LOCUS       NP_001439                556 aa            linear   PRI 06-DEC-2024
DEFINITION  glypican-4 precursor [Homo sapiens].
ACCESSION   NP_001439
VERSION     NP_001439.2
DBSOURCE    REFSEQ: accession NM_001448.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 556)
  AUTHORS   Tatenhorst,L., Maass,F., Paul,H., Dambeck,V., Bahr,M., Dono,R. and
            Lingor,P.
  TITLE     Glypican-4 serum levels are associated with cognitive dysfunction
            and vascular risk factors in Parkinson's disease
  JOURNAL   Sci Rep 14 (1), 5005 (2024)
   PUBMED   38424123
  REMARK    GeneRIF: Glypican-4 serum levels are associated with cognitive
            dysfunction and vascular risk factors in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 556)
  AUTHORS   Muendlein,A., Heinzle,C., Leiherer,A., Brandtner,E.M., Geiger,K.,
            Gaenger,S., Fraunberger,P., Mader,A., Saely,C.H. and Drexel,H.
  TITLE     Circulating glypican-4 is a new predictor of all-cause mortality in
            patients with heart failure
  JOURNAL   Clin Biochem 121-122, 110675 (2023)
   PUBMED   37844682
  REMARK    GeneRIF: Circulating glypican-4 is a new predictor of all-cause
            mortality in patients with heart failure.
REFERENCE   3  (residues 1 to 556)
  AUTHORS   Urschel,K., Hug,K.P., Zuo,H., Buttner,M., Furtmair,R., Kuehn,C.,
            Stumpfe,F.M., Botos,B., Achenbach,S., Yuan,Y., Dietel,B. and
            Tauchi,M.
  TITLE     The Shear Stress-Regulated Expression of Glypican-4 in Endothelial
            Dysfunction In Vitro and Its Clinical Significance in
            Atherosclerosis
  JOURNAL   Int J Mol Sci 24 (14), 11595 (2023)
   PUBMED   37511353
  REMARK    GeneRIF: The Shear Stress-Regulated Expression of Glypican-4 in
            Endothelial Dysfunction In Vitro and Its Clinical Significance in
            Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 556)
  AUTHORS   Muendlein,A., Heinzle,C., Leiherer,A., Geiger,K., Brandtner,E.M.,
            Gaenger,S., Fraunberger,P., Saely,C.H. and Drexel,H.
  TITLE     Serum glypican-4 is associated with the 10-year clinical outcome of
            patients with peripheral artery disease
  JOURNAL   Int J Cardiol 369, 54-59 (2022)
   PUBMED   35944770
  REMARK    GeneRIF: Serum glypican-4 is associated with the 10-year clinical
            outcome of patients with peripheral artery disease.
REFERENCE   5  (residues 1 to 556)
  AUTHORS   Huber,R., Mazzarella,R., Chen,C.N., Chen,E., Ireland,M.,
            Lindsay,S., Pilia,G. and Crisponi,L.
  TITLE     Glypican 3 and glypican 4 are juxtaposed in Xq26.1
  JOURNAL   Gene 225 (1-2), 9-16 (1998)
   PUBMED   9931407
REFERENCE   6  (residues 1 to 556)
  AUTHORS   Veugelers,M., Vermeesch,J., Watanabe,K., Yamaguchi,Y., Marynen,P.
            and David,G.
  TITLE     GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion
            of the GPC3-GPC4 gene cluster in one family with
            Simpson-Golabi-Behmel syndrome
  JOURNAL   Genomics 53 (1), 1-11 (1998)
   PUBMED   9787072
REFERENCE   7  (residues 1 to 556)
  AUTHORS   Watanabe,K., Yamada,H. and Yamaguchi,Y.
  TITLE     K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that
            is highly expressed in developing brain and kidney
  JOURNAL   J Cell Biol 130 (5), 1207-1218 (1995)
   PUBMED   7657705
REFERENCE   8  (residues 1 to 556)
  AUTHORS   Williams,B.O., Schmitt,E.M., Remington,L., Bronson,R.T.,
            Albert,D.M., Weinberg,R.A. and Jacks,T.
  TITLE     Extensive contribution of Rb-deficient cells to adult chimeric mice
            with limited histopathological consequences
  JOURNAL   EMBO J 13 (18), 4251-4259 (1994)
   PUBMED   7925270
REFERENCE   9  (residues 1 to 556)
  AUTHORS   Turner,J.T., Brzezinski,J. and Dome,J.S.
  TITLE     Wilms Tumor Predisposition
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301471
REFERENCE   10 (residues 1 to 556)
  AUTHORS   Nisbet,A.F., Hathaway,E.R. and Kalish,J.M.
  TITLE     Simpson-Golabi-Behmel Syndrome Type 1
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301398
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109623.9 and AL034400.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 26, 2002 this sequence version replaced NP_001439.1.
            
            Summary: Cell surface heparan sulfate proteoglycans are composed of
            a membrane-associated protein core substituted with a variable
            number of heparan sulfate chains. Members of the glypican-related
            integral membrane proteoglycan family (GRIPS) contain a core
            protein anchored to the cytoplasmic membrane via a glycosyl
            phosphatidylinositol linkage.  These proteins may play a role in
            the control of cell division and growth regulation.  The GPC4 gene
            is adjacent to the 3' end of GPC3 and may also play a role in
            Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.223928.1,
                                           SRR1660809.149973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370828.4/ ENSP00000359864.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     Protein         1..556
                     /product="glypican-4 precursor"
                     /note="glypican proteoglycan 4; dJ900E8.1 (glypican 4)"
                     /calculated_mol_wt=60215
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2216
     Region          26..551
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (O75487.4)"
     Site            494
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (glycosaminoglycan) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75487.4)"
     Site            498
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (glycosaminoglycan) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75487.4)"
     Site            500
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (glycosaminoglycan) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75487.4)"
     Site            514
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75487.4)"
     CDS             1..556
                     /gene="GPC4"
                     /gene_synonym="K-glypican; KPTS"
                     /coded_by="NM_001448.3:525..2195"
                     /db_xref="CCDS:CCDS14637.1"
                     /db_xref="GeneID:2239"
                     /db_xref="HGNC:HGNC:4452"
                     /db_xref="MIM:300168"
ORIGIN      
        1 marfglpall ctlavlsaal laaelksksc sevrrlyvsk gfnkndaplh eingdhlkic
       61 pqgstccsqe meekyslqsk ddfksvvseq cnhlqavfas rykkfdeffk ellenaeksl
      121 ndmfvktygh lymqnselfk dlfvelkryy vvgnvnleem lndfwarlle rmfrlvnsqy
      181 hftdeylecv skyteqlkpf gdvprklklq vtrafvaart faqglavagd vvskvsvvnp
      241 taqcthallk miycshcrgl vtvkpcynyc snimrgclan qgdldfewnn fidamlmvae
      301 rlegpfnies vmdpidvkis daimnmqdns vqvsqkvfqg cgppkplpag risrsisesa
      361 fsarfrphhp eerpttaagt sldrlvtdvk eklkqakkfw sslpsnvcnd ermaagngne
      421 ddcwngkgks rylfavtgng lanqgnnpev qvdtskpdil ilrqimalrv mtskmknayn
      481 gndvdffdis dessgegsgs gceyqqcpse fdynatdhag ksanekadsa gvrpgaqayl
      541 ltvfcilflv mqrewr
//
