LOCUS       NM_005814               2548 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens glycoprotein A33 (GPA33), mRNA.
ACCESSION   NM_005814
VERSION     NM_005814.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2548)
  AUTHORS   Lopes,N., Bergsland,C., Bruun,J., Bjornslett,M., Vieira,A.F.,
            Mesquita,P., Pinto,R., Gomes,R., Cavadas,B., Bennett,E.,
            Pereira,L., Lothe,R.A., Almeida,R. and David,L.
  TITLE     A panel of intestinal differentiation markers (CDX2, GPA33, and
            LI-cadherin) identifies gastric cancer patients with favourable
            prognosis
  JOURNAL   Gastric Cancer 23 (5), 811-823 (2020)
   PUBMED   32215766
  REMARK    GeneRIF: A panel of intestinal differentiation markers (CDX2,
            GPA33, and LI-cadherin) identifies gastric cancer patients with
            favourable prognosis.
REFERENCE   2  (bases 1 to 2548)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2548)
  AUTHORS   Wong,N.A.C.S., Adamczyk,L.A., Evans,S., Cullen,J., Oniscu,A. and
            Oien,K.A.
  TITLE     A33 shows similar sensitivity to but is more specific than CDX2 as
            an immunomarker of colorectal carcinoma
  JOURNAL   Histopathology 71 (1), 34-41 (2017)
   PUBMED   28226180
  REMARK    GeneRIF: A33 shows similar sensitivity to but is more specific than
            CDX2 as an immunomarker of colorectal carcinoma
REFERENCE   4  (bases 1 to 2548)
  AUTHORS   Baptistella,A.R., Salles Dias,M.V., Aguiar,S. Jr., Begnami,M.D. and
            Martins,V.R.
  TITLE     Heterogeneous expression of A33 in colorectal cancer: possible
            explanation for A33 antibody treatment failure
  JOURNAL   Anticancer Drugs 27 (8), 734-737 (2016)
   PUBMED   27272411
  REMARK    GeneRIF: A33 expression is directly correlated to colorectal tumor
            differentiation.
REFERENCE   5  (bases 1 to 2548)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2548)
  AUTHORS   Johnstone,C.N., White,S.J., Tebbutt,N.C., Clay,F.J., Ernst,M.,
            Biggs,W.H., Viars,C.S., Czekay,S., Arden,K.C. and Heath,J.K.
  TITLE     Analysis of the regulation of the A33 antigen gene reveals
            intestine-specific mechanisms of gene expression
  JOURNAL   J Biol Chem 277 (37), 34531-34539 (2002)
   PUBMED   12114523
  REMARK    GeneRIF: cloning, chromosomal localizations, exon-intron structures
            and transcription start sites - target gene for the
            intestine-specific homeobox transcription factor, CDX1.
REFERENCE   7  (bases 1 to 2548)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
REFERENCE   8  (bases 1 to 2548)
  AUTHORS   Moritz,R.L., Ritter,G., Catimel,B., Cohen,L.S., Welt,S., Old,L.J.,
            Burgess,A.W., Nice,E.C. and Simpson,R.J.
  TITLE     Micro-sequencing strategies for the human A33 antigen, a novel
            surface glycoprotein of human gastrointestinal epithelium
  JOURNAL   J Chromatogr A 798 (1-2), 91-101 (1998)
   PUBMED   9542130
REFERENCE   9  (bases 1 to 2548)
  AUTHORS   Ritter,G., Cohen,L.S., Nice,E.C., Catimel,B., Burgess,A.W.,
            Moritz,R.L., Ji,H., Heath,J.K., White,S.J., Welt,S., Old,L.J. and
            Simpson,R.J.
  TITLE     Characterization of posttranslational modifications of human A33
            antigen, a novel palmitoylated surface glycoprotein of human
            gastrointestinal epithelium
  JOURNAL   Biochem Biophys Res Commun 236 (3), 682-686 (1997)
   PUBMED   9245713
REFERENCE   10 (bases 1 to 2548)
  AUTHORS   Heath,J.K., White,S.J., Johnstone,C.N., Catimel,B., Simpson,R.J.,
            Moritz,R.L., Tu,G.F., Ji,H., Whitehead,R.H., Groenen,L.C.,
            Scott,A.M., Ritter,G., Cohen,L., Welt,S., Old,L.J., Nice,E.C. and
            Burgess,A.W.
  TITLE     The human A33 antigen is a transmembrane glycoprotein and a novel
            member of the immunoglobulin superfamily
  JOURNAL   Proc Natl Acad Sci U S A 94 (2), 469-474 (1997)
   PUBMED   9012807
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U79725.1 and CA307909.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005814.2.
            
            Summary: The glycoprotein encoded by this gene is a cell surface
            antigen that is expressed in greater than 95% of human colon
            cancers. The open reading frame encodes a 319-amino acid
            polypeptide having a putative secretory signal sequence and 3
            potential glycosylation sites. The predicted mature protein has a
            213-amino acid extracellular region, a single transmembrane domain,
            and a 62-amino acid intracellular tail. The sequence of the
            extracellular region contains 2 domains characteristic of the CD2
            subgroup of the immunoglobulin (Ig) superfamily. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U79725.1, BC069705.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367868.4/ ENSP00000356842.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2539              U79725.1           255-2793
            2540-2548           CA307909.1         18-26               c
FEATURES             Location/Qualifiers
     source          1..2548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.1"
     gene            1..2548
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /note="glycoprotein A33"
                     /db_xref="GeneID:10223"
                     /db_xref="HGNC:HGNC:4445"
                     /db_xref="MIM:602171"
     exon            1..133
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1050
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /note="cell surface A33 antigen; transmembrane
                     glycoprotein A33; glycoprotein A33 (transmembrane)"
                     /codon_start=1
                     /product="cell surface A33 antigen precursor"
                     /protein_id="NP_005805.1"
                     /db_xref="CCDS:CCDS1258.1"
                     /db_xref="GeneID:10223"
                     /db_xref="HGNC:HGNC:4445"
                     /db_xref="MIM:602171"
                     /translation="MVGKMWPVLWTLCAVRVTVDAISVETPQDVLRASQGKSVTLPCT
                     YHTSTSSREGLIQWDKLLLTHTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASI
                     TIDQLTMADNGTYECSVSLMSDLEGNTKSRVRLLVLVPPSKPECGIEGETIIGNNIQL
                     TCQSKEGSPTPQYSWKRYNILNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEG
                     TQFCNITVAVRSPSMNVALYVGIAVGVVAALIIIGIIIYCCCCRGKDDNTEDKEDARP
                     NREAYEEPPEQLRELSREREEEDDYRQEEQRSTGRESPDHLDQ"
     exon            134..288
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /inference="alignment:Splign:2.1.0"
     exon            289..505
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /inference="alignment:Splign:2.1.0"
     exon            506..661
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /inference="alignment:Splign:2.1.0"
     exon            662..781
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /inference="alignment:Splign:2.1.0"
     exon            782..917
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /inference="alignment:Splign:2.1.0"
     exon            918..2548
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2523..2528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /note="hexamer: AATAAA"
     polyA_site      2548
                     /gene="GPA33"
                     /gene_synonym="A33"
                     /note="major polyA site"
ORIGIN      
        1 agaagctgct gtagctttaa ccagacagct cagacctgtc tggaggctgc cagtgacagg
       61 ttaggtttag ggcagagaag aagcaagacc atggtgggga agatgtggcc tgtgttgtgg
      121 acactctgtg cagtcagggt gaccgtcgat gccatctctg tggaaactcc gcaggacgtt
      181 cttcgggctt cgcagggaaa gagtgtcacc ctgccctgca cctaccacac ttccacctcc
      241 agtcgagagg gacttattca atgggataag ctcctcctca ctcatacgga aagggtggtc
      301 atctggccgt tttcaaacaa aaactacatc catggtgagc tttataagaa tcgcgtcagc
      361 atatccaaca atgctgagca gtccgatgcc tccatcacca ttgatcagct gaccatggct
      421 gacaacggca cctacgagtg ttctgtctcg ctgatgtcag acctggaggg caacaccaag
      481 tcacgtgtcc gcctgttggt cctcgtgcca ccctccaaac cagaatgcgg catcgaggga
      541 gagaccataa ttgggaacaa catccagctg acctgccaat caaaggaggg ctcaccaacc
      601 cctcagtaca gctggaagag gtacaacatc ctgaatcagg agcagcccct ggcccagcca
      661 gcctcaggtc agcctgtctc cctgaagaat atctccacag acacatcggg ttactacatc
      721 tgtacctcca gcaatgagga ggggacgcag ttctgcaaca tcacggtggc cgtcagatct
      781 ccctccatga acgtggccct gtatgtgggc atcgcggtgg gcgtggttgc agccctcatt
      841 atcattggca tcatcatcta ctgctgctgc tgccgaggga aggacgacaa cactgaagac
      901 aaggaggatg caaggccgaa ccgggaagcc tatgaggagc caccagagca gctaagagaa
      961 ctttccagag agagggagga ggaggatgac tacaggcaag aagagcagag gagcactggg
     1021 cgtgaatccc cggaccacct cgaccagtga caggccagca gcagagggcg gcggaggaag
     1081 ggttaggggt tcattctccc gcttcctggc ctcccttctc ctttctaagc cctgttctcc
     1141 tgtccctcca tcccagacat tgatggggac atttcttccc cagtgtcagc tgtggggaac
     1201 atggctggcc tggtaagggg gtccctgtgc tgatcctgct gacctcactg tcctgtgaag
     1261 taacccctcc tggctgtgac acctggtgcg ggcctggccc tcactcaaga ccaggctgca
     1321 gcctccactt ccctcgtagt tggcaggagc tcctggaagc acagcgctga gcatggggcg
     1381 ctcccactca gaactctcca gggaggcgat gccagccttg gggggtgggg gctgtcctgc
     1441 tcacctgtgt gcccagcacc tggaggggca ccaggtggag ggtttgcact ccacacatct
     1501 ttcttgaatg aatgaaagaa taagtgagta tgcttgggcc ctgcattggc ctggcctcca
     1561 gctcccactc cctttccaac ctcacttccc gtagctgcca gtatgttcca aaccctcctg
     1621 ggaaggccac ctcccactcc tgctgcacag gccctgggga gcttttgccc acacactttc
     1681 catctctgcc tgtcaatatc gtacctgtcc ctccaggccc atctcaaatc acaaggattt
     1741 ctctaaccct atcctaattg tccacatacg tggaaacaat cctgttactc tgtcccacgt
     1801 ccaatcatgg gccacaaggc acagtcttct gagcgagtgc tctcactgta ttagagcgcc
     1861 agctccttgg ggcagggcct gggcctcatg gcttttgctt tccctgaagc cctagtagct
     1921 ggcgcccatc ctagtgggca cttaagctta attggggaaa ctgctttgat tggttgtgcc
     1981 ttcccttctc tggtctcctt gagatgatcg tagacacagg gatgattccc acccaaaccc
     2041 acgtattcat tcagtgagtt aaacacgaat tgatttaaag tgaacacaca caagggagct
     2101 tgcttgcaga tggtctgagt tcttgtgtcc tggtaattcc tctccaggcc agaataattg
     2161 gcatgtctcc tcaacccaca tggggttcct ggttgttcct gcatcccgat acctcagccc
     2221 tggccctgcc cagcccattt gggctctggt tttctggtgg ggctgtcctg ctgccctccc
     2281 acagcctcct tctgtttgtc gagcatttct tctactcttg agagctcagg cagcgttagg
     2341 gctgcttagg tctcatggac cagtggctgg tctcacccaa ctgcagttta ctattgctat
     2401 cttttctgga tgatcagaaa aataattcca taaatctatt gtctacttgc gattttttaa
     2461 aaaatgtata tttttatata tattgttaaa tcctttgctt cattccaaat gctttcagta
     2521 ataataaaat tgtgggtgga aattctta
//
