LOCUS       NM_201591               2842 bp    mRNA    linear   PRI 17-MAY-2024
DEFINITION  Homo sapiens glycoprotein M6A (GPM6A), transcript variant 2, mRNA.
ACCESSION   NM_201591
VERSION     NM_201591.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2842)
  AUTHORS   Tao,Y., Yu,X., Li,X., Xu,Y., Wang,H., Zhang,L., Lin,R., Wang,Y. and
            Fan,P.
  TITLE     M6A methylation-regulated autophagy may be a new therapeutic target
            for intervertebral disc degeneration
  JOURNAL   Cell Biol Int 48 (4), 389-403 (2024)
   PUBMED   38317355
  REMARK    GeneRIF: M6A methylation-regulated autophagy may be a new
            therapeutic target for intervertebral disc degeneration.
            Review article
REFERENCE   2  (bases 1 to 2842)
  AUTHORS   Guo,X., Qiu,W., Li,B., Qi,Y., Wang,S., Zhao,R., Cheng,B., Han,X.,
            Du,H., Pan,Z., Zhao,S., Qiu,J., Li,G. and Xue,H.
  TITLE     Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes
            Microglia by Potentiating RNA m6A Demethylation
  JOURNAL   Clin Cancer Res 30 (6), 1160-1174 (2024)
   PUBMED   37855702
  REMARK    GeneRIF: Hypoxia-Induced Neuronal Activity in Glioma Patients
            Polarizes Microglia by Potentiating RNA m6A Demethylation.
REFERENCE   3  (bases 1 to 2842)
  AUTHORS   Wang,P., Xie,D., Xiao,T., Cheng,C., Wang,D., Sun,J., Wu,M.,
            Yang,Y., Zhang,A. and Liu,Q.
  TITLE     H3K18 lactylation promotes the progression of arsenite-related
            idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP
  JOURNAL   J Hazard Mater 461, 132582 (2024)
   PUBMED   37742376
  REMARK    GeneRIF: H3K18 lactylation promotes the progression of
            arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
REFERENCE   4  (bases 1 to 2842)
  AUTHORS   Leon,A., Aparicio,G.I. and Scorticati,C.
  TITLE     Neuronal Glycoprotein M6a: An Emerging Molecule in Chemical Synapse
            Formation and Dysfunction
  JOURNAL   Front Synaptic Neurosci 13, 661681 (2021)
   PUBMED   34017241
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2842)
  AUTHORS   Khalid,Z. and Sezerman,O.U.
  TITLE     A comprehensive study on identifying the structural and functional
            SNPs of human neuronal membrane glycoprotein M6A (GPM6A)
  JOURNAL   J Biomol Struct Dyn 39 (8), 2693-2701 (2021)
   PUBMED   32248748
  REMARK    GeneRIF: A comprehensive study on identifying the structural and
            functional SNPs of human neuronal membrane glycoprotein M6A
            (GPM6A).
REFERENCE   6  (bases 1 to 2842)
  AUTHORS   Shin,B.K., Wang,H., Yim,A.M., Le Naour,F., Brichory,F., Jang,J.H.,
            Zhao,R., Puravs,E., Tra,J., Michael,C.W., Misek,D.E. and
            Hanash,S.M.
  TITLE     Global profiling of the cell surface proteome of cancer cells
            uncovers an abundance of proteins with chaperone function
  JOURNAL   J Biol Chem 278 (9), 7607-7616 (2003)
   PUBMED   12493773
REFERENCE   7  (bases 1 to 2842)
  AUTHORS   Mukobata,S., Hibino,T., Sugiyama,A., Urano,Y., Inatomi,A.,
            Kanai,Y., Endo,H. and Tashiro,F.
  TITLE     M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal
            differentiation
  JOURNAL   Biochem Biophys Res Commun 297 (4), 722-728 (2002)
   PUBMED   12359212
REFERENCE   8  (bases 1 to 2842)
  AUTHORS   Yan,Y., Narayanan,V. and Lagenaur,C.
  TITLE     Expression of members of the proteolipid protein gene family in the
            developing murine central nervous system
  JOURNAL   J Comp Neurol 370 (4), 465-478 (1996)
   PUBMED   8807448
REFERENCE   9  (bases 1 to 2842)
  AUTHORS   Olinsky,S., Loop,B.T., DeKosky,A., Ripepi,B., Weng,W., Cummins,J.,
            Wenger,S.L., Yan,Y., Lagenaur,C. and Narayanan,V.
  TITLE     Chromosomal mapping of the human M6 genes
  JOURNAL   Genomics 33 (3), 532-536 (1996)
   PUBMED   8661015
REFERENCE   10 (bases 1 to 2842)
  AUTHORS   Shimizu,F., Watanabe,T.K., Fujiwara,T., Takahashi,E., Nakamura,Y.
            and Maekawa,H.
  TITLE     Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to
            4q33-->q34
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 138-139 (1996)
   PUBMED   8893821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097537.2 and AC093819.4.
            
            On Oct 19, 2020 this sequence version replaced NM_201591.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022508.1, D49958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393658.7/ ENSP00000377268.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC097537.2         33286-33359         c
            75-267              AC093819.4         89144-89336         c
            268-424             AC093819.4         61249-61405         c
            425-578             AC093819.4         39403-39556         c
            579-655             AC093819.4         28322-28398         c
            656-721             AC093819.4         27698-27763         c
            722-2842            AC093819.4         20506-22626         c
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.2"
     gene            1..2842
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /note="glycoprotein M6A"
                     /db_xref="GeneID:2823"
                     /db_xref="HGNC:HGNC:4460"
                     /db_xref="MIM:601275"
     exon            1..74
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..874
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /note="isoform 1 is encoded by transcript variant 2;
                     neuronal membrane glycoprotein M6-a"
                     /codon_start=1
                     /product="neuronal membrane glycoprotein M6-a isoform 1"
                     /protein_id="NP_963885.1"
                     /db_xref="CCDS:CCDS3824.1"
                     /db_xref="GeneID:2823"
                     /db_xref="HGNC:HGNC:4460"
                     /db_xref="MIM:601275"
                     /translation="MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFC
                     GCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVE
                     GFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWT
                     ICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVAL
                     AGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNA
                     YT"
     exon            75..267
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            268..424
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            425..578
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            579..655
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            656..721
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /inference="alignment:Splign:2.1.0"
     exon            722..2842
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /note="hexamer: AATAAA"
     polyA_site      2331
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /note="major polyA site"
     regulatory      2806..2811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
                     /note="hexamer: AATAAA"
     polyA_site      2842
                     /gene="GPM6A"
                     /gene_synonym="GPM6; M6A"
ORIGIN      
        1 aattccgtgt accagattct actgaagaaa ggtagccatg gaagagaata tggaagaggg
       61 acagacacaa aaagggtgtt ttgaatgctg tatcaaatgc ctggggggca ttccctatgc
      121 ctctctgatt gccaccatcc tgctctatgc gggtgttgcc ctgttctgtg gctgcggtca
      181 tgaagcgctt tctggaactg tcaacattct gcaaacctac tttgagatgg caagaactgc
      241 tggagacaca ctggatgttt ttaccatgat tgacatcttt aagtatgtga tctacggcat
      301 cgcagctgcg ttctttgtgt atggcatttt gctgatggtg gaaggtttct tcacaactgg
      361 ggccatcaaa gatctctatg gggatttcaa aatcaccact tgtggcagat gtgtgagcgc
      421 ttggttcatt atgctgacat atcttttcat gttggcctgg ctgggagtca cggctttcac
      481 ctcactgcca gtttacatgt acttcaatct gtggaccatc tgccggaaca ccacattagt
      541 ggagggagca aatctctgct tggaccttcg tcagtttgga attgtgacaa ttggagagga
      601 aaagaaaatt tgtactgtct ctgagaattt cttgaggatg tgcgaatcta ctgagctgaa
      661 catgaccttc cacttgttta ttgtggcact tgctggagct ggggcagcag tcattgctat
      721 ggttcactac cttatggttc tgtctgccaa ctgggcctat gtgaaagacg cctgccggat
      781 gcagaagtat gaagacatca agtcgaagga agagcaagag cttcatgaca tccactctac
      841 tcgctccaaa gagcggctca atgcatacac ataaatgcat cttcctgttc tttctaccat
      901 ttgaatgcat tggtgtttaa ctaagggcca tccaaccatc caacctttaa aaaacaaaac
      961 gaaagtgctt ctcatcaatg atatgtaagg tgacttatga atcacctgag tacaattctt
     1021 tgttgtttag cacttaaatt tcccaattta ttaaattgat gtaaatcaga tcttttctac
     1081 aagctcctat ccagcctttt ttttgaaatt tctcaaactc atttactagt tctgtaaaat
     1141 caaagatact aacattgtca aatgcaaaga tttgtttgat ttttaaccac ttcccatgtg
     1201 ttatacataa caccttttgc attatttctt atgttttgaa aagaaaatag ctttttatac
     1261 tttttagttt tgatttcggt aactagttta actacaggta accttcaaag ggaccattgt
     1321 acattatgaa caatagatag agattacatc ttgatgactc ttgaaatatg gaaattttgt
     1381 ctgaagatca gtggccatat tactgtaggc cctggttcat gttttcatca atctaaggtg
     1441 caatttctaa atttgtaaga gtaggtttaa aaaaaaaagt gcttcttatc tttgttaaca
     1501 ttgtactttt ccttgatgtt cttaaaaggt atttccctca gattactcat gtttatgttg
     1561 tgagcatgta gaaacagtaa tgctaatgca tggctagttg cctttttaag attgtgacac
     1621 caggcttacc ttttaaagtt tagtatatag agacaatttt aatggaaata actactgtag
     1681 actattgaag aatgatctct ttgtgattta agaagtggct ggattggaac ttttaatatg
     1741 ctaatgtgga aaattaatta cctttatgaa ggtggtttat tacaaataag cacactaacc
     1801 cctcggaagt tgttttacct actttaaaag ttttaatgga ttgcacctct gtaaactatt
     1861 cctaaaatgt gtatgatata tttgaaaagg cttccattaa tataatagct ttgcttgcag
     1921 ccttccaatc tatgttggtt tacctgtagt gttttataaa gtgtggtcag aggcccctat
     1981 agaatgtatt gtttgaaagt gtagtgatat atttgtgttt ttatttcaag taagtcattt
     2041 taaccgaatg ttcattcata ttcatttata aaaagtacct gtatcaaagg aattttaaca
     2101 aagagcaatc agtattattg gaccaaattt ggtgtttgtt ttcaccttga cgctcttctt
     2161 ttcattattt ctaatgctac aagaatgctg taaagtgtct tctaaaatga tgtagcctga
     2221 caagacattt ttttcagtgt ataaaactag gtagtattgt gcactgattt gaccattgtg
     2281 aaatcctttc tcagtgtaac tgcatttcta ataaaaattt attgagtgaa acaatctttg
     2341 tacaatgact agtcatgcat catcagtaat tttacaagtt cttgtagtag gtagggggta
     2401 ctactaggga tatctgtggc atgattatgc attccgtagt attatttaat taatttgggg
     2461 ttcattttgc ttccttttct ttatgcttag attatcttac tggttcaaca tttttctgat
     2521 atatgcagta ttacagatat tcagcaaaag tattaatggg cttctttaaa ttctatatta
     2581 tagtatttca gttccgtgtc ttaacagttt gtgataattt ctaaaactgt cttttcaact
     2641 tatgtaatga tgttgacact tttggctttt atttctggta ttagagtttg tattttcaca
     2701 gagtgctttg tagcaggcat tacaattaat ctgttttgta cataaatgtg ccaacagctt
     2761 gatggtggcg tttttgaaat gtagaacaga gtgcttgcaa aatgtaataa atacacttgt
     2821 gtactttgtg tacttattat ta
//
