LOCUS       NP_005699                555 aa            linear   PRI 27-APR-2025
DEFINITION  glypican-6 precursor [Homo sapiens].
ACCESSION   NP_005699
VERSION     NP_005699.1
DBSOURCE    REFSEQ: accession NM_005708.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 555)
  AUTHORS   Crenshaw,M.M., Meyers,M.L., Brown,K., Slegesky,V., Duis,J.,
            Elias,E.R., Saenz,M., Shi,W., Filmus,J. and Meeks,N.J.L.
  TITLE     Five siblings expand the spectrum of GPC6-related skeletal
            dysplasia
  JOURNAL   Am J Med Genet A 191 (10), 2571-2577 (2023)
   PUBMED   37353964
  REMARK    GeneRIF: Five siblings expand the spectrum of GPC6-related skeletal
            dysplasia.
REFERENCE   2  (residues 1 to 555)
  AUTHORS   Wang,F., Li,Y., Li,Z., Zou,Z., Lu,Y., Xu,C., Zhao,Z., Wang,H.,
            Wang,Y., Guo,S., Jin,L., Wang,J., Li,Q., Jiang,G., Xia,F., Shen,B.
            and Wu,J.
  TITLE     Prognostic value of GPC5 polymorphism rs2352028 and clinical
            characteristics in Chinese lung cancer patients
  JOURNAL   Future Oncol 18 (28), 3165-3177 (2022)
   PUBMED   36165234
  REMARK    GeneRIF: Prognostic value of GPC5 polymorphism rs2352028 and
            clinical characteristics in Chinese lung cancer patients.
REFERENCE   3  (residues 1 to 555)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 555)
  AUTHORS   Lehmkuhl,E.M., Loganathan,S., Alsop,E., Blythe,A.D., Kovalik,T.,
            Mortimore,N.P., Barrameda,D., Kueth,C., Eck,R.J., Siddegowda,B.B.,
            Joardar,A., Ball,H., Macias,M.E., Bowser,R., Van Keuren-Jensen,K.
            and Zarnescu,D.C.
  TITLE     TDP-43 proteinopathy alters the ribosome association of multiple
            mRNAs including the glypican Dally-like protein (Dlp)/GPC6
  JOURNAL   Acta Neuropathol Commun 9 (1), 52 (2021)
   PUBMED   33762006
  REMARK    GeneRIF: TDP-43 proteinopathy alters the ribosome association of
            multiple mRNAs including the glypican Dally-like protein
            (Dlp)/GPC6.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 555)
  AUTHORS   Levy,D., Larson,M.G., Benjamin,E.J., Newton-Cheh,C., Wang,T.J.,
            Hwang,S.J., Vasan,R.S. and Mitchell,G.F.
  TITLE     Framingham Heart Study 100K Project: genome-wide associations for
            blood pressure and arterial stiffness
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S3 (2007)
   PUBMED   17903302
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 555)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   7  (residues 1 to 555)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (residues 1 to 555)
  AUTHORS   Veugelers,M., De Cat,B., Ceulemans,H., Bruystens,A.M., Coomans,C.,
            Durr,J., Vermeesch,J., Marynen,P. and David,G.
  TITLE     Glypican-6, a new member of the glypican family of cell surface
            heparan sulfate proteoglycans
  JOURNAL   J Biol Chem 274 (38), 26968-26977 (1999)
   PUBMED   10480909
REFERENCE   9  (residues 1 to 555)
  AUTHORS   Paine-Saunders,S., Viviano,B.L. and Saunders,S.
  TITLE     GPC6, a novel member of the glypican gene family, encodes a product
            structurally related to GPC4 and is colocalized with GPC5 on human
            chromosome 13
  JOURNAL   Genomics 57 (3), 455-458 (1999)
   PUBMED   10329016
REFERENCE   10 (residues 1 to 555)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354811.13, DA267422.1,
            AF111178.2, AY358462.1, AK290144.1, BX640888.1, AL137144.14 and
            BQ009005.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The glypicans comprise a family of
            glycosylphosphatidylinositol-anchored heparan sulfate
            proteoglycans, and they have been implicated in the control of cell
            growth and cell division. The glypican encoded by this gene is a
            putative cell surface coreceptor for growth factors, extracellular
            matrix proteins, proteases and anti-proteases. Mutations in this
            gene are associated with omodysplasia 1. [provided by RefSeq, Nov
            2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.111997.1,
                                           SRR1803613.235929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377047.9/ ENSP00000366246.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..555
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q31.3-q32.1"
     Protein         1..555
                     /product="glypican-6 precursor"
                     /note="glypican proteoglycan 6"
                     /calculated_mol_wt=60451
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2303
     Region          22..548
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     mat_peptide     24..529
                     /product="Glypican-6. /id=PRO_0000012323"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y625.1)"
                     /calculated_mol_wt=57586
     Region          348..376
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y625.1)"
     Region          480..501
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y625.1)"
     CDS             1..555
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /coded_by="NM_005708.5:651..2318"
                     /db_xref="CCDS:CCDS9469.1"
                     /db_xref="GeneID:10082"
                     /db_xref="HGNC:HGNC:4454"
                     /db_xref="MIM:604404"
ORIGIN      
        1 mpswigavil pllglllslp agadvkarsc gevrqaygak gfsladipyq eiagehlric
       61 pqeytcctte medklsqqsk lefenlveet shfvrttfvs rhkkfdeffr ellenaeksl
      121 ndmfvrtygm lymqnsevfq dlftelkryy tggnvnleem lndfwarlle rmfqlinpqy
      181 hfsedylecv skytdqlkpf gdvprklkiq vtrafiaart fvqgltvgre vanrvskvsp
      241 tpgciralmk mlycpycrgl ptvrpcnnyc lnvmkgclan qadldtewnl fidamllvae
      301 rlegpfnies vmdpidvkis eaimnmqens mqvsakvfqg cgqpkpapal rsarsapenf
      361 ntrfrpynpe erpttaagts ldrlvtdike klklskkvws alpytickde svtagtsnee
      421 ecwnghskar ylpeimndgl tnqinnpevd vditrpdtfi rqqimalrvm tnklknayng
      481 ndvnfqdtsd essgsgsgsg cmddvcptef efvtteapav dpdrrevdss aaqrghslls
      541 wsltcivlal qrlcr
//
