LOCUS       NM_021639               3641 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens GC-rich promoter binding protein 1 like 1 (GPBP1L1),
            mRNA.
ACCESSION   NM_021639
VERSION     NM_021639.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3641)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3641)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3641)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3641)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC068578.1, BC022218.1 and BU627076.1.
            
            On Nov 24, 2018 this sequence version replaced NM_021639.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.142735.1,
                                           SRR1660803.241498.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355105.8/ ENSP00000347224.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1875              BC068578.1         78-1952
            1876-3452           BC022218.1         1056-2632
            3453-3641           BU627076.1         17-205              c
FEATURES             Location/Qualifiers
     source          1..3641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..3641
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /note="GC-rich promoter binding protein 1 like 1"
                     /db_xref="GeneID:60313"
                     /db_xref="HGNC:HGNC:28843"
     exon            1..122
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            123..167
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            168..1209
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1324
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     CDS             1265..2689
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /codon_start=1
                     /product="vasculin-like protein 1"
                     /protein_id="NP_067652.1"
                     /db_xref="CCDS:CCDS528.1"
                     /db_xref="GeneID:60313"
                     /db_xref="HGNC:HGNC:28843"
                     /translation="MAQHDFVPAWLNFSTPQSAKSPTATFEKHGEHLPRGEGRFGVSR
                     RRHNSSDGFFNNGPLRTAGDSWHQPSLFRHDSVDSGVSKGAYAGITGNPSGWHSSSRG
                     HDGMSQRSGGGTGNHRHWNGSFHSRKGCAFQEKPPMEIREEKKEDKVEKLQFEEEDFP
                     SLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPG
                     SHHANGNKLSSVVPSVYKNLVPKPVPPPSKPNAWKANRMEHKSGSLSSSRESAFTSPI
                     SVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRN
                     GDFSENRDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLL
                     KAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGFGKNGFLQSRSSSLFSPWRST
                     CKAEFEDSDTETSSSETSDDDAWK"
     exon            1325..1454
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1741
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1814
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2008
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2149
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2308
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2433
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2536
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..3641
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3433..3438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /note="hexamer: AATAAA"
     polyA_site      3457
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /note="major polyA site"
     regulatory      3610..3615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /note="hexamer: AATAAA"
     regulatory      3624..3629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
                     /note="hexamer: AATAAA"
     polyA_site      3637
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
     polyA_site      3641
                     /gene="GPBP1L1"
                     /gene_synonym="SP192"
ORIGIN      
        1 gcagccattt tgggaagagc tttgttatgg ttgtggacta gccgcctctg ccgggtcgac
       61 aagctgggga cgcgtcctca gacgcagcgt ctagtccctg gccatagctc cgccgctgcc
      121 cgttggtgtc tcacctttaa ctctccttat gctgggtgaa aacaaagagt gatagattcg
      181 tgtggccttt caaatgattg tgaagtggtg gaaatggatc caaaataata agtgacttct
      241 ctaccaaagc atagaagatt cttcatatct ccttccagtg gctcaattta gattttggga
      301 aggagcagaa caagtgaaac acagaaaact gaagagaaga aatcctcatt ttggacctat
      361 atttctcctt gactatttct taatatccat cctacccatc gttctaatgt tttaactttg
      421 ctctgaattt ataaatagta aaggccaaag acatagaata tacatttagt agctttatac
      481 caagaaattt gccttgaaag ctgctgttcg tggagggaaa agtgtagcaa attcctgtct
      541 atttttattt tttatttttt tttaacaaag acaagattta tgtccctaga ttttgaaggt
      601 taaggcaaat ataaatacat atctgcacac tattttttag cagttgcatg agtaagagta
      661 atgagatttg tattttaagg actttgtcat gtggatgttt tggagttgac tgctcagatc
      721 ttttataggg ctttaatatt tttgatctat taccttgatg acattatttg tccacacttg
      781 agcccatctg tctttctagc tatgaccttg ttatgaacag tatttgcact cggtgcaaat
      841 atccatgtct tacctaatta agcaacatca tagtgccata actcaaggaa gttgaatgag
      901 gtgaacatag atacagctct ttccccttcc cccccttttt aaatgtaaca aatacttttt
      961 atgttcccct tccccccttc cccttttccc ctttcccctt ttggaaacgt gtcaggaacc
     1021 aaatagttta agatgagcag ttgaggggac tgagagagtg atcgacacag aacctggctt
     1081 cttcgtgctt catcataagt cgtgctgccg gccaggttac ttaagcaccc ttttaacaag
     1141 gaaaccttgt gggagatcca gctggccgac tcgagttcag aaacaggacc acagaggtta
     1201 cactctggga tcctggccat gaggttggat gcctcacctt actgaaagga gacactggac
     1261 ctaaatggcg cagcatgatt ttgttcctgc ttggctaaat ttctcaacac cacagtcagc
     1321 taagtcacct actgccacct tcgaaaaaca cggagagcac ctacccagag gagaaggtag
     1381 atttggagta agccgccgtc gacataattc ctctgatggt ttttttaaca atggtcccct
     1441 acgaactgca ggagattctt ggcaccagcc ctccctgttc cgccatgatt ctgtggactc
     1501 tggtgtctct aagggagcat atgctggaat cacagggaac ccatctggtt ggcatagctc
     1561 ttcccgaggt catgatggca tgagccaacg tagtggaggt ggcacaggga accatcgcca
     1621 ttggaatggc agcttccact cccggaaagg gtgtgctttt caggaaaagc cacctatgga
     1681 gattagggaa gaaaagaaag aagacaaggt ggaaaagttg cagtttgaag aggaggactt
     1741 tccttccttg aatccagaag ctggcaaaca gcatcagcca tgcagaccta ttgggacacc
     1801 ttctggagta tgggaaaacc cgcctagtgc caagcaaccc tccaagatgc tagttatcaa
     1861 aaaagtttcc aaagaggatc ctgctgctgc cttctctgct gcattcacct caccaggatc
     1921 tcaccatgca aatgggaaca aattgtcatc cgtggttcca agtgtctata agaacctggt
     1981 tcctaagcct gtaccacctc cttccaagcc taatgcatgg aaagctaaca ggatggagca
     2041 caagtcagga tccctttcct ctagccggga gtctgctttt accagtccaa tctctgttac
     2101 caaaccagtg gtactggcta gtggtgcagc tctgagttct cccaaagaga gtccctccag
     2161 caccacccct ccaattgaga tcagctcctc tcgtctgacc aagttgaccc gccgaaccac
     2221 cgacaggaag agtgagttcc tgaaaactct gaaggatgac cggaatggag acttctcaga
     2281 gaatagagac tgtgacaagc tggaagattt ggaggacaac agcacacctg aaccaaagga
     2341 aaatggggag gaaggctgtc atcaaaatgg tcttgccctc cctgtagtgg aagaagggga
     2401 ggttctctca cactctctag aagcagagca caggttattg aaagctatgg gttggcagga
     2461 atatcctgaa aatgatgaga attgccttcc cctcacagag gatgagctca aagagttcca
     2521 catgaagaca gagcagctga gaagaaatgg ctttggaaag aatggcttct tgcagagccg
     2581 cagttccagt ctgttctccc cttggagaag cacttgcaaa gcagagtttg aggactcaga
     2641 caccgaaacc agtagcagtg aaacatcaga tgacgatgcc tggaagtagg catataaatg
     2701 ctcacagtta aatctgaccc agtaaactct gtgtgtttag ggagtataca aaagaaatcg
     2761 ttcttttcct tttcttatgt tgttgaatac ttcattcaca agggaaataa tcatatccca
     2821 aagagagagc aattggcttg ttttgctttt gttattgttc ttccctgtta tctgctttat
     2881 agagagaagt ttgtgtggtg ggacagattt tttaaacaca ctcacacaca cacacacata
     2941 cacacccagt atatatgggg cgatgcacag gtaggagctg gcagtgcagg gaagaggaga
     3001 cactggtctg cagcaacagc ttctactacc agcccttggg gcactcaccc ctgtgatcaa
     3061 gcaatcattg tcaatgacaa agtgactatt gaagttataa ttgtattaaa ttaatgctaa
     3121 taatttggat attttatttt atttttggct gctcgggtaa ctttagccct taaccaagca
     3181 tatgtgggtt tttttggttg tttttttttg tttttttttt ctttttcctt tttgggtaca
     3241 gctgtaaaat atttggatat aggaaatgtt gtgttattct tgcagccttg atattcaggg
     3301 tggattgtaa aatataaatt tttgtgagat ttcaaagatt aagattattt tgataacatt
     3361 atttacagat ttaaaagatg tggttatcac aagtctcgag ggggaaacta ctgcataaaa
     3421 taactaactt ggaataaata ttttgcatca gtttggattg tcttgtgtaa gaagtatatt
     3481 ttctttaaaa ttagatgagt ggattctttt ttaggggaaa tatttttaga agttgggggg
     3541 aaatgtgaat tcagacacaa ctgtttctct attttagcag atactttttt gatgcagaaa
     3601 aacctgtgca ataaattacc agtaataaag tcagaaacca a
//
