LOCUS       NM_018066               4665 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens GPN-loop GTPase 2 (GPN2), mRNA.
ACCESSION   NM_018066
VERSION     NM_018066.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4665)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4665)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4665)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4665)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4665)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001211.1, BC007815.2 and AL034380.26.
            
            On Nov 22, 2018 this sequence version replaced NM_018066.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022535.1, SRR1803611.204903.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374135.9/ ENSP00000363250.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AK001211.1         15-244
            231-976             BC007815.2         168-913
            977-1415            AK001211.1         991-1429
            1416-4665           AL034380.26        16851-20100
FEATURES             Location/Qualifiers
     source          1..4665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..4665
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /note="GPN-loop GTPase 2"
                     /db_xref="GeneID:54707"
                     /db_xref="HGNC:HGNC:25513"
     exon            1..598
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1120
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /note="ATP-binding domain 1 family member B"
                     /codon_start=1
                     /product="GPN-loop GTPase 2"
                     /protein_id="NP_060536.3"
                     /db_xref="CCDS:CCDS289.1"
                     /db_xref="GeneID:54707"
                     /db_xref="HGNC:HGNC:25513"
                     /translation="MAGAAPTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVN
                     LDPANEGLPYECAVDVGELVGLGDVMDALRLGPNGGLLYCMEYLEANLDWLRAKLDPL
                     RGHYFLFDCPGQVELCTHHGALRSIFSQMAQWDLRLTAVHLVDSHYCTDPAKFISVLC
                     TSLATMLHVELPHINLLSKMDLIEHYGKLAFNLDYYTEVLDLSYLLDHLASDPFFRHY
                     RQLNEKLVQLIEDYSLVSFIPLNIQDKESIQRVLQAVDKANGYCFRAQEQRSLEAMMS
                     AAMGADFHFSSTLGIQEKYLAPSNQSVEQEAMQL"
     exon            599..755
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /inference="alignment:Splign:2.1.0"
     exon            756..916
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1047
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..4665
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1396..1401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /note="hexamer: AATACA"
     polyA_site      1416
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /note="major polyA site"
     regulatory      4643..4648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
                     /note="hexamer: AATAAA"
     polyA_site      4665
                     /gene="GPN2"
                     /gene_synonym="ATPBD1B"
ORIGIN      
        1 agtctagtta gtatcggcct gttatctcct tttgcgcgac acggtctcag ctgttccgcc
       61 tgaggcgagt gacgctggcc gccaacgagg tatacgtact gggaccctcg ccctcagtct
      121 cgtctccggc gcggctacct gccccgtttt ccctgtgagt tgacctgctc cgggccgcgg
      181 gccgccaatg gcaggggccg ctccgaccac ggccttcggg caggcggtga tcggcccgcc
      241 gggctcaggg aagaccacgt actgcctggg catgagtgag ttcctgcgcg cgctgggccg
      301 gcgcgtggcg gtggtgaacc tggacccggc caacgagggg ctgccgtacg agtgtgccgt
      361 ggacgtgggc gagctggtgg ggctgggcga cgtgatggac gcgctgcgcc tggggcccaa
      421 cggcggcctg ctctactgca tggagtacct ggaagccaac ctggactggc tgcgtgccaa
      481 gctcgacccc ctccgcggcc actacttcct cttcgactgc ccaggccagg tggagctctg
      541 cacgcatcac ggcgccttgc gcagcatctt ctcccaaatg gcgcagtggg acctcaggct
      601 gactgccgtc cacctcgtgg attctcacta ctgcacagac cctgccaagt tcatttcagt
      661 actgtgtacc tccctggcca ccatgctgca cgtggaactg ccccacatca acctcctttc
      721 caagatggac ctcattgagc attatgggaa gctggccttc aacctggact actacacaga
      781 ggttctggac ctctcctacc tgcttgacca cctggcttct gaccctttct tccgccacta
      841 ccgccagctc aatgagaagc tagtgcagct catcgaagac tatagccttg tctcctttat
      901 ccctctcaac atccaggaca aggagagcat ccagcgagtc ctgcaggctg tggataaagc
      961 caatggatac tgtttcagag cccaagagca gcgaagcttg gaagccatga tgtctgccgc
     1021 aatgggagcc gacttccatt tctcttccac actgggcatc caggagaagt acctggcacc
     1081 ctcgaaccag tcagtggagc aggaagccat gcagctgtag caacaaggtg gaccctggag
     1141 agcaggatgc ataatccagc actggggaaa gtggaggctc ctgatgcagg ctgcagaccc
     1201 aagagcaagt cctcccagcc agagctggcg ggctggcaag gggatattca gctctgcaaa
     1261 ggacttctgg ccaaaaagcc agacatggtg ccaagcagaa caccccccat actgtcagtg
     1321 gtgtccgtga gctctgggcc ctgccaccag aaagtcgagc actggtccta gtcaggctgt
     1381 gatgaaatgt gctacaatac aagagtttat tttctacttt ttgtgacttc caaacttttc
     1441 ttcagtcttc cgggcccagg ggtttgggga agaatgaggg agtgtcacct agccttggaa
     1501 taatcagtat ttccccaaag catataattc acattcagtc acataggatt tacattcagt
     1561 ctccagtcat gtgtttttat taatcttcag tttttggttc tgaggtttgt tttttaaaag
     1621 atggggtctt gctatatggc ccaggctgga ctcaaactcc tgggctcatg tgatcttccc
     1681 gcctcagacg cctgagtaac tgggactaca ggtgtgagcc accatgtccc acaattttca
     1741 gttttaacag agcctcaagc ttcagctttc acaggcaaca cttcctaact agaactttgt
     1801 taatgtttta tattcactgt atttgtttta tggttttatt ctattgttga caagtgttaa
     1861 ctagttttcc atttacagta gtggttaaaa gtttacttca aggctgggtg cggtggctca
     1921 cgcctgtaat cccagcactt tgggaggccg aggcaggcgg atcccaaggt caagagatcg
     1981 agaccatcct ggccaacatg gtgaaacccc atctctacca aaaaattttt ttaattagct
     2041 gggcataggt ggcgcgtacc tgtagttcca gctacttggg aggctgaggc aggagaatca
     2101 tttgaaccca ggagtcagag gttacagtga gctgagattg caccactgca ctccagcctg
     2161 gtgacagagc gagactttgt ctcaaaaaaa aggtgtactt caaaaatgaa atacaaggct
     2221 gggcgtgttc actcatgcct gtaagcccag cactttggga ggctgaggcg ggcggatcac
     2281 ctgaggtcag gagttcgaga ccagcctggc caacatggtg aaacccctct ctactaaaaa
     2341 cataaaaatt agctgggcat ggtgttgcac gcctataatc ccagctattg gggaggctga
     2401 ggcagaagaa ttgcttgaac ccaggaggcg gaggttgcag tgagccaaga ttgtgcctac
     2461 attccaacct gggcgacaga gcaagactct gtctcaaaaa aaaatagtaa gttgtgtaaa
     2521 gaaaaatatt aattatataa tatggcagtt cctatgagag tgtggcaaaa atcaagaggg
     2581 cttggaagtt ttttctttgc tcttgcaact ggctggatgc agttcatata tttttcaacc
     2641 agtaggtggc accccaacct aattttttgc agttgtaacc tggtggcaga aggggcagga
     2701 ctgatggctt gggcaagact gttatgccaa gttttatttg catgtatttg gactttcttt
     2761 ttttggagac aaagtctctc tctgtcgccc aggctggagt ccagtggcac aatctcggct
     2821 cactgcaacc tccgcctccc aggttcaagc aattctctgc ctcagcctcc cgagtagctg
     2881 ggattacagg cgcctaccac atgcccggct aatttttgta tttttagtaa agacggggtt
     2941 tcaccatgtt gttcaggctg gtcttgaact actgacctca tgatttaccc gccttggcct
     3001 cccaaagtgc tgggattaca ggcgtgagcc actgcacccg gccacatttg gacttattaa
     3061 cacatatgaa gtgcttggta ttttagagtg cttccacaca cacaatcctc attagagata
     3121 gacaggatgg ggagaattaa taagccattg cccgtgttac agtgaggaag cagaaagatg
     3181 agaagtttga actttggtca gcctggcttt ctcataaccc attttgctga ctaaattgcg
     3241 agtatccctc ctttggtata tttattggtg agaagtcaca gcccttgtcc cacaggtttt
     3301 gcagccaatc aggagaaaga aattaggcac ctgtaaagta ttactgaatc atagatagtt
     3361 caccagtggt ttgggcagtt ggcaaattaa tttagggaca tctgttctga aacagcattg
     3421 aaataggact gactgctttg ctttctggtt gtggcagcca gagccaaagg cagatgaatg
     3481 aggggctatg aggaggctac tgtggctgga acagtatgaa agcaacctca gctcccacgc
     3541 ctggctgtaa aggggataat aactgggtgc tgcttcccag cctctttcat ctgagaagtt
     3601 caaagcacct cacccctatt aacaccccac agagtaggta ggaagtacca atagagcaag
     3661 ccaggaaaac tgaggccagg aggcacagcc tggggctagc tgtgaatcac ctgtggggcc
     3721 tagagcccag gaatcctgac gcccaggcta ctggacaaat cctttatcag ggcattaggg
     3781 tgggtgctat gcttttgaaa gcagtaccaa cggctgtggt cgtgggtttt gatgcttgcc
     3841 actcacagag gccccagctc tcaccataac aaaccaaatg ggggctggaa ggcatccttt
     3901 acaactttat ggtctcgtat gcaagcaccc tcagcattct ctgcacccat ggagtggaga
     3961 tgggtgggag taatccaagg cctttatttt caggccatgg tttgacagca agggtatttt
     4021 cttccccaat aaacgtagct tctgtctacc ttccactggc agcaaaatga ttttctgttc
     4081 tctgcatata ctgaggggat ctgcacagtg cagaaaggaa gatgtccgag atccaagtga
     4141 ggcctgttca gtgtgaaatg tctagggtag aagaaagacc atcctccatt atggctggca
     4201 tgtggcagtc atccttaaga ttatttttaa atttcctaat aaatatagga aagtaaaaaa
     4261 cttagaaaat gaaagagaag gccgagcacg gtggctcacg cctgtaatcc cagcactttg
     4321 ggaggccaag gcgggctgat cacctgaggt caggagtgta agacaagcct gaccaacatg
     4381 gtgaaaacct gtctctgcta aaaatacaaa aaaatgagca gggcatggtg gcatgcgcct
     4441 gtaattccag ctacttagga gactgaggca ggagaatcgc ttgaacctgg gaggcggaag
     4501 tttcagtgag cggagatcgc gccattgcac tccagcctgg gtaacaagat ggaaagtaca
     4561 tctcaaaaaa aaaaaaaacg aaaatgagtc acccagaatc ccataacgga aactttctat
     4621 ggggtcatct gtttaagaga aaaataaatt ctatattcaa atgta
//
