LOCUS       NM_022913               4506 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens GC-rich promoter binding protein 1 (GPBP1), transcript
            variant 1, mRNA.
ACCESSION   NM_022913
VERSION     NM_022913.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4506)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4506)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4506)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 4506)
  AUTHORS   Yu,X., Noll,R.R., Romero Duenas,B.P., Allgood,S.C., Barker,K.,
            Caplan,J.L., Machner,M.P., LaBaer,J., Qiu,J. and Neunuebel,M.R.
  TITLE     Legionella effector AnkX interacts with host nuclear protein
            PLEKHN1
  JOURNAL   BMC Microbiol 18 (1), 5 (2018)
   PUBMED   29433439
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4506)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   6  (bases 1 to 4506)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: occurrence of an unusual TG 3' splice site in intron 9
REFERENCE   7  (bases 1 to 4506)
  AUTHORS   Hsu,L.C., Liu,S., Abedinpour,F., Beech,R.D., Lahti,J.M., Kidd,V.J.,
            Greenspan,J.A. and Yeung,C.Y.
  TITLE     The murine G+C-rich promoter binding protein mGPBP is required for
            promoter-specific transcription
  JOURNAL   Mol Cell Biol 23 (23), 8773-8785 (2003)
   PUBMED   14612417
REFERENCE   8  (bases 1 to 4506)
  AUTHORS   Bijnens,A.P., Gils,A., Jutten,B., Faber,B.C., Heeneman,S.,
            Kitslaar,P.J., Tordoir,J.H., de Vries,C.J., Kroon,A.A., Daemen,M.J.
            and Cleutjens,K.B.
  TITLE     Vasculin, a novel vascular protein differentially expressed in
            human atherogenesis
  JOURNAL   Blood 102 (8), 2803-2810 (2003)
   PUBMED   12842993
  REMARK    GeneRIF: Vasculin is a novel vascular protein differentially
            expressed in human atherogenesis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB271841.1, BC113004.2,
            AC008435.6, AL136844.1, CN358821.1, AI200911.1 and BQ023353.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022913.3.
            
            Summary: This gene was originally isolated by subtractive
            hybridization of cDNAs expressed in atherosclerotic plaques with a
            thrombus, and was found to be expressed only in vascular smooth
            muscle cells. However, a shorter splice variant was found to be
            more ubiquitously expressed. This protein is suggested to play a
            role in the development of atherosclerosis. Studies in mice suggest
            that it may also function as a GC-rich promoter-specific
            trans-activating transcription factor. Several alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.73940.1,
                                           SRR1660807.181203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000506184.7/ ENSP00000421202.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               DB271841.1         67-206
            141-1336            BC113004.2         1-1196
            1337-1337           AC008435.6         68068-68068         c
            1338-2809           BC113004.2         1198-2669
            2810-2918           AL136844.1         1678-1786
            2919-3596           CN358821.1         94-771
            3597-3831           AI200911.1         5-239               c
            3832-4151           AC008435.6         34706-35025         c
            4152-4506           BQ023353.1         24-378              c
FEATURES             Location/Qualifiers
     source          1..4506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..4506
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /note="GC-rich promoter binding protein 1"
                     /db_xref="GeneID:65056"
                     /db_xref="HGNC:HGNC:29520"
                     /db_xref="MIM:608412"
     exon            1..153
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            154..1106
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1226
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             1164..2585
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vascular wall-linked protein"
                     /codon_start=1
                     /product="vasculin isoform 1"
                     /protein_id="NP_075064.1"
                     /db_xref="CCDS:CCDS34162.1"
                     /db_xref="GeneID:65056"
                     /db_xref="HGNC:HGNC:29520"
                     /db_xref="MIM:608412"
                     /translation="MAQHDFAPAWLNFPTPPSSTKSSLNFEKHSENFAWTENRYDVNR
                     RRHNSSDGFDSAIGRPNGGNFGRKEKNGWRTHGRNGTENINHRGGYHGGSSRSRSSIF
                     HAGKSQGLHENNIPDNETGRKEDKRERKQFEAEDFPSLNPEYEREPNHNKSLAAGVWE
                     YPPNPKSRAPRMLVIKKGNTKDLQLSGFPVVGNLPSQPVKNGTGPSVYKGLVPKPAAP
                     PTKPTQWKSQTKENKVGTSFPHESTFGVGNFNAFKSTAKNFSPSTNSVKECNRSNSSS
                     PVDKLNQQPRLTKLTRMRTDKKSEFLKALKRDRVEEEHEDESRAGSEKDDDSFNLHNS
                     NSTHQERDINRNFDENEIPQENGNASVISQQIIRSSTFPQTDVLSSSLEAEHRLLKEM
                     GWQEDSENDETCAPLTEDEMREFQVISEQLQKNGLRKNGILKNGLICDFKFGPWKNST
                     FKPTTENDDTETSSSDTSDDDDV"
     exon            1227..1350
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1574
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1641
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1826
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1967
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2135
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2323
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2426
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..4506
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2891..2896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /note="hexamer: AATAAA"
     polyA_site      2918
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /note="major polyA site"
     regulatory      3399..3404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /note="hexamer: AATAAA"
     polyA_site      3418
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /note="major polyA site"
     regulatory      3601..3606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /note="hexamer: AATGAA"
     polyA_site      3624
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
     polyA_site      3831
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
     regulatory      4487..4492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
                     /note="hexamer: TATAAA"
     polyA_site      4506
                     /gene="GPBP1"
                     /gene_synonym="GPBP; SSH6; VASCULIN"
ORIGIN      
        1 attgcggatc gggtcggcgc cattttggga ctgagactgg ttgtggggga gggaaaagcg
       61 gcaaaagggg attattcaaa gtaccgaaaa ccttctcccg ggatcaggcg cggcggcacc
      121 cccaggccag gggcacctct ggtggggcag aaggtgattg aattactcag atatgaagat
      181 catcatctag gttttgtgta aaaggccctg gatattttaa gtggccattt tggatttaca
      241 gtgtttttgg ataattttgc cccagaagtt tattaaaatt ggcaagaatc gtctgtgaag
      301 tgaattgata gtagtgaaca attcagcaag ctacttaaaa agagacccag gcagcatttc
      361 ttcagtattt tggttcaaac ggattatata actggttaca gtatttcagc tggtggtaat
      421 ttttgcctcc ccttccccca ccccgttgtt ggggttcttc agccgaaact gagagacgtt
      481 gatttgtgta ctgagtagtt tcagcagttt caaatgactg agtattgctg aagtttcatg
      541 gcagtttatt tttaccttta ttgaaagttt taggaatttt tgacttcagc tctttcatgt
      601 cacaatggga cactttttct gaatgaagag attgaaagaa tacagagttt ttttcctttt
      661 atcttttatt tacgtggaaa tttaagatgt tgcagttttc cggcagcatg gtagtattga
      721 gatagctatg tgtgtctctg tatatgctga tgtttaggaa tgctcttcag atgtgaaatt
      781 ttctttttgt ttttgctttt tggctcgtaa attggatatt tcatctggag tggacaagta
      841 caacagtggc aagtacatgg aataataaag aagactttga tcttaaatct aaagaacttg
      901 gctaattcgg gagatagcca tatgaaaact ttaaaacaga agtatgggta gctgacttga
      961 agtaactcta tgtcaaatag tcgtaggtta agtatcttca aagaacttcg atattatttc
     1021 agaggataca aaataaaaat acaaactgga aaataaagat tacagagaaa aaaccaacac
     1081 cttcctgtgc agtcctgttg gaatttggac ttgccatgag gtgttgaagc cttgtttcac
     1141 tgagttggag agactggacc taaatggcgc agcatgactt tgctccagcc tggcttaatt
     1201 tccctactcc accatcatca acaaagtcgt cattgaattt tgagaagcat tctgaaaact
     1261 ttgcatggac agagaatcgt tatgatgtga accgtcgacg acacaactct tcagatggct
     1321 ttgattctgc tattgggcgt cctaatggag gtaactttgg aaggaaagaa aaaaatggat
     1381 ggcgtacaca tggaagaaat ggtacagaaa acataaatca tcgaggtgga taccatggtg
     1441 gaagttcccg ttctcgtagc agtattttcc atgcaggaaa aagccaagga ctacatgaaa
     1501 acaacatacc tgacaatgaa accgggagga aagaagacaa gagagaacgc aaacagtttg
     1561 aagctgagga ttttccgtct ttaaatcctg agtatgagag agaaccaaat cacaataagt
     1621 ctttagctgc aggtgtgtgg gaatatcctc cgaatcctaa atctagagct ccaaggatgc
     1681 tggtcattaa gaaaggtaat acaaaagact tacagctatc tggattccca gtagtaggaa
     1741 atcttccgtc acagccagtt aagaatggaa ctggtccaag tgtttataaa ggtttagtcc
     1801 ctaaacctgc tgctccacct acaaaaccta cacaatggaa aagccaaaca aaagaaaata
     1861 aagttggaac ttctttccct catgagtcca catttggcgt tggcaacttt aatgctttta
     1921 aatcaactgc caagaacttt agtccatcta caaattcagt gaaagagtgt aatcgctcaa
     1981 attcctcttc tcctgttgac aaacttaatc agcagcctcg tctaaccaaa ctgacacgaa
     2041 tgcgcactga taagaagagt gaatttttga aagcattgaa aagagacaga gtagaagagg
     2101 aacatgaaga tgaaagccgt gctggctcag agaaggatga cgactcattt aatttacata
     2161 acagcaatag tactcaccaa gaaagggata taaaccgaaa cttcgatgaa aatgaaattc
     2221 ctcaagagaa tggcaatgcc tcagtgattt cccagcagat cattcggtct tcaaccttcc
     2281 cacaaactga tgttctttca agttcacttg aggcagaaca cagattgtta aaggaaatgg
     2341 gctggcagga agacagtgaa aatgatgaaa catgtgctcc cttaactgag gatgaaatga
     2401 gagaattcca agttattagt gaacagttac agaagaatgg tctgagaaaa aatggtattt
     2461 tgaaaaatgg cttgatctgt gacttcaagt ttggaccgtg gaagaacagc actttcaaac
     2521 ccacaactga gaatgatgac acagagacaa gtagcagtga tacatcagat gacgacgatg
     2581 tgtgaaggat ttcctaacag ctttagaaat cttagtgtga tacatctctc atacagtttg
     2641 gggtgaattg taaaaatgaa gaactataat ttatgtagtg aaatacccca ttagaagagg
     2701 attttttggg ggacttcaat atgaagaaaa ccaagaatgt tttgttgggc tgtgttgaac
     2761 attatttctt tgtaaatgaa tgttgtagga atgaggactt gggttggtcc aacattgact
     2821 ttcttcatca ctgcaacatt tctctgacta gcaatgtgac gatgtaacaa atgagatttt
     2881 ctcatttaat aataaaaaat tgtgtaatgt tttgcaaagc ttctgtctta aaatgtccag
     2941 gtcttaagaa aaaaggcagc ttacactgtt ttgcttgcag agtcatatct ttttcgtaca
     3001 atggaaatcc tcaagtccac tttgtgcggt ctccctctcc ttcccccaaa aaacaacaac
     3061 aacaaaacaa aaaccaaaaa ggaaaatgta gcatgttggc taaaactgga gcaaagtgca
     3121 ctaaaacaat ttcctgaact cacctgttgt actattcacc ttttaaacca taaattgctc
     3181 tttagccatt tgtagtgcag taaatgttac aggaaaagac ttggcacatt ttcttccaaa
     3241 ttttaagagg tgattttcaa aagctttatt ggggtatgtt gtcagaccag ggttttcaga
     3301 gttgatggaa aagagtcttg tgagaaaact tattttgata aattattaca cacgcagaaa
     3361 aactgatcac actgactgga tctgtccacg acatggaaaa taaactggat tttcagaata
     3421 ttgttgtttt ctgtagtgtt caaggtattg tttctaaaca taaacatact ctaaacatgc
     3481 tttattcact tgttaaagtc atacttttaa aagtaatacc ttactaaaga tggtgattac
     3541 ttttccgagg tcagaaaagg aaagctaagc gttttcatta tcaaatacac aagcttatta
     3601 aatgaatgac tgttaactac tttattttca tttgcacatt aattttggaa ttgtttctgt
     3661 tttgctgctg acggaaatac tattttggct ctgtgtatat ttgtattttg atttttctgg
     3721 tttgtttacc cccatttgct tttagctccc ccttatgttt aaatatattc taacttatgt
     3781 aaagagcata atcttagagc aaaaatactt gaggttttat gtcagatcta atcttaagtg
     3841 tttgttgttt tttaaaaagt gttttctcag atggctgcag tgtttttgct atttctgcat
     3901 aaatacccta cctggactcc ccagttttca ccagaaactg ttattttttt ttgttgttgt
     3961 tcccactgag actgatggtg atggggaaat taaaaacaac acactagcac actcccacaa
     4021 aacttgagga agagttagaa tggtaataaa atattaaata gaccttatac ttaaaataag
     4081 gtttcactat ataatttgtc acaattcaat ctaatcagct aaagttaaat gtagttagaa
     4141 ttagccacag gagaatgtaa agcatgcttt gacgaagcta tcggtaacac atattgaatg
     4201 tctttgagac tcttagattg tactatttgc ttaatagatt aatgaaattt atcagataca
     4261 acctgtattt ccaaaaacaa gctagaagga acctgaggaa tgtggtttac atttgagatc
     4321 caccttactg tgttttctac tttcagaaaa gattctgtag ttttggtttt tggcatcttt
     4381 cttatactca gttttttctg ccttaattcc catttaccag cagttaactc atgtttattg
     4441 tgctttcatg cattgtgata tggaatgtgt ttagtaattt actccttata aatatggtaa
     4501 agtaca
//
