LOCUS       NM_018025               3191 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens G-patch domain containing 1 (GPATCH1), transcript
            variant 1, mRNA.
ACCESSION   NM_018025
VERSION     NM_018025.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3191)
  AUTHORS   Krishnan,S., Chen,S., Turcatel,G., Arditi,M. and Prasadarao,N.V.
  TITLE     Regulation of Toll-like receptor 2 interaction with Ecgp96 controls
            Escherichia coli K1 invasion of brain endothelial cells
  JOURNAL   Cell Microbiol 15 (1), 63-81 (2013)
   PUBMED   22963587
  REMARK    GeneRIF: In vitro, OmpA+ Escherichia coli infection selectively
            upregulates Ecgp96 and TLR2 in human brain microvascular
            endothelial cells (HBMEC), whereas OmpA- E. coli upregulates TLR4
            in these cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC006108.1 and AC008521.5.
            
            On May 17, 2019 this sequence version replaced NM_018025.2.
            
            Transcript Variant: This variant (1) is the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.51100.1,
                                           SRR1803613.199913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000170564.7/ ENSP00000170564.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3061              BC006108.1         302-3362
            3062-3191           AC008521.5         113686-113815
FEATURES             Location/Qualifiers
     source          1..3191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..3191
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /note="G-patch domain containing 1"
                     /db_xref="GeneID:55094"
                     /db_xref="HGNC:HGNC:24658"
     exon            1..86
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..2809
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /note="evolutionarily conserved G patch domain containing;
                     evolutionarily conserved G-patch domain-containing
                     protein"
                     /codon_start=1
                     /product="G patch domain-containing protein 1"
                     /protein_id="NP_060495.2"
                     /db_xref="CCDS:CCDS12428.1"
                     /db_xref="GeneID:55094"
                     /db_xref="HGNC:HGNC:24658"
                     /translation="MAARDSDSEEDLVSYGTGLEPLEEGERPKKPIPLQDQTVRDEKG
                     RYKRFHGAFSGGFSAGYFNTVGSKEGWTPSTFVSSRQNRADKSVLGPEDFMDEEDLSE
                     FGIAPKAIVTTDDFASKTKDRIREKARQLAAATAPIPGATLLDDLITPAKLSVGFELL
                     RKMGWKEGQGVGPRVKRRPRRQKPDPGVKIYGCALPPGSSEGSEGEDDDYLPDNVTFA
                     PKDVTPVDFTPKDNVHGLAYKGLDPHQALFGTSGEHFNLFSGGSERAGDLGEIGLNKG
                     RKLGISGQAFGVGALEEEDDDIYATETLSKYDTVLKDEEPGDGLYGWTAPRQYKNQKE
                     SEKDLRYVGKILDGFSLASKPLSSKKIYPPPELPRDYRPVHYFRPMVAATSENSHLLQ
                     VLSESAGKATPDPGTHSKHQLNASKRAELLGETPIQGSATSVLEFLSQKDKERIKEMK
                     QATDLKAAQLKARSLAQNAQSSRAQLSPAAAAGHCSWNMALGGGTATLKASNFKPFAK
                     DPEKQKRYDEFLVHMKQGQKDALERCLDPSMTEWERGRERDEFARAALLYASSHSTLS
                     SRFTHAKEEDDSDQVEVPRDQENDVGDKQSAVKMKMFGKLTRDTFEWHPDKLLCKRFN
                     VPDPYPDSTLVGLPRVKRDKYSVFNFLTLPETASLPTTQASSEKVSQHRGPDKSRKPS
                     RWDTSKHEKKEDSISEFLSLARSKAEPPKQQSSPLVNKEEEHAPELSANQTVNKDVDA
                     QAEGEGSRPSMDLFRAIFASSSDEKSSSSEDEQGDSEDDQAGSGEANFQSSQDTDLGE
                     TSSVAHALVPAPQEPPPSFPIQKMQIDEREEFGPRLPPVFCPNARQTLEVPQKEKHKK
                     NKDKHKAKKEHRRKKEKKKKHRKHKHKGKQKNKKPEKSSSSESSDSSDSQSDEETADV
                     SPQELLRRLKSLPLRRQ"
     exon            87..221
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            222..307
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..468
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..566
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..625
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..865
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1013
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1093
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1298
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1598
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1777
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1905
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2042
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2209
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2426
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2534
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2632
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2778
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..3191
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3037..3042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /note="hexamer: ATTAAA"
     polyA_site      3056
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
                     /note="major polyA site"
     polyA_site      3114
                     /gene="GPATCH1"
                     /gene_synonym="ECGP; GPATC1"
ORIGIN      
        1 ccggaagagc aggatggcgg cgcgggacag tgacagcgaa gaagatctgg tcagctatgg
       61 gaccgggctg gagcctctgg aagaaggtga aagaccaaag aaaccaatcc ctcttcagga
      121 tcagactgtc agagatgaaa aaggaaggta taaacgattc cacggggcct ttagtggagg
      181 tttctctgct ggatacttca atactgttgg ctcaaaagaa ggatggacac cctctacctt
      241 tgtgtcttca cgacagaaca gagcagacaa atctgttctt ggtcctgaag attttatgga
      301 tgaagaggat cttagtgaat ttgggatagc acctaaagcg attgtcacca cagacgattt
      361 tgcctccaaa accaaagaca gaatacgaga aaaggctagg cagttggccg ctgctactgc
      421 ccctattcct ggagccaccc tccttgatga cctcataacg ccagcaaaat tatctgttgg
      481 tttcgaattg ctaagaaaaa tgggttggaa agaaggacaa ggagttggtc ctcgagtaaa
      541 gagacggcca cgccgacaga aacctgatcc tggagtcaaa atctatggct gtgcattacc
      601 ccctggaagc tcggaaggat ctgagggtga agatgatgac tacttgcctg ataatgtgac
      661 ctttgcaccc aaagatgtca cacctgtgga tttcacacct aaagataatg tgcatggtct
      721 agcttacaag ggcctggatc cccaccaggc actgtttgga acttcgggag aacattttaa
      781 tcttttcagt ggtggttctg agagagctgg cgatcttgga gaaattggac tgaataaagg
      841 aagaaaattg ggaatttcag gccaggcttt tggtgtaggt gccctggaag aggaagatga
      901 tgatatctat gccacagaaa ctctatccaa gtatgacact gttctgaagg acgaggagcc
      961 tggagacgga ctctatggct ggacagcacc caggcagtat aaaaaccaga aagaatcaga
     1021 gaaagacctt cggtacgttg gcaaaatttt ggatggattt tccttggctt ctaaaccttt
     1081 atcttctaag aaaatctatc cacctccaga gctgccaaga gactatcgac cagtgcatta
     1141 tttcagaccc atggtggccg ccacctccga gaactcacac ttactgcagg tattatcaga
     1201 gtcagctgga aaggcaacgc ctgacccagg gacacacagt aagcaccaac tgaatgcctc
     1261 caaacgggct gagttgcttg gagagacgcc tattcaaggt tcagctactt cagtgttaga
     1321 atttctgtcc caaaaagaca aagagagaat caaagaaatg aagcaggcaa ctgacctgaa
     1381 agcagctcag ctcaaggcca ggagtctggc ccagaacgct cagagcagca gagcccagct
     1441 ctcccctgca gcggctgctg ggcactgctc ttggaacatg gcattaggtg gtgggacggc
     1501 caccttaaaa gccagcaact tcaagccttt cgccaaagat ccggaaaagc aaaagcgata
     1561 cgacgagttc ttagtacaca tgaaacaggg tcagaaagat gctctggaac gctgtctgga
     1621 ccccagcatg acagagtggg agcgaggccg tgagcgggat gagtttgccc gggcggccct
     1681 gctgtacgca tcttcccatt cgaccttgtc ctccaggttc actcacgcca aggaggagga
     1741 tgactcagat caggttgaag tccctcgaga ccaagagaat gatgtcgggg ataagcagtc
     1801 ggctgtgaag atgaagatgt ttgggaagct cacccgagac acgtttgagt ggcaccctga
     1861 caagcttcta tgtaagagat ttaatgtccc tgacccttat ccagattcaa ctttagttgg
     1921 cttaccaaga gtgaagcgtg acaagtactc agtcttcaac tttctgacgc tcccagagac
     1981 agcttccttg cccaccactc aagcatcaag tgaaaaagta tcacagcacc gaggtcccga
     2041 caaatcaaga aaaccatcca gatgggatac ctctaaacac gaaaagaaag aagattccat
     2101 tagtgaattt ttaagtttgg ctagatcaaa agccgagcca cctaaacaac agtccagccc
     2161 cttagtaaac aaagaggaag agcatgcacc agaattatcc gcaaatcaga ccgtcaacaa
     2221 agatgtggac gcacaggctg aaggagaagg gagccgccca tccatggact tattcagggc
     2281 catctttgcc agttcctcag atgaaaagtc ctcatcctcc gaggatgagc aaggtgacag
     2341 tgaagatgat caggcaggct ctggggaggc caacttccaa agctcccaag acactgactt
     2401 gggggaaaca tcatctgtgg ctcacgctct tgtgccagca ccccaggagc cgccaccttc
     2461 cttcccgata caaaagatgc agatagatga aagagaagag ttcggcccgc ggctgcctcc
     2521 cgtcttctgc cccaatgctc gtcagacact tgaggttcct caaaaagaga aacataaaaa
     2581 gaacaaagac aagcacaagg ccaagaaaga gcacaggcgg aagaaagaga agaaaaagaa
     2641 acacaggaag cacaaacaca aaggcaagca aaagaataaa aaaccagaga aaagtagtag
     2701 ctccgagagt tccgacagca gcgacagcca gagtgacgag gaaaccgcag acgtgtcgcc
     2761 ccaggagctg ctgagacggc tgaaaagtct tccactaaga aggcagtaat tgaatgctgc
     2821 cctggctcgt cctagaatca tttctcctcc atgatggaag cccagtgatt gttcagttaa
     2881 cgcattgtac agagtgtatt tatatgtaaa ttcctgctgt aaaataattt ttaaaacctt
     2941 gacatttcaa agactgcctt gaaaggtcgc agaaattgat ttctattttt aatttcagtt
     3001 agtatcgggg gaaaaaaatc cagactgaac agtttaatta aagtggaatt tttctatttt
     3061 cttcttgatt tttaaaaaat ttcctgggac gttaaaaaag aagttaaaag tgaaggcttc
     3121 tctctggttt tgtgatgaag acagcctgga ctcactgaag gacaagcgtg tgagaagggg
     3181 cggttgcggc c
//
