LOCUS       NM_020806               3557 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens gephyrin (GPHN), transcript variant 1, mRNA.
ACCESSION   NM_020806
VERSION     NM_020806.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Dos Reis,R., Kornobis,E., Pereira,A., Tores,F., Carrasco,J.,
            Gautier,C., Jahannault-Talignani,C., Nitschke,P., Muchardt,C.,
            Schlosser,A., Maric,H.M., Ango,F. and Allemand,E.
  TITLE     Complex regulation of Gephyrin splicing is a determinant of
            inhibitory postsynaptic diversity
  JOURNAL   Nat Commun 13 (1), 3507 (2022)
   PUBMED   35717442
  REMARK    GeneRIF: Complex regulation of Gephyrin splicing is a determinant
            of inhibitory postsynaptic diversity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Mammoto,A., Sasaki,T., Asakura,T., Hotta,I., Imamura,H.,
            Takahashi,K., Matsuura,Y., Shirao,T. and Takai,Y.
  TITLE     Interactions of drebrin and gephyrin with profilin
  JOURNAL   Biochem Biophys Res Commun 243 (1), 86-89 (1998)
   PUBMED   9473484
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Meyer,G., Kirsch,J., Betz,H. and Langosch,D.
  TITLE     Identification of a gephyrin binding motif on the glycine receptor
            beta subunit
  JOURNAL   Neuron 15 (3), 563-572 (1995)
   PUBMED   7546736
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Misko,A., Mahtani,K., Abbott,J., Schwarz,G. and Atwal,P.
  TITLE     Molybdenum Cofactor Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   34870926
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Balint,B. and Thomas,R.
  TITLE     Hereditary Hyperekplexia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301437
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Prior,P., Schmitt,B., Grenningloh,G., Pribilla,I., Multhaup,G.,
            Beyreuther,K., Maulet,Y., Werner,P., Langosch,D., Kirsch,J. et al.
  TITLE     Primary structure and alternative splice variants of gephyrin, a
            putative glycine receptor-tubulin linker protein
  JOURNAL   Neuron 8 (6), 1161-1170 (1992)
   PUBMED   1319186
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Kirsch,J., Langosch,D., Prior,P., Littauer,U.Z., Schmitt,B. and
            Betz,H.
  TITLE     The 93-kDa glycine receptor-associated protein binds to tubulin
  JOURNAL   J Biol Chem 266 (33), 22242-22245 (1991)
   PUBMED   1657993
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355093.3, AL133241.3,
            AL117667.4, AL049835.3, AL159179.3 and AL135978.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 22, 2020 this sequence version replaced NM_020806.4.
            
            Summary: This gene encodes a neuronal assembly protein that anchors
            inhibitory neurotransmitter receptors to the postsynaptic
            cytoskeleton via high affinity binding to a receptor subunit domain
            and tubulin dimers. In nonneuronal tissues, the encoded protein is
            also required for molybdenum cofactor biosynthesis. Mutations in
            this gene may be associated with the neurological condition
            hyperplexia and also lead to molybdenum cofactor deficiency.
            Numerous alternatively spliced transcript variants encoding
            different isoforms have been described; however, the full-length
            nature of all transcript variants is not currently known. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as GephP1,
            represents the longer transcript and encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030016.2, AK315569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000478722.6/ ENSP00000417901.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AL355093.3         32583-33027         c
            446-524             AL133241.3         16070-16148
            525-582             AL133241.3         111427-111484
            583-675             AL117667.4         2091-2183
            676-770             AL117667.4         57556-57650
            771-837             AL049835.3         184210-184276       c
            838-1110            AL049835.3         177341-177613       c
            1111-1209           AL049835.3         175987-176085       c
            1210-1344           AL049835.3         134954-135088       c
            1345-1387           AL049835.3         76604-76646         c
            1388-1525           AL049835.3         41493-41630         c
            1526-1618           AL049835.3         11204-11296         c
            1619-1674           AL159179.3         46633-46688
            1675-1794           AL159179.3         55917-56036
            1795-1853           AL159179.3         57638-57696
            1854-2007           AL159179.3         58795-58948
            2008-2129           AL159179.3         68033-68154
            2130-2217           AL159179.3         89139-89226
            2218-2291           AL159179.3         105192-105265
            2292-2356           AL135978.4         168729-168793       c
            2357-2460           AL135978.4         164919-165022       c
            2461-2557           AL135978.4         154281-154377       c
            2558-3557           AL135978.4         152152-153151       c
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3-q24.1"
     gene            1..3557
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /note="gephyrin"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
     exon            1..445
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..2691
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /EC_number="2.10.1.1"
                     /EC_number="2.7.7.75"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="gephyrin isoform 1"
                     /protein_id="NP_065857.1"
                     /db_xref="CCDS:CCDS9777.1"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
                     /translation="MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQ
                     DPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKE
                     VIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILP
                     ALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEE
                     KKDSGVASTEDSSSSHITAAAIAAKKHPFYTSPAVVMAHGEQPIPGLINYSHHSTDER
                     IPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILR
                     ASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDV
                     YAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPI
                     PCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGT
                     HMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLAT
                     IQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLH
                     AQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGI
                     LDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSAN
                     GLLMLPPKTEQYVELHKGEVVDVMVIGRL"
     exon            446..524
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            525..582
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            583..675
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            676..770
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            771..837
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1110
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1209
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1344
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1387
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1525
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1618
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1674
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1794
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1853
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2007
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2129
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2217
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2291
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2356
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2460
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2557
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..3557
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3526..3531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /note="hexamer: AATAAA"
     polyA_site      3557
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /note="major polyA site"
ORIGIN      
        1 cctttcctct cagtcctgcc atctagctgc cttgggtctc gcgctccgca gagcgttccg
       61 acactctccg gcctcgttct gccgcctccg cgcgctctcc ccgtgcggcc accgcgcccc
      121 ccaagcttgc ctccttcttg ccggacttgg ggccgcgcgc cctgactcct tcccctcccg
      181 cggacccgcg cactcccggc gcggcctctc ccccacgcag gccaccgtgc actctgtggc
      241 ctccccctcc ttccccgctc tcctcgcgct tctctggctc cctagctgtc gcgctctcct
      301 cggcgagcgc gctcccggcc cgcgcgctcc gggctccggt ttctcccggc tcctgtcagt
      361 gcggtgactg cgctgggaaa catggcgacc gagggaatga tccttactaa ccacgaccat
      421 caaatccgtg tcggagtcct tacagtgagt gatagttgct tcaggaatct tgcagaagac
      481 cgcagtggga taaatctcaa agatctcgta caagatcctt ctttgttggg tgggactata
      541 tcagcataca agatagtacc agatgaaata gaagaaatca aggaaaccct gatagattgg
      601 tgtgatgaaa aggaacttaa tttgatatta acaactggag gaacaggatt tgcaccacga
      661 gatgtcactc cagaggccac aaaagaagta atagaacggg aagcaccagg gatggccctg
      721 gcaatgctga tgggatcact taatgttaca cctctgggca tgctctctag gcctgtatgt
      781 ggaatcagag ggaaaacgct cataattaac ctgccaggta gcaagaaagg atctcaggaa
      841 tgctttcaat tcatactgcc agctctacct catgccattg accttttacg tgatgccatt
      901 gtaaaagtaa aggaggtgca tgatgaactt gaagatttgc cttccccacc tccccctctt
      961 tcccctcctc ctactaccag cccccataaa cagacagaag acaaaggagt tcaatgtgag
     1021 gaagaggaag aagagaagaa agacagtggt gttgcttcaa cagaagatag ttcctcatca
     1081 catataactg cagcagccat tgctgccaag aagcatccat tctacaccag tcctgctgtt
     1141 gtcatggcac acggtgaaca gcccatccct ggtctcatca attattccca tcattcaaca
     1201 gatgaacgga ttccagactc catcatttct cgtggtgttc aggtgctccc acgagacaca
     1261 gcctccctca gcactactcc ttcagaatcg cctcgtgctc aggctacatc tcgcctctct
     1321 acagcttcct gcccaacacc aaaagtccag tccaggtgca gcagcaagga gaacattctc
     1381 agagccagtc acagtgctgt cgatatcacc aaggtggcta gaagacatcg catgtctcct
     1441 tttcctctga catctatgga caaagccttt atcacagtcc tggagatgac tccggtgctt
     1501 gggacagaaa tcatcaatta ccgagatgga atggggcgag tccttgctca agatgtatat
     1561 gcaaaagaca atttaccccc cttcccagca tcagtaaaag atggctatgc tgtccgagct
     1621 gctgatggcc caggagatcg tttcatcatt ggggaatccc aagctggtga acagccaact
     1681 cagacagtaa tgccaggaca agtcatgcgg gttacaacag gtgctccaat accctgcggt
     1741 gctgatgcag tagtacaagt ggaagatacc gaacttatca gggaatcaga tgatggcact
     1801 gaagaacttg aagtgcgaat tctggtgcaa gctcggccag gccaagatat cagacccatc
     1861 ggccatgaca ttaaaagagg ggaatgtgtt ttggccaaag gaacccacat gggcccctca
     1921 gagattggtc ttctggcaac tgtaggtgtc acagaggttg aagttaataa gtttccagtg
     1981 gttgcagtca tgtcaacagg gaatgagctg ctaaatcctg aagatgacct cttaccaggg
     2041 aagattcgag acagcaatcg ttcaactctt ctagcaacaa ttcaggaaca tggttacccc
     2101 acgatcaact tgggtattgt aggagacaac ccagatgact tactcaatgc cttgaatgag
     2161 ggtatcagtc gtgctgatgt catcatcaca tcagggggtg tatccatggg ggaaaaggac
     2221 tatctcaagc aggtgctgga cattgatctt catgctcaga tccattttgg cagggttttt
     2281 atgaaaccag gcttgccaac aacatttgca actttggata ttgatggtgt aagaaaaata
     2341 atctttgcac tacctgggaa tcctgtatcg gctgtggtca cctgcaatct ctttgttgtg
     2401 cctgcactga ggaaaatgca gggcatcttg gatcctcggc caaccatcat caaagcaagg
     2461 ttatcatgtg atgtaaaact tgatcctcgt ccagaatacc atcggtgtat actaacttgg
     2521 catcaccaag aaccactacc ttgggcacag agtacaggta atcaaatgag cagccgtctg
     2581 atgagcatgc gcagtgccaa tggattgttg atgctacctc caaagacaga acagtacgtg
     2641 gagctccaca aaggcgaggt ggtggatgtc atggtcattg gacggctatg atggtcacca
     2701 gcaggagaaa gctttgatgc atgtccacat atcattgact gtatcctgta atatgcaacg
     2761 gcacagctag ttttcccgat ttggataaaa gttgatctgt atagtcaaca tcttgaacta
     2821 tatttcaaat gaatttaaat atcttttaaa gaaaaaaaca cctaaaaata aatcttaaca
     2881 gaaaattctg ttctgattat atcaaggcaa atttttcctt tcttgcaaat tgctttgtgt
     2941 gttcaatgct aggtctgata gcgatagctt ttagtagaca gcggtaggtg cctgcagaac
     3001 ttgtgttttt ctcatcttta aaatacaact acttatgctc ttaaatcaag gctgtctgct
     3061 tatttatact agcgtaggca acacttggat ttcccttctt agtatgcttc ataactgctt
     3121 tacagagagc ttttgcttgt tctttctcat gtatctcgtg tttatgtgca cagtgccaaa
     3181 agaagactga ctgggtggag gctctgcctt gcctcaagaa ccatcccctg cagagcatcc
     3241 agggaggttt ctcgccccaa tagcctcacg gcacagtact cttgggcagt aactggacac
     3301 cttttatttg aagaaacaaa ctgaagaaaa aatgcttcct taagtgctga cagccttttt
     3361 aaccaataca tttaaaattg tacagaacaa aaaaataaaa tcaaagactg atcttgtaca
     3421 gatattagtg ttaccagcat tcatgtggaa atcaagagca aagacaaaat aatgttaaac
     3481 aattctgtac cataacattt tctgtaatga tactgaaact taatgaataa aaaaattcct
     3541 tgatcattat ttaaaaa
//
