LOCUS       NM_170699               1384 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens G protein-coupled bile acid receptor 1 (GPBAR1),
            transcript variant 3, mRNA.
ACCESSION   NM_170699
VERSION     NM_170699.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1384)
  AUTHORS   Zhuang,L., Jia,N., Zhang,L., Zhang,Q., Antwi,S.O., Sartorius,K.,
            Wu,K., Sun,D., Xi,D. and Lu,Y.
  TITLE     Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute
            cholestatic liver injury via antagonizing NLRP3-ASC inflammasome
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167266 (2024)
   PUBMED   38806072
  REMARK    GeneRIF: Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated
            acute cholestatic liver injury via antagonizing NLRP3-ASC
            inflammasome.
REFERENCE   2  (bases 1 to 1384)
  AUTHORS   Vanden Brink,H., Vandeputte,D., Brito,I.L., Ronnekleiv,O.K.,
            Roberson,M.S. and Lomniczi,A.
  TITLE     Changes in the Bile Acid Pool and Timing of Female Puberty:
            Potential Novel Role of Hypothalamic TGR5
  JOURNAL   Endocrinology 165 (9) (2024)
   PUBMED   39082696
  REMARK    GeneRIF: Changes in the Bile Acid Pool and Timing of Female
            Puberty: Potential Novel Role of Hypothalamic TGR5.
REFERENCE   3  (bases 1 to 1384)
  AUTHORS   Li,C., Wang,L., Xie,W., Chen,E., Chen,Y., Li,H., Can,D., Lei,A.,
            Wang,Y. and Zhang,J.
  TITLE     TGR5 deficiency in excitatory neurons ameliorates Alzheimer's
            pathology by regulating APP processing
  JOURNAL   Sci Adv 10 (26), eado1855 (2024)
   PUBMED   38941459
  REMARK    GeneRIF: TGR5 deficiency in excitatory neurons ameliorates
            Alzheimer's pathology by regulating APP processing.
REFERENCE   4  (bases 1 to 1384)
  AUTHORS   Buchynskyi,M., Oksenych,V., Kamyshna,I., Vorobets,I., Halabitska,I.
            and Kamyshnyi,O.
  TITLE     Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in
            Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes
  JOURNAL   Viruses 16 (6), 985 (2024)
   PUBMED   38932276
  REMARK    GeneRIF: Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene
            Expression in Metabolic-Associated Fatty Liver Disease and COVID-19
            Outcomes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1384)
  AUTHORS   Zhan,K., Wu,H., Xu,Y., Rao,K., Zheng,H., Qin,S., Yang,Y., Jia,R.,
            Chen,W. and Huang,S.
  TITLE     The function of the gut microbiota-bile acid-TGR5 axis in
            diarrhea-predominant irritable bowel syndrome
  JOURNAL   mSystems 9 (3), e0129923 (2024)
   PUBMED   38329942
  REMARK    GeneRIF: The function of the gut microbiota-bile acid-TGR5 axis in
            diarrhea-predominant irritable bowel syndrome.
REFERENCE   6  (bases 1 to 1384)
  AUTHORS   Watanabe,M., Houten,S.M., Mataki,C., Christoffolete,M.A., Kim,B.W.,
            Sato,H., Messaddeq,N., Harney,J.W., Ezaki,O., Kodama,T.,
            Schoonjans,K., Bianco,A.C. and Auwerx,J.
  TITLE     Bile acids induce energy expenditure by promoting intracellular
            thyroid hormone activation
  JOURNAL   Nature 439 (7075), 484-489 (2006)
   PUBMED   16400329
REFERENCE   7  (bases 1 to 1384)
  AUTHORS   Kawamata,Y., Fujii,R., Hosoya,M., Harada,M., Yoshida,H., Miwa,M.,
            Fukusumi,S., Habata,Y., Itoh,T., Shintani,Y., Hinuma,S.,
            Fujisawa,Y. and Fujino,M.
  TITLE     A G protein-coupled receptor responsive to bile acids
  JOURNAL   J Biol Chem 278 (11), 9435-9440 (2003)
   PUBMED   12524422
  REMARK    GeneRIF: TGR5 is implicated in the suppression of macrophage
            functions by bile acids
REFERENCE   8  (bases 1 to 1384)
  AUTHORS   Maruyama,T., Miyamoto,Y., Nakamura,T., Tamai,Y., Okada,H.,
            Sugiyama,E., Nakamura,T., Itadani,H. and Tanaka,K.
  TITLE     Identification of membrane-type receptor for bile acids (M-BAR)
  JOURNAL   Biochem Biophys Res Commun 298 (5), 714-719 (2002)
   PUBMED   12419312
  REMARK    GeneRIF: Expression of BG37 was detected in various specific
            tissues, suggesting its physiological role.
REFERENCE   9  (bases 1 to 1384)
  AUTHORS   Feldman,D.S., Zamah,A.M., Pierce,K.L., Miller,W.E., Kelly,F.,
            Rapacciuolo,A., Rockman,H.A., Koch,W.J. and Luttrell,L.M.
  TITLE     Selective inhibition of heterotrimeric Gs signaling. Targeting the
            receptor-G protein interface using a peptide minigene encoding the
            Galpha(s) carboxyl terminus
  JOURNAL   J Biol Chem 277 (32), 28631-28640 (2002)
   PUBMED   12036966
REFERENCE   10 (bases 1 to 1384)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK122660.1, BC033625.1 and
            AC021016.5.
            
            On Nov 23, 2018 this sequence version replaced NM_170699.2.
            
            Summary: This gene encodes a member of the G protein-coupled
            receptor (GPCR) superfamily. This enzyme functions as a cell
            surface receptor for bile acids. Treatment of cells expressing this
            GPCR with bile acids induces the production of intracellular cAMP,
            activation of a MAP kinase signaling pathway, and internalization
            of the receptor. The receptor is implicated in the suppression of
            macrophage functions and regulation of energy homeostasis by bile
            acids. Alternative splicing results in multiple transcript variants
            encoding the same protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033625.1, BX365038.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519574.2/ ENSP00000430202.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AK122660.1         1-83
            84-1305             BC033625.1         68-1289
            1306-1306           AC021016.5         9658-9658
            1307-1382           BC033625.1         1291-1366
            1383-1384           AC021016.5         9735-9736
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..1384
                     /gene="GPBAR1"
                     /gene_synonym="BG37; GPCR19; GPR131; M-BAR; TGR5"
                     /note="G protein-coupled bile acid receptor 1"
                     /db_xref="GeneID:151306"
                     /db_xref="HGNC:HGNC:19680"
                     /db_xref="MIM:610147"
     exon            1..202
                     /gene="GPBAR1"
                     /gene_synonym="BG37; GPCR19; GPR131; M-BAR; TGR5"
                     /inference="alignment:Splign:2.1.0"
     exon            203..1384
                     /gene="GPBAR1"
                     /gene_synonym="BG37; GPCR19; GPR131; M-BAR; TGR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1240
                     /gene="GPBAR1"
                     /gene_synonym="BG37; GPCR19; GPR131; M-BAR; TGR5"
                     /note="G-protein coupled bile acid receptor BG37; membrane
                     bile acid receptor; membrane-type receptor for bile acids;
                     G-protein coupled receptor GPCR19"
                     /codon_start=1
                     /product="G-protein coupled bile acid receptor 1"
                     /protein_id="NP_733800.1"
                     /db_xref="CCDS:CCDS46515.1"
                     /db_xref="GeneID:151306"
                     /db_xref="HGNC:HGNC:19680"
                     /db_xref="MIM:610147"
                     /translation="MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRR
                     LRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLAN
                     LLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAI
                     FPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARAL
                     TWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAV
                     PVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPBAR1"
                     /gene_synonym="BG37; GPCR19; GPR131; M-BAR; TGR5"
                     /note="hexamer: AATAAA"
     polyA_site      1384
                     /gene="GPBAR1"
                     /gene_synonym="BG37; GPCR19; GPR131; M-BAR; TGR5"
                     /note="major polyA site"
ORIGIN      
        1 gagaacccag acgggcagag cctgggtagg agagcctggc cccgctgtcc ccactgggtg
       61 gagacaccat gcacttggtc cacttgtgct cttcagccag gacaccagac atggtccaaa
      121 ccgctgcagg gctggctgca gcaactccct gacactcagg aaggcccagg ctgggcaggc
      181 aatacctgct cccaacagcc atgcatgccg gctgccgctc caggactccc ctgtccccag
      241 gaccaagatg acgcccaaca gcactggcga ggtgcccagc cccattccca agggggcttt
      301 ggggctctcc ctggccctgg caagcctcat catcaccgcg aacctgctcc tagccctggg
      361 catcgcctgg gaccgccgcc tgcgcagccc acctgctggc tgcttcttcc tgagcctact
      421 gctggctggg ctgctcacgg gtctggcatt gcccacattg ccagggctgt ggaaccagag
      481 tcgccggggt tactggtcct gcctcctcgt ctacttggct cccaacttct ccttcctctc
      541 cctgcttgcc aacctcttgc tggtgcacgg ggagcgctac atggcagtcc tgaggccact
      601 ccagccccct gggagcattc ggctggccct gctcctcacc tgggctggtc ccctgctctt
      661 tgccagtctg cccgctctgg ggtggaacca ctggacccct ggtgccaact gcagctccca
      721 ggctatcttc ccagccccct acctgtacct cgaagtctat gggctcctgc tgcccgccgt
      781 gggtgctgct gccttcctct ctgtccgcgt gctggccact gcccaccgcc agctgcagga
      841 catctgccgg ctggagcggg cagtgtgccg cgatgagccc tccgccctgg cccgggccct
      901 tacctggagg caggcaaggg cacaggctgg agccatgctg ctcttcgggc tgtgctgggg
      961 gccctacgtg gccacactgc tcctctcagt cctggcctat gagcagcgcc cgccactggg
     1021 gcctgggaca ctgttgtccc tcctctccct aggaagtgcc agtgcagcgg cagtgcccgt
     1081 agccatgggg ctgggcgatc agcgctacac agccccctgg agggcagccg cccaaaggtg
     1141 cctgcagggg ctgtggggaa gagcctcccg ggacagtccc ggccccagca ttgcctacca
     1201 cccaagcagc caaagcagtg tcgacctgga cttgaactaa aggaagggcc tctgctgact
     1261 cctaccagag catccgtcca gctcagccat ccagcctgtc tctaccgggc cccacttctc
     1321 tggatcagag accctgcctc tgtttgaccc cgcactgact gaataaagct cctctggccg
     1381 ttta
//
