LOCUS       NM_015590               2080 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens G-patch domain containing 4 (gene/pseudogene)
            (GPATCH4), transcript variant 1, mRNA.
ACCESSION   NM_015590 XM_351302
VERSION     NM_015590.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Kanwal,N., Krogh,N., Memet,I., Lemus-Diaz,N., Thome,C.C.,
            Welp,L.M., Mizi,A., Hackert,P., Papantonis,A., Urlaub,H.,
            Nielsen,H., Bohnsack,K.E. and Bohnsack,M.T.
  TITLE     GPATCH4 regulates rRNA and snRNA 2'-O-methylation in both
            DHX15-dependent and DHX15-independent manners
  JOURNAL   Nucleic Acids Res 52 (4), 1953-1974 (2024)
   PUBMED   38113271
  REMARK    GeneRIF: GPATCH4 regulates rRNA and snRNA 2'-O-methylation in both
            DHX15-dependent and DHX15-independent manners.
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Kodera,K., Hishida,R., Sakai,A., Nyuzuki,H., Matsui,N.,
            Yamanaka,T., Saitoh,A. and Matsui,H.
  TITLE     GPATCH4 contributes to nucleolus morphology and its dysfunction
            impairs cell viability
  JOURNAL   Biochem Biophys Res Commun 693, 149384 (2024)
   PUBMED   38113722
  REMARK    GeneRIF: GPATCH4 contributes to nucleolus morphology and its
            dysfunction impairs cell viability.
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Hirawake-Mogi,H., Thanh Nhan,N.T. and Okuwaki,M.
  TITLE     G-patch domain-containing protein 4 localizes to both the nucleoli
            and Cajal bodies and regulates cell growth and nucleolar structure
  JOURNAL   Biochem Biophys Res Commun 559, 99-105 (2021)
   PUBMED   33933995
  REMARK    GeneRIF: G-patch domain-containing protein 4 localizes to both the
            nucleoli and Cajal bodies and regulates cell growth and nucleolar
            structure.
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA087471.1, CB109133.1, BC056904.1, AK293026.1, BE326312.1 and
            AL365181.24.
            
            On Aug 13, 2020 this sequence version replaced NM_015590.3.
            
            Transcript Variant: This variant (1) lacks an internal segment in
            the 5' region, resulting in an upstream AUG start codon, as
            compared to variant 2. The resulting isoform (1) has a longer and
            distinct N-terminus, as compared to isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.734079.1, CB109133.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            polymorphic pseudogene :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA087471.1         9-17
            10-306              CB109133.1         1-297
            307-1123            BC056904.1         374-1190
            1124-1887           AK293026.1         1202-1965
            1888-2073           BE326312.1         21-206              c
            2074-2080           AL365181.24        105438-105444       c
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22-q23.1"
     gene            1..2080
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /note="G-patch domain containing 4 (gene/pseudogene)"
                     /db_xref="GeneID:54865"
                     /db_xref="HGNC:HGNC:25982"
     exon            1..71
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1168
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /note="isoform 1 is encoded by transcript variant 1; g
                     patch domain-containing protein 4"
                     /codon_start=1
                     /product="G patch domain-containing protein 4 isoform 1"
                     /protein_id="NP_056405.2"
                     /db_xref="GeneID:54865"
                     /db_xref="HGNC:HGNC:25982"
                     /translation="MFPRSGPSNDEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQ
                     ALRVTLKQDTHGVGHDPAKEFTNHWWNELFNKTAANLVVETGQDGVQIRSLSKETTRY
                     NHPKPNLLYQKFVKMATLTSGGEKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGR
                     TAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKE
                     EEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGT
                     SGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAY
                     ADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ"
     exon            72..134
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /inference="alignment:Splign:2.1.0"
     exon            135..208
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /inference="alignment:Splign:2.1.0"
     exon            209..301
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /inference="alignment:Splign:2.1.0"
     exon            302..388
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /inference="alignment:Splign:2.1.0"
     exon            389..480
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /inference="alignment:Splign:2.1.0"
     exon            481..531
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /inference="alignment:Splign:2.1.0"
     exon            532..2080
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1858..1863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /note="hexamer: AATAAA"
     polyA_site      1894
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /note="major polyA site"
     regulatory      2049..2054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
                     /note="hexamer: AATAAG"
     polyA_site      2080
                     /gene="GPATCH4"
                     /gene_synonym="GPATC4"
ORIGIN      
        1 atttccggga agatggcggc gcacaagtca ggtccggcac atgtttccgc ggagcggacc
       61 cagcaatgac gaggtcaaga gtcgtgggat gaagtttgct gaggagcagc tgctaaagca
      121 tggatggact caaggcaaag gcctcggccg gaaggagaat ggtatcactc aggctctcag
      181 ggtgacactg aagcaagaca ctcatggggt aggacatgac cctgccaagg agttcacaaa
      241 ccactggtgg aatgagctct tcaacaagac tgcggccaac ttggtagtgg aaactgggca
      301 ggatggagta cagataagga gcctttctaa ggagaccacc cgttataatc atcccaagcc
      361 caacttgctg tatcagaagt ttgtgaagat ggctacattg acttcaggtg gagagaagcc
      421 aaacaaagac ttggagagct gcagtgatga cgacaaccag gggtccaagt ccccaaagat
      481 tctgactgat gagatgctgc tccaagcctg tgaggggcga acagcacaca aggctgcccg
      541 tcttgggatc acaatgaagg ccaagcttgc tcgcctagag gcccaggagc aggccttcct
      601 ggctcgtctc aaaggccagg accctggggc ccctcaactg cagtcagaga gcaagccccc
      661 caaaaaaaag aaaaagaaaa ggaggcagaa agaggaggaa gaagctacag catctgaaag
      721 gaatgatgca gatgagaagc acccagaaca tgctgagcag aacatcagaa aaagcaagaa
      781 gaagaaaagg cgacatcaag aaggaaaggt ctcagatgaa agagagggta caactaaagg
      841 gaatgagaag gaggacgctg caggaacaag tgggcttggg gaattgaata gcagagagca
      901 aaccaatcag tccctcagga aagggaagaa aaagaagagg tggcaccatg aagaggagaa
      961 gatgggggtc ttggaggaag gaggaaaagg caaggaggct gcaggcagtg tcaggacaga
     1021 ggaggtagag agcagggcat atgctgaccc atgcagccga agaaagaaga ggcagcaaca
     1081 ggaggaggag gacttgaacc tagaagatag aggtgaggaa acttttaggt ggtggaacca
     1141 gggaagcaga gagcagagca tgcagtgatg gaagaagcag gaaaagcaag aagaaaagac
     1201 agcagcatca agaggaggag gacatcttgg atgtaaggga tgagaaggat ggcggggcta
     1261 gggaagcaga gagcagagca cacactggct caagcagcag aggtaagagg aagaggcagc
     1321 agcatcccaa gaaggaaaga gctggagtca gcactgtcca gaaagccaaa aagaaacaga
     1381 agaagagaga ctaaaggtct ggtaaaggta gggctcaatt gattgatttt caggagttga
     1441 agcctcaaag accagggttg atgcaggtct gcaggtcttc tgcacccccc tcaatgagga
     1501 gtccctccca gaaaggaaac tgatctctgg gacgtcagct gctgagagga gcaagcggta
     1561 gtaccacccc ttagttgagg gagtcagcac agtcctttct gcagcttcta acccaggacc
     1621 atgaactcag gtgcctagag aagccaggca gctaaaggac aaggaatgct gggggctgtg
     1681 ggaacaggaa tgcagatacc ctttgaagga gcattcctgc taaaagaagc tgaaaatgta
     1741 gacctatgtg aagtgctctg atttctaaat attgtgaagg ttaagaaaaa cataaattta
     1801 ggtctatggg ctagatttag cccacagttg ccagtttcta gcgctaccaa atgaatgaat
     1861 aaacatgagc ttgcgctcct agcctagaga taaatcctga ctggcatctc tgttcccagc
     1921 ctgggaaggt cctgaataca aattagaaga tattccttgg aggcctttga agaaattcct
     1981 tcggttaacc tctttgtagt cttgctacac tgataagtag aagtagctcc ctgtctgtgt
     2041 cccaaatgaa taagaattgt gtaaaggaca gcacaactca
//
