LOCUS       NM_005708               7121 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens glypican 6 (GPC6), mRNA.
ACCESSION   NM_005708
VERSION     NM_005708.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7121)
  AUTHORS   Crenshaw,M.M., Meyers,M.L., Brown,K., Slegesky,V., Duis,J.,
            Elias,E.R., Saenz,M., Shi,W., Filmus,J. and Meeks,N.J.L.
  TITLE     Five siblings expand the spectrum of GPC6-related skeletal
            dysplasia
  JOURNAL   Am J Med Genet A 191 (10), 2571-2577 (2023)
   PUBMED   37353964
  REMARK    GeneRIF: Five siblings expand the spectrum of GPC6-related skeletal
            dysplasia.
REFERENCE   2  (bases 1 to 7121)
  AUTHORS   Wang,F., Li,Y., Li,Z., Zou,Z., Lu,Y., Xu,C., Zhao,Z., Wang,H.,
            Wang,Y., Guo,S., Jin,L., Wang,J., Li,Q., Jiang,G., Xia,F., Shen,B.
            and Wu,J.
  TITLE     Prognostic value of GPC5 polymorphism rs2352028 and clinical
            characteristics in Chinese lung cancer patients
  JOURNAL   Future Oncol 18 (28), 3165-3177 (2022)
   PUBMED   36165234
  REMARK    GeneRIF: Prognostic value of GPC5 polymorphism rs2352028 and
            clinical characteristics in Chinese lung cancer patients.
REFERENCE   3  (bases 1 to 7121)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7121)
  AUTHORS   Lehmkuhl,E.M., Loganathan,S., Alsop,E., Blythe,A.D., Kovalik,T.,
            Mortimore,N.P., Barrameda,D., Kueth,C., Eck,R.J., Siddegowda,B.B.,
            Joardar,A., Ball,H., Macias,M.E., Bowser,R., Van Keuren-Jensen,K.
            and Zarnescu,D.C.
  TITLE     TDP-43 proteinopathy alters the ribosome association of multiple
            mRNAs including the glypican Dally-like protein (Dlp)/GPC6
  JOURNAL   Acta Neuropathol Commun 9 (1), 52 (2021)
   PUBMED   33762006
  REMARK    GeneRIF: TDP-43 proteinopathy alters the ribosome association of
            multiple mRNAs including the glypican Dally-like protein
            (Dlp)/GPC6.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7121)
  AUTHORS   Levy,D., Larson,M.G., Benjamin,E.J., Newton-Cheh,C., Wang,T.J.,
            Hwang,S.J., Vasan,R.S. and Mitchell,G.F.
  TITLE     Framingham Heart Study 100K Project: genome-wide associations for
            blood pressure and arterial stiffness
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S3 (2007)
   PUBMED   17903302
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7121)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   7  (bases 1 to 7121)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 7121)
  AUTHORS   Veugelers,M., De Cat,B., Ceulemans,H., Bruystens,A.M., Coomans,C.,
            Durr,J., Vermeesch,J., Marynen,P. and David,G.
  TITLE     Glypican-6, a new member of the glypican family of cell surface
            heparan sulfate proteoglycans
  JOURNAL   J Biol Chem 274 (38), 26968-26977 (1999)
   PUBMED   10480909
REFERENCE   9  (bases 1 to 7121)
  AUTHORS   Paine-Saunders,S., Viviano,B.L. and Saunders,S.
  TITLE     GPC6, a novel member of the glypican gene family, encodes a product
            structurally related to GPC4 and is colocalized with GPC5 on human
            chromosome 13
  JOURNAL   Genomics 57 (3), 455-458 (1999)
   PUBMED   10329016
REFERENCE   10 (bases 1 to 7121)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354811.13, DA267422.1,
            AF111178.2, AY358462.1, AK290144.1, BX640888.1, AL137144.14 and
            BQ009005.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005708.4.
            
            Summary: The glypicans comprise a family of
            glycosylphosphatidylinositol-anchored heparan sulfate
            proteoglycans, and they have been implicated in the control of cell
            growth and cell division. The glypican encoded by this gene is a
            putative cell surface coreceptor for growth factors, extracellular
            matrix proteins, proteases and anti-proteases. Mutations in this
            gene are associated with omodysplasia 1. [provided by RefSeq, Nov
            2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.111997.1,
                                           SRR1803613.235929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377047.9/ ENSP00000366246.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL354811.13        177301-177301
            2-35                DA267422.1         1-34
            36-1984             AF111178.2         1-1949
            1985-2664           AY358462.1         1900-2579
            2665-2892           AK290144.1         2170-2397
            2893-3948           BX640888.1         124-1179
            3949-4580           AL137144.14        78158-78789
            4581-6004           BX640888.1         1812-3235
            6005-6151           AL137144.14        80214-80360
            6152-6500           BX640888.1         3383-3731
            6501-7121           BQ009005.1         12-632              c
FEATURES             Location/Qualifiers
     source          1..7121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q31.3-q32.1"
     gene            1..7121
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /note="glypican 6"
                     /db_xref="GeneID:10082"
                     /db_xref="HGNC:HGNC:4454"
                     /db_xref="MIM:604404"
     exon            1..810
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             651..2318
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /note="glypican proteoglycan 6"
                     /codon_start=1
                     /product="glypican-6 precursor"
                     /protein_id="NP_005699.1"
                     /db_xref="CCDS:CCDS9469.1"
                     /db_xref="GeneID:10082"
                     /db_xref="HGNC:HGNC:4454"
                     /db_xref="MIM:604404"
                     /translation="MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSL
                     ADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRH
                     KKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
                     LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAA
                     RTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKG
                     CLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVS
                     AKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKL
                     KLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVD
                     VDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPT
                     EFEFVTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR"
     exon            811..969
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1361
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1527
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1658
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1802
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1939
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2115
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..7121
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6479..6484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /note="hexamer: ATTAAA"
     polyA_site      6502
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /note="major polyA site"
     regulatory      7098..7103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /note="hexamer: AATAAA"
     polyA_site      7121
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
ORIGIN      
        1 cctttctcct tccctcttgc ctccagtgac tgtctccagg atttctctct tcctatttca
       61 ggaggactct cacaggctcc cacagcctgt gttaagctga ggtttcccct agatctcgta
      121 tatccccaac acatacctcc acgcacacac atccccaaga acctcgagct cacaccaaca
      181 gacacacgcg cgcatacaca ctcgctctcg cttgtccatc tccctcccgg gggagccggc
      241 gcgcgctccc acctttgccg cacactccgg cgagccgagc ccgcagcgct ccaggattct
      301 gcggctcgga actcggattg cagctctgaa cccccatggt ggttttttaa acacttcttt
      361 tccttctctt cctcgttttg attgcaccgt ttccatctgg gggctagagg agcaaggcag
      421 cagccttccc agccagccct tgttggcttg ccatcgtcca tctggcttat aaaagtttgc
      481 tgagcgcagt ccagagggct gcgctgctcg tcccctcggc tggcagaagg gggtgacgct
      541 gggcagcggc gaggagcgcg ccgctgcctc tggcgggctt tcggcttgag gggcaaggtg
      601 aagagcgcac cggccgtggg gtttaccgag ctggatttgt atgttgcacc atgccttctt
      661 ggatcggggc tgtgattctt cccctcttgg ggctgctgct ctccctcccc gccggggcgg
      721 atgtgaaggc tcggagctgc ggagaggtcc gccaggcgta cggtgccaag ggattcagcc
      781 tggcggacat cccctaccag gagatcgcag gggaacactt aagaatctgt cctcaggaat
      841 atacatgctg caccacagaa atggaagaca agttaagcca acaaagcaaa ctcgaatttg
      901 aaaaccttgt ggaagagaca agccattttg tgcgcaccac ttttgtgtcc aggcataaga
      961 aatttgacga atttttccga gagctcctgg agaatgcaga aaagtcacta aatgatatgt
     1021 ttgtacggac ctatggcatg ctgtacatgc agaattcaga agtcttccag gacctcttca
     1081 cagagctgaa aaggtactac actgggggta atgtgaatct ggaggaaatg ctcaatgact
     1141 tttgggctcg gctcctggaa cggatgtttc agctgataaa ccctcagtat cacttcagtg
     1201 aagactacct ggaatgtgtg agcaaataca ctgaccagct caagccattt ggagacgtgc
     1261 cccggaaact gaagattcag gttacccgcg ccttcattgc tgccaggacc tttgtccagg
     1321 ggctgactgt gggcagagaa gttgcaaacc gagtttccaa ggtcagccca accccagggt
     1381 gtatccgtgc cctcatgaag atgctgtact gcccatactg tcgggggctt cccactgtga
     1441 ggccctgcaa caactactgt ctcaacgtca tgaagggctg cttggcaaat caggctgacc
     1501 tcgacacaga gtggaatctg tttatagatg caatgctctt ggtggcagag cgactggagg
     1561 ggccattcaa cattgagtcg gtcatggacc cgatagatgt caagatttct gaagccatta
     1621 tgaacatgca agaaaacagc atgcaggtgt ctgcaaaggt ctttcaggga tgtggtcagc
     1681 ccaaacctgc tccagccctc agatctgccc gctcagctcc tgaaaatttt aatacacgtt
     1741 tcaggcccta caatcctgag gaaagaccaa caactgctgc aggcacaagc ttggaccggc
     1801 tggtcacaga cataaaagag aaattgaagc tctctaaaaa ggtctggtca gcattaccct
     1861 acactatctg caaggacgag agcgtgacag cgggcacgtc caacgaggag gaatgctgga
     1921 acgggcacag caaagccaga tacttgcctg agatcatgaa tgatgggctc accaaccaga
     1981 tcaacaatcc cgaggtggat gtggacatca ctcggcctga cactttcatc agacagcaga
     2041 ttatggctct ccgtgtgatg accaacaaac taaaaaacgc ctacaatggc aatgatgtca
     2101 atttccagga cacaagtgat gaatccagtg gctcagggag tggcagtggg tgcatggatg
     2161 acgtgtgtcc cacggagttt gagtttgtca ccacagaggc ccccgcagtg gatcccgacc
     2221 ggagagaggt ggactcttct gcagcccagc gtggccactc cctgctctcc tggtctctca
     2281 cctgcattgt cctggcactg cagagactgt gcagataatc ttgggttttt ggtcagatga
     2341 aactgcattt tagctatctg aatggccaac tcacttcttt tcttacactc ttggacaatg
     2401 gaccatgcca caaaaactta ccgttttcta tgagaagaga gcagtaatgc aatctgcctc
     2461 cctttttgtt ttcccaaaga gtaccgggtg ccagactgaa ctgcttcctc tttccttcag
     2521 ctatctgtgg ggaccttgtt tattctagag agaattctta ctcaaatttt tcgtaccagg
     2581 agattttctt accttcattt gcttttatgc tgcagaagta aaggaatctc acgttgtgag
     2641 ggtttttttt ttctcattta aaataaaaaa ggaagaaaga aaataatttt ccttgtaaaa
     2701 tcgggccaaa ccccaagaca gctacatttt caacaaaaaa gcaaacagag aaaaataaat
     2761 gaactttaac actgtaagtt cagcattgac agccaacttc cagtgtaagc ttttttgtga
     2821 caaatccggg tttaaaaatg cttatgggga gaaagcttaa agtttgttct aaatgtagtg
     2881 aaaatgcact gttgtcttgg aggtatcatc ttgcactcta accaaacaac accaaattaa
     2941 tctggaggta ctgatactaa atttggaatc ccgtctttaa tatgagaaca caaattacta
     3001 caactcagta cctctgtctt actctgccca atttcaattt agtaatggca ccattattct
     3061 taattccctt aatgtctgtc cgctgtatcc aattggcaca gattttcccc ttcatcttca
     3121 attactagta gctaccccca tcaattcacc ttcctcaaga gtctcaattg aaaataatct
     3181 ttgatgatac aatctctgct tttgccacag gtttgacatt aactagacgt ttctgcccct
     3241 gtgctcatta ccctcccaaa acaatagttt ttttaatgaa ttgaaacaca attagatcca
     3301 ttcctgagtt ttcattttta actatttact ttgtgtcagt tggtttctgc atcacaaggg
     3361 cattctctta caaaacaact cacaacagaa aaaaaaagtc aagacaaaaa atatatatat
     3421 atagtattga catggagatt tctttcactt ttttagtctt agtatgatca tctattttta
     3481 tatctatgta tatataaatc acagatttta acttcttaat tccaagctca gggttgacac
     3541 acctttgtaa gaaaatgttt tgtcaaccag ctcttcttgt tttgtgctgc tcaaagaagg
     3601 gattcctcag tgatcggtga gcaccaagaa tcaagaaaga gaacttttta tgtatctaac
     3661 tgtccattta ttaaaaattt gccagggcac acccttctgc atgagtgtgc ttcagcctgg
     3721 gtgctccaga ctacaccaaa ctcatgggat gagccattgg tgtgcagggc tttaccggtg
     3781 atggaaactg tatgtgtaaa gaatgttatt catgaaaaac cattgctttc atgtaaaaca
     3841 ccttcggcct aggattcctg cctggcactt ggatacatta cctaactcaa taggccagtt
     3901 tagagccaca gcctaacctg ttcaccaagt aggccaaagc caggcctttc gctccccctg
     3961 acagagagaa gcaaaataaa cccaactggg ggctttatga atacagttgg ctatccatat
     4021 gtttcttagt ttttatgatg catctggagt agggaaaagt aatgtttcaa gacaccatag
     4081 taggccagtt acattttaat taactcatcg acagtattga cacgtaaatg gtatttttca
     4141 atctgttctc atcaaaatta aaattagtta ttgatttagt catcacattt aagtagaaca
     4201 catgtggcac aatagtatta agtatatttg agcacttttg caagacagaa agtatttaca
     4261 agcatctatt gctactttat gcctaatgaa atataaaatg taggatgatg agagactttg
     4321 tggcattctt tcatttaaac ctttatgaaa ttaaccatct agttcatcat tacatactcc
     4381 tagaaaacca tccatttcac tgcccacatt ttggcttcct accacaaatt ccacataaga
     4441 cttctctatg aaggaccagt catttacatt gctcatttca ttctgtgttc agaagtcagt
     4501 attgtctttc tccaataatt aaggtgcaat acaaattaaa tcaaccttga ttttccagac
     4561 tatttgaata ataacttgct tttatggctt taaactccag gtctttcctt tttaaaatat
     4621 ttctgcattc tcttttatga actagatcag gatgccttgt ttttcctgtg ctttcacccc
     4681 caaaaggttt tgtgcatgtg tatgaataca cataatatta gtgaatgtga acccatgttc
     4741 tatacgcact aaacacacag ttaatatata aacgcctgct tcatttgttt caacaccttc
     4801 attatcaata tgattcatat tgatgagata tagtgatgca taatgagcca ggcagagagc
     4861 tgaaatgata tcagttaatg atgtcacagt gttagcaccc tgcatggatg tggtcaaaat
     4921 atcattcaag ttgtacttcc tagtttttat catcatacta ctatgtcata tgattttcag
     4981 actaatttaa catgagaaat gttttggccc taaaggattt cacttaacct agttacccta
     5041 tttcagtaag tattttggaa ttcaaccctc gaattatttt ttctcatttc agcatagtga
     5101 taggggatgc aatgaggctt cattattttt tatgacctgc ccctcatttg ctctgatgtt
     5161 ccctaaattc tgtaatcata tcataacttt tgttatgaat agagaggaat gggctcactg
     5221 aaacctgaca ctagaaattg gtgggtgatg ctcataactg caaacactta gcttattgaa
     5281 gtgcctctat ttacatgttc tttagttata atatgtattt ttctaacaga aatacacgtc
     5341 tgtaattggt atatattata ctttgtatgt gtcacaacaa aagctaaaca gaggctaaag
     5401 tctttagcag agaagaatga attacaaatt taccaataag agctctgttt atggttctgt
     5461 attgaaggac aaccatgaca accttctgtc attttcacga aggccaagtt ggtactttga
     5521 ttatagccat cgtagaacat tagcactaga aatctgtctc ccttacaatg acttacctag
     5581 ctagcatcaa gtaacttgta tcacctgctt taaatgtaag ggatagaaaa tactattttg
     5641 tctacactga aaaacattat tattcattga taagtagtaa taattataaa agtaacattc
     5701 tttaaagcaa acacattgaa aatattatta caggcagaac cctgattttt aatttatatt
     5761 ccctgctgca gacattagcc ttctttaatt cttttgccat tacatacatg tttcggctac
     5821 agactgaaca cgaactaaag tccctaagga ggaaaaaacc ttaacatatt cctgagatgt
     5881 gattctttta ttacttcttt ttgcaaagct aattatcaaa tgatttgatt aaacctagac
     5941 gcattaggaa atgcaagttt tacctaaaac ttgcagaaat ttaaacacat ttccatttac
     6001 ttactaacga acagacctga tttttattta aaaacacaat ttagctttgc caacagaaga
     6061 gtaaaggaaa ccataactta taaatttgta atgtgttcct ccttgttgga gacattagcc
     6121 agtgtttagt tttagaccaa cttatacaaa gagagtattg atttgtacac attctggaga
     6181 cttgctatat catggtttgc tatggcacag actcagctta gcatggggac attttgaact
     6241 tcattcaaag ttgagtagtt actggaacct ttgacattgc cttgtaatga ggtacttcca
     6301 aaaaaagacc cctaacaatg gcataatagt gaggtctctc tgtgcatata cataatatat
     6361 atgcaggata aatgtgtgca ccaatcaaat ctaaaatttt atgtgactgt caaatgaata
     6421 ttatttgggt taagattttt catttctgat ttggatagaa aattgctatt aatcttgtat
     6481 taaaatagtt tttaaaaatc taccagtgcc ctttctgcat tttcttaatt attgtcatag
     6541 tctaaatttc agagccatgg aattttttgt gtttgagaca tttttagaag cttcaatatt
     6601 aaaaaacaac aacaaacctc gtatattaaa acagtgccac tctcctaagt acactcagca
     6661 tctgaaatca ggaactattt gaactttaga acatttagag cttcccaaat gtgtatggaa
     6721 aatactgtag cgctgttctt ttgtactgat ttcttctcag aggataaatt tagtgacttg
     6781 aaaactgatg tcaatacttt ataaatgagg tcagaaaata agatcaaatg tgaaaagact
     6841 aataatttcc caatttagcc aattgcattg atttttatac ttctgaaatg tttccatcct
     6901 ctcaggcatg ctaaatattg tataacctgc taaagattta tttcacaaat gcttattgaa
     6961 ctcttattct ctataaaccc tgctctaggg gatttatcac tggctgtgaa aaaccaccag
     7021 ttgaaaatta ttcattcctt aatgcagcta atcataatta ttacagataa ataatgtatt
     7081 tcaagaatga tcttataaat aaaggaaccc atacaaacaa a
//
