LOCUS       NM_174931               3839 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens G-patch domain containing 11 (GPATCH11), transcript
            variant 1, mRNA.
ACCESSION   NM_174931
VERSION     NM_174931.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3839)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3839)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 3839)
  AUTHORS   Ohta,S., Bukowski-Wills,J.C., Sanchez-Pulido,L., Alves Fde,L.,
            Wood,L., Chen,Z.A., Platani,M., Fischer,L., Hudson,D.F.,
            Ponting,C.P., Fukagawa,T., Earnshaw,W.C. and Rappsilber,J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
REFERENCE   4  (bases 1 to 3839)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   5  (bases 1 to 3839)
  AUTHORS   Chen,J., Sun,M., Lee,S., Zhou,G., Rowley,J.D. and Wang,S.M.
  TITLE     Identifying novel transcripts and novel genes in the human genome
            by using novel SAGE tags
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12257-12262 (2002)
   PUBMED   12213963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK095667.1, AK294697.1 and AC007899.3.
            
            On Jan 15, 2020 this sequence version replaced NM_174931.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.18195.1,
                                           SRR14038194.4424072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000674370.2/
                                                ENSP00000501347.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK095667.1         1-19
            20-907              AK294697.1         1-888
            908-3839            AC007899.3         91961-94892         c
FEATURES             Location/Qualifiers
     source          1..3839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..3839
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /note="G-patch domain containing 11"
                     /db_xref="GeneID:253635"
                     /db_xref="HGNC:HGNC:26768"
     exon            1..53
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     exon            54..125
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..858
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 75; g patch
                     domain-containing protein 11; centromere protein Y;
                     coiled-coil domain containing 75"
                     /codon_start=1
                     /product="G patch domain-containing protein 11 isoform 1"
                     /protein_id="NP_777591.4"
                     /db_xref="CCDS:CCDS1785.4"
                     /db_xref="GeneID:253635"
                     /db_xref="HGNC:HGNC:26768"
                     /translation="MKLNMAEEEDYMSDSFINVQEDIRPGLPMLRQIREARRKEEKQQ
                     EANLKNRQKSLKEEEQERRDIGLKNALGCENKGFALLQKMGYKSGQALGKSGGGIVEP
                     IPLNIKTGKSGIGHEASLKRKAEEKLESYRKKIHMKNQAEEKAAEQFRMRLKNKQDEM
                     KLEGDLRRSQRACQQLDVQKNIQVPREAWYWLRLEEETEEDEEEKEQDEDEYKSEDLS
                     VLEKLQILTSYLREEHLYCIWCGTAYEDKEDLSSNCPGPTSADHD"
     exon            126..352
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     exon            353..394
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     exon            395..515
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     exon            516..606
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     exon            607..720
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     exon            721..802
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     exon            803..3839
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3782..3787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /note="hexamer: AATAAA"
     polyA_site      3804
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /note="major polyA site"
     regulatory      3816..3821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
                     /note="hexamer: AATAAA"
     polyA_site      3839
                     /gene="GPATCH11"
                     /gene_synonym="CCDC75; CENP-Y; CENPY"
ORIGIN      
        1 atgcgcagcg cgcgctctac ggcgctgaac cggggcgagc agagagctgt cagatactat
       61 agccatatga agttgaacat ggcagaagaa gaggactata tgtctgattc cttcattaat
      121 gtccaagaag atatcagacc aggattgcca atgctaaggc aaatccgaga agcccgtcga
      181 aaagaagaaa agcaacagga agccaatttg aaaaacaggc agaagagttt aaaagaagaa
      241 gaacaagaaa gacgtgacat tgggttgaag aatgcactag gctgtgaaaa caaagggttt
      301 gccttgctcc aaaagatggg ctataaaagt ggtcaggcac ttggcaagag tgggggtggt
      361 attgttgaac caattcctct caatatcaaa acagggaaaa gtggcattgg tcatgaggca
      421 tcattaaaac ggaaagcaga ggaaaaattg gaaagctaca gaaaaaagat tcacatgaaa
      481 aaccaagctg aagaaaaagc tgcagaacag tttcgaatgc gacttaaaaa taagcaagat
      541 gaaatgaagc tagaaggaga tctcagaaga agccagcgag cctgtcaaca actggatgtc
      601 cagaaaaata ttcaggttcc cagggaagca tggtactggt tgaggcttga agaggagact
      661 gaagaagatg aagaagaaaa agaacaggat gaagatgaat ataagagtga agatttaagc
      721 gtactggaaa aattacaaat attgactagt tatttaagag aagaacatct atattgtatt
      781 tggtgtggaa cagcctatga agataaagaa gacctatctt caaattgtcc aggaccaact
      841 tctgcagatc atgactaaga ttattcccaa taaagtggaa acttgaaaaa tgttattact
      901 tcctagggat agacaattta gcagttggaa atctcaaatt ttttatgcca gtaaagaaag
      961 ggggacttta tataatgttt tgttcttttt gtactttaga atatgaatgt tcattgactt
     1021 gaaaaaaata atgcaatggc atttcagaac acaagtatca cagagatgga cagttacaat
     1081 ttattgctat attgtgatac gtgaggggtt taaggacacc aacaggtaac ttcttattcc
     1141 cctcttcact ttggaacaaa ttgagaaata agaaatggga gtcagaggaa gagaaaaata
     1201 tccactttat cagtgaataa actgatacag agaagaaggt tgactttttc tccagtcaga
     1261 gactgtaata tttctccctg attggagaga acagcgggtc tctgccttgt tggggcagag
     1321 cccatctttg cattctgaga ccagttagct ttcaaggtca gggaaaccac caggggctgg
     1381 accacacatg ctcagttcct tcttgtatca cccatgggat aagacagttc tctcttggga
     1441 aggaatgaat gagggttcag agagcttttt cctacacttc ttgctttgaa ggagcaagga
     1501 gaagttccct tccctccatc caagcatgaa gaggagggga aaagtattcc cctcaataag
     1561 gctgatgtca gaggcaatgt tcgaccagta ctactaaatt ctaatccatt taactgtgat
     1621 aatttctggt aaaatcatga gttttcatga caatgtctat atccattata tgtgatctgt
     1681 tggaagtttt ggctagagaa acttaattgt gaggaaattt aaatattgtg tgatgcaagt
     1741 acttactgaa tttggaaacc ccttgatagc attcccagca agtgatagtt caacctttgc
     1801 ttttattctt ccagccacag agaactcact gctttaaaac cattccatta ctgggtagct
     1861 ctgaattgtt ttcattgttt tctcttaaac tgaaatctgc ttccctgtaa tattaatgaa
     1921 tacagctaag gacataccgt gtggcatact atgagagagc tccatccagg gtgaggcatc
     1981 aaaatcatga acctttttaa aagttcatat gctcaggtgt ctctcctagt gattgatttt
     2041 gatttgtctt ggctaaggtg gttcctggat atctatatat ttattttgaa gtcccaagaa
     2101 tgagtgataa gcacctgagg ataagaacta gtactgaggt taaggatgga gcaccaccat
     2161 tctttggata gagttgtgat cacctgtgtg attttatagc tcacctgtta gttagattga
     2221 gcaagagaac aacccctttt attagaaaca gcatacataa gaagattgta aaaattaacc
     2281 tacacttgct agggtaagat aatcagtagt acaatttgta ttaatctctg acctaatatg
     2341 acctaattca cttttcaagt ttaacttggg gagctttaca aaatagtaat aaaagggtcc
     2401 catcccaaga gattctgatg ccattagtca ctgtgacttg ggcatcactg cccttgattc
     2461 taaaatgcag cctaccttga gccactaatc tagttaactt ctgggcctca gttcttcatc
     2521 cagaaaacta atcattattt ttatgaatgt aaatatgtgt atatatataa tatttatatg
     2581 tttggatgct attgtttaat atttactttt ttgtttttaa aaaaattata aaattggctg
     2641 agcgcagtgg ttcactcctg taatcccagc actttaggac gccaaggcag gcagatcact
     2701 tgaagccagg agttcaagac caacctggcc aacatggtga aaccccatct ctactaaaaa
     2761 tacaaaaatt agctgggcgt ggtggcattc gcctgtaatc ccagctactc agaaggcgga
     2821 ggcatgagaa ttgcttgaac ctgggaggca gatattgcag tgagctgaga tcatgctgct
     2881 gcactccagc ctgggtgaca gagcaagacc ctgtctcaaa aaaaaaaatt atatatatat
     2941 atgtatgtat atatatatat atatagagag agagagagag agagagctat taataaaaca
     3001 gaggagtaca ttttaccctt gcaattccag tcaatactgt ggtgtcattt cagccaacat
     3061 accaacattc agtcaaatcc caaagccaaa tggataattt cagatggaat ggagttagac
     3121 aggaactggc ttccctttct cctgttacta tgaggacaac ccacacctgc tcagtggcct
     3181 aaaatatttt aaatatgttc atgacaatta tgctgagaat gccaggataa cactgatgga
     3241 acccatgact tcaccaggat tgtggtctac atttacaggc ctagtactag aactagaccg
     3301 gcttagagag tgggagatat ccctctgttg tccatcgaaa gataaaaata caggctttca
     3361 gccgggtgca gtggtgcatg cctttggtcc cagctactca gggggctgag atggggaatc
     3421 ctttgagccc agaagtttga aaccagcctg ggcaacatag tgagagacct ccatcttaag
     3481 ggaataaaaa aaaaatcaga ctttcaatat gagtaacaag ttatttttag gccttttatg
     3541 actttataaa taggcaataa tgaacaccaa gggaagcaaa acactgaaaa gaattttaaa
     3601 atttgttgta gaacattaat acgaaatttg aaactgcaaa acaatgtaaa atttaatgtc
     3661 atgttgtcat ttacttttgt gtatattgtg ccatgtttat tttcaaagtc ctatctagaa
     3721 attctaaaat gtctaatttt cttaattaaa aatccagaat tctgtagttt ctgaaattca
     3781 aaataaatac tttaacatac caaattggtt tttctaataa acatttattt caagtgtta
//
