LOCUS       NM_018040               5859 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens G-patch domain containing 2 (GPATCH2), transcript
            variant 1, mRNA.
ACCESSION   NM_018040
VERSION     NM_018040.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5859)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5859)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 5859)
  AUTHORS   Hu,F., Gou,L., Liu,Q., Zhang,W., Luo,M. and Zhang,X.
  TITLE     G-patch domain containing 2, a gene highly expressed in testes,
            inhibits nuclear factor-kappaB and cell proliferation
  JOURNAL   Mol Med Rep 11 (2), 1252-1257 (2015)
   PUBMED   25376275
  REMARK    GeneRIF: GPATC2 may be involved in inhibiting G1-S phase transition
            in 293T cells.
REFERENCE   4  (bases 1 to 5859)
  AUTHORS   Lin,M.L., Fukukawa,C., Park,J.H., Naito,K., Kijima,K., Shimo,A.,
            Ajiro,M., Nishidate,T., Nakamura,Y. and Katagiri,T.
  TITLE     Involvement of G-patch domain containing 2 overexpression in breast
            carcinogenesis
  JOURNAL   Cancer Sci 100 (8), 1443-1450 (2009)
   PUBMED   19432882
  REMARK    GeneRIF: Involvement of GPATCH2 overexpression in breast
            carcinogensis is reported.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354659.14, AK001114.1,
            AC096641.2 and CA311820.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018040.4.
            
            Summary: The gene encodes a nuclear factor that may play a role in
            spermatogenesis and in tumor growth during breast cancer. The
            encoded protein contains a G-patch domain with an RNA binding
            motif. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.23504.1, AK001114.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366935.8/ ENSP00000355902.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL354659.14        81959-81981         c
            24-2359             AK001114.1         3-2338
            2360-5578           AC096641.2         61312-64530         c
            5579-5859           CA311820.1         13-293              c
FEATURES             Location/Qualifiers
     source          1..5859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..5859
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /note="G-patch domain containing 2"
                     /db_xref="GeneID:55105"
                     /db_xref="HGNC:HGNC:25499"
                     /db_xref="MIM:616836"
     exon            1..175
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1706
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 110; protein phosphatase 1,
                     regulatory subunit 30; G patch domain-containing protein
                     2"
                     /codon_start=1
                     /product="G patch domain-containing protein 2 isoform 1"
                     /protein_id="NP_060510.1"
                     /db_xref="CCDS:CCDS1518.1"
                     /db_xref="GeneID:55105"
                     /db_xref="HGNC:HGNC:25499"
                     /db_xref="MIM:616836"
                     /translation="MFGAAGRQPIGAPAAGNSWHFSRTMEELVHDLVSALEESSEQAR
                     GGFAETGDHSRSISCPLKRQARKRRGRKRRSYNVHHPWETGHCLSEGSDSSLEEPSKD
                     YRENHNNNKKDHSDSDDQMLVAKRRPSSNLNNNVRGKRPLWHESDFAVDNVGNRTLRR
                     RRKVKRMAVDLPQDISNKRTMTQPPEGCRDQDMDSDRAYQYQEFTKNKVKKRKLKIIR
                     QGPKIQDEGVVLESEETNQTNKDKMECEEQKVSDELMSESDSSSLSSTDAGLFTNDEG
                     RQGDDEQSDWFYEKESGGACGITGVVPWWEKEDPTELDKNVPDPVFESILTGSFPLMS
                     HPSRRGFQARLSRLHGMSSKNIKKSGGTPTSMVPIPGPVGNKRMVHFSPDSHHHDHWF
                     SPGARTEHDQHQLLRDNRAERGHKKNCSVRTASRQTSMHLGSLCTGDIKRRRKAAPLP
                     GPTTAGFVGENAQPILENNIGNRMLQNMGWTPGSGLGRDGKGISEPIQAMQRPKGLGL
                     GFPLPKSTSATTTPNAGKSA"
     exon            176..892
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     exon            893..954
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1137
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1217
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1285
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1325
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1396
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1485
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..5859
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /note="hexamer: AATAAA"
     polyA_site      2358
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
     regulatory      5833..5838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /note="hexamer: ATTAAA"
     polyA_site      5859
                     /gene="GPATCH2"
                     /gene_synonym="CT110; GPATC2; Pfa1; PPP1R30"
                     /note="major polyA site"
ORIGIN      
        1 gtcggcttcc ggaagctcat ctcaaaatgc tgaactgctc tttggaagtc gccggtgctg
       61 ttgtagttgg agtctgttca cgggcctgag cttcgaggcc aggctcccgg gtgtcgttaa
      121 tgttcggggc cgccgggcgc caaccgatcg gagctccagc agccgggaac agctggcatt
      181 tcagtagaac catggaggag ctggttcatg accttgtctc agcattggaa gagagctcag
      241 agcaagctcg aggtggattt gctgaaacag gagaccattc tcgaagtata tcttgccctc
      301 tgaaacgcca ggcaaggaaa aggagaggga gaaaacggag gtcgtataat gtgcatcacc
      361 cgtgggagac tggtcactgc ttaagtgaag gctctgattc tagtttagaa gaaccaagca
      421 aggactatag agagaatcac aataataata aaaaagatca cagtgactct gatgaccaaa
      481 tgttagtagc aaagcgcagg ccgtcatcaa acttaaataa taatgttcga gggaaaagac
      541 ctctatggca tgagtctgat tttgctgtgg acaatgttgg gaatagaact ctgcgcagga
      601 ggagaaaggt aaaacgcatg gcagtagatc tcccacagga catctctaac aaacggacaa
      661 tgacccagcc acctgagggt tgtagagatc aggacatgga cagtgataga gcctaccagt
      721 atcaagaatt taccaagaac aaagtcaaaa aaagaaagtt gaaaataatc agacaaggac
      781 caaaaatcca agatgaagga gtagttttag aaagtgagga aacgaaccag accaataagg
      841 acaaaatgga atgtgaagag caaaaagtct cagatgagct catgagtgaa agtgattcca
      901 gcagtctcag cagcactgat gctggattgt ttaccaatga tgagggaaga caaggtgatg
      961 atgaacagag tgactggttc tacgaaaagg aatcaggtgg agcatgtggt atcactggag
     1021 ttgtgccctg gtgggaaaag gaagatccta ctgagctaga caaaaatgta ccagatcctg
     1081 tctttgaaag tatcttaact ggttcttttc cccttatgtc acacccaagc agaagaggtt
     1141 tccaagctag actcagtcgc cttcatggaa tgtcttcaaa gaatattaaa aaatctggag
     1201 ggactccaac ttcaatggta cccattcctg gcccagtggg taacaagaga atggttcatt
     1261 tttccccgga ttctcatcac catgaccatt ggtttagccc tggggctagg acagagcatg
     1321 accagcatca gcttctgaga gataatcgag ctgaaagagg acacaagaaa aattgttctg
     1381 tgagaacagc cagcaggcaa acaagcatgc atttaggatc cttatgcacg ggagatatca
     1441 aacggagaag aaaagctgca cctttgcctg gacctactac tgcaggattt gtaggtgaaa
     1501 atgcccagcc aatcctagaa aataatattg gaaaccgaat gcttcagaat atgggctgga
     1561 cgcctgggtc aggccttgga cgagatggca aggggatctc tgagccaatt caagccatgc
     1621 agaggccaaa gggattagga cttggatttc ctctaccaaa aagtacttcc gcaactacta
     1681 cccccaatgc aggaaaatcc gcctaagaaa agcaaagaag aaatgtttta cagactttat
     1741 tcactatgtc ccattgttct aaaatgataa catgacttct gtttttgaag caaaaatcta
     1801 cattgcctca aacacatcac tctagcttcc ttactgcata cagtcctgcc atagtgagag
     1861 aaatgggatt tcatcacaat tcatggtgct aaaatgaaaa cctctgcact ttaatttttt
     1921 tcagtaattt ccagctattt ctaggtataa agagcagctc gtttctctta tttattttag
     1981 tctcatgtgt caatactttc cgatgctttg cttaattcat gtatgtgtgc agtgctgcaa
     2041 tgcccagaca aacgtgagca cacccaccag tttctaaaat ggaatagaca ggaaaagatt
     2101 gtgttttata tcatccctat ctattgtaac ccaaaagacc taccatcgca tcagtgaagt
     2161 ccgaacacat ctttgtttga aaggcttgtc aatttcatat tccttgaatt ggcttcttgg
     2221 tgaggatttt ctgacagagt gatacccatc aattttctat ccttagacaa tgtagtgtga
     2281 agttcacagt tgacaaacaa caattaatgt ttcccttgga tgttttgaca aaaataaacc
     2341 tcatcgttgt tatcaccaga gtgccctcta ccttacttta atgcagattt tataaatttt
     2401 acctcattta gaacataaaa taattattga aagaaaaatg tattttttaa attcaccgtg
     2461 attgaactgt aaattctatt aatccagatg tacttctacc tctgttttcc caaagattga
     2521 tattattttt aagatcaact caagtgtagt aaacggattt aaaattttaa tcattggagt
     2581 aatttattac aatattgaat caatttacat gaaaagttaa atggctctcc cagaactcag
     2641 atttctggca atgacccaac ccatttagaa ggtgaacaaa agaagtaaat ggtactgatt
     2701 tgccctttct aggacccaag atgttacttt aaaacctagc aaaagaggtc gtttgtatta
     2761 cgtgcctagt attgagctgt ttctgagtca tttgcttcat agtatcagaa attctaaatt
     2821 gcttttagtt tagaagatct ttatttatta tcttcattat taacaactta ttatgatgat
     2881 gattattatc attctattta taatggcctt tgctggttga gtaaagactg agataacaca
     2941 tgtgaatcac ctttctaatg ggtttttaaa atcttgtcac tttccaaaag agtttttttg
     3001 tttctttttt tttttttttt tttttgacag agtctgcctc tgtcgcccag gctggagtgc
     3061 agtggcgcac tctcggctca ctgcagcctc cccctcctgg gttcaagtga ttgttctgcc
     3121 tcagcctccc aaatagcagg gattacaggc acccacgacc atacccggat aatttttgta
     3181 tttttagtat agacggagtt tcaccatgtt ggccaggctg gtctcgaact cctgacctca
     3241 agtgatccgc ccaccttggc ctcccaaaga gctgggatta caggcatgaa ccacagcgcc
     3301 cagcccccag aagagttttt aaaaggtgtt aaaggaggtt tatgcacgta acagaccttt
     3361 ctcaggtggt cccctaaaaa aaatcctgcc aactagggag gggaagtcca acctgctatt
     3421 tgaaagcctt cacggtttgc caaatgtaca tttcttgaga attatcttct ttcccaggga
     3481 tattgtacct agaggacagg ttggttaggg aactatggac gaccagaaga gatgttcttt
     3541 tgaagcattc ttactggata aagtaacccc atggtatcat tactttctac aagtttttta
     3601 cttacaaatt tgccattttt ttaactgata ttttctaaat gctcattctg tctatgtagc
     3661 cggggggaga ttatatacaa gttttaaaac ttctttgtga tagtgtattg tgctctgggg
     3721 tctattcaaa atttggtgtt tgaggttttg ttaatttgat tgcctggaga tctgctaaaa
     3781 tcctagaatc tcaaaaagcc aagtttgaag ccactgagag caaacaatga ggtcattgtt
     3841 agcctggttc cacactcctg aggacttggc tgttcttttt caccttatta tgttctaatg
     3901 gaagtaaaaa ccctcatagt gaagaagagc agtatataca ccagactagt gtataggaac
     3961 ttcttcatta aatattgcag tccttatgag tgctctttat tgttgctgtt ctggacaggt
     4021 acaaatcttc tgaagcaact tctgtgggat gttaacttag cttctctaac acctaaaaaa
     4081 attcttcttt gtattttcag ctaatagaag acagttcttc ttcatcttga cacctagagc
     4141 cctctatgtg attcacagag gacttaaaat acttcttact ctgttgaagt gtttaattgt
     4201 acagaatata tgtactctac agtatatgtg aatcagcact caaagcagag aagtgataac
     4261 atcccaagct tcccccatac ttctactgac atgccctcag tctttaagaa aactcagtac
     4321 agacctgatg ttctggttgt acctgaactt aattggagaa acaaacgcaa ttaaaatacg
     4381 aattttttag tgcaaatcaa atgtctttca ccatctgaag cccactaatt tgtcttttat
     4441 atatagttaa ttttttgcca gttacaacgt ccatagaacc ccaagattta gaatgtatca
     4501 tttatatttc ctctaaaagg tagtaagata tttcttctgc tgttttgtga agccactctt
     4561 ctacagtatc tgtagcctta tagcaaatta attggttgta ctaaaaattt tagagactgc
     4621 ataggtctcc cttttctatc ctaattacct gcaatagcct agagacgctg agcatgatta
     4681 cattagcaac ttgactgttt aaaaaatttg ttatacttga taatgaccag actgtgtgct
     4741 ggagtcattt gtttccttct tttctgctcc ccgaatacac tatttaattt ggttactttt
     4801 atttttaaac tatatggcac ccttttaaat aaacattcat tgctaattaa aatctgccaa
     4861 taaattggtc tcagcattta aataccatat attttataac tcatactgtg gctatcaaac
     4921 agaagttaac acagtagggg taaagatata cataatgtgt acctataggt gtatttataa
     4981 tgcctgtgtg cagtatacag acataattac aaaatactgc attttattaa tgtttatttt
     5041 aatattgaga attggcattc ttgtaaattg aactgacaat tgcttctatt cagtacactt
     5101 tattttgagc agatatttcc gaaaagagaa aaaatcactg ttgacatgct ttttaaaact
     5161 gttttcacct gtattttgtc tttcaaaaag aaaagtgatc taagttggca ttgtaaagaa
     5221 attgttagca aagaatattt ttttttattt tttcttttgg tagaaagtca tgttaatagt
     5281 acaacaaaga atcaaagaat aaaacataat gtttaagaac attatttata agtagtcatt
     5341 gtctttgtgc tttaaatgtt tcccttttac cttagagtta ttttttaaaa gttgaaagta
     5401 ctttaaaaat tggtttaaat gagtacccat tgacaattat catttaatag tgcagttaag
     5461 ttcagcgaaa aatttcaata tctcaaaaaa attagagaaa aatattggta aatgtatttg
     5521 attcacaaat gtattcatag ccgattgtga gctgctctac cacattttcc tgtttttatt
     5581 gtttctgtga agcttgatta gactaacttg cttaaggtct ctttcccctc aaggattctg
     5641 tgattctaat gtaacaaggt acacacgctc tctctgacca cttaaagtat cagagttcaa
     5701 atctgttaca atcactccat ttccttttgg aaagttgtgc ctctcataaa gctgcttgga
     5761 cattttaagt gttttgtaat atgcattgaa gtgttgagtt ttgtttgctg taagaggcat
     5821 ttcactatgt tgattaaact tatcttttct cccaaaaaa
//
