LOCUS       NM_015698               1658 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens G-patch domain and KOW motifs (GPKOW), mRNA.
ACCESSION   NM_015698
VERSION     NM_015698.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1658)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1658)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1658)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1658)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1658)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 1658)
  AUTHORS   Aksaas,A.K., Larsen,A.C., Rogne,M., Rosendal,K., Kvissel,A.K. and
            Skalhegg,B.S.
  TITLE     G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear
            RNA-binding protein regulated by protein kinase A
  JOURNAL   J Mol Signal 6, 10 (2011)
   PUBMED   21880142
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1658)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 1658)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   9  (bases 1 to 1658)
  AUTHORS   Glesne,D. and Huberman,E.
  TITLE     Smad6 is a protein kinase X phosphorylation substrate and is
            required for HL-60 cell differentiation
  JOURNAL   Oncogene 25 (29), 4086-4098 (2006)
   PUBMED   16491121
REFERENCE   10 (bases 1 to 1658)
  AUTHORS   Schindelhauer,D., Hellebrand,H., Grimm,L., Bader,I., Meitinger,T.,
            Wehnert,M., Ross,M. and Meindl,A.
  TITLE     Long-range map of a 3.5-Mb region in Xp11.23-22 with a
            sequence-ready map from a 1.1-Mb gene-rich interval
  JOURNAL   Genome Res 6 (11), 1056-1069 (1996)
   PUBMED   8938429
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE795098.1 and BC003148.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015698.5.
            
            Summary: This gene encodes a putative RNA-binding protein
            containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The
            encoded protein interacts directly with protein kinase A and
            protein kinase X and is also found associated with the spliceosome.
            [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000397.2, AB209806.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000156109.7/ ENSP00000156109.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BE795098.1         67-72
            7-1658              BC003148.1         1-1652
FEATURES             Location/Qualifiers
     source          1..1658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..1658
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /note="G-patch domain and KOW motifs"
                     /db_xref="GeneID:27238"
                     /db_xref="HGNC:HGNC:30677"
                     /db_xref="MIM:301003"
     exon            1..189
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1444
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /note="G patch domain and KOW motifs-containing protein;
                     protein MOS2 homolog"
                     /codon_start=1
                     /product="G-patch domain and KOW motifs-containing
                     protein"
                     /protein_id="NP_056513.2"
                     /db_xref="CCDS:CCDS35251.1"
                     /db_xref="GeneID:27238"
                     /db_xref="HGNC:HGNC:30677"
                     /db_xref="MIM:301003"
                     /translation="MADSKEGVLPLTAASTAPISFGFTRTSARRRLADSGDGAGPSPE
                     EKDFLKTVEGRELQSVKPQEAPKELVIPLIQNGHRRQPPARPPGPSTDTGALADGVVS
                     QAVKELIAESKKSLEERENAGVDPTLAIPMIQKGCTPSGEGADSEPRAETVPEEANYE
                     AVPVEAYGLAMLRGMGWKPGEGIGRTFNQVVKPRVNSLRPKGLGLGANLTEAQALTPT
                     GPSRMPRPDEEQEKDKEDQPQGLVPGGAVVVLSGPHRGLYGKVEGLDPDNVRAMVRLA
                     VGSRVVTVSEYYLRPVSQQEFDKNTLDLRQQNGTASSRKTLWNQELYIQQDNSERKRK
                     HLPDRQDGPAAKSEKAAPRSQHWLHRDLRVRFVDNMYKGGQYYNTKMIIEDVLSPDTC
                     VCRTDEGRVLEGLREDMLETLVPKAEGDRVMVVLGPQTGRVGHLLSRDRARSRALVQL
                     PRENQVVELHYDAICQYMGPSDTDDD"
     exon            190..344
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            345..469
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            470..579
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            580..793
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            794..926
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1029
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1153
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1223
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1309
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1658
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1639..1644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /note="hexamer: AATAAA"
     polyA_site      1658
                     /gene="GPKOW"
                     /gene_synonym="GPATC5; GPATCH5; Mos2; Spp2; T54"
                     /note="major polyA site"
ORIGIN      
        1 gaaaaggagc aagatggctg actccaaaga gggtgttttg ccgctgacgg ctgcttccac
       61 tgccccaatt tcattcggct tcactcgcac gtccgcacgg aggcggctgg ccgactcggg
      121 agacggcgcg gggccatctc cggaggagaa ggatttcttg aaaaccgtgg aagggaggga
      181 gctgcagagt gtgaagcccc aggaggcccc caaggaactc gtcatccctt tgatccagaa
      241 tggccatcgc aggcagccac cagcccggcc ccctgggcca tccacagata ctggggcctt
      301 ggcggatggg gtggtgtccc aggctgtgaa ggagctcatt gcggaatcca agaagtctct
      361 ggaagagaga gagaatgcgg gtgtcgaccc cacgctcgct atccccatga tccagaaagg
      421 atgcaccccc agcggggaag gggcagacag cgaaccccgg gcagagacag tgccagagga
      481 ggctaattat gaggcggtcc ccgtggaggc ctatgggctg gccatgctgc ggggcatggg
      541 ctggaaacct ggcgagggca tcggccgcac cttcaatcaa gtagtgaagc cccgtgtcaa
      601 ctcactgagg cccaaggggt tagggctggg tgccaacctg accgaggccc aggccttgac
      661 ccccactggc ccctcccgca tgccaagacc agatgaggag caagagaaag ataaggaaga
      721 tcagcctcaa gggctggtgc ctggaggagc tgtggtggtt ctttctggcc ctcaccgagg
      781 cctctatggg aaggtggaag gccttgatcc tgacaatgtt cgggccatgg ttcgtctggc
      841 tgtggggagc cgggtggtga ctgttagtga gtactacctg cggcctgtct cccagcagga
      901 gtttgacaag aacaccttgg atctcaggca acagaacgga actgcctcat cacggaagac
      961 cctctggaat caagaactct acatccagca ggacaactca gagaggaagc ggaaacacct
     1021 tccagaccga caggatgggc ctgcagccaa gagtgagaaa gcagccccca gaagtcagca
     1081 ctggttgcac agggacctgc gtgtgcggtt tgtggacaac atgtacaaag gaggccaata
     1141 ttacaacacc aagatgataa ttgaagatgt cctaagccca gatacctgtg tatgtcggac
     1201 agatgaaggc cgagtcctgg aaggcctgag ggaagacatg ctggagaccc tggttcccaa
     1261 ggcagagggt gaccgtgtga tggtggtgct gggcccacag actggaaggg tgggacattt
     1321 gctgagccgg gacagagcac ggagccgggc tttggtgcaa ctgccaagag aaaatcaggt
     1381 ggtggagctt cactacgatg ccatctgcca gtacatgggc cctagtgaca cagatgatga
     1441 ctgacccatg ggactcctcc catcccccag gctggtacca gttctgtacc atatgagaaa
     1501 gttgccttca gaaggtggga agatcattgt tccatcctct acttctggtg cagtcctggg
     1561 acaaggacaa gggaaaggga tgggtgaacc agtagggaag ctagaaacaa acccaatatt
     1621 taccaaaatt tagggtataa taaaaaccat ttcaagta
//
