LOCUS       NP_689955                579 aa            linear   PRI 27-APR-2025
DEFINITION  glypican-2 precursor [Homo sapiens].
ACCESSION   NP_689955
VERSION     NP_689955.1
DBSOURCE    REFSEQ: accession NM_152742.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 579)
  AUTHORS   Chen,S., Liao,J., Li,J. and Wang,S.
  TITLE     GPC2 promotes prostate cancer progression via MDK-mediated
            activation of PI3K/AKT signaling pathway
  JOURNAL   Funct Integr Genomics 24 (4), 127 (2024)
   PUBMED   39014225
  REMARK    GeneRIF: GPC2 promotes prostate cancer progression via MDK-mediated
            activation of PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 579)
  AUTHORS   Li,M., Zhang,X., Liu,J., Zhou,C., Miao,L., He,J., Wu,H. and
            Zhang,R.
  TITLE     Association between GPC2 polymorphisms and neuroblastoma risk in
            Chinese children
  JOURNAL   J Clin Lab Anal 37 (5), e24866 (2023)
   PUBMED   36920409
  REMARK    GeneRIF: Association between GPC2 polymorphisms and neuroblastoma
            risk in Chinese children.
REFERENCE   3  (residues 1 to 579)
  AUTHORS   Chen,G., Luo,D., Zhong,N., Li,D., Zheng,J., Liao,H., Li,Z., Lin,X.,
            Chen,Q., Zhang,C., Lu,Y., Chan,Y.T., Ren,Q., Wang,N. and Feng,Y.
  TITLE     GPC2 Is a Potential Diagnostic, Immunological, and Prognostic
            Biomarker in Pan-Cancer
  JOURNAL   Front Immunol 13, 857308 (2022)
   PUBMED   35345673
  REMARK    GeneRIF: GPC2 Is a Potential Diagnostic, Immunological, and
            Prognostic Biomarker in Pan-Cancer.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 579)
  AUTHORS   Li,N., Torres,M.B., Spetz,M.R., Wang,R., Peng,L., Tian,M.,
            Dower,C.M., Nguyen,R., Sun,M., Tai,C.H., de Val,N., Cachau,R.,
            Wu,X., Hewitt,S.M., Kaplan,R.N., Khan,J., St Croix,B., Thiele,C.J.
            and Ho,M.
  TITLE     CAR T cells targeting tumor-associated exons of glypican 2 regress
            neuroblastoma in mice
  JOURNAL   Cell Rep Med 2 (6), 100297 (2021)
   PUBMED   34195677
  REMARK    GeneRIF: CAR T cells targeting tumor-associated exons of glypican 2
            regress neuroblastoma in mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 579)
  AUTHORS   Bouguenina,H., Salaun,D., Mangon,A., Muller,L., Baudelet,E.,
            Camoin,L., Tachibana,T., Cianferani,S., Audebert,S.,
            Verdier-Pinard,P. and Badache,A.
  TITLE     EB1-binding-myomegalin protein complex promotes centrosomal
            microtubules functions
  JOURNAL   Proc Natl Acad Sci U S A 114 (50), E10687-E10696 (2017)
   PUBMED   29162697
REFERENCE   6  (residues 1 to 579)
  AUTHORS   Bosse,K.R., Raman,P., Zhu,Z., Lane,M., Martinez,D., Heitzeneder,S.,
            Rathi,K.S., Kendsersky,N.M., Randall,M., Donovan,L., Morrissy,S.,
            Sussman,R.T., Zhelev,D.V., Feng,Y., Wang,Y., Hwang,J., Lopez,G.,
            Harenza,J.L., Wei,J.S., Pawel,B., Bhatti,T., Santi,M., Ganguly,A.,
            Khan,J., Marra,M.A., Taylor,M.D., Dimitrov,D.S., Mackall,C.L. and
            Maris,J.M.
  TITLE     Identification of GPC2 as an Oncoprotein and Candidate
            Immunotherapeutic Target in High-Risk Neuroblastoma
  JOURNAL   Cancer Cell 32 (3), 295-309 (2017)
   PUBMED   28898695
  REMARK    GeneRIF: these findings validate GPC2 as a non-mutated
            neuroblastoma oncoprotein and candidate immunotherapeutic target.
REFERENCE   7  (residues 1 to 579)
  AUTHORS   Lugert,S., Kremer,T., Jagasia,R., Herrmann,A., Aigner,S.,
            Giachino,C., Mendez-David,I., Gardier,A.M., Carralot,J.P.,
            Meistermann,H., Augustin,A., Saxe,M.D., Lamerz,J.,
            Duran-Pacheco,G., Ducret,A., Taylor,V., David,D.J. and Czech,C.
  TITLE     Glypican-2 levels in cerebrospinal fluid predict the status of
            adult hippocampal neurogenesis
  JOURNAL   Sci Rep 7, 46543 (2017)
   PUBMED   28440309
  REMARK    GeneRIF: Gpc2 is enriched in neurogenic regions of the adult brain.
            Its expression is increased by physiological stimuli that increase
            hippocampal neurogenesis and decreased in transgenic models in
            which neurogenesis is selectively ablated. Changes in neurogenesis
            also result in changes in Gpc2 protein level in cerebrospinal fluid
            (CSF).
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 579)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (residues 1 to 579)
  AUTHORS   Stipp,C.S., Litwack,E.D. and Lander,A.D.
  TITLE     Cerebroglycan: an integral membrane heparan sulfate proteoglycan
            that is unique to the developing nervous system and expressed
            specifically during neuronal differentiation
  JOURNAL   J Cell Biol 124 (1-2), 149-160 (1994)
   PUBMED   8294498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY045249.1, BC027972.1, AK096281.1 and AI863264.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027972.1, AK096281.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292377.4/ ENSP00000292377.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     Protein         1..579
                     /product="glypican-2 precursor"
                     /note="cerebroglycan proteoglycan; glypican proteoglycan
                     2, cerebroglycan proteoglycan"
                     /calculated_mol_wt=60565
     sig_peptide     1..23
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8N158.1)"
                     /calculated_mol_wt=2283
     mat_peptide     24..554
                     /product="Glypican-2. /id=PRO_0000012303"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N158.1)"
                     /calculated_mol_wt=58033
     Region          29..512
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     Site            55
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (heparan sulfate) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8N158.1)"
     Site            92
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (heparan sulfate) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8N158.1)"
     Site            155
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (heparan sulfate) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8N158.1)"
     Region          444..468
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N158.1)"
     Region          485..555
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N158.1)"
     Site            500
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (heparan sulfate) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8N158.1)"
     Site            502
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (heparan sulfate) serine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8N158.1)"
     CDS             1..579
                     /gene="GPC2"
                     /coded_by="NM_152742.3:183..1922"
                     /db_xref="CCDS:CCDS5689.1"
                     /db_xref="GeneID:221914"
                     /db_xref="HGNC:HGNC:4450"
                     /db_xref="MIM:618446"
ORIGIN      
        1 msalrpllll llplcpgpgp gpgseakvtr scaetrqvlg argyslnlip palisgehlr
       61 vcpqeytccs seteqrlire teatfrglve dsgsflvhtl aarhrkfdef flemlsvaqh
      121 sltqlfshsy grlyaqhali fnglfsrlrd fygesgegld dtladfwaql lervfpllhp
      181 qysfppdyll clsrlasstd gslqpfgdsp rrlrlqitrt lvaarafvqg letgrnvvse
      241 alkvpvsegc sqalmrligc plcrgvpslm pcqgfclnvv rgclssrgle pdwgnyldgl
      301 liladklqgp fsfeltaesi gvkiseglmy lqensakvsa qvfqecgppd pvparnrrap
      361 ppreeagrlw smvteeerpt taagtnlhrl vwelrerlar mrgfwarlsl tvcgdsrmaa
      421 dasleaapcw tgagrgrylp pvvggspaeq vnnpelkvda sgpdvptrrr rlqlraatar
      481 mktaalghdl dgqdadedas gsgggqqyad dwmagavapp arpprppypp rrdgsggkgg
      541 ggsarynqgr srsggasigf htqtililsl salallgpr
//
