LOCUS       NM_019593               5434 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens glycerophosphocholine phosphodiesterase 1 (GPCPD1),
            mRNA.
ACCESSION   NM_019593
VERSION     NM_019593.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5434)
  AUTHORS   Glotzbach,A., Rohlf,K., Gonscharow,A., Luke,S., Demirci,O.,
            Begher-Tibbe,B., Overbeck,N., Reinders,J., Cadenas,C.,
            Hengstler,J.G., Edlund,K. and Marchan,R.
  TITLE     EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden
            and improves survival in two mouse models of experimental
            metastasis
  JOURNAL   Breast Cancer Res 26 (1), 87 (2024)
   PUBMED   38816770
  REMARK    GeneRIF: EDI3 knockdown in ER-HER2+ breast cancer cells reduces
            tumor burden and improves survival in two mouse models of
            experimental metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5434)
  AUTHORS   Cikes,D., Leutner,M., Cronin,S.J.F., Novatchkova,M., Pfleger,L.,
            Klepochova,R., Lair,B., Lac,M., Bergoglio,C., Viguerie,N.,
            Durnberger,G., Roitinger,E., Grivej,M., Rullman,E., Gustafsson,T.,
            Hagelkruys,A., Tavernier,G., Bourlier,V., Knauf,C., Krebs,M.,
            Kautzky-Willer,A., Moro,C., Krssak,M., Orthofer,M. and
            Penninger,J.M.
  TITLE     Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its
            deficiency severely perturbs glucose metabolism
  JOURNAL   Nat Aging 4 (1), 80-94 (2024)
   PUBMED   38238601
  REMARK    GeneRIF: Gpcpd1-GPC metabolic pathway is dysfunctional in aging and
            its deficiency severely perturbs glucose metabolism.
REFERENCE   3  (bases 1 to 5434)
  AUTHORS   Liu,Y., Zhang,H., Liu,Y., Zhang,S., Su,P., Wang,L., Li,Y.,
            Liang,Y., Wang,X., Zhao,W., Chen,B., Luo,D., Zhang,N. and Yang,Q.
  TITLE     Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via
            regulating PRKN-mediated ubiquitination of VDAC1
  JOURNAL   Autophagy 19 (9), 2443-2463 (2023)
   PUBMED   36803235
  REMARK    GeneRIF: Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy
            via regulating PRKN-mediated ubiquitination of VDAC1.
REFERENCE   4  (bases 1 to 5434)
  AUTHORS   Keller,M., Rohlf,K., Glotzbach,A., Leonhardt,G., Luke,S.,
            Derksen,K., Demirci,O., Gocener,D., AlWahsh,M., Lambert,J.,
            Lindskog,C., Schmidt,M., Brenner,W., Baumann,M., Zent,E.,
            Zischinsky,M.L., Hellwig,B., Madjar,K., Rahnenfuhrer,J.,
            Overbeck,N., Reinders,J., Cadenas,C., Hengstler,J.G., Edlund,K. and
            Marchan,R.
  TITLE     Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast
            cancer cells resistant to HER2-targeted therapy reduces viability
            and tumour growth
  JOURNAL   J Exp Clin Cancer Res 42 (1), 25 (2023)
   PUBMED   36670508
  REMARK    GeneRIF: Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+
            breast cancer cells resistant to HER2-targeted therapy reduces
            viability and tumour growth.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5434)
  AUTHORS   Huang,K.B., Pan,Y.H., Shu,G.N., Yao,H.H., Liu,X., Zhou,M.,
            Wei,J.H., Chen,Z.H., Lu,J., Feng,Z.H., Chen,W., Han,H., Zheng,Z.S.,
            Luo,J.H. and Zhang,J.X.
  TITLE     Circular RNA circSNX6 promotes sunitinib resistance in renal cell
            carcinoma through the miR-1184/GPCPD1/ lysophosphatidic acid axis
  JOURNAL   Cancer Lett 523, 121-134 (2021)
   PUBMED   34626691
  REMARK    GeneRIF: Circular RNA circSNX6 promotes sunitinib resistance in
            renal cell carcinoma through the miR-1184/GPCPD1/ lysophosphatidic
            acid axis.
REFERENCE   6  (bases 1 to 5434)
  AUTHORS   Lesjak,M.S., Marchan,R., Stewart,J.D., Rempel,E., Rahnenfuhrer,J.
            and Hengstler,J.G.
  TITLE     EDI3 links choline metabolism to integrin expression, cell adhesion
            and spreading
  JOURNAL   Cell Adh Migr 8 (5), 499-508 (2014)
   PUBMED   25482527
  REMARK    GeneRIF: EDI3 links choline metabolism to integrin expression, cell
            adhesion and spreading
REFERENCE   7  (bases 1 to 5434)
  AUTHORS   Stewart,J.D., Marchan,R., Lesjak,M.S., Lambert,J., Hergenroeder,R.,
            Ellis,J.K., Lau,C.H., Keun,H.C., Schmitz,G., Schiller,J.,
            Eibisch,M., Hedberg,C., Waldmann,H., Lausch,E., Tanner,B.,
            Sehouli,J., Sagemueller,J., Staude,H., Steiner,E. and
            Hengstler,J.G.
  TITLE     Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell
            migration and metastasis
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8155-8160 (2012)
   PUBMED   22570503
  REMARK    GeneRIF: We have identified EDI3, a key enzyme controlling GPC and
            choline metabolism; Because inhibition of it corrects the GPC/PC
            ratio and decreases the migration capacity of tumor cells, it
            represents a possible target for therapeutic intervention.
REFERENCE   8  (bases 1 to 5434)
  AUTHORS   Bakken,T.E., Roddey,J.C., Djurovic,S., Akshoomoff,N., Amaral,D.G.,
            Bloss,C.S., Casey,B.J., Chang,L., Ernst,T.M., Gruen,J.R.,
            Jernigan,T.L., Kaufmann,W.E., Kenet,T., Kennedy,D.N.,
            Kuperman,J.M., Murray,S.S., Sowell,E.R., Rimol,L.M.,
            Mattingsdal,M., Melle,I., Agartz,I., Andreassen,O.A., Schork,N.J.,
            Dale,A.M., Weiner,M., Aisen,P., Petersen,R., Jack,C.R. Jr.,
            Jagust,W., Trojanowki,J.Q., Toga,A.W., Beckett,L., Green,R.C.,
            Saykin,A.J., Morris,J., Liu,E., Montine,T., Gamst,A., Thomas,R.G.,
            Donohue,M., Walter,S., Gessert,D., Sather,T., Harvey,D., Kornak,J.,
            Dale,A., Bernstein,M., Felmlee,J., Fox,N., Thompson,P., Schuff,N.,
            Alexander,G., DeCarli,C., Bandy,D., Koeppe,R.A., Foster,N.,
            Reiman,E.M., Chen,K., Mathis,C., Cairns,N.J., Taylor-Reinwald,L.,
            Trojanowki,J.Q., Shaw,L., Lee,V.M., Korecka,M., Crawford,K.,
            Neu,S., Foroud,T.M., Potkin,S., Shen,L., Kachaturian,Z., Frank,R.,
            Snyder,P.J., Molchan,S., Kaye,J., Quinn,J., Lind,B., Dolen,S.,
            Schneider,L.S., Pawluczyk,S., Spann,B.M., Brewer,J., Vanderswag,H.,
            Heidebrink,J.L., Lord,J.L., Johnson,K., Doody,R.S.,
            Villanueva-Meyer,J., Chowdhury,M., Stern,Y., Honig,L.S., Bell,K.L.,
            Morris,J.C., Ances,B., Carroll,M., Leon,S., Mintun,M.A.,
            Schneider,S., Marson,D., Griffith,R., Clark,D., Grossman,H.,
            Mitsis,E., Romirowsky,A., deToledo-Morrell,L., Shah,R.C., Duara,R.,
            Varon,D., Roberts,P., Albert,M., Onyike,C., Kielb,S., Rusinek,H.,
            de Leon,M.J., Glodzik,L., De Santi,S., Doraiswamy,P.M.,
            Petrella,J.R., Coleman,R.E., Arnold,S.E., Karlawish,J.H., Wolk,D.,
            Smith,C.D., Jicha,G., Hardy,P., Lopez,O.L., Oakley,M.,
            Simpson,D.M., Porsteinsson,A.P., Goldstein,B.S., Martin,K.,
            Makino,K.M., Ismail,M.S., Brand,C., Mulnard,R.A., Thai,G.,
            Mc-Adams-Ortiz,C., Womack,K., Mathews,D., Quiceno,M.,
            Diaz-Arrastia,R., King,R., Weiner,M., Martin-Cook,K., DeVous,M.,
            Levey,A.I., Lah,J.J., Cellar,J.S., Burns,J.M., Anderson,H.S.,
            Swerdlow,R.H., Apostolova,L., Lu,P.H., Bartzokis,G.,
            Silverman,D.H., Graff-Radford,N.R., Parfitt,F., Johnson,H.,
            Farlow,M.R., Hake,A.M., Matthews,B.R., Herring,S., van Dyck,C.H.,
            Carson,R.E., MacAvoy,M.G., Chertkow,H., Bergman,H., Hosein,C.,
            Black,S., Stefanovic,B., Caldwell,C., Ging-Yuek, Hsiung,R.,
            Feldman,H., Mudge,B., Assaly,M., Kertesz,A., Rogers,J., Trost,D.,
            Bernick,C., Munic,D., Kerwin,D., Mesulam,M.M., Lipowski,K.,
            Wu,C.K., Johnson,N., Sadowsky,C., Martinez,W., Villena,T.,
            Turner,R.S., Johnson,K., Reynolds,B., Sperling,R.A., Johnson,K.A.,
            Marshall,G., Frey,M., Yesavage,J., Taylor,J.L., Lane,B., Rosen,A.,
            Tinklenberg,J., Sabbagh,M., Belden,C., Jacobson,S., Kowall,N.,
            Killiany,R., Budson,A.E., Norbash,A., Johnson,P.L., Obisesan,T.O.,
            Wolday,S., Bwayo,S.K., Lerner,A., Hudson,L., Ogrocki,P.,
            Fletcher,E., Carmichael,O., Olichney,J., Kittur,S., Borrie,M.,
            Lee,T.Y., Bartha,R., Johnson,S., Asthana,S., Carlsson,C.M.,
            Potkin,S.G., Preda,A., Nguyen,D., Tariot,P., Fleisher,A.,
            Reeder,S., Bates,V., Capote,H., Rainka,M., Scharre,D.W., Kataki,M.,
            Zimmerman,E.A., Celmins,D., Brown,A.D., Pearlson,G.D., Blank,K.,
            Anderson,K., Santulli,R.B., Schwartz,E.S., Sink,K.M.,
            Williamson,J.D., Garg,P., Watkins,F., Ott,B.R., Querfurth,H.,
            Tremont,G., Salloway,S., Malloy,P., Correia,S., Rosen,H.J.,
            Miller,B.L., Mintzer,J., Longmire,C.F., Spicer,K., Finger,E.,
            Rachinsky,I., Drost,D., Jernigan,T., McCabe,C., Grant,E., Ernst,T.,
            Kuperman,J., Chung,Y., Murray,S., Bloss,C., Darst,B., Pritchett,L.,
            Saito,A., Amaral,D., DiNino,M., Eyngorina,B., Sowell,E.,
            Houston,S., Soderberg,L., Kaufmann,W., van Zijl,P.,
            Rizzo-Busack,H., Javid,M., Mehta,N., Ruberry,E., Powers,A.,
            Rosen,B., Gebhard,N., Manigan,H., Frazier,J., Kennedy,D.,
            Yakutis,L., Hill,M., Gruen,J., Bosson-Heenan,J. and Carlson,H.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative; Pediatric Imaging,
            Neurocognition, and Genetics Study
  TITLE     Association of common genetic variants in GPCPD1 with scaling of
            visual cortical surface area in humans
  JOURNAL   Proc Natl Acad Sci U S A 109 (10), 3985-3990 (2012)
   PUBMED   22343285
  REMARK    GeneRIF: common genetic variants in GPCPD1 are associated with
            scaling of visual cortical surface area in humans
REFERENCE   9  (bases 1 to 5434)
  AUTHORS   Okazaki,Y., Ohshima,N., Yoshizawa,I., Kamei,Y., Mariggio,S.,
            Okamoto,K., Maeda,M., Nogusa,Y., Fujioka,Y., Izumi,T., Ogawa,Y.,
            Shiro,Y., Wada,M., Kato,N., Corda,D. and Yanaka,N.
  TITLE     A novel glycerophosphodiester phosphodiesterase, GDE5, controls
            skeletal muscle development via a non-enzymatic mechanism
  JOURNAL   J Biol Chem 285 (36), 27652-27663 (2010)
   PUBMED   20576599
REFERENCE   10 (bases 1 to 5434)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC027588.2, BI561344.1, AL049446.1, AB037855.1, BG674365.1,
            T79323.1 and BP421674.1.
            
            On Aug 31, 2019 this sequence version replaced NM_019593.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037855.1, SRR11853563.20187.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379019.7/ ENSP00000368305.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BC027588.2         21-79
            60-252              BI561344.1         14-206
            253-3231            BC027588.2         272-3250
            3232-3410           AL049446.1         416-594
            3411-4405           AB037855.1         3422-4416
            4406-4497           BG674365.1         631-722
            4498-4681           T79323.1           6-189
            4682-5432           AB037855.1         4693-5443
            5433-5434           BP421674.1         43-44               c
FEATURES             Location/Qualifiers
     source          1..5434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.3"
     gene            1..5434
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /note="glycerophosphocholine phosphodiesterase 1"
                     /db_xref="GeneID:56261"
                     /db_xref="HGNC:HGNC:26957"
                     /db_xref="MIM:614124"
     exon            1..165
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            166..242
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..2212
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /EC_number="3.1.4.2"
                     /note="preimplantation protein 4; glycerophosphocholine
                     phosphodiesterase GDE1 homolog; putative
                     glycerophosphodiester phosphodiesterase 5; putative
                     glycerophosphocholine phosphodiesterase GPCPD1;
                     endometrial differential 3"
                     /codon_start=1
                     /product="glycerophosphocholine phosphodiesterase GPCPD1"
                     /protein_id="NP_062539.1"
                     /db_xref="CCDS:CCDS13090.1"
                     /db_xref="GeneID:56261"
                     /db_xref="HGNC:HGNC:26957"
                     /db_xref="MIM:614124"
                     /translation="MTPSQVAFEIRGTLLPGEVFAICGSCDALGNWNPQNAVALLPEN
                     DTGESMLWKATIVLSRGVSVQYRYFKGYFLEPKTIGGPCQVIVHKWETHLQPRSITPL
                     ESEIIIDDGQFGIHNGVETLDSGWLTCQTEIRLRLHYSEKPPVSITKKKLKKSRFRVK
                     LTLEGLEEDDDDRVSPTVLHKMSNSLEISLISDNEFKCRHSQPECGYGLQPDRWTEYS
                     IQTMEPDNLELIFDFFEEDLSEHVVQGDALPGHVGTACLLSSTIAESGKSAGILTLPI
                     MSRNSRKTIGKVRVDYIIIKPLPGYSCDMKSSFSKYWKPRIPLDVGHRGAGNSTTTAQ
                     LAKVQENTIASLRNAASHGAAFVEFDVHLSKDFVPVVYHDLTCCLTMKKKFDADPVEL
                     FEIPVKELTFDQLQLLKLTHVTALKSKDRKESVVQEENSFSENQPFPSLKMVLESLPE
                     DVGFNIEIKWICQQRDGMWDGNLSTYFDMNLFLDIILKTVLENSGKRRIVFSSFDADI
                     CTMVRQKQNKYPILFLTQGKSEIYPELMDLRSRTTPIAMSFAQFENLLGINVHTEDLL
                     RNPSYIQEAKAKGLVIFCWGDDTNDPENRRKLKELGVNGLIYDRIYDWMPEQPNIFQV
                     EQLERLKQELPELKSCLCPTVSRFVPSSLCGESDIHVDANGIDNVENA"
     exon            243..339
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            340..424
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            425..500
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            501..542
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            543..666
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            667..898
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1061
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1194
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1249
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1342
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1420
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1460
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1522
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1588
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1725
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1861
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2022
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..5434
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5414..5419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /note="hexamer: AATAAA"
     polyA_site      5434
                     /gene="GPCPD1"
                     /gene_synonym="EDI3; GDE5; GDPD6; PREI4"
                     /note="major polyA site"
ORIGIN      
        1 aaaccggttt gagcgtggct gcttcctgcc gctcgacgcc gcggcaggcc gcctgggggg
       61 agcgctggcg aggcacggac ggcgggcgcc cggtacctct gcccgcggtc ctcgctctcg
      121 ggcggggcgg cggcgacgcg gacctgcgga ctagcgaacc cggagcacga catcataaaa
      181 taaatccatc agaatgacac cttctcaggt tgcctttgaa ataagaggaa ctcttttacc
      241 aggagaagtt tttgcgatat gtggaagctg tgatgctttg ggaaactgga atcctcaaaa
      301 tgctgtggct cttcttccag agaatgacac aggtgaaagc atgctatgga aagcaaccat
      361 tgtactcagt agaggagtat cagttcagta tcgctacttc aaagggtact ttttagaacc
      421 aaagactatc ggtggtccat gtcaagtgat agttcacaag tgggagactc atctacaacc
      481 acgatcaata acccctttag aaagcgaaat tattattgac gatggacaat ttggaatcca
      541 caatggtgtt gaaactctgg attctggatg gctgacatgt cagactgaaa taagattacg
      601 tttgcattat tctgaaaaac ctcctgtgtc aataaccaag aaaaaattaa aaaaatctag
      661 atttagggtg aagctgacac tagaaggcct ggaggaagat gacgatgata gggtatctcc
      721 cactgtactc cacaaaatgt ccaatagctt ggagatatcc ttaataagcg acaatgagtt
      781 caagtgcagg cattcacagc cggagtgtgg ttatggcttg cagcctgatc gttggacaga
      841 gtacagcata cagacgatgg aaccagataa cctggaacta atctttgatt ttttcgaaga
      901 agatctcagt gagcacgtag ttcagggtga tgcccttcct ggacatgtgg gtacagcttg
      961 tctcttatca tccaccattg ctgagagtgg aaagagtgct ggaattctta ctcttcccat
     1021 catgagcaga aattcccgga aaacaatagg caaagtgaga gttgactata taattattaa
     1081 gccattacca ggatacagtt gtgacatgaa atcttcattt tccaagtatt ggaagccaag
     1141 aataccattg gatgttggcc atcgaggtgc aggaaactct acaacaactg cccagctggc
     1201 taaagttcaa gaaaatacta ttgcttcttt aagaaatgct gctagtcatg gtgcagcctt
     1261 tgtagaattt gacgtacacc tttcaaagga ctttgtgccc gtggtatatc atgatcttac
     1321 ctgttgtttg actatgaaaa agaaatttga tgctgatcca gttgaattat ttgaaattcc
     1381 agtaaaagaa ttaacatttg accaactcca gttgttaaag ctcactcatg tgactgcact
     1441 gaaatctaag gatcggaaag aatctgtggt tcaggaggaa aattcctttt cagaaaatca
     1501 gccatttcct tctcttaaga tggttttaga gtctttgcca gaagatgtag ggtttaacat
     1561 tgaaataaaa tggatctgcc agcaaaggga tggaatgtgg gatggtaact tatcaacata
     1621 ttttgacatg aatctgtttt tggatataat tttaaaaact gttttagaaa attctgggaa
     1681 gaggagaata gtgttttctt catttgatgc agatatttgc acaatggttc ggcaaaagca
     1741 gaacaaatat ccgatactat ttttaactca aggaaaatct gagatttatc ctgaactcat
     1801 ggacctcaga tctcggacaa cccccattgc aatgagcttt gcacagtttg aaaatctact
     1861 ggggataaat gtacatactg aagacttgct cagaaaccca tcctatattc aagaggcaaa
     1921 agctaaggga ctagtcatat tctgctgggg tgatgatacc aatgatcctg aaaacagaag
     1981 gaaattgaag gaacttggag ttaatggtct aatttatgat aggatatatg attggatgcc
     2041 tgaacaacca aatatattcc aagtggagca attggaacgc ctgaagcagg aattgccaga
     2101 gcttaagagc tgtttgtgtc ccactgttag ccgctttgtt ccctcatctt tgtgtgggga
     2161 gtctgatatc catgtggatg ccaacggcat tgataacgtg gagaatgctt agtttttatt
     2221 gcacagaggt cattttgggg gcgtgcaccg ctgttctggg tattcatttt tcatcactga
     2281 gcattgttga tctatgcctt ttgggcttct cagttcaatg aagcaataat gaagtattta
     2341 actctttcac tacagttctt gcaagtatgc tatttaaatt acttggccag gtataattgc
     2401 cagtcagtct ctttatagtg agaaaattta ttggttagta atataaatat tttaaactaa
     2461 atatataaat ctataatgtt aaacatatgt tcattaaaag catagcactt tgaaattaac
     2521 tatataaata gctcatattt acacttacag cttttcattt gatcaggtct gaaatcttta
     2581 gcacttaagg aaaatgacta tgcataatta tacctgacca tgaaaaaaat aagtacctca
     2641 aatgcatgca tttgcactgg tgattccaac tgcacaaatc tttgtgccat cttgtatata
     2701 ggtatttttt acatgggttg acatgcacac aacaccattt tcattcagta tgaaccttga
     2761 ggctgctgcc atttttccac ttaaccaaac cagcctgaag gtgaacctcg aaacttgttt
     2821 cataaatctt tcaaaagttg ttttacatca atgttaaaat ttcaaaatgc tgcagggtaa
     2881 tttaatgtat aaaatattag taagaaaaag tatgtattgc atacttagta gaatagatca
     2941 caacatacaa attcaattca gtgcatgctt taggtgttaa gcatgagatt gtacatgttt
     3001 actgttaggt ccttgcatct gtggtgctag gtgagtatga gaagatgtca aggactggac
     3061 gtattttgtt gcctaaaaaa aaaaggctgt ttgtaggcgt tttaaatatg cttattttgt
     3121 gtgtctctca ctacctatta cacactgttg ctttgtgggt ttgttttgta tgtgcgtgtg
     3181 ttatacagta gttaaatttc catgcagaaa aataaatgtc ctgaattttc atattagtat
     3241 tctttattgt atatcatgca tgtaatttat ttagaaatgt aggtcttact aaatgtatat
     3301 gcatgtattt cagattatac taggatttct tggattagaa gcagattgtg ttaactgtaa
     3361 cttaaagaat gaatgttaaa taaaatgata cagatttatt ttcttcatta caaaatgaaa
     3421 tttcaagaag gtgttacttt tgtagaatgg ttttataata tgacaagaaa ttttaatata
     3481 gtgtctaccc taaagggatg gcttatttgc atctaccttt tactgcatgt ttttcacaag
     3541 gcagtttatt catatattga catattttgg tagtagctga gaacctaaga cttgaaatta
     3601 tacattgtgt agtatttttt aagctaagca atgcaatttt ggtcagatct tatttgtgtg
     3661 aagataggct ctgaaatcct atggtattgc gtttgtaacg ttgatattaa tgcaaaatag
     3721 tttaggaaat ggagtcttct gcaagggttc tgtatacttt tcccacattg tatgagattt
     3781 tccaaaattt tggtgtgaat tgggcacttt tggaaaactc ctgaaaaaga attagtttcc
     3841 ttcatctgca gacctttgtc caatacggtt accatttctt tatagtaact cgattagcca
     3901 tatatgtttg tttctagtcc tgctcctttg ctcctctcct atgccttccc agtgctggct
     3961 ccattttgaa gactcaagga cagaggggaa gcagatcata aagagaaaaa ggagacagaa
     4021 gaaaggatga aggaaggagg tcatggggag tgtggcttct gagcagttta gttgctgggg
     4081 agagcagaca gtcactgcct acaatacaga cagaaccttc ctgctcactt tctgtcctat
     4141 ctcttcctga ccttatgaac cagtgttagt agatgattaa aacatgacaa gcaatggctc
     4201 cttattttca caggactaag tccgggcctt cgtatcacta gctgttgcct tttacaccct
     4261 gcttcagcca ccctgtccct gtcattggcc ctggacttcc tctctgtgcc cgtgtgtcct
     4321 ctgcctggga gccctctcct cccatagtca ctttctctct gccaaactca tttcttcttg
     4381 tgcccaagac ctctctcctg agcccttgtg gaaacttcag gaaggatgaa tccgtctttg
     4441 tgctccacgg ctcgtacctt gatcaggctg tgcatcacag taattctgtt ctaggtaggc
     4501 agagttgatc tttgtctcat ctgccaggct gcaggctctt caagggcagg gaccttgtca
     4561 tagtcatttt tattttcaca gtgcttggaa catggtggaa aatgaatgtt ggaattattg
     4621 gagtaatata atttgtatca aatgtccttt tgaattaaga gatttagtta tgtttactaa
     4681 gaatgtaaac tttgaattgg tttgcatttt aacaattagg atggtttatt gatgtgaatt
     4741 ttgaaatgta gaggtataat gttaaattat tttatacttt atggaaatca agtgaaatgt
     4801 ttgaaaaaat gccgccatta tcctctggta ttttctactc tctggaatta tgtgctgtaa
     4861 atgatcggct gtaaatgtga ggcacaccac ccacccctgt gtggaaagtg ttgtggcgct
     4921 tcctgccacc cacccacctc tctgccgttg ctccttgtga cacttgtctg tcgtctccca
     4981 tccaaactcc aagcttacag ctacctcagt actgctttgc ttgtctgaaa cacctccttt
     5041 gccttccttc agtgtcccgc tcaggtgcag cctcctccct aaagctcatc tcagcttttg
     5101 atctgaatga tgatggaaac atgcagacag cctctcagtc ttactattta atgttgtagc
     5161 tgggaaaaaa cccagagagg ttaactgata tactgggttg ggactaggat gtgggttttg
     5221 tgactctgaa tcccatgttc tcaaactacg ctgccttccg aagtctggca tttgttagct
     5281 catgcttcct tgtagtccag cttcttatgt gcctgttata ttctccagta agattgtaag
     5341 ccccttaagg gcagggacgt ctttgcatct ctagcactgc tatagtgttc tatccttagt
     5401 tatgaactag ataaataaat ggtggtggca acaa
//
