaagaagt tcttctgcaa ggaaaagccc ccgaaagaag atagccaccc
     1741 agacctgccc ggaacagagg gtgggactga aggcaagatt gtcccttcct acgattctgc
     1801 tacttttcct tgaagttagt tctaaggcaa accttgaact gtccataaca cgagaaacaa
     1861 gaggagattt cttttcaatg gacccacaat tcattaatgc caaaccatac catttcaggc
     1921 aaaggtgttg cacacacatg ctcttcacca caaggtagat aaatatatag aagaggcagg
     1981 aactggggtc tttccgtaaa agcatggact tgaggattct gactgaaatt ttccccccaa
     2041 agattattag gctctacatt tcttaaagca acaagggcta tccattttgg acttgtagtt
     2101 ggtattctat cttttccaga gctacaacat gccaacttta gctctgaagg aaagggaaga
     2161 tgatgcttgt gaacttaagg acttttcggc cctcgggtcg ggagctcatg ggccagagct
     2221 acagcttgtg ttcaactgaa agaaaggcaa tggaccaaat cattcatgga gcccaagaaa
     2281 cagaacctaa tggactgatc aacatatgag ccaaattctg aactgaacag ccccacagtc
     2341 gggtgcaaag actgttacac aaactaaaac aaagggcctc ctacagttag aatctcaaga
     2401 aggtttctag atcccctaaa gggatccaga aaagtagaag gacatgtatg aaatgggaag
     2461 ctagtccaag ggaaaagatt gagaaataac acacatctgg agagctaaac agttgacttt
     2521 ttttcctata aaatcttggg tttatgcatg ggctggaact gaggtcatta agtgtaaatt
     2581 gtcaattgac acaaatattt tctgtctcct gtttgaataa tagtggggca gaaatcatgc
     2641 cactatttta caacttccct tatgtgactg aattgagatg ctggtgggaa ttcttcagat
     2701 ctctgccaac acttctgttt tcttttggtt tgtttttgtc aaataagcct tttttagtca
     2761 aacagtattt acagaaaaaa agaaattcaa ctagaagtgg cctaagtcct acaaaattca
     2821 tgatgtcact gaggaataat ttgttcatca gaaatatatt ttgtgtccat gagatcatag
     2881 acaataaatg tgatctccac atggggagca aggaaggcag aatgaacatt tttcttcctc
     2941 caggcacacc catgtgtctt ttccacctgt ggctctcttt aaagctttta agctctctgc
     3001 agatgtgaaa gagaaatatc agagagtcag aaatgacaaa gaggatgatt tcacaatacc
     3061 tagaaaacat gtaacctatt ccaaacagtc ctaaaatcag agcattcaga tcagacatat
     3121 cctaattaat gctgttgaaa taaatcacgt tgggaaaact ttaacaatat ctaaattatc
     3181 cctagggtca attcacagga acattcctca aatcccaaac cgcaaaataa ctttgggcag
     3241 ggatatacat atacatttct gagggcatgg gccgtatgta tgtgaccaag taacatggaa
     3301 ccaaaaaaac agtcaagcca gtgtttttga tcctcctaca gaacaagtta aagcaactcc
     3361 agagtcaacc aactgttcat gcagaaatcc actgtcaata tgggtggagg gagtgtttgg
     3421 ttgaaaatgg ttaatcaggt agttgtatga tgtaagatga ccatcttcag agtttagcct
     3481 cattcttgtg tgattgtcat gcctttatta gaactcaagt ttcatttaaa taaatgccca
     3541 gctcatttat ttttttttat ctcttcctcc tcacagattt caacatgaac ttctcaaggg
     3601 gtaaacagca atgtatttgg actgtgaata actctgcatg ggaatttggg attgccatgt
     3661 tcagaattta ggaaagtaga gggaatagaa ccaaataata tagagctgac ccatccaata
     3721 aaaataccat gataacctta ttaattccaa ctccattaat ttggaacttg tagttattca
     3781 gacaaggcat gggggctaaa gtttaccctt acactatcat ttatttttct accaaaatgc
     3841 ataaagtgaa ttaacagtca taaatttgtt ctaccaattt attgccaaac tcttgaactg
     3901 acctttcctt aaaggatatc tgggtgaaga aatggcctat gtgatcaatc ctcctacagg
     3961 ggaggggcag tgccttcagg tctgttcaaa ttgtcaaagg agttcaaggt agctatagcc
     4021 tatcctttga gtagaaatgc ttacttgggt aggaaacagg atttcaaaca taaatgtctc
     4081 caaacattgt gttaaaactg aacttcttgt tttattttta aagctcaccc ccttcaaagt
     4141 gtatcagaga aaattgtttg ccaaaatctc aaatcaaaat ggaaccagaa cctgtacaag
     4201 tatggtaagt ccatttaaca gcacacacaa cattctcaag ggcactgaga ttccctttcc
     4261 tttttgaagt tcctcttttc cctattttag tcattgtcca ttattttggt aaattggatt
     4321 cctcaaaagt gaagaccttt tgaaactatg agcctggaaa agaggacctt ttaattaaga
     4381 gcattctgct ttgatgacat tttcttctaa atgaacaata aggcctatgg ttagcttgga
     4441 gatagcaagt actcgaaatt ttttgctatt ttgaataaag cactatcaac ttaatgaggt
     4501 tttactgcac atactgtttt gtcatttgaa aatctgaaag cacacaaaaa aagtcatcat
     4561 tagcctcaca gatcctcatg tgcaatagct ttccctgaat gtttttaaag gatgtattct
     4621 tttgccaagg ccacttcata tgtgcagtaa aaaaaaaaaa aaaaatccca ttaaagtaca
     4681 ggggccagac aaaccagact atgaaatgat gtgattttaa atttaatgat tttccttatt
     4741 tacgaataat agagcatcta gtttgccaag aagtcgcagg tgctttgact aacacaccaa
     4801 tttccacaag cttgggaagg cagtaataag gagcaagccc tgggcttctg tgacttctgt
     4861 gatgctaggg tcccacttct ctgagacacc acaagtacca gctgcttgga aggcctctgc
     4921 acttccagct ccctgcctac ctcttgccat cagcccactg ccttcacctg cctcactccc
     4981 tctccctctg ctgcactggc ccttcaggaa tagtccatgc ttgaagctct gcgtgttcac
     5041 ctactcccca tccatccctt cccaacccag agctgacaga ttcacaggga cctgggggcc
     5101 tatggaagca gggaaggaga gaagtgagcc ataggagcaa tgaaaggtat ttttctgtct
     5161 cctacccaac tccaatccaa tttagagatg acgggatacc tacttcaaat tcaacaggta
     5221 aggaaaagtg ccagttatta tttagtagaa ggtaggcacc taatttttta ccaaaaaagc
     5281 actcgatatt acacatcatt gggggaatag tcaatactgt agatactgtc caattatttc
     5341 agcaaaaata gaacactaaa aaatgtttca cctacagaat tataagatgc ctaacattgc
     5401 cttattttat atataattag ccaattaagc taggtaaagt tacttcaaga agattttttc
     5461 atactacctg aagaataatt tacatgatta aactaggctt acttagactt tgccaaaaaa
     5521 gcttttaaaa gtgtctgaaa cacatcattt ggaagaaaaa aaatacgcat catctggtaa
     5581 tttggactct caagataaaa ctctcatggg ttgttgggat aaaacaatga gcaacaattt
     5641 aaactactgg actgtatttt tctctcataa ccaccctgcc caatattttg aggaaaaaaa
     5701 taacgtgttt tcccctcata atgtcttttc tgttgtattc ctctttaaga aagacctcac
     5761 gctgtcagga gaggtttctc taagcaaaat gccgtttcct tctagaccag acaaaagatt
     5821 acaggaacag ttagctgtta gccagtggcc aagataagga gagaaaatct ggccactcaa
     5881 tggcttttaa ccctctccct ccttatctct tcctcttact ttccatgggc tggactagtg
     5941 ctctcggccc ctcaaagccc ctctaagcta aggcatgagg agacagaagc aatgagctgg
     6001 aaacagcaaa tgcgatagtc taaaatccaa aaagaagaga aatccttgtc ataaattctt
     6061 tccaattact tagcaatgat ctcttcctct acgtcaaatg cccagcttgc ttacagcagt
     6121 cttttgccct aagcaacaaa actggctaga ggaagaaaca gtgaagctaa aatccactga
     6181 acctggccac agattgccag gtcactgaca agttcactgc tctttggtaa atagaataag
     6241 aatcctcaag gtaaacgaag gttgctaata ggtgtcaagt gtttccatca ttgcctccca
     6301 aagcctccat atctcagagt acacacacca agggaaaacc acagtgactt agacactcag
     6361 caggaggttt actatgtctg aggaataatt attctatctg tcttgttcta aaatgtagag
     6421 aaaaacaaga ttggttttag tttgatgttt caaacgtgag tggattttcc cccctcttca
     6481 tctgtgctac aactttaatg ttaaaagttt ggtattttca tctttagtga tgtagtattt
     6541 tttgtagtaa ttctcctaaa tgtaaactat aactgtatat aaaatgtaag tgttcttgga
     6601 gatacggtgc tagatattag attgtgtttg tagatagtgt tgtcctcaaa ggtagtatgt
     6661 acttgtaaag ttagttaata aaatgcatgc caaattctat gtgtgaccta caacttagtc
     6721 agtttctgat gtagaacatg gtacatttgt tttttaaatt tatttttgaa gtatatacta
     6781 caggatatgt aaaatagtgc caaggtgggg ttgcaggaag tgttgccttt cattccttaa
     6841 atccctaata tgatatatga caggtgagga cttattctgg tacaattggt cattagtgtg
     6901 aactaatcat cgtggctgaa gtccttgctg acagttttcc acaacacact tggcactggt
     6961 gtgcctgttt tctattcact gaatatatag aatgcaaact caaagaagac catccttctc
     7021 cattaaaaag gaaggactcc aggataggca agtagagtcc agttagcagg acgaaaagaa
     7081 tactgcaccc tgaagaccca accaacacct gaccgtgaac tgacaggttt cgcgcttggc
     7141 agatccataa tgtgaccatc catgccctcc taaagcagta gcaaaaccca gaaaaaggct
     7201 gctctgtttt tccccctttg gttggttgtc tgagagacaa gatagagaca gcatggatgg
     7261 ctaactagat agagaggtag tgggactcct ctatggggtc acagctacgg tgtttgatag
     7321 ttacagtact gtatcaatgg aatttgtgtc agacaagaaa agaaaactat aagatgattt
     7381 tgttatattt tcagaacaaa atattacaac taaaaaacta tatataccct cattaaattg
     7441 tttttaaaac tgcctttaat accaaatttt gtgagctgct ttgaaactga aaacagaaaa
     7501 atgtatttaa tcaataaata gttctcttta atattttaac gtttgaattt aaaagtttca
     7561 tttttcttta aaaacagtaa gaatttgtaa ttgaaaagtg ccttctcaaa ggattgtcaa
     7621 actacagtcc tgaggccaag ttcccattgg cacgacttac cttcaggtgc acaaaacagg
     7681 taggctttat cttcctcccc tcaacaagaa gagaatccca ctcacacccc aatcaaattc
     7741 ataaatcaac actattacat gggccagcag tcccagagat tctgcccaag gccaaggttt
     7801 cacatattgg ttggctttaa ttggatcctt tctaaaatgg ttacaatgcc tttttttttc
     7861 ttttgctgga aaggaataac ggactcctgc ttgggaaatg cggagaaatt gatgtttgtg
     7921 atttaactaa gtattattaa gtgatgtttg tgtttcttaa ataggtgctg ttattctatc
     7981 cttggtatat tcctcttaaa tattctaaat aaagtcaaat tttatgtgtg ta
//
