LOCUS       NM_001098201            2613 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens G protein-coupled estrogen receptor 1 (GPER1),
            transcript variant 4, mRNA.
ACCESSION   NM_001098201
VERSION     NM_001098201.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Doelker,T., Gallwas,J. and Grundker,C.
  TITLE     Suppressing Expression of SERPINE1/PAI1 Through Activation of GPER1
            Reduces Progression of Vulvar Carcinoma
  JOURNAL   Cancer Genomics Proteomics 21 (6), 566-579 (2024)
   PUBMED   39467628
  REMARK    GeneRIF: Suppressing Expression of SERPINE1/PAI1 Through Activation
            of GPER1 Reduces Progression of Vulvar Carcinoma.
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Venglovecz,V. and Hegyi,P.
  TITLE     GPR30 is a potential player between islet cells and ductal HCO3-
            secretion
  JOURNAL   Cell Calcium 123, 102922 (2024)
   PUBMED   38924880
  REMARK    GeneRIF: GPR30 is a potential player between islet cells and ductal
            HCO3[-] secretion.
            Review article
REFERENCE   3  (bases 1 to 2613)
  AUTHORS   Tirado-Garibay,A.C., Ruiz-Barcenas,B., Rescala-Ponce de Leon,J.I.,
            Ochoa-Zarzosa,A. and Lopez-Meza,J.E.
  TITLE     The GPR30 Receptor Is Involved in IL-6-Induced Metastatic
            Properties of MCF-7 Luminal Breast Cancer Cells
  JOURNAL   Int J Mol Sci 25 (16), 8988 (2024)
   PUBMED   39201674
  REMARK    GeneRIF: The GPR30 Receptor Is Involved in IL-6-Induced Metastatic
            Properties of MCF-7 Luminal Breast Cancer Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2613)
  AUTHORS   Filardo,E.J., Quinn,J.A., Bland,K.I. and Frackelton,A.R. Jr.
  TITLE     Estrogen-induced activation of Erk-1 and Erk-2 requires the G
            protein-coupled receptor homolog, GPR30, and occurs via
            trans-activation of the epidermal growth factor receptor through
            release of HB-EGF
  JOURNAL   Mol Endocrinol 14 (10), 1649-1660 (2000)
   PUBMED   11043579
REFERENCE   5  (bases 1 to 2613)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Marchese,A., Cheng,R., Lynch,K.R.,
            Heng,H.H., Kolakowski,L.F. Jr. and George,S.R.
  TITLE     Discovery of three novel G-protein-coupled receptor genes
  JOURNAL   Genomics 47 (2), 310-313 (1998)
   PUBMED   9479505
REFERENCE   6  (bases 1 to 2613)
  AUTHORS   Takada,Y., Kato,C., Kondo,S., Korenaga,R. and Ando,J.
  TITLE     Cloning of cDNAs encoding G protein-coupled receptor expressed in
            human endothelial cells exposed to fluid shear stress
  JOURNAL   Biochem Biophys Res Commun 240 (3), 737-741 (1997)
   PUBMED   9398636
REFERENCE   7  (bases 1 to 2613)
  AUTHORS   Carmeci,C., Thompson,D.A., Ring,H.Z., Francke,U. and Weigel,R.J.
  TITLE     Identification of a gene (GPR30) with homology to the
            G-protein-coupled receptor superfamily associated with estrogen
            receptor expression in breast cancer
  JOURNAL   Genomics 45 (3), 607-617 (1997)
   PUBMED   9367686
REFERENCE   8  (bases 1 to 2613)
  AUTHORS   Kvingedal,A.M. and Smeland,E.B.
  TITLE     A novel putative G-protein-coupled receptor expressed in lung,
            heart and lymphoid tissue
  JOURNAL   FEBS Lett 407 (1), 59-62 (1997)
   PUBMED   9141481
REFERENCE   9  (bases 1 to 2613)
  AUTHORS   Feng,Y. and Gregor,P.
  TITLE     Cloning of a novel member of the G protein-coupled receptor family
            related to peptide receptors
  JOURNAL   Biochem Biophys Res Commun 231 (3), 651-654 (1997)
   PUBMED   9070864
REFERENCE   10 (bases 1 to 2613)
  AUTHORS   Owman,C., Blay,P., Nilsson,C. and Lolait,S.J.
  TITLE     Cloning of human cDNA encoding a novel heptahelix receptor
            expressed in Burkitt's lymphoma and widely distributed in brain and
            peripheral tissues
  JOURNAL   Biochem Biophys Res Commun 228 (2), 285-292 (1996)
   PUBMED   8920907
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC381205.1, U63917.1 and
            BC082766.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001098201.2.
            
            Summary: This gene encodes a multi-pass membrane protein that
            localizes to the endoplasmic reticulum and a member of the
            G-protein coupled receptor 1 family. This receptor binds estrogen
            and activates multiple downstream signaling pathways, leading to
            stimulation of adenylate cyclase and an increase in cyclic AMP
            levels, while also promoting intracellular calcium mobilization and
            synthesis of phosphatidylinositol 3,4,5-trisphosphate in the
            nucleus. This protein therefore plays a role in the rapid
            nongenomic signaling events widely observed following stimulation
            of cells and tissues with estrogen. This receptor has been shown to
            play a role in diverse biological processes, including bone and
            nervous system development, metabolism, cognition, male fertility
            and uterine function. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 3. Variants 2-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.869093.1,
                                           SRR1803612.69646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397088.4/ ENSP00000380277.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DC381205.1         29-55
            28-2270             U63917.1           1-2243
            2271-2613           BC082766.1         1556-1898
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..2613
                     /gene="GPER1"
                     /gene_synonym="CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER;
                     GPR30; LERGU; LERGU2; LyGPR; mER"
                     /note="G protein-coupled estrogen receptor 1"
                     /db_xref="GeneID:2852"
                     /db_xref="HGNC:HGNC:4485"
                     /db_xref="MIM:601805"
     exon            1..209
                     /gene="GPER1"
                     /gene_synonym="CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER;
                     GPR30; LERGU; LERGU2; LyGPR; mER"
                     /inference="alignment:Splign:2.1.0"
     exon            210..2613
                     /gene="GPER1"
                     /gene_synonym="CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER;
                     GPR30; LERGU; LERGU2; LyGPR; mER"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..1659
                     /gene="GPER1"
                     /gene_synonym="CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER;
                     GPR30; LERGU; LERGU2; LyGPR; mER"
                     /note="chemokine receptor-like 2; G protein-coupled
                     receptor 30; constitutively expressed peptide-like
                     receptor; heptahelix receptor; IL8-related receptor DRY12;
                     membrane estrogen receptor; chemoattractant receptor-like
                     2; lymphocyte-derived G-protein coupled receptor;
                     flow-induced endothelial G-protein coupled receptor 1"
                     /codon_start=1
                     /product="G-protein coupled estrogen receptor 1"
                     /protein_id="NP_001091671.1"
                     /db_xref="CCDS:CCDS5322.1"
                     /db_xref="GeneID:2852"
                     /db_xref="HGNC:HGNC:4485"
                     /db_xref="MIM:601805"
                     /translation="MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALAN
                     GTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLA
                     VADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALA
                     RAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLE
                     VTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPEN
                     VFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDK
                     LRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV"
     regulatory      2593..2598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPER1"
                     /gene_synonym="CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER;
                     GPR30; LERGU; LERGU2; LyGPR; mER"
                     /note="hexamer: AATAAA"
     polyA_site      2613
                     /gene="GPER1"
                     /gene_synonym="CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER;
                     GPR30; LERGU; LERGU2; LyGPR; mER"
                     /note="major polyA site"
ORIGIN      
        1 actggctcag agggaggacg cacccgccag ccagccggga accttccctc gcgggctccc
       61 agggcgggtc tcttcctctc tctagccctg ctcaggcatt cggcaggtcc agcagaggta
      121 cacctcctgc agcgggttcc aagtgcacct ccagcctgat gggcctgacc aaggaggctt
      181 ccaggagcac agaaggggct gcaacccagg tacccagaga gtgagcagct ccacgcggga
      241 ctgtgcacgg tggccgacac ccgcagggac gcccgccgga cgagcacgcg gagggccctc
      301 gcctccacgg atgcaccatg ccggtgtgag gagcatctgt tcttcccact ctctgcagtt
      361 aacaaaccca acccaaacca ccacaggtgc tcctcctggg gagtttcctg tctgacaaat
      421 gccaggctca cttcaaggag aatcacgctt ctttctaaag atggattcac catttaaaac
      481 agagctctgg gagcctttcg gcaaatcttg aaagctgcac ggtgcagaga catggatgtg
      541 acttcccaag cccggggcgt gggcctggag atgtacccag gcaccgcgca gcctgcggcc
      601 cccaacacca cctcccccga gctcaacctg tcccacccgc tcctgggcac cgccctggcc
      661 aatgggacag gtgagctctc ggagcaccag cagtacgtga tcggcctgtt cctctcgtgc
      721 ctctacacca tcttcctctt ccccatcggc tttgtgggca acatcctgat cctggtggtg
      781 aacatcagct tccgcgagaa gatgaccatc cccgacctgt acttcatcaa cctggcggtg
      841 gcggacctca tcctggtggc cgactccctc attgaggtgt tcaacctgca cgagcggtac
      901 tacgacatcg ccgtcctgtg caccttcatg tcgctcttcc tgcaggtcaa catgtacagc
      961 agcgtcttct tcctcacctg gatgagcttc gaccgctaca tcgccctggc cagggccatg
     1021 cgctgcagcc tgttccgcac caagcaccac gcccggctga gctgtggcct catctggatg
     1081 gcatccgtgt cagccacgct ggtgcccttc accgccgtgc acctgcagca caccgacgag
     1141 gcctgcttct gtttcgcgga tgtccgggag gtgcagtggc tcgaggtcac gctgggcttc
     1201 atcgtgccct tcgccatcat cggcctgtgc tactccctca ttgtccgggt gctggtcagg
     1261 gcgcaccggc accgtgggct gcggccccgg cggcagaagg cgctccgcat gatcctcgcg
     1321 gtggtgctgg tcttcttcgt ctgctggctg ccggagaacg tcttcatcag cgtgcacctc
     1381 ctgcagcgga cgcagcctgg ggccgctccc tgcaagcagt ctttccgcca tgcccacccc
     1441 ctcacgggcc acattgtcaa cctcgccgcc ttctccaaca gctgcctaaa ccccctcatc
     1501 tacagctttc tcggggagac cttcagggac aagctgaggc tgtacattga gcagaaaaca
     1561 aatttgccgg ccctgaaccg cttctgtcac gctgccctga aggccgtcat tccagacagc
     1621 accgagcagt cggatgtgag gttcagcagt gccgtgtaga cagccttggc cgcataggcc
     1681 cagccagggt gtgactcggg agctgcacac acctgggtgg acacaaggca cggccacgtc
     1741 atgtctctaa actgcggtca gatgtggctt ctggctcctc ggggcctcgc gagggtcacg
     1801 cttgcctggt caccctgggg ctgcttagga aacctcacga ctggtcacct tgcactcctc
     1861 acacagaatt gctacaatcc caaagcgctc gccccgcagg gtccaaaggc cagcggtgac
     1921 cagcctgtca cccagctcct ccccgccaac cctgcctgcc gctgcacctg cctgccgctg
     1981 caggaaacat ttctgacacc gtcgaccagg aaagccacac ggagaggcca ctgtgggtga
     2041 agcgcctcag ttacacagga accctaaagc aaatctgcca ccgtggggga actgacgctg
     2101 gagatgcaag gtgctggtgg gtctgagctg gacgtcgcgg tgtgtcctct gtgcccacgg
     2161 tctgagctag ctagcgcacc gccgagttaa agaggagaag gaaaacatgc tgctctggtg
     2221 cacgcctgag cgtcctccat cttccaggat ggcagcaatg gcgctgtgcg gcctcaccag
     2281 gcccacgagg agcagcagcg ctcggcccgg agcagcagga aggcccctct gtggagcgcc
     2341 cgccgtctgc tccggggtgg ttcagtcact gcttgttgac atcaacatgg caattgcact
     2401 catgtggact gggaccgtgc gagctgccgt gtgggttagt cgggtgccag gacaatgaaa
     2461 tactccagca cctgtggctg acgaatttgt ttctacagaa ataacagctg gggacaactg
     2521 cggtgatgat gtaaaaacct tcccataaaa tgtaagaaaa gctgatgagg ctggtgacgt
     2581 tcagcctttg tcaataaacc tgtcatgtgc gga
//
