LOCUS       NM_001083899            2268 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens glycoprotein VI platelet (GP6), transcript variant 1,
            mRNA.
ACCESSION   NM_001083899
VERSION     NM_001083899.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2268)
  AUTHORS   Benson,T.W., Pike,M.M., Spuzzillo,A., Hicks,S.M., Ali,S., Pham,M.,
            Mix,D.S., Brunner,S.I., Wadding-Lee,C., Conrad,K.A., Russell,H.M.,
            Jennings,C., Coughlin,T.M., Aggarwal,A., Lyden,S., Mani,K.,
            Bjorck,M., Wanhainen,A., Bhandari,R., Lipworth-Elliot,L.,
            Robinson-Cohen,C., Caputo,F.J., Shim,S., Quesada,O., Tourdot,B.,
            Edwards,T.L., Tranter,M., Gardiner,E.E., Mackman,N., Cameron,S.J.
            and Owens,A.P. 3rd.
  TITLE     Soluble glycoprotein VI predicts abdominal aortic aneurysm growth
            rate and is a novel therapeutic target
  JOURNAL   Blood 144 (16), 1663-1678 (2024)
   PUBMED   38900973
  REMARK    GeneRIF: Soluble glycoprotein VI predicts abdominal aortic aneurysm
            growth rate and is a novel therapeutic target.
REFERENCE   2  (bases 1 to 2268)
  AUTHORS   Rudran,T., Antoniak,S., Flick,M.J., Ginsberg,M.H., Wolberg,A.S.,
            Bergmeier,W. and Lee,R.H.
  TITLE     Protease-activated receptors and glycoprotein VI cooperatively
            drive the platelet component in thromboelastography
  JOURNAL   J Thromb Haemost 21 (8), 2236-2247 (2023)
   PUBMED   37068592
  REMARK    GeneRIF: Protease-activated receptors and glycoprotein VI
            cooperatively drive the platelet component in thromboelastography.
REFERENCE   3  (bases 1 to 2268)
  AUTHORS   Zhang,P., Solari,F.A., Heemskerk,J.W.M., Kuijpers,M.J.E.,
            Sickmann,A., Walter,U. and Jurk,K.
  TITLE     Differential Regulation of GPVI-Induced Btk and Syk Activation by
            PKC, PKA and PP2A in Human Platelets
  JOURNAL   Int J Mol Sci 24 (9), 7776 (2023)
   PUBMED   37175486
  REMARK    GeneRIF: Differential Regulation of GPVI-Induced Btk and Syk
            Activation by PKC, PKA and PP2A in Human Platelets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2268)
  AUTHORS   Bigalke,B., Kramer,B.F., Seizer,P., Fateh-Moghadam,S., Gawaz,M. and
            Lindemann,S.
  TITLE     Diagnostic and therapeutic potentials of platelet glycoprotein VI
  JOURNAL   Semin Thromb Hemost 36 (2), 203-211 (2010)
   PUBMED   20414836
  REMARK    GeneRIF: [review]role of GP6 in platelet activation and blood
            clotting; blockade of collagen binding to GPVI
            Review article
REFERENCE   5  (bases 1 to 2268)
  AUTHORS   Dumont,B., Lasne,D., Rothschild,C., Bouabdelli,M., Ollivier,V.,
            Oudin,C., Ajzenberg,N., Grandchamp,B. and Jandrot-Perrus,M.
  TITLE     Absence of collagen-induced platelet activation caused by compound
            heterozygous GPVI mutations
  JOURNAL   Blood 114 (9), 1900-1903 (2009)
   PUBMED   19549989
REFERENCE   6  (bases 1 to 2268)
  AUTHORS   Ezumi,Y., Uchiyama,T. and Takayama,H.
  TITLE     Molecular cloning, genomic structure, chromosomal localization, and
            alternative splice forms of the platelet collagen receptor
            glycoprotein VI
  JOURNAL   Biochem Biophys Res Commun 277 (1), 27-36 (2000)
   PUBMED   11027634
REFERENCE   7  (bases 1 to 2268)
  AUTHORS   Jandrot-Perrus,M., Busfield,S., Lagrue,A.H., Xiong,X., Debili,N.,
            Chickering,T., Le Couedic,J.P., Goodearl,A., Dussault,B.,
            Fraser,C., Vainchenker,W. and Villeval,J.L.
  TITLE     Cloning, characterization, and functional studies of human and
            mouse glycoprotein VI: a platelet-specific collagen receptor from
            the immunoglobulin superfamily
  JOURNAL   Blood 96 (5), 1798-1807 (2000)
   PUBMED   10961879
REFERENCE   8  (bases 1 to 2268)
  AUTHORS   Peters,J.D., Furlong,M.T., Asai,D.J., Harrison,M.L. and
            Geahlen,R.L.
  TITLE     Syk, activated by cross-linking the B-cell antigen receptor,
            localizes to the cytosol where it interacts with and phosphorylates
            alpha-tubulin on tyrosine
  JOURNAL   J Biol Chem 271 (9), 4755-4762 (1996)
   PUBMED   8617742
REFERENCE   9  (bases 1 to 2268)
  AUTHORS   Huang,M.M., Bolen,J.B., Barnwell,J.W., Shattil,S.J. and Brugge,J.S.
  TITLE     Membrane glycoprotein IV (CD36) is physically associated with the
            Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7844-7848 (1991)
   PUBMED   1715582
REFERENCE   10 (bases 1 to 2268)
  AUTHORS   Moroi,M., Jung,S.M., Okuma,M. and Shinmyozu,K.
  TITLE     A patient with platelets deficient in glycoprotein VI that lack
            both collagen-induced aggregation and adhesion
  JOURNAL   J Clin Invest 84 (5), 1440-1445 (1989)
   PUBMED   2808700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB043821.1 and AC011476.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 6, 2013 this sequence version replaced NM_001083899.1.
            
            Summary: This gene encodes a platelet membrane glycoprotein of the
            immunoglobulin superfamily. The encoded protein is a receptor for
            collagen and plays a critical role in collagen-induced platelet
            aggregation and thrombus formation. The encoded protein forms a
            complex with the Fc receptor gamma-chain that initiates the
            platelet activation signaling cascade upon collagen binding.
            Mutations in this gene are a cause of platelet-type bleeding
            disorder-11 (BDPLT11). Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB043821.1, BC069485.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               AB043821.1         1-511
            512-604             AC011476.8         130358-130450       c
            605-682             AB043821.1         605-682
            683-683             AC011476.8         127973-127973       c
            684-736             AB043821.1         684-736
            737-737             AC011476.8         121413-121413       c
            738-772             AB043821.1         738-772
            773-773             AC011476.8         118459-118459       c
            774-967             AB043821.1         774-967
            968-2268            AC011476.8         116451-117751       c
FEATURES             Location/Qualifiers
     source          1..2268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2268
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /note="glycoprotein VI platelet"
                     /db_xref="GeneID:51206"
                     /db_xref="HGNC:HGNC:14388"
                     /db_xref="MIM:605546"
     exon            1..62
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1891
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; platelet collagen receptor; glycoprotein 6"
                     /codon_start=1
                     /product="platelet glycoprotein VI isoform 1 precursor"
                     /protein_id="NP_001077368.2"
                     /db_xref="CCDS:CCDS42626.1"
                     /db_xref="GeneID:51206"
                     /db_xref="HGNC:HGNC:14388"
                     /db_xref="MIM:605546"
                     /translation="MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPV
                     TLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQ
                     LELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERW
                     YRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPS
                     PVAEFSEATAELTVSFTNEVFTTETSRSITASPKESDSPAGESCPPVLHQGQPGPDMP
                     RGCDPNNPGGVSGRGLAQPEEAPAAQGQGCAEAASAPPAPPADPEIKRGSGWRPTGCS
                     QPRVMFMTAEPQARSYPREGSWHGRRLKDWRVWSVEAGGQRLQLWKRGHAASSWCSIR
                     EPFGQCLSVCLPLCLRAPSIWDGRNLWRPHPPPCTLWMTWYPGWTTYWPLSSTSLIWA
                     PDGSLRFPALRVDSVPSSVQNPPVLPFGPLCSCLVFPRNSHPHSISHCGLTNLLSSLR
                     TGLAGSLGMSFIFLSVKLARCPLPFTLENKISLCNMVKPHLYQQNKKTQKLARCGGAS
                     LYSQQLRGLRWENGLSLGGRGCSELRSHHCTLARVTKPDFVSKNTGMNMSITLI"
     exon            63..95
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            96..353
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            354..638
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            639..692
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            693..752
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            753..807
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     exon            808..2268
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /note="hexamer: CATAAA"
     polyA_site      1996
                     /gene="GP6"
                     /gene_synonym="BDPLT11; GPIV; GPVI"
                     /note="major polyA site"
ORIGIN      
        1 acagagctca ggacagggct gaggaaccat gtctccatcc ccgaccgccc tcttctgtct
       61 tgggctgtgt ctggggcgtg tgccagcgca gagtggaccg ctccccaagc cctccctcca
      121 ggctctgccc agctccctgg tgcccctgga gaagccagtg accctccggt gccagggacc
      181 tccgggcgtg gacctgtacc gcctggagaa gctgagttcc agcaggtacc aggatcaggc
      241 agtcctcttc atcccggcca tgaagagaag tctggctgga cgctaccgct gctcctacca
      301 gaacggaagc ctctggtccc tgcccagcga ccagctggag ctcgttgcca cgggagtttt
      361 tgccaaaccc tcgctctcag cccagcccgg cccggcggtg tcgtcaggag gggacgtaac
      421 cctacagtgt cagactcggt atggctttga ccaatttgct ctgtacaagg aaggggaccc
      481 tgcgccctac aagaatcccg agagatggta cagggctagt tttcccatca tcacggtgac
      541 cgccgcccac agcggaacct accgatgcta cagcttctcc agcagggacc catacctgtg
      601 gtcagccccc agcgaccccc tggagcttgt ggtcacagga acctctgtga cccccagccg
      661 gttaccaaca gaaccacctt ccccggtagc agaattctca gaagccaccg ctgaactgac
      721 cgtctcattc acaaacgaag tcttcacaac tgagacttct aggagtatca ccgccagtcc
      781 aaaggagtca gactctccag ctggtgagtc ctgcccgcca gtactacacc aagggcaacc
      841 tggtccggat atgcctcggg gctgtgatcc taataatcct ggcggggttt ctggcagagg
      901 actggcacag ccggaggaag cgcctgcggc acaggggcag ggctgtgcag aggccgcttc
      961 cgcccctccc gcccctcccg ctgacccgga aatcaaacgg gggtcaggat ggaggccgac
     1021 aggatgttca cagccgcggg ttatgttcat gaccgctgaa ccccaggcac ggtcgtatcc
     1081 aagggaggga tcatggcatg ggaggcgact caaagactgg cgtgtgtgga gcgtggaagc
     1141 aggagggcag aggctacagc tgtggaaacg aggccatgct gcctcctcct ggtgttccat
     1201 cagggagccg ttcggccagt gtctgtctgt ctgtctgcct ctctgtctga gggcaccctc
     1261 catttgggat ggaaggaatc tgtggagacc ccatcctcct ccctgcacac tgtggatgac
     1321 atggtaccct ggctggacca catactggcc tctttcttca acctctctaa tatgggctcc
     1381 agacggatct ctaaggttcc cagctctcag ggttgactct gttccatcct ctgtgcaaaa
     1441 tcctcccgtg cttccctttg gccctctgtg ctcttgtctg gttttcccca gaaactctca
     1501 ccctcactcc atctcccact gcggtctaac aaatctcctt tcgtctctca gaacgggtct
     1561 tgcaggcagt ttgggtatgt cattcatttt ccttagtgta aaactagcac gttgcccgct
     1621 tcccttcaca ttagaaaaca agatcagcct gtgcaacatg gtgaaacctc atctctacca
     1681 acaaaacaaa aaaacacaaa aattagccag gtgtggtggt gcatccctat actcccagca
     1741 actcaggggg ctgaggtggg agaatggctt gagcctggga ggcagaggtt gcagtgagct
     1801 gagatcacac cactgcactc tagctcgggt gacgaagcct gactttgtct caaaaaatac
     1861 agggatgaat atgtcaatta ccctgatttg atcatagcac gttgtataca tgtactgcaa
     1921 tattgctgtc caccccataa atatgtacaa ttctgtatac atttttaaaa tcataaaaat
     1981 aagataatgc accgtctcca cccctctcat atttactttc tgaaggaaat gttaggtctt
     2041 ctcaaggtaa agttctatat ttattatagc gtttaggcat ttcttgacca tctaatgagt
     2101 gtaaaactgt accactgggc caagtgcagt ggatcatgtc tgtaatccta gcactgtggg
     2161 aggccaaggc aggaggatcg cttgagccca ggagttcaag accagcctgg gcaacatagt
     2221 gagaccccat ctctacttaa aataaagaag ataaaaattg ttttaaaa
//
