LOCUS       NM_001448               4959 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens glypican 4 (GPC4), mRNA.
ACCESSION   NM_001448
VERSION     NM_001448.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4959)
  AUTHORS   Tatenhorst,L., Maass,F., Paul,H., Dambeck,V., Bahr,M., Dono,R. and
            Lingor,P.
  TITLE     Glypican-4 serum levels are associated with cognitive dysfunction
            and vascular risk factors in Parkinson's disease
  JOURNAL   Sci Rep 14 (1), 5005 (2024)
   PUBMED   38424123
  REMARK    GeneRIF: Glypican-4 serum levels are associated with cognitive
            dysfunction and vascular risk factors in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4959)
  AUTHORS   Muendlein,A., Heinzle,C., Leiherer,A., Brandtner,E.M., Geiger,K.,
            Gaenger,S., Fraunberger,P., Mader,A., Saely,C.H. and Drexel,H.
  TITLE     Circulating glypican-4 is a new predictor of all-cause mortality in
            patients with heart failure
  JOURNAL   Clin Biochem 121-122, 110675 (2023)
   PUBMED   37844682
  REMARK    GeneRIF: Circulating glypican-4 is a new predictor of all-cause
            mortality in patients with heart failure.
REFERENCE   3  (bases 1 to 4959)
  AUTHORS   Urschel,K., Hug,K.P., Zuo,H., Buttner,M., Furtmair,R., Kuehn,C.,
            Stumpfe,F.M., Botos,B., Achenbach,S., Yuan,Y., Dietel,B. and
            Tauchi,M.
  TITLE     The Shear Stress-Regulated Expression of Glypican-4 in Endothelial
            Dysfunction In Vitro and Its Clinical Significance in
            Atherosclerosis
  JOURNAL   Int J Mol Sci 24 (14), 11595 (2023)
   PUBMED   37511353
  REMARK    GeneRIF: The Shear Stress-Regulated Expression of Glypican-4 in
            Endothelial Dysfunction In Vitro and Its Clinical Significance in
            Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4959)
  AUTHORS   Muendlein,A., Heinzle,C., Leiherer,A., Geiger,K., Brandtner,E.M.,
            Gaenger,S., Fraunberger,P., Saely,C.H. and Drexel,H.
  TITLE     Serum glypican-4 is associated with the 10-year clinical outcome of
            patients with peripheral artery disease
  JOURNAL   Int J Cardiol 369, 54-59 (2022)
   PUBMED   35944770
  REMARK    GeneRIF: Serum glypican-4 is associated with the 10-year clinical
            outcome of patients with peripheral artery disease.
REFERENCE   5  (bases 1 to 4959)
  AUTHORS   Huber,R., Mazzarella,R., Chen,C.N., Chen,E., Ireland,M.,
            Lindsay,S., Pilia,G. and Crisponi,L.
  TITLE     Glypican 3 and glypican 4 are juxtaposed in Xq26.1
  JOURNAL   Gene 225 (1-2), 9-16 (1998)
   PUBMED   9931407
REFERENCE   6  (bases 1 to 4959)
  AUTHORS   Veugelers,M., Vermeesch,J., Watanabe,K., Yamaguchi,Y., Marynen,P.
            and David,G.
  TITLE     GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion
            of the GPC3-GPC4 gene cluster in one family with
            Simpson-Golabi-Behmel syndrome
  JOURNAL   Genomics 53 (1), 1-11 (1998)
   PUBMED   9787072
REFERENCE   7  (bases 1 to 4959)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
REFERENCE   8  (bases 1 to 4959)
  AUTHORS   Williams,B.O., Schmitt,E.M., Remington,L., Bronson,R.T.,
            Albert,D.M., Weinberg,R.A. and Jacks,T.
  TITLE     Extensive contribution of Rb-deficient cells to adult chimeric mice
            with limited histopathological consequences
  JOURNAL   EMBO J 13 (18), 4251-4259 (1994)
   PUBMED   7925270
REFERENCE   9  (bases 1 to 4959)
  AUTHORS   Turner,J.T., Brzezinski,J. and Dome,J.S.
  TITLE     Wilms Tumor Predisposition
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301471
REFERENCE   10 (bases 1 to 4959)
  AUTHORS   Nisbet,A.F., Hathaway,E.R. and Kalish,J.M.
  TITLE     Simpson-Golabi-Behmel Syndrome Type 1
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301398
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109623.9 and AL034400.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_001448.2.
            
            Summary: Cell surface heparan sulfate proteoglycans are composed of
            a membrane-associated protein core substituted with a variable
            number of heparan sulfate chains. Members of the glypican-related
            integral membrane proteoglycan family (GRIPS) contain a core
            protein anchored to the cytoplasmic membrane via a glycosyl
            phosphatidylinositol linkage.  These proteins may play a role in
            the control of cell division and growth regulation.  The GPC4 gene
            is adjacent to the 3' end of GPC3 and may also play a role in
            Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.223928.1,
                                           SRR1660809.149973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370828.4/ ENSP00000359864.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-684               AL109623.9         11590-12273         c
            685-843             AL034400.2         77629-77787         c
            844-1235            AL034400.2         62591-62982         c
            1236-1401           AL034400.2         49704-49869         c
            1402-1532           AL034400.2         44470-44600         c
            1533-1679           AL034400.2         44218-44364         c
            1680-1816           AL034400.2         43171-43307         c
            1817-1992           AL034400.2         41612-41787         c
            1993-4959           AL034400.2         38549-41515         c
FEATURES             Location/Qualifiers
     source          1..4959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     gene            1..4959
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /note="glypican 4"
                     /db_xref="GeneID:2239"
                     /db_xref="HGNC:HGNC:4452"
                     /db_xref="MIM:300168"
     exon            1..684
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..2195
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /note="glypican proteoglycan 4; dJ900E8.1 (glypican 4)"
                     /codon_start=1
                     /product="glypican-4 precursor"
                     /protein_id="NP_001439.2"
                     /db_xref="CCDS:CCDS14637.1"
                     /db_xref="GeneID:2239"
                     /db_xref="HGNC:HGNC:4452"
                     /db_xref="MIM:300168"
                     /translation="MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNK
                     NDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRY
                     KKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEM
                     LNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAA
                     RTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRG
                     CLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVS
                     QKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEK
                     LKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEV
                     QVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCP
                     SEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR"
     exon            685..843
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1235
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1401
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1532
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1679
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1816
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1992
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..4959
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4009..4014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /note="hexamer: AATAAA"
     polyA_site      4028
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /note="major polyA site"
     regulatory      4488..4493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /note="hexamer: AATAAA"
     polyA_site      4516
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
     regulatory      4934..4939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /note="hexamer: AATAAA"
     polyA_site      4959
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
ORIGIN      
        1 agtcaatcag cggcagagct gagaagggca cagccgcgcg gcggagggca gagtcagccg
       61 agccgagtcc agccggacga gcggaccagc gcagggcagc ccaagcagcg cgcagcgaac
      121 gcccgccgcc gcccacaccc tctgcggtcc ccgcggcgcc tgccaccctt ccctccttcc
      181 ccgcgtcccc gcctcgccgg ccagtcagct tgccgggttc gctgccccgc gaaaccccga
      241 ggtcaccagc ccgcgcctct gcttccctgg gccgcgcgcc gcctccacgc cctccttctc
      301 ccctggcccg gcgcctggca ccggggaccg ttgcctgacg cgaggcccag ctctactttt
      361 cgccccgcgt ctcctccgcc tgctcgcctc ttccaccaac tccaactcct tctccctcca
      421 gctccactcg ctagtccccg actccgccag ccctcggccc gctgccgtag cgccgcttcc
      481 cgtccggtcc caaaggtggg aacgcgtccg ccccggcccg caccatggca cggttcggct
      541 tgcccgcgct tctctgcacc ctggcagtgc tcagcgccgc gctgctggct gccgagctca
      601 agtcgaaaag ttgctcggaa gtgcgacgtc tttacgtgtc caaaggcttc aacaagaacg
      661 atgcccccct ccacgagatc aacggtgatc atttgaagat ctgtccccag ggttctacct
      721 gctgctctca agagatggag gagaagtaca gcctgcaaag taaagatgat ttcaaaagtg
      781 tggtcagcga acagtgcaat catttgcaag ctgtctttgc ttcacgttac aagaagtttg
      841 atgaattctt caaagaacta cttgaaaatg cagagaaatc cctgaatgat atgtttgtga
      901 agacatatgg ccatttatac atgcaaaatt ctgagctatt taaagatctc ttcgtagagt
      961 tgaaacgtta ctacgtggtg ggaaatgtga acctggaaga aatgctaaat gacttctggg
     1021 ctcgcctcct ggagcggatg ttccgcctgg tgaactccca gtaccacttt acagatgagt
     1081 atctggaatg tgtgagcaag tatacggagc agctgaagcc cttcggagat gtccctcgca
     1141 aattgaagct ccaggttact cgtgcttttg tagcagcccg tactttcgct caaggcttag
     1201 cggttgcggg agatgtcgtg agcaaggtct ccgtggtaaa ccccacagcc cagtgtaccc
     1261 atgccctgtt gaagatgatc tactgctccc actgccgggg tctcgtgact gtgaagccat
     1321 gttacaacta ctgctcaaac atcatgagag gctgtttggc caaccaaggg gatctcgatt
     1381 ttgaatggaa caatttcata gatgctatgc tgatggtggc agagaggcta gagggtcctt
     1441 tcaacattga atcggtcatg gatcccatcg atgtgaagat ttctgatgct attatgaaca
     1501 tgcaggataa tagtgttcaa gtgtctcaga aggttttcca gggatgtgga ccccccaagc
     1561 ccctcccagc tggacgaatt tctcgttcca tctctgaaag tgccttcagt gctcgcttca
     1621 gaccacatca ccccgaggaa cgcccaacca cagcagctgg cactagtttg gaccgactgg
     1681 ttactgatgt caaggagaaa ctgaaacagg ccaagaaatt ctggtcctcc cttccgagca
     1741 acgtttgcaa cgatgagagg atggctgcag gaaacggcaa tgaggatgac tgttggaatg
     1801 ggaaaggcaa aagcaggtac ctgtttgcag tgacaggaaa tggattagcc aaccagggca
     1861 acaacccaga ggtccaggtt gacaccagca aaccagacat actgatcctt cgtcaaatca
     1921 tggctcttcg agtgatgacc agcaagatga agaatgcata caatgggaac gacgtggact
     1981 tctttgatat cagtgatgaa agtagtggag aaggaagtgg aagtggctgt gagtatcagc
     2041 agtgcccttc agagtttgac tacaatgcca ctgaccatgc tgggaagagt gccaatgaga
     2101 aagccgacag tgctggtgtc cgtcctgggg cacaggccta cctcctcact gtcttctgca
     2161 tcttgttcct ggttatgcag agagagtgga gataattctc aaactctgag aaaaagtgtt
     2221 catcaaaaag ttaaaaggca ccagttatca cttttctacc atcctagtga ctttgctttt
     2281 taaatgaatg gacaacaatg tacagttttt actatgtggc cactggttta agaagtgctg
     2341 actttgtttt ctcattcagt tttgggagga aaagggactg tgcattgagt tggttcctgc
     2401 tcccccaaac catgttaaac gtggctaaca gtgtaggtac agaactatag ttagttgtgc
     2461 atttgtgatt ttatcactct attatttgtt tgtatgtttt tttctcattt cgtttgtggg
     2521 tttttttttc caactgtgat ctcgccttgt ttcttacaag caaaccaggg tcccttcttg
     2581 gcacgtaaca tgtacgtatt tctgaaatat taaatagctg tacagaagca ggttttattt
     2641 atcatgttat cttattaaaa gaaaaagccc aaaaagcagt aaaatttcca tttctccctg
     2701 ttattttagt tgccttatct ggagagacgt ggaggtgatt ttcttttttt taaattatta
     2761 ttaagacaga atgtgagggc acaagcaggc ttctgagcca cttgtcagat tgtattcaaa
     2821 gcatcaatcc aagaaggagg ttatgtgtac ttcatttatt ggtgatagtt ggaagagact
     2881 gcagactact gctttgaatg agttgaatta cataagctaa gatcactata ggtccatttc
     2941 ttgaacccac ttatacataa aatgtaaccc atttagaaaa agattctgga tatcatcccc
     3001 cttgaaagat agaaagcatt caggatgtcc cagttatcac atgttcacac ttgggtttag
     3061 gggtgttttt ttttaaaacc aggcaggtta gctagcccac cctgtgctag ttttcatgtt
     3121 cacactgacc ctatttgaat taatatcctt tgttagagtg gtcgagattt caaacccaat
     3181 tatgtacagg gagctgtctg agagctagcc agaactgggg tacagcctgg gctcagggaa
     3241 tagctgtcaa cactcgggca aagtttttgt ctgtgcatgt gtatctccat ttgttttggg
     3301 atcccagttt ttgttttaag agagtataag gtgtctcatt tgagtctttt tcttacctag
     3361 ccccctctta tcagtaaaac aaaggacttg ccatggttca cagcaatgtg ctacgatcca
     3421 agatatcagc caaggagccc acttagggga gaactaggtg tccagatttt tgtatgtgtt
     3481 gtttttcttg ggggatgggg tggggtggga gtaggtagag ctgagaatac tacatcttag
     3541 tggtgacctt tagccacgtg ggtgaagtgg caaaggccat ggccatatct gttgtcccag
     3601 gccaaagact aacaactgcc ttgggaatcc cttccttgtg tccttaccaa atgatagctc
     3661 ataaaactct gataatgtaa caaatcactt tcaaaggagt tcccagaagt cttcagaaag
     3721 actaaaattc tgtctcttcc tgctttagac agccattaag atcccaacta attttaccga
     3781 acctaaaacc cacaaagagg ttgtttgtgt tattgttcaa tcttcagttg taagagtaat
     3841 tctctatttt tatattgaaa cataattact tgatagctca gggtctacat ttcattcaac
     3901 tttttacacc aaattctgca gagtggtcaa aatggaatat tgggggctgt tgtaaacaga
     3961 ggcttaattt tattagaagt agccagttat ttattaaagc atgatgttaa taaaataggc
     4021 atattctggc tggtgtgtat aagtggtttt ttttttaaaa caaatcagaa gacataaaat
     4081 tgaaaaggca ctccatttat atataaggga aaatagattg taaatagcta aggggccttg
     4141 tgagaacttg gaaaatgtgc tgatacttag taactacctc agttgtgagg aatttccttt
     4201 ttagcttaga ctgctattac ttttacttgg tagaaatgaa tctggtctcc aaaatatggc
     4261 tcagagagtt atccccatag accttgttag attgttttta atttaaaacc ttgaactctg
     4321 cccagctgtt ttcttccagt caaattctct aaaccaataa cattttccaa attaagtatt
     4381 cttgaaggtt cttctgaact cttactgatt tgttttcttt ctttgcattt tttcctgtta
     4441 ctcttttatt atttaaattg tctcttgctt ttgaacttca actatgaaat aaacaaatca
     4501 tagatttttc cattcaggtc tgactggata actcttggct tctaagcagc tggcaagctc
     4561 acccccactc cccaaaaaag aagaaaggca agttgaatat tttaaaacct taagagtttg
     4621 gagtatgaag tagaataaaa gccttgttag gagaagacct gacttttcca aagttaacag
     4681 catgtgaagg gcttgtgttt tacaaagtca tttataaatt atttttcttt aaaacacatc
     4741 acctactctg taccttaaag attttacaac tcttagattt atattttatt tcaaaaatcg
     4801 taactagcac ctgttatttt gattaaaaga cactgcgaag aattgacgta aatttctaaa
     4861 gtttagttac tgagtgttca aaacctaaca gttcacatga agtaaaaatt gtcatttgtg
     4921 attacagaat caaaataaaa ataggtatga atggtgcta
//
