LOCUS       NM_033177               2365 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens G-patch domain and ankyrin repeats 1 (GPANK1),
            transcript variant 2, mRNA.
ACCESSION   NM_033177
VERSION     NM_033177.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2365)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2365)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2365)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2365)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2365)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2365)
  AUTHORS   Harney,S.M., Vilarino-Guell,C., Adamopoulos,I.E., Sims,A.M.,
            Lawrence,R.W., Cardon,L.R., Newton,J.L., Meisel,C., Pointon,J.J.,
            Darke,C., Athanasou,N., Wordsworth,B.P. and Brown,M.A.
  TITLE     Fine mapping of the MHC Class III region demonstrates association
            of AIF1 and rheumatoid arthritis
  JOURNAL   Rheumatology (Oxford) 47 (12), 1761-1767 (2008)
   PUBMED   18835879
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2365)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   8  (bases 1 to 2365)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 2365)
  AUTHORS   Spies,T., Bresnahan,M. and Strominger,J.L.
  TITLE     Human major histocompatibility complex contains a minimum of 19
            genes between the complement cluster and HLA-B
  JOURNAL   Proc Natl Acad Sci U S A 86 (22), 8955-8958 (1989)
   PUBMED   2813433
REFERENCE   10 (bases 1 to 2365)
  AUTHORS   Spies,T., Blanck,G., Bresnahan,M., Sands,J. and Strominger,J.L.
  TITLE     A new cluster of genes within the human major histocompatibility
            complex
  JOURNAL   Science 243 (4888), 214-217 (1989)
   PUBMED   2911734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC018875.2, AK123707.1 and
            AL662899.5.
            
            On Nov 23, 2018 this sequence version replaced NM_033177.3.
            
            Summary: This gene is located in a cluster of HLA-B-associated
            transcripts, which is included in the human major
            histocompatability complex III region. This gene encodes a protein
            which is thought to play a role in immunity. Multiple alternatively
            spliced variants, encoding the same protein, have been identified.
            [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.127969.1, BC008783.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375896.9/ ENSP00000365060.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1508              BC018875.2         390-1897
            1509-1764           AK123707.1         1938-2193
            1765-1765           AL662899.5         4169-4169           c
            1766-2364           AK123707.1         2195-2793
            2365-2365           AL662899.5         3569-3569           c
FEATURES             Location/Qualifiers
     source          1..2365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2365
                     /gene="GPANK1"
                     /gene_synonym="ANKRD59; BAT4; D6S54E; G5; GPATCH10"
                     /note="G-patch domain and ankyrin repeats 1"
                     /db_xref="GeneID:7918"
                     /db_xref="HGNC:HGNC:13920"
                     /db_xref="MIM:142610"
     exon            1..157
                     /gene="GPANK1"
                     /gene_synonym="ANKRD59; BAT4; D6S54E; G5; GPATCH10"
                     /inference="alignment:Splign:2.1.0"
     exon            158..882
                     /gene="GPANK1"
                     /gene_synonym="ANKRD59; BAT4; D6S54E; G5; GPATCH10"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1327
                     /gene="GPANK1"
                     /gene_synonym="ANKRD59; BAT4; D6S54E; G5; GPATCH10"
                     /note="G patch domain containing 10; protein BAT4; G patch
                     domain and ankyrin repeats-containing protein 1; protein
                     G5; HLA-B-associated transcript 4; g patch
                     domain-containing protein 10; ankyrin repeat
                     domain-containing protein 59"
                     /codon_start=1
                     /product="G patch domain and ankyrin repeat-containing
                     protein 1"
                     /protein_id="NP_149417.1"
                     /db_xref="CCDS:CCDS4711.1"
                     /db_xref="GeneID:7918"
                     /db_xref="HGNC:HGNC:13920"
                     /db_xref="MIM:142610"
                     /translation="MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFY
                     EALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAED
                     KMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVS
                     YLLGRGAAWVGVCELSGRDAAQLAEEAGFPEVARMVRESHGETRSPENRSPTPSLQYC
                     ENCDTHFQDSNHRTSTAHLLSLSQGPQPPNLPLGVPISSPGFKLLLRGGWEPGMGLGP
                     RGEGRANPIPTVLKRDQEGLGYRSAPQPRVTHFPAWDTRAVAGRERPPRVATLSWREE
                     RRREEKDRAWERDLRTYMNLEF"
     exon            883..2365
                     /gene="GPANK1"
                     /gene_synonym="ANKRD59; BAT4; D6S54E; G5; GPATCH10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPANK1"
                     /gene_synonym="ANKRD59; BAT4; D6S54E; G5; GPATCH10"
                     /note="hexamer: AATAAA"
     polyA_site      1508
                     /gene="GPANK1"
                     /gene_synonym="ANKRD59; BAT4; D6S54E; G5; GPATCH10"
                     /note="major polyA site"
     polyA_site      2365
                     /gene="GPANK1"
                     /gene_synonym="ANKRD59; BAT4; D6S54E; G5; GPATCH10"
ORIGIN      
        1 gccattttgc ggtacggaag ctacacagca acacgtatag gagactctcc ccgagatctt
       61 ctagggagtg acccatctat ttttgtttgg gaagaggaaa ctccgaaatg ggatcgcgga
      121 agacttaaag ggccaggctg attttttttt cctactggtc tctgaggctg tggttgctac
      181 agggtcacca cgagcttggc ttacttgtct catccttccc ttgcctggta tcattttctc
      241 agttctccca aaagccatgt cccggccctt gctcatcacc ttcaccccag ccactgaccc
      301 cagcgacctc tggaaggatg ggcagcagca gccacagccc gagaagccag agtccaccct
      361 ggatggggct gcagcccgag ctttctatga ggccctgatt ggggatgaga gcagcgctcc
      421 tgactcccag agatctcaga ctgaacctgc cagagaaaga aagagaaaga aaagaagaat
      481 aatgaaggca ccagcagcag aagcagtggc agaaggagca tcaggaagac atggacaagg
      541 gagatccctt gaggctgagg ataagatgac tcaccggata ctgagggcag cccaggaggg
      601 ggacctgcca gaacttagga gactgctgga accgcatgag gcaggaggag ctggggggaa
      661 tatcaacgcc cgggatgcct tctggtggac cccactgatg tgtgctgctc gagcgggcca
      721 gggggcagct gtgagctatc tcctgggccg tggggctgcc tgggtggggg tctgtgagct
      781 gagtggcagg gatgcggctc agctcgctga agaagctggc ttccctgagg tagcccgcat
      841 ggtcagggag agccatggag agacaaggag cccggaaaac cggtctccta ctccctccct
      901 ccagtactgc gagaactgtg acacccactt ccaagattcc aaccaccgca catccactgc
      961 tcacctgctg tcactgtcgc agggtcctca gcctcccaac cttccacttg gggtgcccat
     1021 ctccagcccg ggcttcaaac tgctgctgag ggggggctgg gagccaggaa tggggctggg
     1081 accccggggt gagggccgtg ccaatcccat ccccactgtc ctcaagaggg accaggaagg
     1141 actaggctac agatcagcac cccagccccg agtgacacat ttcccagctt gggatacccg
     1201 agctgtggct gggagggaga gaccccctcg ggtggccaca ctgagctgga gggaggagag
     1261 aaggagggag gagaaagaca gggcttggga gcgggatcta aggacttaca tgaacctcga
     1321 gttctgactt tggtaaagtc tgaccctagt ctgctgctga agtctgaact tgggcctctg
     1381 acctgggccc tttgacttcc ccttcctggg atctgctcag atgcagatcc tgaagttttt
     1441 ggtcaatagg ctctgtcttc gtgagagacg ggctgagagt cagaaataaa tcaaccattt
     1501 gtggtttatt cacttttctg gaagctattt tgaggaagcc aaacagaagc ctgggagcca
     1561 catgcaagtc ccacctgagt cagaaggggc agcctctcca ggtggcatga taaggtcacc
     1621 tccctgccaa tctgggttca ctttcaggtc ccagaccctc ctgggagtcc cccacctatt
     1681 ctttcaaccc ccctggacca agaattgccc agcttcgtgc aagtctcact tcccccagga
     1741 ggagttccct gactacagcc aattcactga tttcacaaac ataagtccat atactatgtg
     1801 ccaagaatac aggtaaagac attcccaacc ctcaaagagt tcacagctgg agagggaaag
     1861 tgccatgtta tcaatttttt tctttttttt ttgagatgca gtttcgctct cattgcccag
     1921 gctggagtgc aatggcatga tctcggctca ccacaacctc tgccccccga gttcaaggga
     1981 ttctcctgcc tcagcctccc cagtagctgg gattacaggc atgccccacc acgcccagct
     2041 aattttgtat ttttagtaga gacggggttt ctccatgttg gccaagctgg tcttgaactc
     2101 ccgacctcag gtgatccgcc ggcctcggct tcccaaagtg ctggggttgc aggcatgagc
     2161 caccactccc ggcccatgtt atcaaatatt ataatgcagg gtgataaggg aagtcaaggc
     2221 ctctagagat gagaatgggt agggttttgc tggaagaggc cagtgtgata ggaaggccca
     2281 cgattatcaa gcttgtacac ttagttgaac tgggaccaga actctagccc ccaaatctaa
     2341 actttaaact tctttgttcc accca
//
