LOCUS       NM_032717               2928 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens glycerol-3-phosphate acyltransferase 3 (GPAT3),
            transcript variant 1, mRNA.
ACCESSION   NM_032717
VERSION     NM_032717.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2928)
  AUTHORS   Fan,G., Li,Y., Zong,Y., Suo,X., Jia,Y., Gao,M. and Yang,X.
  TITLE     GPAT3 regulates the synthesis of lipid intermediate LPA and
            exacerbates Kupffer cell inflammation mediated by the ERK signaling
            pathway
  JOURNAL   Cell Death Dis 14 (3), 208 (2023)
   PUBMED   36964139
  REMARK    GeneRIF: GPAT3 regulates the synthesis of lipid intermediate LPA
            and exacerbates Kupffer cell inflammation mediated by the ERK
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2928)
  AUTHORS   Tanigawa,K., Hayashi,Y., Hama,K., Yamashita,A., Yokoyama,K.,
            Luo,Y., Kawashima,A., Maeda,Y., Nakamura,Y., Harada,A., Kiriya,M.,
            Karasawa,K. and Suzuki,K.
  TITLE     Mycobacterium leprae promotes triacylglycerol de novo synthesis
            through induction of GPAT3 expression in human premonocytic THP-1
            cells
  JOURNAL   PLoS One 16 (3), e0249184 (2021)
   PUBMED   33770127
  REMARK    GeneRIF: Mycobacterium leprae promotes triacylglycerol de novo
            synthesis through induction of GPAT3 expression in human
            premonocytic THP-1 cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2928)
  AUTHORS   Sim,M.F.M., Persiani,E., Talukder,M.M.U., Mcilroy,G.D., Roumane,A.,
            Edwardson,J.M. and Rochford,J.J.
  TITLE     Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3
            and AGPAT2 enzymes to facilitate adipocyte differentiation
  JOURNAL   Sci Rep 10 (1), 3259 (2020)
   PUBMED   32094408
  REMARK    GeneRIF: Oligomers of the lipodystrophy protein seipin may
            co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte
            differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2928)
  AUTHORS   Fan,S.H., Wang,Y.Y., Wu,Z.Y., Zhang,Z.F., Lu,J., Li,M.Q., Shan,Q.,
            Wu,D.M., Sun,C.H., Hu,B. and Zheng,Y.L.
  TITLE     AGPAT9 suppresses cell growth, invasion and metastasis by
            counteracting acidic tumor microenvironment through
            KLF4/LASS2/V-ATPase signaling pathway in breast cancer
  JOURNAL   Oncotarget 6 (21), 18406-18417 (2015)
   PUBMED   26110566
  REMARK    GeneRIF: Data show that 1-acylglycerol-3-phosphate
            O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating
            expression of KLF4/LASS2/V-ATPase proteins in breast cancer.
REFERENCE   5  (bases 1 to 2928)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 2928)
  AUTHORS   Cao,J., Li,J.L., Li,D., Tobin,J.F. and Gimeno,R.E.
  TITLE     Molecular identification of microsomal
            acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de
            novo triacylglycerol synthesis
  JOURNAL   Proc Natl Acad Sci U S A 103 (52), 19695-19700 (2006)
   PUBMED   17170135
REFERENCE   7  (bases 1 to 2928)
  AUTHORS   Tang,W., Yuan,J., Chen,X., Gu,X., Luo,K., Li,J., Wan,B., Wang,Y.
            and Yu,L.
  TITLE     Identification of a novel human lysophosphatidic acid
            acyltransferase, LPAAT-theta, which activates mTOR pathway
  JOURNAL   J Biochem Mol Biol 39 (5), 626-635 (2006)
   PUBMED   17002884
  REMARK    GeneRIF: LPAAT-theta gene consisted of 12 exons and 11 introns, and
            mapped to chromosome 4q21.23, was ubiquitously expressed in 18
            human tissues and overexpression of LPAAT-theta can induce
            mTOR-dependent p70S6K and 4EBP1 phosphorylation in HEK293T cells.
REFERENCE   8  (bases 1 to 2928)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 2928)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
REFERENCE   10 (bases 1 to 2928)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096768.3, DA673378.1, AY358100.1 and BM841009.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032717.4.
            
            Summary: This gene encodes a member of the lysophosphatidic acid
            acyltransferase protein family. The encoded protein is an enzyme
            which catalyzes the conversion of glycerol-3-phosphate to
            lysophosphatidic acid in the synthesis of triacylglycerol. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ345298.1, SRR1660809.33345.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264409.5/ ENSP00000264409.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC096768.3         153321-153529
            210-392             DA673378.1         1-183
            393-2926            AY358100.1         1-2534
            2927-2928           BM841009.1         295-296
FEATURES             Location/Qualifiers
     source          1..2928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.23"
     gene            1..2928
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /note="glycerol-3-phosphate acyltransferase 3"
                     /db_xref="GeneID:84803"
                     /db_xref="HGNC:HGNC:28157"
                     /db_xref="MIM:610958"
     exon            1..656
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..1820
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /EC_number="2.3.1.51"
                     /EC_number="2.3.1.15"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 8;
                     lysophosphatidic acid acyltransferase theta; MAG-1;
                     GPAT-3; hGPAT3; 1-AGPAT 9; 1-AGP acyltransferase 9; lung
                     cancer metastasis-associated protein 1;
                     acyl-CoA:glycerol-3-phosphate acyltransferase 3;
                     endoplasmic reticulum associated GPAT;
                     1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; testis
                     secretory sperm-binding protein Li 213e;
                     1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10;
                     1-acylglycerol-3-phosphate O-acyltransferase 9"
                     /codon_start=1
                     /product="glycerol-3-phosphate acyltransferase 3"
                     /protein_id="NP_116106.2"
                     /db_xref="CCDS:CCDS3606.1"
                     /db_xref="GeneID:84803"
                     /db_xref="HGNC:HGNC:28157"
                     /db_xref="MIM:610958"
                     /translation="MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVK
                     TLEWATIRIEKGTPKESILKNSASVGIIQRDESPMEKGLSGLRGRDFELSDVFYFSKK
                     GLEAIVEDEVTQRFSSEELVSWNLLTRTNVNFQYISLRLTMVWVLGVIVRYCVLLPLR
                     VTLAFIGISLLVIGTTLVGQLPDSSLKNWLSELVHLTCCRICVRALSGTIHYHNKQYR
                     PQKGGICVANHTSPIDVLILTTDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERSEM
                     KDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIHPVAIKYN
                     PQFGDAFWNSSKYNMVSYLLRMMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAIA
                     IQGGLTELPWDGGLKRAKVKDIFKEEQQKNYSKMIVGNGSLS"
     exon            657..723
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..994
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1069
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1159
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1253
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1369
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1425
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1511
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1640
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1720
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..2928
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /note="hexamer: AATAAA"
     polyA_site      2928
                     /gene="GPAT3"
                     /gene_synonym="AGPAT 10; AGPAT10; AGPAT8; AGPAT9;
                     HMFN0839; LPAAT-theta; MAG1"
                     /note="major polyA site"
ORIGIN      
        1 agcttccagc acagcccgcg gcccggtgcc agctccgccg gcgaccggtg tgccaaagtg
       61 cggtgctccc gcagggaacc tggctcgggg agggcctccg tgagtcatct gctgagttgt
      121 cgcaatcgcc acccagagga aatcaggcac cgggcggggc gggttcctgg ctgcgctcgc
      181 gcgctctgcc cgcgccgcgg tgtgcctccg cttacccgca gctccgacca ctggctcgcg
      241 ctacccaggt ctccgcacgc cgcggtggct tcagcccaga cctgggcagc cagcggagaa
      301 agagttaact ggcaggggcg aggaggagcc cagggaggaa ggaaggatat tgccgtaatt
      361 ctgaaagttt ttttccttcc tctcttccct tcgcagaggt gagtgccggg ctcggcgctc
      421 tgctcctgga gctcccgcgg gactgcctgg ggacagggac tgctgtggcg ctcggccctc
      481 cactgcggac ctctcctgag tgggtgcgcc gagtcatgga gggcgcagag ctggccggga
      541 agatcctttc cacctggctg acgctggttc tcggcttcat ccttttacct tcggtcttcg
      601 gagtgtctct gggcatctcc gagatctaca tgaagatcct agtgaaaact ttagagtggg
      661 ccacaatacg aattgaaaaa ggaaccccaa aggagtcgat tcttaaaaac tctgcttctg
      721 ttggtattat ccaaagagat gagtcaccca tggaaaaagg gctctctggt ctacgaggaa
      781 gggactttga gctgtctgac gtgttttatt tctccaagaa gggattggaa gccattgtag
      841 aagatgaagt gacccagagg ttttcctcag aggagctagt gtcatggaat ctcctcacaa
      901 gaaccaatgt aaatttccag tacatcagtc tgcggctcac tatggtgtgg gtgctgggcg
      961 tcatagtgcg ctattgtgtc ctactgcctc tgagggttac cttggctttc attgggatca
     1021 gtttgctggt tataggaact acactggttg ggcagctgcc agacagcagc ctcaaaaact
     1081 ggctgagtga actggtccat ctgacttgct gccggatctg tgtgcgagcc ctctctggta
     1141 ccattcatta tcataacaag cagtacagac cccagaaggg aggcatttgt gttgccaacc
     1201 atacttcccc cattgatgtt ttaatcttga caacggatgg atgttatgct atggttggcc
     1261 aggttcatgg cggcttgatg ggaattattc agagagctat ggtcaaggct tgtcctcatg
     1321 tctggtttga acgctcagaa atgaaggatc gacacctggt tactaagaga ctaaaagaac
     1381 atattgctga taagaagaaa ctacccatac taatttttcc tgaaggaact tgcatcaaca
     1441 atacttcagt catgatgttt aaaaagggga gctttgaaat tggaggaacc atacatccag
     1501 ttgcaattaa gtataaccct cagttcggtg atgcattttg gaacagtagt aaatacaaca
     1561 tggtgagcta cctgcttcga atgatgacca gctgggccat cgtctgtgac gtgtggtaca
     1621 tgccccccat gaccagagag gaaggagaag atgcagtcca gtttgctaac agggttaagt
     1681 ctgctattgc tatacaagga ggcctgactg aacttccctg ggatggagga ctaaagagag
     1741 caaaggtgaa ggacatcttt aaggaagagc agcagaaaaa ttacagcaag atgattgtgg
     1801 gcaatggatc tctcagctaa gaggacggat gacagccttt agatctagaa ctagccctta
     1861 gaaatggaat ggcttttttt gttttgtttt gttttattgt tttgttttta ttattgttaa
     1921 tcttttctac agaatgattg tctctacctc tttatgccag aggcagaacc tacaggtgcc
     1981 ctttttggct tttgttgttg ttgtaacatt agccccatgg attgtaaggt ggtttactga
     2041 gttaaaacag attctgcttt tgtaaaatga tggcatcact gtggactgaa tgaaatattt
     2101 gtatagaaaa aagtgcttga aaagtgtgtt tggaactcat cgatagggta attctccaaa
     2161 aatgcccaaa ctctttttct gtaattagcc ttgccacttt cttcagtcac ttaaatggtg
     2221 agattacaca tcagtgcaag atgaccatta tggttatggt ctactgcaag gttgaaagga
     2281 aaaatggagg attgtattta ggaaaaggga caactttgtg gccacctgct ctgaaagtca
     2341 aaaggaaatg taaattagtg tcattagtgt gttggaagag aaatactatt cagtaagctt
     2401 cgccaaagaa aagtgagtca aagttaatgt gtgtgcgcat ttatatgtag gcagctcgta
     2461 gaccacattt taaccagcaa ctggtaacaa agagcttagt tttccttgtt tgaatgctgt
     2521 agatctgtac ctagtacccc tcccatctac tgatttgttt gtttttgtaa ccaaacacat
     2581 tttcagatag aaggagcctt aaaaaaaaaa aatcacattg agtaacttca gtatgaatga
     2641 atgagagtgt gtggagctac ccctcaccct ccaccccttt gtgcttttta ttcccgaatt
     2701 ttcccagtct cttaaacaga aaaatgactg atataattat cttttggaaa ctgagcctta
     2761 atttttttta gagggggaaa taagttttcc ccaactcaca cagcataagc aatgtttgac
     2821 agcaatataa tgccgttgta aactactgag agtattgtat ctgttctggt aaccatgtac
     2881 agaatgtgaa actgtcttat gaatataaat aaattctata tttctaaa
//
