LOCUS       NM_152742               2546 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens glypican 2 (GPC2), mRNA.
ACCESSION   NM_152742
VERSION     NM_152742.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2546)
  AUTHORS   Chen,S., Liao,J., Li,J. and Wang,S.
  TITLE     GPC2 promotes prostate cancer progression via MDK-mediated
            activation of PI3K/AKT signaling pathway
  JOURNAL   Funct Integr Genomics 24 (4), 127 (2024)
   PUBMED   39014225
  REMARK    GeneRIF: GPC2 promotes prostate cancer progression via MDK-mediated
            activation of PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2546)
  AUTHORS   Li,M., Zhang,X., Liu,J., Zhou,C., Miao,L., He,J., Wu,H. and
            Zhang,R.
  TITLE     Association between GPC2 polymorphisms and neuroblastoma risk in
            Chinese children
  JOURNAL   J Clin Lab Anal 37 (5), e24866 (2023)
   PUBMED   36920409
  REMARK    GeneRIF: Association between GPC2 polymorphisms and neuroblastoma
            risk in Chinese children.
REFERENCE   3  (bases 1 to 2546)
  AUTHORS   Chen,G., Luo,D., Zhong,N., Li,D., Zheng,J., Liao,H., Li,Z., Lin,X.,
            Chen,Q., Zhang,C., Lu,Y., Chan,Y.T., Ren,Q., Wang,N. and Feng,Y.
  TITLE     GPC2 Is a Potential Diagnostic, Immunological, and Prognostic
            Biomarker in Pan-Cancer
  JOURNAL   Front Immunol 13, 857308 (2022)
   PUBMED   35345673
  REMARK    GeneRIF: GPC2 Is a Potential Diagnostic, Immunological, and
            Prognostic Biomarker in Pan-Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2546)
  AUTHORS   Li,N., Torres,M.B., Spetz,M.R., Wang,R., Peng,L., Tian,M.,
            Dower,C.M., Nguyen,R., Sun,M., Tai,C.H., de Val,N., Cachau,R.,
            Wu,X., Hewitt,S.M., Kaplan,R.N., Khan,J., St Croix,B., Thiele,C.J.
            and Ho,M.
  TITLE     CAR T cells targeting tumor-associated exons of glypican 2 regress
            neuroblastoma in mice
  JOURNAL   Cell Rep Med 2 (6), 100297 (2021)
   PUBMED   34195677
  REMARK    GeneRIF: CAR T cells targeting tumor-associated exons of glypican 2
            regress neuroblastoma in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2546)
  AUTHORS   Bouguenina,H., Salaun,D., Mangon,A., Muller,L., Baudelet,E.,
            Camoin,L., Tachibana,T., Cianferani,S., Audebert,S.,
            Verdier-Pinard,P. and Badache,A.
  TITLE     EB1-binding-myomegalin protein complex promotes centrosomal
            microtubules functions
  JOURNAL   Proc Natl Acad Sci U S A 114 (50), E10687-E10696 (2017)
   PUBMED   29162697
REFERENCE   6  (bases 1 to 2546)
  AUTHORS   Bosse,K.R., Raman,P., Zhu,Z., Lane,M., Martinez,D., Heitzeneder,S.,
            Rathi,K.S., Kendsersky,N.M., Randall,M., Donovan,L., Morrissy,S.,
            Sussman,R.T., Zhelev,D.V., Feng,Y., Wang,Y., Hwang,J., Lopez,G.,
            Harenza,J.L., Wei,J.S., Pawel,B., Bhatti,T., Santi,M., Ganguly,A.,
            Khan,J., Marra,M.A., Taylor,M.D., Dimitrov,D.S., Mackall,C.L. and
            Maris,J.M.
  TITLE     Identification of GPC2 as an Oncoprotein and Candidate
            Immunotherapeutic Target in High-Risk Neuroblastoma
  JOURNAL   Cancer Cell 32 (3), 295-309 (2017)
   PUBMED   28898695
  REMARK    GeneRIF: these findings validate GPC2 as a non-mutated
            neuroblastoma oncoprotein and candidate immunotherapeutic target.
REFERENCE   7  (bases 1 to 2546)
  AUTHORS   Lugert,S., Kremer,T., Jagasia,R., Herrmann,A., Aigner,S.,
            Giachino,C., Mendez-David,I., Gardier,A.M., Carralot,J.P.,
            Meistermann,H., Augustin,A., Saxe,M.D., Lamerz,J.,
            Duran-Pacheco,G., Ducret,A., Taylor,V., David,D.J. and Czech,C.
  TITLE     Glypican-2 levels in cerebrospinal fluid predict the status of
            adult hippocampal neurogenesis
  JOURNAL   Sci Rep 7, 46543 (2017)
   PUBMED   28440309
  REMARK    GeneRIF: Gpc2 is enriched in neurogenic regions of the adult brain.
            Its expression is increased by physiological stimuli that increase
            hippocampal neurogenesis and decreased in transgenic models in
            which neurogenesis is selectively ablated. Changes in neurogenesis
            also result in changes in Gpc2 protein level in cerebrospinal fluid
            (CSF).
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2546)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 2546)
  AUTHORS   Stipp,C.S., Litwack,E.D. and Lander,A.D.
  TITLE     Cerebroglycan: an integral membrane heparan sulfate proteoglycan
            that is unique to the developing nervous system and expressed
            specifically during neuronal differentiation
  JOURNAL   J Cell Biol 124 (1-2), 149-160 (1994)
   PUBMED   8294498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY045249.1, BC027972.1, AK096281.1 and AI863264.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152742.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027972.1, AK096281.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292377.4/ ENSP00000292377.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                HY045249.1         47-60
            15-2187             BC027972.1         1-2173
            2188-2545           AK096281.1         2171-2528
            2546-2546           AI863264.1         25-25               c
FEATURES             Location/Qualifiers
     source          1..2546
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2546
                     /gene="GPC2"
                     /note="glypican 2"
                     /db_xref="GeneID:221914"
                     /db_xref="HGNC:HGNC:4450"
                     /db_xref="MIM:618446"
     exon            1..348
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1922
                     /gene="GPC2"
                     /note="cerebroglycan proteoglycan; glypican proteoglycan
                     2, cerebroglycan proteoglycan"
                     /codon_start=1
                     /product="glypican-2 precursor"
                     /protein_id="NP_689955.1"
                     /db_xref="CCDS:CCDS5689.1"
                     /db_xref="GeneID:221914"
                     /db_xref="HGNC:HGNC:4450"
                     /db_xref="MIM:618446"
                     /translation="MSALRPLLLLLLPLCPGPGPGPGSEAKVTRSCAETRQVLGARGY
                     SLNLIPPALISGEHLRVCPQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAA
                     RHRKFDEFFLEMLSVAQHSLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLD
                     DTLADFWAQLLERVFPLLHPQYSFPPDYLLCLSRLASSTDGSLQPFGDSPRRLRLQIT
                     RTLVAARAFVQGLETGRNVVSEALKVPVSEGCSQALMRLIGCPLCRGVPSLMPCQGFC
                     LNVVRGCLSSRGLEPDWGNYLDGLLILADKLQGPFSFELTAESIGVKISEGLMYLQEN
                     SAKVSAQVFQECGPPDPVPARNRRAPPPREEAGRLWSMVTEEERPTTAAGTNLHRLVW
                     ELRERLARMRGFWARLSLTVCGDSRMAADASLEAAPCWTGAGRGRYLPPVVGGSPAEQ
                     VNNPELKVDASGPDVPTRRRRLQLRAATARMKTAALGHDLDGQDADEDASGSGGGQQY
                     ADDWMAGAVAPPARPPRPPYPPRRDGSGGKGGGGSARYNQGRSRSGGASIGFHTQTIL
                     ILSLSALALLGPR"
     exon            349..507
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..830
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..911
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1074
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1205
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1352
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1492
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1668
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..2546
                     /gene="GPC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2526..2531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPC2"
                     /note="hexamer: AATAAA"
     polyA_site      2546
                     /gene="GPC2"
                     /note="major polyA site"
ORIGIN      
        1 gctcccattg tctcggcaga tgccgcctgg tccagctatc gtgctcggta ttcagttttc
       61 cggagcagcg ctctttctct ggcccgcgga gcggtcccgc ggccgagtac cggattcccg
      121 agtttgggag gctctgcttt cctccttagg acccactttg ccgtcctggg gtggctgcag
      181 ttatgtccgc gctgcgacct ctcctgcttc tgctgctgcc tctgtgtccc ggtcctggtc
      241 ccggacccgg gagcgaggca aaggtcaccc ggagttgtgc agagacccgg caggtgctgg
      301 gggcccgggg atatagctta aacctaatcc ctcccgccct gatctcaggt gagcacctcc
      361 gggtctgtcc ccaggagtac acctgctgtt ccagtgagac agagcagagg ctgatcaggg
      421 agactgaggc caccttccga ggcctggtgg aggacagcgg ctcctttctg gttcacacac
      481 tggctgccag gcacagaaaa tttgatgagt tttttctgga gatgctctca gtagcccagc
      541 actctctgac ccagctcttc tcccactcct acggccgcct gtatgcccag cacgccctca
      601 tattcaatgg cctgttctct cggctgcgag acttctatgg ggaatctggt gaggggttgg
      661 atgacaccct ggcggatttc tgggcacagc tcctggagag agtgttcccg ctgctgcacc
      721 cacagtacag cttcccccct gactacctgc tctgcctctc acgcttggcc tcatctaccg
      781 atggctctct gcagcccttt ggggactcac cccgccgcct ccgcctgcag ataacccgga
      841 ccctggtggc tgcccgagcc tttgtgcagg gcctggagac tggaagaaat gtggtcagcg
      901 aagcgcttaa ggtgccggtg tctgaaggct gcagccaggc tctgatgcgt ctcatcggct
      961 gtcccctgtg ccggggggtc ccctcactta tgccctgcca gggcttctgc ctcaacgtgg
     1021 ttcgtggctg tctcagcagc aggggactgg agcctgactg gggcaactat ctggatggtc
     1081 tcctgatcct ggctgataag ctccagggcc ccttttcctt tgagctgacg gccgagtcca
     1141 ttggggtgaa gatctcggag ggtttgatgt acctgcagga aaacagtgcg aaggtgtccg
     1201 cccaggtgtt tcaggagtgc ggcccccccg acccggtgcc tgcccgcaac cgtcgagccc
     1261 cgccgccccg ggaagaggcg ggccggctgt ggtcgatggt gaccgaggag gagcggccca
     1321 cgacggccgc aggcaccaac ctgcaccggc tggtgtggga gctccgcgag cgtctggccc
     1381 ggatgcgggg cttctgggcc cggctgtccc tgacggtgtg cggagactct cgcatggcag
     1441 cggacgcctc gctggaggcg gcgccctgct ggaccggagc cgggcggggc cggtacttgc
     1501 cgccagtggt cgggggctcc ccggccgagc aggtcaacaa ccccgagctc aaggtggacg
     1561 cctcgggccc cgatgtcccg acacggcggc gtcggctaca gctccgggcg gccacggcca
     1621 gaatgaaaac ggccgcactg ggacacgacc tggacgggca ggacgcggat gaggatgcca
     1681 gcggctctgg agggggacag cagtatgcag atgactggat ggctggggct gtggctcccc
     1741 cagcccggcc tcctcggcct ccataccctc ctagaaggga tggttctggg ggcaaaggag
     1801 gaggtggcag tgcccgctac aaccagggcc ggagcaggag tgggggggca tctattggtt
     1861 ttcacaccca aaccatcctc attctctccc tctcagccct ggccctgctt ggacctcgat
     1921 aacgggggag gggtgcccta gcatcagaag ggttcatggc cctttcccct cctcccccct
     1981 cagctgggcc tggggaggag tcgaaggggg ctgcagagag ggtagagaag ggactttgca
     2041 ggtgaatggc tggggcccca aatccaggag attttcatca gaggtgggtg ggtgttcaca
     2101 atatttattt tttcatttgg taatgggagg ggggcctggg ggtatttatt taggagggag
     2161 tgtggtttcc ttagaaggta tagtctctag ccctctaagg ctggggctgg tgatcagccc
     2221 caacagagaa aatgaggagt ttagagttgc agctggggaa ggggtttgaa ggaagttgga
     2281 agtggggagg ggtgggggca tctggtctca gaaatggacc agctggatgc agggcagggg
     2341 actgagggtg cttgagtagg atgtgagact tcatgggcct gggttctgtt gagttttttc
     2401 agtatcaatt tcttaaacca aattttaaaa aaaacaaggt gggggggtgc tcatctcgtg
     2461 acctctgcca cccacatcct tcacaaactc catgtttcag tgtttgagtc catgtttatt
     2521 ctgcaaataa atggtaatgt attgga
//
