LOCUS       NM_001001995            3118 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glycoprotein M6B (GPM6B), transcript variant 1, mRNA.
ACCESSION   NM_001001995
VERSION     NM_001001995.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3118)
  AUTHORS   He,S., Huang,Z., Li,X., Ding,Y., Sheng,H., Liu,B. and Jia,Z.
  TITLE     GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell
            Serotonin Absorptive Capacity
  JOURNAL   Dis Markers 2020, 8810756 (2020)
   PUBMED   33294057
  REMARK    GeneRIF: GPM6B Inhibit PCa Proliferation by Blocking Prostate
            Cancer Cell Serotonin Absorptive Capacity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3118)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3118)
  AUTHORS   Zhang,X., Xie,H., Chang,P., Zhao,H., Xia,Y., Zhang,L., Guo,X.,
            Huang,C., Yan,F., Hu,L., Lin,C., Li,Y., Xiong,Z., Wang,X., Li,G.,
            Deng,L., Wang,S. and Tao,L.
  TITLE     Glycoprotein M6B Interacts with TbetaRI to Activate
            TGF-beta-Smad2/3 Signaling and Promote Smooth Muscle Cell
            Differentiation
  JOURNAL   Stem Cells 37 (2), 190-201 (2019)
   PUBMED   30372567
  REMARK    GeneRIF: Findings demonstrate that GPM6B plays a crucial role in
            SMC differentiation and regulates SMC differentiation through the
            activation of TGF-beta-Smad2/3 signaling via direct interactions
            with TbetaRI.
REFERENCE   4  (bases 1 to 3118)
  AUTHORS   Urban,P., Rabajdova,M.B., Varga,J., Kruzliak,P., Fialkovicova,V.,
            Durovcova,E. and Marekova,M.
  TITLE     Vascular marker expression during the development of various types
            of gynaecological malignancy
  JOURNAL   Tumour Biol 35 (11), 11229-11235 (2014)
   PUBMED   25113253
  REMARK    GeneRIF: Increase in the expression levels of mRNA and protein for
            the Gpm6B is associated with various types of gynaecological
            malignancy.
REFERENCE   5  (bases 1 to 3118)
  AUTHORS   Henneke,M., Wehner,L.E., Hennies,H.C., Preuss,N. and Gartner,J.
  TITLE     Mutation analysis of the M6b gene in patients with
            Pelizaeus-Merzbacher-like syndrome
  JOURNAL   Am J Med Genet A 128A (2), 156-158 (2004)
   PUBMED   15214007
  REMARK    GeneRIF: it is unlikely that mutations in M6B have a role in
            Pelizaeus-Merzbacher-like syndrome, as examined in eight patients
REFERENCE   6  (bases 1 to 3118)
  AUTHORS   Werner,H., Dimou,L., Klugmann,M., Pfeiffer,S. and Nave,K.A.
  TITLE     Multiple splice isoforms of proteolipid M6B in neurons and
            oligodendrocytes
  JOURNAL   Mol Cell Neurosci 18 (6), 593-605 (2001)
   PUBMED   11749036
REFERENCE   7  (bases 1 to 3118)
  AUTHORS   Yoshida,M., Shan,W.S. and Colman,D.R.
  TITLE     Conserved and divergent expression patterns of the proteolipid
            protein gene family in the amphibian central nervous system
  JOURNAL   J Neurosci Res 57 (1), 13-22 (1999)
   PUBMED   10397631
REFERENCE   8  (bases 1 to 3118)
  AUTHORS   Narayanan,V., Olinsky,S., Dahle,E., Naidu,S. and Zoghbi,H.Y.
  TITLE     Mutation analysis of the M6b gene in patients with Rett syndrome
  JOURNAL   Am J Med Genet 78 (2), 165-168 (1998)
   PUBMED   9674909
REFERENCE   9  (bases 1 to 3118)
  AUTHORS   Olinsky,S., Loop,B.T., DeKosky,A., Ripepi,B., Weng,W., Cummins,J.,
            Wenger,S.L., Yan,Y., Lagenaur,C. and Narayanan,V.
  TITLE     Chromosomal mapping of the human M6 genes
  JOURNAL   Genomics 33 (3), 532-536 (1996)
   PUBMED   8661015
REFERENCE   10 (bases 1 to 3118)
  AUTHORS   Yan,Y., Lagenaur,C. and Narayanan,V.
  TITLE     Molecular cloning of M6: identification of a PLP/DM20 gene family
  JOURNAL   Neuron 11 (3), 423-431 (1993)
   PUBMED   8398137
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA191910.1, BC047295.1,
            BG532134.1, AK095657.1, AL119977.1, AA991690.1, BI669888.1 and
            AC003037.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001001995.2.
            
            Summary: This gene encodes a membrane glycoprotein that belongs to
            the proteolipid protein family. Proteolipid protein family members
            are expressed in most brain regions and are thought to be involved
            in cellular housekeeping functions such as membrane trafficking and
            cell-to-cell communication. This protein may also be involved in
            osteoblast differentiation. Alternate splicing results in multiple
            transcript variants. Pseudogenes of this gene are located on
            chromosomes Y and 22. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.34840.1,
                                           SRR1660807.75799.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316715.9/ ENSP00000316861.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               DA191910.1         267-382
            117-1026            BC047295.1         93-1002
            1027-1585           BG532134.1         95-653
            1586-2095           AK095657.1         1606-2115
            2096-2650           AL119977.1         6-560
            2651-2966           AA991690.1         67-382              c
            2967-3114           BI669888.1         206-353
            3115-3118           AC003037.1         74113-74116         c
FEATURES             Location/Qualifiers
     source          1..3118
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..3118
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /note="glycoprotein M6B"
                     /db_xref="GeneID:2824"
                     /db_xref="HGNC:HGNC:4461"
                     /db_xref="MIM:300051"
     exon            1..250
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1176
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protolipid M6B; neuronal membrane glycoprotein M6-b"
                     /codon_start=1
                     /product="neuronal membrane glycoprotein M6-b isoform 1"
                     /protein_id="NP_001001995.1"
                     /db_xref="CCDS:CCDS35206.1"
                     /db_xref="GeneID:2824"
                     /db_xref="HGNC:HGNC:4461"
                     /db_xref="MIM:300051"
                     /translation="MKPAMETAAEENTEQSQERKVNSRAEMEIGRYHWMYPGSKNHQY
                     HPVPTLGDRASPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGT
                     VAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELH
                     GEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNG
                     TTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATV
                     IALIHFLMILSSNWAYLKDASKMQAYQDIKAKEEQELQDIQSRSKEQLNSYT"
     exon            251..370
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            371..557
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            558..714
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            715..886
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            887..960
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1026
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..3118
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /note="hexamer: ATTAAA"
     polyA_site      2601
                     /gene="GPM6B"
                     /gene_synonym="M6B"
     regulatory      3003..3008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /note="hexamer: AATAAA"
     polyA_site      3028
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /note="major polyA site"
     regulatory      3097..3102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPM6B"
                     /gene_synonym="M6B"
                     /note="hexamer: AATAAA"
     polyA_site      3118
                     /gene="GPM6B"
                     /gene_synonym="M6B"
ORIGIN      
        1 agagcgaaat tgacgctgac aagacttttg catcttggaa gggactgtaa tctactgtag
       61 tgaagaacag agcctctcaa tcagacgggt gtaaataaga gacggagggg agtccaaaag
      121 aaaaggaaga ggaggaaaaa caagtgtgtg ttggggggaa cagggggaaa agcatttttg
      181 gtggatggta tgaagccagc catggaaact gcagccgagg aaaatactga acaaagccaa
      241 gagagaaaag tgaacagcag agctgaaatg gaaattggca ggtaccactg gatgtaccca
      301 ggctcaaaga accaccagta ccatcccgtg ccaaccctgg gggacagggc tagccccttg
      361 agcagtccag gctgctttga atgctgcatc aagtgtctgg gaggagtccc ctacgcctcc
      421 ctggtggcca ccatcctctg cttctccggg gtggccttat tctgcggctg tgggcatgtg
      481 gctctcgcag gcaccgtggc gattcttgag caacacttct ccaccaacgc cagtgaccat
      541 gccttgctga gcgaggtgat acaactgatg cagtatgtca tctatggaat tgcgtccttt
      601 ttcttcttgt atgggatcat tctgttggca gaaggctttt acaccacaag tgcagtgaaa
      661 gaactgcacg gtgagtttaa aacaaccgct tgtggccgat gcatcagtgg aatgttcgtt
      721 ttcctcacct atgtgcttgg agtggcctgg ctgggtgtgt ttggtttctc agcggtgccc
      781 gtgtttatgt tctacaacat atggtcaact tgtgaagtca tcaagtcacc gcagaccaac
      841 gggaccacgg gtgtggagca gatctgtgtg gatatccgac aatacggtat cattccttgg
      901 aatgctttcc ccggaaaaat atgtggctct gccctggaga acatctgcaa cacaaacgag
      961 ttctacatgt cctatcacct gttcattgtg gcctgtgcag gagctggtgc caccgtcatt
     1021 gccctgatcc acttcctcat gatactgtct tctaactggg cttacttaaa ggatgcgagc
     1081 aaaatgcagg cttaccagga tatcaaagca aaggaagaac aggaactgca agatatccag
     1141 tctcggtcaa aagaacaact caattcttac acataaatgt ttgccagagt gtttcggccg
     1201 acgtatttac agctctgaca aatcatcaga cagctgctct gcagtacaga tgtgtatccc
     1261 accaaactaa tgtagatgta caaacacttc actgtctgtc tcaagctgct gggatgtatc
     1321 tctaggaaaa ccttccagtg ggtaaatctt tttctttaga acaaatattg gaggtttcat
     1381 gttagccatt ttaaaaggca acactttgac aaaatgatcg ttcatacttt gggaatttgt
     1441 ggcatgttca catttattgc tagggcaatt ctaccaagac actcaatgga atatgtcaca
     1501 ctccttaata gggacctgtg actccttaat aaggacctgt gacatgccca gcatcaaggg
     1561 ataagaccgt aaattcacat atatgccatc tgtcctcaag tgttatctac ataggaaata
     1621 aaatggaatt gatgtaaagt tccatttctg acagctgaca tttattaaac tttggatcaa
     1681 agataatgtg attcttatga ttgatttctc aaactagctt ttccctccca agtccaggac
     1741 ccattaattt cctgagccaa tcagaaatat atttttcaat aatgctaaaa ttagctacaa
     1801 ttctgctgac cctactatta aagaatctgg atgctggact cactgacaag ctttccagaa
     1861 gcaattttat aacagatttc attttaacaa aatactgatc caattttcat tattcttgag
     1921 aaatgtcagc tttgccttaa tgagtatttg ctttaaattt ctaagaattt atatcataac
     1981 tagagaccca aatatctttc acagaatttt gttccataaa tgtttttctt aattattaag
     2041 aagtgttacc ttattaaaat gaccaccatt ctaaaccatt tttcagtggt ctggatacga
     2101 agtttacagt ttcataccaa ctatctaaaa cctaattgca aattgaccac agacctctaa
     2161 cctcctactt ttatagactt gaatacttaa gtaatttaaa ttagggttgg tatttcattt
     2221 ttttcttatc taaatcttag tttcctggaa taataaagtt tgatgttcag caagagaact
     2281 gcttgagttt aagccatttt caaaagaaac ttgcctttta cattattgtg ttccagaaca
     2341 ttaagtgact gtaggtactg ggtattagtg atggtaaact ttgtgttgct ctttatgaaa
     2401 tgatccatat aactgttggg tgcatcagtg cttttcaaag gggctgctta ctatagggtt
     2461 aactatgtat attcattgtt aagagttaac ttgtggtttg gctgtttcct ggattttata
     2521 acatacatgt gcagaaatgt attcaaatga aaggaagcat acctttatca agatgctatt
     2581 aaaattgaac atcaagtata atatttcatt tggattctct tttttggtta atgcctaaaa
     2641 atgcctattt gggatttttt ttttttttta aattaagaga agctctcttc tgtgtagaac
     2701 agttgttcca aaatagctta gtgttttgtt ttcctgttgc atgacagatt taactattct
     2761 ttccagcagt ggaggtgctg tcagagtcca gtgttctaga agaggcagtg tctaaagcct
     2821 aattttactt ttctaattct ggtagctatt accaggaatt tttgaaagtt ttgtttaagt
     2881 agtctaatat tttttatgta aagagcatta aattttgcta tgtataaatt tttgtaacct
     2941 aacagtgaat caatattttc tatcagtgcc aagggcttcc tgtagttcta ttcaagtgtt
     3001 acaataaata tttgtagata atagtcaata cttgtgtatg cttattttaa agatctattt
     3061 aggtggaaat agttgtggat gtactaagag taatgaaata aaattatagc ttcattca
//
