LOCUS       NM_016363               2264 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens glycoprotein VI platelet (GP6), transcript variant 2,
            mRNA.
ACCESSION   NM_016363
VERSION     NM_016363.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2264)
  AUTHORS   Benson,T.W., Pike,M.M., Spuzzillo,A., Hicks,S.M., Ali,S., Pham,M.,
            Mix,D.S., Brunner,S.I., Wadding-Lee,C., Conrad,K.A., Russell,H.M.,
            Jennings,C., Coughlin,T.M., Aggarwal,A., Lyden,S., Mani,K.,
            Bjorck,M., Wanhainen,A., Bhandari,R., Lipworth-Elliot,L.,
            Robinson-Cohen,C., Caputo,F.J., Shim,S., Quesada,O., Tourdot,B.,
            Edwards,T.L., Tranter,M., Gardiner,E.E., Mackman,N., Cameron,S.J.
            and Owens,A.P. 3rd.
  TITLE     Soluble glycoprotein VI predicts abdominal aortic aneurysm growth
            rate and is a novel therapeutic target
  JOURNAL   Blood 144 (16), 1663-1678 (2024)
   PUBMED   38900973
  REMARK    GeneRIF: Soluble glycoprotein VI predicts abdominal aortic aneurysm
            growth rate and is a novel therapeutic target.
REFERENCE   2  (bases 1 to 2264)
  AUTHORS   Rudran,T., Antoniak,S., Flick,M.J., Ginsberg,M.H., Wolberg,A.S.,
            Bergmeier,W. and Lee,R.H.
  TITLE     Protease-activated receptors and glycoprotein VI cooperatively
            drive the platelet component in thromboelastography
  JOURNAL   J Thromb Haemost 21 (8), 2236-2247 (2023)
   PUBMED   37068592
  REMARK    GeneRIF: Protease-activated receptors and glycoprotein VI
            cooperatively drive the platelet component in thromboelastography.
REFERENCE   3  (bases 1 to 2264)
  AUTHORS   Zhang,P., Solari,F.A., Heemskerk,J.W.M., Kuijpers,M.J.E.,
            Sickmann,A., Walter,U. and Jurk,K.
  TITLE     Differential Regulation of GPVI-Induced Btk and Syk Activation by
            PKC, PKA and PP2A in Human Platelets
  JOURNAL   Int J Mol Sci 24 (9), 7776 (2023)
   PUBMED   37175486
  REMARK    GeneRIF: Differential Regulation of GPVI-Induced Btk and Syk
            Activation by PKC, PKA and PP2A in Human Platelets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2264)
  AUTHORS   Bigalke,B., Kramer,B.F., Seizer,P., Fateh-Moghadam,S., Gawaz,M. and
            Lindemann,S.
  TITLE     Diagnostic and therapeutic potentials of platelet glycoprotein VI
  JOURNAL   Semin Thromb Hemost 36 (2), 203-211 (2010)
   PUBMED   20414836
  REMARK    GeneRIF: [review]role of GP6 in platelet activation and blood
            clotting; blockade of collagen binding to GPVI
            Review article
REFERENCE   5  (bases 1 to 2264)
  AUTHORS   Dumont,B., Lasne,D., Rothschild,C., Bouabdelli,M., Ollivier,V.,
            Oudin,C., Ajzenberg,N., Grandchamp,B. and Jandrot-Perrus,M.
  TITLE     Absence of collagen-induced platelet activation caused by compound
            heterozygous GPVI mutations
  JOURNAL   Blood 114 (9), 1900-1903 (2009)
   PUBMED   19549989
REFERENCE   6  (bases 1 to 2264)
  AUTHORS   Ezumi,Y., Uchiyama,T. and Takayama,H.
  TITLE     Molecular cloning, genomic structure, chromosomal localization, and
            alternative splice forms of the platelet collagen receptor
            glycoprotein VI
  JOURNAL   Biochem Biophys Res Commun 277 (1), 27-36 (2000)
   PUBMED   11027634
REFERENCE   7  (bases 1 to 2264)
  AUTHORS   Jandrot-Perrus,M., Busfield,S., Lagrue,A.H., Xiong,X., Debili,N.,
            Chickering,T., Le Couedic,J.P., Goodearl,A., Dussault,B.,
            Fraser,C., Vainchenker,W. and Villeval,J.L.
  TITLE     Cloning, characterization, and functional studies of human and
            mouse glycoprotein VI: a platelet-specific collagen receptor from
            the immunoglobulin superfamily
  JOURNAL   Blood 96 (5), 1798-1807 (2000)
   PUBMED   10961879
REFERENCE   8  (bases 1 to 2264)
  AUTHORS   Peters,J.D., Furlong,M.T., Asai,D.J., Harrison,M.L. and
            Geahlen,R.L.
  TITLE     Syk, activated by cross-linking the B-cell antigen receptor,
            localizes to the cytosol where it interacts with and phosphorylates
            alpha-tubulin on tyrosine
  JOURNAL   J Biol Chem 271 (9), 4755-4762 (1996)
   PUBMED   8617742
REFERENCE   9  (bases 1 to 2264)
  AUTHORS   Huang,M.M., Bolen,J.B., Barnwell,J.W., Shattil,S.J. and Brugge,J.S.
  TITLE     Membrane glycoprotein IV (CD36) is physically associated with the
            Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7844-7848 (1991)
   PUBMED   1715582
REFERENCE   10 (bases 1 to 2264)
  AUTHORS   Moroi,M., Jung,S.M., Okuma,M. and Shinmyozu,K.
  TITLE     A patient with platelets deficient in glycoprotein VI that lack
            both collagen-induced aggregation and adhesion
  JOURNAL   J Clin Invest 84 (5), 1440-1445 (1989)
   PUBMED   2808700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB043819.1 and AC011476.8.
            
            On Dec 6, 2013 this sequence version replaced NM_016363.4.
            
            Summary: This gene encodes a platelet membrane glycoprotein of the
            immunoglobulin superfamily. The encoded protein is a receptor for
            collagen and plays a critical role in collagen-induced platelet
            aggregation and thrombus formation. The encoded protein forms a
            complex with the Fc receptor gamma-chain that initiates the
            platelet activation signaling cascade upon collagen binding.
            Mutations in this gene are a cause of platelet-type bleeding
            disorder-11 (BDPLT11). Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1, that results in a
            frameshift. It encodes isoform 2 which has a shorter and distinct
            C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB043819.1, BC111963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529, SAMN03465405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417454.5/ ENSP00000394922.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               AB043819.1         1-511
            512-604             AC011476.8         130358-130450       c
            605-682             AB043819.1         605-682
            683-683             AC011476.8         127973-127973       c
            684-736             AB043819.1         684-736
            737-737             AC011476.8         121413-121413       c
            738-772             AB043819.1         738-772
            773-773             AC011476.8         118459-118459       c
            774-963             AB043819.1         774-963
            964-2264            AC011476.8         116451-117751       c
FEATURES             Location/Qualifiers
     source          1..2264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2264
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /note="glycoprotein VI platelet"
                     /db_xref="GeneID:51206"
                     /db_xref="HGNC:HGNC:14388"
                     /db_xref="MIM:605546"
     exon            1..62
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1048
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; platelet collagen receptor; glycoprotein 6"
                     /codon_start=1
                     /product="platelet glycoprotein VI isoform 2 precursor"
                     /protein_id="NP_057447.5"
                     /db_xref="CCDS:CCDS46184.1"
                     /db_xref="GeneID:51206"
                     /db_xref="HGNC:HGNC:14388"
                     /db_xref="MIM:605546"
                     /translation="MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPV
                     TLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQ
                     LELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERW
                     YRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPS
                     PVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGPARQYYTKGNLVRICLG
                     AVILIILAGFLAEDWHSRRKRLRHRGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHS
                     RGLCS"
     exon            63..95
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            96..353
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            354..638
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            639..692
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            693..752
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            753..803
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            804..2264
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /note="hexamer: CATAAA"
     polyA_site      1992
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /note="major polyA site"
ORIGIN      
        1 acagagctca ggacagggct gaggaaccat gtctccatcc ccgaccgccc tcttctgtct
       61 tgggctgtgt ctggggcgtg tgccagcgca gagtggaccg ctccccaagc cctccctcca
      121 ggctctgccc agctccctgg tgcccctgga gaagccagtg accctccggt gccagggacc
      181 tccgggcgtg gacctgtacc gcctggagaa gctgagttcc agcaggtacc aggatcaggc
      241 agtcctcttc atcccggcca tgaagagaag tctggctgga cgctaccgct gctcctacca
      301 gaacggaagc ctctggtccc tgcccagcga ccagctggag ctcgttgcca cgggagtttt
      361 tgccaaaccc tcgctctcag cccagcccgg cccggcggtg tcgtcaggag gggacgtaac
      421 cctacagtgt cagactcggt atggctttga ccaatttgct ctgtacaagg aaggggaccc
      481 tgcgccctac aagaatcccg agagatggta cagggctagt tttcccatca tcacggtgac
      541 cgccgcccac agcggaacct accgatgcta cagcttctcc agcagggacc catacctgtg
      601 gtcagccccc agcgaccccc tggagcttgt ggtcacagga acctctgtga cccccagccg
      661 gttaccaaca gaaccacctt ccccggtagc agaattctca gaagccaccg ctgaactgac
      721 cgtctcattc acaaacgaag tcttcacaac tgagacttct aggagtatca ccgccagtcc
      781 aaaggagtca gactctccag ctggtcctgc ccgccagtac tacaccaagg gcaacctggt
      841 ccggatatgc ctcggggctg tgatcctaat aatcctggcg gggtttctgg cagaggactg
      901 gcacagccgg aggaagcgcc tgcggcacag gggcagggct gtgcagaggc cgcttccgcc
      961 cctcccgccc ctcccgctga cccggaaatc aaacgggggt caggatggag gccgacagga
     1021 tgttcacagc cgcgggttat gttcatgacc gctgaacccc aggcacggtc gtatccaagg
     1081 gagggatcat ggcatgggag gcgactcaaa gactggcgtg tgtggagcgt ggaagcagga
     1141 gggcagaggc tacagctgtg gaaacgaggc catgctgcct cctcctggtg ttccatcagg
     1201 gagccgttcg gccagtgtct gtctgtctgt ctgcctctct gtctgagggc accctccatt
     1261 tgggatggaa ggaatctgtg gagaccccat cctcctccct gcacactgtg gatgacatgg
     1321 taccctggct ggaccacata ctggcctctt tcttcaacct ctctaatatg ggctccagac
     1381 ggatctctaa ggttcccagc tctcagggtt gactctgttc catcctctgt gcaaaatcct
     1441 cccgtgcttc cctttggccc tctgtgctct tgtctggttt tccccagaaa ctctcaccct
     1501 cactccatct cccactgcgg tctaacaaat ctcctttcgt ctctcagaac gggtcttgca
     1561 ggcagtttgg gtatgtcatt cattttcctt agtgtaaaac tagcacgttg cccgcttccc
     1621 ttcacattag aaaacaagat cagcctgtgc aacatggtga aacctcatct ctaccaacaa
     1681 aacaaaaaaa cacaaaaatt agccaggtgt ggtggtgcat ccctatactc ccagcaactc
     1741 agggggctga ggtgggagaa tggcttgagc ctgggaggca gaggttgcag tgagctgaga
     1801 tcacaccact gcactctagc tcgggtgacg aagcctgact ttgtctcaaa aaatacaggg
     1861 atgaatatgt caattaccct gatttgatca tagcacgttg tatacatgta ctgcaatatt
     1921 gctgtccacc ccataaatat gtacaattct gtatacattt ttaaaatcat aaaaataaga
     1981 taatgcaccg tctccacccc tctcatattt actttctgaa ggaaatgtta ggtcttctca
     2041 aggtaaagtt ctatatttat tatagcgttt aggcatttct tgaccatcta atgagtgtaa
     2101 aactgtacca ctgggccaag tgcagtggat catgtctgta atcctagcac tgtgggaggc
     2161 caaggcagga ggatcgcttg agcccaggag ttcaagacca gcctgggcaa catagtgaga
     2221 ccccatctct acttaaaata aagaagataa aaattgtttt aaaa
//
