LOCUS       NM_001002909            6832 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens G-patch domain containing 8 (GPATCH8), transcript
            variant 1, mRNA.
ACCESSION   NM_001002909 XM_290758
VERSION     NM_001002909.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6832)
  AUTHORS   Benbarche,S., Pineda,J.M.B., Galvis,L.B., Biswas,J., Liu,B.,
            Wang,E., Zhang,Q., Hogg,S.J., Lyttle,K., Dahi,A., Lewis,A.M.,
            Sarchi,M., Rahman,J., Fox,N., Ai,Y., Mehta,S., Garippa,R.,
            Ortiz-Pacheco,J., Li,Z., Monetti,M., Stanley,R.F., Doulatov,S.,
            Bradley,R.K. and Abdel-Wahab,O.
  TITLE     GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in
            hematologic malignancies
  JOURNAL   Mol Cell 84 (10), 1886-1903 (2024)
   PUBMED   38688280
  REMARK    GeneRIF: GPATCH8 modulates mutant SF3B1 mis-splicing and
            pathogenicity in hematologic malignancies.
REFERENCE   2  (bases 1 to 6832)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   3  (bases 1 to 6832)
  AUTHORS   Kaneko,H., Kitoh,H., Matsuura,T., Masuda,A., Ito,M., Mottes,M.,
            Rauch,F., Ishiguro,N. and Ohno,K.
  TITLE     Hyperuricemia cosegregating with osteogenesis imperfecta is
            associated with a mutation in GPATCH8
  JOURNAL   Hum Genet 130 (5), 671-683 (2011)
   PUBMED   21594610
  REMARK    GeneRIF: Two missense single-nucleotide variants in ZPBP2 and
            GPATCH8 on chromosome 17 were identified that cosegregated with
            hyperuricemia in the Japanese family.
REFERENCE   4  (bases 1 to 6832)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 6832)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 6832)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 6832)
  AUTHORS   Thornton,M.A., Poncz,M., Korostishevsky,M., Yakobson,E., Usher,S.,
            Seligsohn,U. and Peretz,H.
  TITLE     The human platelet alphaIIb gene is not closely linked to its
            integrin partner beta3
  JOURNAL   Blood 94 (6), 2039-2047 (1999)
   PUBMED   10477733
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY048299.1, AK025600.1,
            BC136629.1 and BC024147.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001002909.3.
            
            Summary: The protein encoded by this gene contains an
            RNA-processing domain, a zinc finger domain, a lysine-rich region
            and a serine-rich region. A mutation in the serine-rich region of
            the protein is thought to be associated with hyperuricemia (PMID:
            21594610). Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Feb
            2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.12881.1,
                                           SRR1660805.222318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000591680.6/ ENSP00000467556.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                HY048299.1         198-263
            67-612              AK025600.1         65-610
            613-4693            BC136629.1         626-4706
            4694-6832           BC024147.2         1669-3807
FEATURES             Location/Qualifiers
     source          1..6832
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..6832
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /note="G-patch domain containing 8"
                     /db_xref="GeneID:23131"
                     /db_xref="HGNC:HGNC:29066"
                     /db_xref="MIM:614396"
     exon            1..81
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..4545
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /note="isoform 1 is encoded by transcript variant 1; g
                     patch domain-containing protein 8"
                     /codon_start=1
                     /product="G patch domain-containing protein 8 isoform 1"
                     /protein_id="NP_001002909.1"
                     /db_xref="CCDS:CCDS32666.1"
                     /db_xref="GeneID:23131"
                     /db_xref="HGNC:HGNC:29066"
                     /db_xref="MIM:614396"
                     /translation="MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIG
                     HRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLE
                     VEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDH
                     AHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKP
                     TTVAVDEEGGEDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAP
                     GLASQGISFGIKNNLGTPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKP
                     DEKSSDQGLQKVGDSDGSSNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGAGATEPE
                     YYHYIPPAHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAA
                     SQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMC
                     ESNSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSIS
                     YSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVR
                     SSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHK
                     KSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGS
                     PAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRR
                     AGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRS
                     GRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDS
                     DYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKR
                     RSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKI
                     YRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSV
                     TAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLP
                     LIGKLPATRKPNKKCEESGLERGEEQEQSETEEGPPGSSDALFGHQFPSEETTGPLLD
                     PPPEESKSGEATADHPVAPLGTPAHSDCYPGDPTISHNYLPDPSDGDTLESLDSSSQP
                     GPVESSLLPIAPDLEHFPSYAPPSGDPSIESTDGAEDASLAPLESQPITFTPEEMEKY
                     SKLQQAAQQHIQQQLLAKQVKAFPASAALAPATPALQPIHIQQPATASATSITTVQHA
                     ILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLAS
                     HPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDL
                     QHPPSHGT"
     exon            82..156
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            157..229
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            230..297
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            298..384
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            385..528
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            529..659
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /inference="alignment:Splign:2.1.0"
     exon            660..6832
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6810..6815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /note="hexamer: AATAAA"
     polyA_site      6832
                     /gene="GPATCH8"
                     /gene_synonym="GPATC8; KIAA0553"
                     /note="major polyA site"
ORIGIN      
        1 ggagagcgtc gtcctgagag gagtgaaggc ggcaaaatgg cggaccgctt ctcccgcttc
       61 aacgaagacc gagactttca gggtaatcac tttgatcagt atgaggaagg acacttggaa
      121 attgaacaag cgtcacttga caagcctata gaatcggata atattggaca ccgcttactc
      181 cagaaacatg ggtggaagct gggccaggga ttgggaaaat ctcttcaggg gagaacagat
      241 cccattccaa tcgttgtcaa gtatgatgtc atgggcatgg gtcgcatgga aatggagctt
      301 gattatgctg aagatgctac cgaacggcgc cgtgtcctag aagtagaaaa agaagacaca
      361 gaagagctga gacaaaagta caaggattat gttgacaaag agaaggcaat tgccaaagcc
      421 ttggaagacc tcagagccaa cttttattgt gaactgtgtg ataagcaata tcagaaacat
      481 caggaatttg ataaccatat caactcctat gatcatgcac acaagcagag attaaaagat
      541 ctgaagcaga gagagtttgc tcgaaatgtc tcttcaagat cccgcaagga tgagaaaaaa
      601 caggaaaaag cccttcggcg gctccatgag ttggcagagc aaagaaaaca agctgaatgt
      661 gcacctggaa gtggtcccat gttcaaacca accacagtgg ctgtagatga agaaggtgga
      721 gaagatgata aagatgaatc agctacaaat agtggcacag gtgccactgc ttcttgtggc
      781 ctgggatctg aattctccac agataaagga ggccctttca ctgcagtaca aatcactaat
      841 accactggac tggcccaggc tcctgggtta gcctcccaag gcatcagctt tggcattaag
      901 aataatctgg ggaccccatt gcaaaaattg ggagtgtcat tttcttttgc caaaaaggct
      961 cctgtcaaac tcgaatcaat agcatcagtt ttcaaggacc atgcggagga agggacctct
     1021 gaagatggaa caaaacccga tgagaagagt tctgaccaag gactgcagaa ggtaggagac
     1081 tctgatggga gcagtaatct tgatggtaaa aaagaggatg aagaccctca ggatggaggg
     1141 tcccttgcct caacattatc caaattaaaa aggatgaaac gagaagaagg agctggggct
     1201 acagagcctg agtattacca ctacatcccc ccagcacact gcaaagtaaa acctaatttt
     1261 ccctttctac tttttatgag agccagtgaa caaatggatg gtgataatac tacacaccca
     1321 aagaatgccc cagagagtaa aaaaggcagt tctcccaagc ctaaaagctg catcaaggcg
     1381 gcagcaagcc aaggagcaga aaagacagtt agtgaagtct ctgagcagcc gaaggaaacc
     1441 agcatgaccg agccctcaga accaggaagc aaagctgagg caaagaaggc cttaggaggg
     1501 gatgtaagtg atcagagttt agaaagtcat agtcagaagg tttcagagac ccaaatgtgt
     1561 gagtccaact cttctaaaga aacctctctg gccaccccag cagggaaaga aagccaagaa
     1621 ggacccaaac atcctactgg tcccttcttc ccagttttga gcaaagatga aagcactgcc
     1681 ctccagtggc catcagaact attaattttc accaaggcag aaccctccat ttcatacagt
     1741 tgtaaccctt tatattttga ctttaaactt tcaaggaaca aagatgccag aactaaagga
     1801 acagaaaaac caaaggatat aggaagctcc tcaaaggacc atctccaagg cctagatcct
     1861 ggtgagccaa ataaaagcaa ggaagtgggc ggagagaaaa tagtacgttc ctcaggaggc
     1921 agaatggacg cacctgcttc agggtctgcc tgtagcggcc tgaacaagca ggagcctggg
     1981 ggtagccatg ggtctgagac agaagacaca gggagaagcc ttcccagcaa gaaagaacga
     2041 tctgggaagt cccaccggca caaaaagaaa aagaagcaca aaaaatccag caaacacaaa
     2101 cgtaaacaca aggctgacac agaagagaaa agctctaagg cagagtcagg ggagaaatct
     2161 aagaagcgca agaaacgaaa acgaaagaag aataagtcat cagccccagc agattctgaa
     2221 cgaggaccca aaccagaacc ccctgggagt ggcagtcccg caccaccaag aagaaggcgg
     2281 agagctcaag atgactccca gcggagatcc ctcccagctg aagaggggag cagtggcaaa
     2341 aaggatgaag gtgggggtgg tagcagctcc caagaccatg gtgggaggaa acacaaaggt
     2401 gaacttccac cttcatcctg ccagcgaaga gcaggcacca aacggagcag ccggtctagc
     2461 catcggagcc aacccagtag tggagatgag gatagtgatg atgcttcctc acaccggctg
     2521 caccagaagt ctccatccca gtacagtgag gaagaagaag aggaagattc aggcagtgag
     2581 cattcccgca gccgctcaag gtctggccgg cgccattcct cgcatcgttc ctcccggcgt
     2641 tcttactcaa gtagctcaga tgcctcttca gaccagagct gctatagtag acagcgcagt
     2701 tactctgatg acagctacag tgactacagt gacagatcac gaaggcactc caagcgctcc
     2761 catgactcag atgactcaga ctatgccagc tccaaacacc gatcaaaacg gcacaaatat
     2821 tcatcttctg atgatgacta tagcctcagt tgcagccagt cccgaagccg atctcggagt
     2881 cataccagag agcgctcaag atcccggggc cgcagccgca gcagcagttg tagtcgtagt
     2941 cgaagcaagc ggagaagccg tagcaccaca gcccacagct ggcaacggag ccggagctat
     3001 agccgggacc gcagccgcag caccaggagc ccttcccaga gatcaggctc caggaagaga
     3061 tcatggggtc acgagagccc tgaggagagg cattctgggc gtcgggactt cattcgttct
     3121 aagatctacc gctcccagtc cccccactat ttccgatcag gccggggaga aggtcctggg
     3181 aagaaagatg atggcagagg agatgacagt aaagcaacag gtccaccttc ccagaacagc
     3241 aacattggca caggaagagg gtcagaaggt gactgcagtc ctgaagacaa gaactctgtc
     3301 actgccaaac tgctactgga gaagatccag tcaaggaaag tggagaggaa acctagtgtg
     3361 agtgaggagg tgcaggccac ccctaataaa gctgggccca agctcaagga ccccccacaa
     3421 ggttactttg ggcccaagct ccccccatct cttggcaata agcctgtcct tccactgata
     3481 gggaagctcc cagctacccg aaagcccaat aagaagtgtg aagagtctgg cttggaaagg
     3541 ggggaagagc aagaacagtc agagacagaa gaggggcccc cagggagtag tgatgcccta
     3601 tttgggcatc agttcccttc agaggaaaca actggcccct tattagaccc acccccagaa
     3661 gagtcaaagt ctggagaagc tactgctgat caccctgtgg ctccactagg caccccagca
     3721 cattctgact gctaccctgg ggacccaacc atctcccata actacctccc cgaccccagt
     3781 gatggggaca ccctggagtc cctggatagc agcagtcagc caggccctgt ggagtccagc
     3841 ttgctgccta tagcaccaga ccttgagcat ttccccagtt atgcacctcc cagtggggat
     3901 cctagtattg agtcaacaga tggggctgag gatgcttcac tggcccccct ggaaagccag
     3961 cccatcacct tcacccctga ggagatggag aagtacagca agctccagca ggctgctcag
     4021 caacacatcc agcagcagct tctggccaag caagtaaagg cctttccagc ctcagctgcc
     4081 ctggccccag ccacaccagc cctgcaaccc atccacattc agcagccagc tacagcctct
     4141 gccacctcca tcacaactgt tcagcatgcc atcctacaac atcatgctgc cgcagctgct
     4201 gccgccatcg gcattcaccc tcacccccat ccccaaccac ttgcccaggt gcatcatatt
     4261 ccccagcccc atctgacccc catttctttg tcccacctca ctcactcaat catccctggc
     4321 caccctgcca cctttctcgc tagccatccc atccacatca ttcccgcctc agccatccat
     4381 cctgggccct tcacctttca ccctgtccca catgctgccc tctaccccac cctacttgct
     4441 ccacggcctg ctgcagcagc tgccactgca cttcaccttc acccactact tcaccccatc
     4501 ttctcaggtc aggacctgca acatcccccc agccatggca cgtgagttgg gggatgggat
     4561 cctaggtagg gccaggggag gagacccata aatgttccct tgggggtgtt gagccattaa
     4621 taccagcaag tagaagctgg gatgggcagt gtctgacagc caaagaattg agttttggct
     4681 tgcaggggtg ggtttagatt tgaagtttgc tttcagttta ctatcaggga tttctttttc
     4741 ctgtcctcct ctcaatttgt ccctccctct tctgtgtttc taagctaggg aacaccagta
     4801 agtgctaccc acccctctgc agcaacatct ccaaactgtc aagtttagat aatcccctcc
     4861 tccctctgct tttttcctct gctcttccct tctgtaaatt ttaaaacatt ttcctcccct
     4921 ctggccagtg ggttgtcacc agagcacttg ctgtgggccc atctggtctt gccttctcag
     4981 cgccacaggg aaggccaagc tgttctagtg gtggaagtgc caccattttg gggtagtatc
     5041 tttgaccatc tttggtgacg ttacgttatc ccaggtgagg tggaaagcgt ctcacctgga
     5101 acctgatata actcaggctg caattccatc cagttcccac atcaacggag ccacacattt
     5161 ggcactgtta tcttggtatc cctcatccca gaagaggcat ctccatatcc cagaaaagaa
     5221 gatcctatca tgaataaaag ctgtatggcc cagagaggag ctcatgtgtc taaagtgaag
     5281 ggtatatttt cttctgttgt gttgatgttt ccttcttaat ttataggatt tttttaatgt
     5341 aaaaaattgc actgaactct ataaacgtaa atgctgcttt ttgtagctca tataaaaaag
     5401 gttccatatt tgtagtatac tgcaataata ttttttacat ccagctcttt aagtgatcct
     5461 cgttctggtg gctttgtgta aatatgtttg ccctagttga attaagaaac tctaaaggtt
     5521 ataaaatgaa aacaaaaaat aaaatatttg ttttctgcta gatgcaaaac tgactaagca
     5581 tgtatatttt accaaactta tgtatttttt gaagttatga actataaaat gttaaaacat
     5641 tttttgctgg gacaaaatgt taagtaattt gcagtatgta gtgcccccag tattgggatt
     5701 tttgagctaa tgggcagcag tcagctgggg gcttctgagg gatgctcatc tttaacagtc
     5761 tccctcatgt acttttgctg ttttacacag agaaacaggt agaccccaca gaggagaagg
     5821 aggggattca acagctttat tgtctggaag cagtgagatt tggtgattgt ctggggggat
     5881 tcctgggttt ccctgggtac cttgttccag gcagtcagtc catttgcctt cctagtactt
     5941 agccccctct gacaattttt tttttaatgt gccttttggg ttggtagaaa cggaagtaga
     6001 agtaggctgg aggatgagtt gggacagtct tccttttgtt gggaggtgag cacatttaca
     6061 gatattttgc ttcatagttt ccatgccctc tgcccagctc agtttagaca gtaaacgttc
     6121 cttgtttctt ttctcccatg acactgacaa gaggaattac cacctcagcc tcttttgccc
     6181 ctcttcttgc ctttcaccca ggctctcagc cctaattaac acactgaccc aaaggtgctt
     6241 gtgttgcagg tcccatctcc tttgatgagg ttaacaattc ccactttggc attttcctaa
     6301 ctattcgtgt ggctagaatt ggttggttgg tcacttgaca agaaaaacca tacttacctg
     6361 ggccaaggct ctgttcctgc cttcgcaaat tctcaaaaga gtaaagttta tgaaaagaaa
     6421 gtggcaggca aacacaactc ttgactgccc tcccaccctc ctacctgttc agtactcatc
     6481 tgattcagaa gcatcacttc ttggataact agcactggaa aaatgaaatc atctgtgtaa
     6541 gtgaagggac tcatttttct ttgctttcag cccatgtaaa taaataatac agtattaaca
     6601 ttttcgtgct gcttcccatt agcttgtaga ttgagccata ctctggctgc ctctttgcct
     6661 tcctaggggc attttcttta acttccagaa tagtgatttt aaaagtaaaa ataaaaataa
     6721 accttactta caagcataac agattgtatt taactttatc acatatgata gagatatata
     6781 tgctgtaaaa tgagggaaag gaactttcta ataaaccaat gatttgtgga aa
//
