LOCUS       NM_002081               3719 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens glypican 1 (GPC1), mRNA.
ACCESSION   NM_002081
VERSION     NM_002081.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Cheng,F., Fransson,L.A. and Mani,K.
  TITLE     Interplay between glypican-1, amyloid-beta and tau phosphorylation
            in human neural stem cells
  JOURNAL   Neuroscience 553, 121-127 (2024)
   PUBMED   38992568
  REMARK    GeneRIF: Interplay between glypican-1, amyloid-beta and tau
            phosphorylation in human neural stem cells.
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Cao,L., Li,F., Cai,S., Zhang,J., Guo,C., Ali,S., Zhou,J., Jing,X.,
            Wang,X., Qin,Y. and Wu,F.
  TITLE     Pan-cancer analysis and the oncogenic role of Glypican 1 in
            hepatocellular carcinoma
  JOURNAL   Sci Rep 14 (1), 15870 (2024)
   PUBMED   38982153
  REMARK    GeneRIF: Pan-cancer analysis and the oncogenic role of Glypican 1
            in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Li,H., Chiang,C.L., Kwak,K.J., Wang,X., Doddi,S., Ramanathan,L.V.,
            Cho,S.M., Hou,Y.C., Cheng,T.S., Mo,X., Chang,Y.S., Chang,H.L.,
            Cheng,W., Tsai,W.N., Nguyen,L.T.H., Pan,J., Ma,Y., Rima,X.Y.,
            Zhang,J., Reategui,E., Chu,Y.S., Chang,P.M., Chang,P.H.,
            Huang,C.F., Wang,C.H., Shan,Y.S., Li,C.P., Fleisher,M. and Lee,L.J.
  TITLE     Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for
            Pancreatic Cancer Diagnosis and Prognosis
  JOURNAL   Adv Sci (Weinh) 11 (11), e2306373 (2024)
   PUBMED   38204202
  REMARK    GeneRIF: Extracellular Vesicular Analysis of Glypican 1 mRNA and
            Protein for Pancreatic Cancer Diagnosis and Prognosis.
REFERENCE   4  (bases 1 to 3719)
  AUTHORS   Wang,C., Han,Y. and Li,X.
  TITLE     Glypican-1 may be a plasma biomarker for predicting the rupture of
            small intracranial aneurysms
  JOURNAL   J Proteomics 293, 105060 (2024)
   PUBMED   38154549
  REMARK    GeneRIF: Glypican-1 may be a plasma biomarker for predicting the
            rupture of small intracranial aneurysms.
REFERENCE   5  (bases 1 to 3719)
  AUTHORS   Cheng,F., Hansson,V.C., Georgolopoulos,G. and Mani,K.
  TITLE     Attenuation of cancer proliferation by suppression of glypican-1
            and its pleiotropic effects in neoplastic behavior
  JOURNAL   Oncotarget 14, 219-235 (2023)
   PUBMED   36944188
  REMARK    GeneRIF: Attenuation of cancer proliferation by suppression of
            glypican-1 and its pleiotropic effects in neoplastic behavior.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3719)
  AUTHORS   Gengrinovitch,S., Berman,B., David,G., Witte,L., Neufeld,G. and
            Ron,D.
  TITLE     Glypican-1 is a VEGF165 binding proteoglycan that acts as an
            extracellular chaperone for VEGF165
  JOURNAL   J Biol Chem 274 (16), 10816-10822 (1999)
   PUBMED   10196157
REFERENCE   7  (bases 1 to 3719)
  AUTHORS   Kleeff,J., Ishiwata,T., Kumbasar,A., Friess,H., Buchler,M.W.,
            Lander,A.D. and Korc,M.
  TITLE     The cell-surface heparan sulfate proteoglycan glypican-1 regulates
            growth factor action in pancreatic carcinoma cells and is
            overexpressed in human pancreatic cancer
  JOURNAL   J Clin Invest 102 (9), 1662-1673 (1998)
   PUBMED   9802880
REFERENCE   8  (bases 1 to 3719)
  AUTHORS   Vermeesch,J.R., Mertens,G., David,G. and Marynen,P.
  TITLE     Assignment of the human glypican gene (GPC1) to 2q35-q37 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 25 (1), 327-329 (1995)
   PUBMED   7774946
REFERENCE   9  (bases 1 to 3719)
  AUTHORS   Karthikeyan,L., Maurel,P., Rauch,U., Margolis,R.K. and
            Margolis,R.U.
  TITLE     Cloning of a major heparan sulfate proteoglycan from brain and
            identification as the rat form of glypican
  JOURNAL   Biochem Biophys Res Commun 188 (1), 395-401 (1992)
   PUBMED   1417860
REFERENCE   10 (bases 1 to 3719)
  AUTHORS   David,G., Lories,V., Decock,B., Marynen,P., Cassiman,J.J. and Van
            den Berghe,H.
  TITLE     Molecular cloning of a phosphatidylinositol-anchored membrane
            heparan sulfate proteoglycan from human lung fibroblasts
  JOURNAL   J Cell Biol 111 (6 Pt 2), 3165-3176 (1990)
   PUBMED   2148568
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110619.3, X54232.1 and
            BG825129.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002081.2.
            
            Summary: Cell surface heparan sulfate proteoglycans are composed of
            a membrane-associated protein core substituted with a variable
            number of heparan sulfate chains. Members of the glypican-related
            integral membrane proteoglycan family (GRIPS) contain a core
            protein anchored to the cytoplasmic membrane via a glycosyl
            phosphatidylinositol linkage.  These proteins may play a role in
            the control of cell division and growth regulation. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54232.1, BC051279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264039.7/ ENSP00000264039.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC110619.3         40033-40067         c
            36-1314             X54232.1           1-1279
            1315-1474           BG825129.1         486-645
            1475-1753           X54232.1           1440-1718
            1754-3719           AC110619.3         7654-9619           c
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..3719
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /note="glypican 1"
                     /db_xref="GeneID:2817"
                     /db_xref="HGNC:HGNC:4449"
                     /db_xref="MIM:600395"
     exon            1..422
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1933
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /note="glypican proteoglycan 1; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="glypican-1 precursor"
                     /protein_id="NP_002072.2"
                     /db_xref="CCDS:CCDS2534.1"
                     /db_xref="GeneID:2817"
                     /db_xref="HGNC:HGNC:4449"
                     /db_xref="MIM:600395"
                     /translation="MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGF
                     SLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLAT
                     QLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLE
                     ETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFV
                     AARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVL
                     KGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDT
                     LTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDF
                     WISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPD
                     MTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSS
                     SSRTPLTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR"
     exon            423..581
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            582..973
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1139
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1270
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1390
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1524
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1700
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..3719
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1981..1986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /note="hexamer: AATACA"
     polyA_site      2007
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /note="major polyA site"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /note="hexamer: AATAAA"
     polyA_site      3719
                     /gene="GPC1"
                     /gene_synonym="glypican"
                     /note="major polyA site"
ORIGIN      
        1 gccgagccgg gactgcgcta gcccgccgcg ctctgggctg cccgagcgag cgttcggacc
       61 tcgcaccccg cgcgccccgc gccgccgccg ccgccggctt ttgttgtctc cgcctcctcg
      121 gccgccgccg cctctggacc gcgagccgcg cgcgccggga ccttggctct gcccttcgcg
      181 ggcgggaact gcgcaggacc cggccaggat ccgagagagg cgcgggcggg tggccggggg
      241 cgccgccggc cccgccatgg agctccgggc ccgaggctgg tggctgctat gtgcggccgc
      301 agcgctggtc gcctgcgccc gcggggaccc ggccagcaag agccggagct gcggcgaggt
      361 ccgccagatc tacggagcca agggcttcag cctgagcgac gtgccccagg cggagatctc
      421 gggtgagcac ctgcggatct gtccccaggg ctacacctgc tgcaccagcg agatggagga
      481 gaacctggcc aaccgcagcc atgccgagct ggagaccgcg ctccgggaca gcagccgcgt
      541 cctgcaggcc atgcttgcca cccagctgcg cagcttcgat gaccacttcc agcacctgct
      601 gaacgactcg gagcggacgc tgcaggccac cttccccggc gccttcggag agctgtacac
      661 gcagaacgcg agggccttcc gggacctgta ctcagagctg cgcctgtact accgcggtgc
      721 caacctgcac ctggaggaga cgctggccga gttctgggcc cgcctgctcg agcgcctctt
      781 caagcagctg cacccccagc tgctgctgcc tgatgactac ctggactgcc tgggcaagca
      841 ggccgaggcg ctgcggccct tcggggaggc cccgagagag ctgcgcctgc gggccacccg
      901 tgccttcgtg gctgctcgct cctttgtgca gggcctgggc gtggccagcg acgtggtccg
      961 gaaagtggct caggtccccc tgggcccgga gtgctcgaga gctgtcatga agctggtcta
     1021 ctgtgctcac tgcctgggag tccccggcgc caggccctgc cctgactatt gccgaaatgt
     1081 gctcaagggc tgccttgcca accaggccga cctggacgcc gagtggagga acctcctgga
     1141 ctccatggtg ctcatcaccg acaagttctg gggtacatcg ggtgtggaga gtgtcatcgg
     1201 cagcgtgcac acgtggctgg cggaggccat caacgccctc caggacaaca gggacacgct
     1261 cacggccaag gtcatccagg gctgcgggaa ccccaaggtc aacccccagg gccccgggcc
     1321 tgaggagaag cggcgccggg gcaagctggc cccgcgggag aggccacctt caggcacgct
     1381 ggagaagctg gtctccgaag ccaaggccca gctccgcgac gtccaggact tctggatcag
     1441 cctcccaggg acactgtgca gtgagaagat ggccctgagc actgccagtg atgaccgctg
     1501 ctggaacggg atggccagag gccggtacct ccccgaggtc atgggtgacg gcctggccaa
     1561 ccagatcaac aaccccgagg tggaggtgga catcaccaag ccggacatga ccatccggca
     1621 gcagatcatg cagctgaaga tcatgaccaa ccggctgcgc agcgcctaca acggcaacga
     1681 cgtggacttc caggacgcca gtgacgacgg cagcggctcg ggcagcggtg atggctgtct
     1741 ggatgacctc tgcagccgga aggtcagcag gaagagctcc agctcccgga cgcccttgac
     1801 ccatgccctc ccaggcctgt cagagcagga aggacagaag acctcggctg ccagctgccc
     1861 ccagcccccg accttcctcc tgcccctcct cctcttcctg gcccttacag tagccaggcc
     1921 ccggtggcgg taactgcccc aaggccccag ggacagaggc caaggactga ctttgccaaa
     1981 aatacaacac agacgatatt taattcacct cagcctggag aggcctgggg tgggacaggg
     2041 agggccggcg gctctgagca ggggcaggcg cagaggtccc agccccaggc ctggcctcgc
     2101 ctgcctttct gccttttaat tttgtatgag gtcctcaggt cagctgggag ccagtgtgcc
     2161 caaaagccat gtatttcagg gacctcaggg gcacctccgg ctgcctagcc ctccccccag
     2221 ctccctgcac cgccgcagaa gcagcccctc gaggcctaca gaggaggcct caaagcaacc
     2281 cgctggagcc cacagcgagc ctgtgccttc ctccccgcct cctcccactg ggactcccag
     2341 cagagcccac cagccagccc tggcccaccc cccagcctcc agagaagccc cgcacgggct
     2401 gtctgggtgt ccgccatcca gggtctggca gagcctctga gatgatgcat gatgccctcc
     2461 cctcagcgca ggctgcagag cccggcccca cctccctgcg cccttgaggg gccccagcgt
     2521 ctgcagggtg acgcctgaga cagcaccact gctgaggagt ctgaggactg tcctcccaca
     2581 gacctgcagt gaggggccct ccatgcgcag atgaggggcc actgacccac ctgcgcttct
     2641 gctggaggag gggaagctgg gcccaaaggc ccagggaggc agcgtgggct ctgccaatgt
     2701 gggctgcccc tcgcacacag ggctcacagg gcaggccttg ctggggtcca gggctgttgg
     2761 aggaccccga gggctgagga gcagccagga cccgcctgct cccatcctca cccagatcag
     2821 gaaccagggc ctccctgttc acggtgacac aggtcagggc tcagagtgac cctcagctgt
     2881 cacctgctca cagggatgct ggtggctggt gagaccccgc actgcagacg ggaatgccta
     2941 ggtcccttcc cgacccagcc agctgcaggg cacggggacc tggatagtta agggcttttc
     3001 caaacatgca tccatttact gacacttcct gtccttgttc atggagagct gttcgctcct
     3061 cccagatggc ttcggagggc cgcagggccc accttggacc ctggtgacct cctgtcactc
     3121 actgaggcca tcagggccct gccccaggcc tggacgggcc ctccttccct cctgtgcccc
     3181 agctgccagg cggccctggg gaggggtggt gtggtgttgg gaaggggtcc tgcaggggga
     3241 ggaggacttg gagggtctgg gggcagctgt cctgaaccga ctgaccctga ggaggccgct
     3301 tagtgctgct ttgcttttca tcaccgtccc gcacagtgga cggaggtccc cggttgctgg
     3361 tcaggtcccc atggcttgtt ctctggaacc tgactttaga tgttttggga tcaggagccc
     3421 ccaacacagg caagtccacc ccataataac cctgccagtg ccagggtggg ctggggactc
     3481 tggcacagtg atgccgggcg ccaggacagc agcactcccg ctgcacacag acggcctagg
     3541 ggtggcgctc agaccccacc ctacgctcat ctctggaagg ggcagccctg agtggtcact
     3601 ggtcagggca gtggccaagc ctgctgtgtc cttcctccac aaggtccccc caccgctcag
     3661 tgtcagcggg tgacgtgtgt tcttttgagt ccttgtatga ataaaaggct ggaaaccta
//
