LOCUS       NM_004488               3493 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens glycoprotein V platelet (GP5), mRNA.
ACCESSION   NM_004488
VERSION     NM_004488.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3493)
  AUTHORS   Xiang,K., Yanshan,H., Chunmei,Z., Minmin,G., Yan,W. and Xiaojia,Y.
  TITLE     GP5 regulates epithelial-mesenchymal transition in breast cancer
            via the PI3K/AKT signaling pathway
  JOURNAL   Exp Biol Med (Maywood) 247 (17), 1501-1517 (2022)
   PUBMED   35880886
  REMARK    GeneRIF: GP5 regulates epithelial-mesenchymal transition in breast
            cancer via the PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 3493)
  AUTHORS   Andrews,R.K. and Berndt,M.C.
  TITLE     Bernard-Soulier syndrome: an update
  JOURNAL   Semin Thromb Hemost 39 (6), 656-662 (2013)
   PUBMED   23929303
  REMARK    GeneRIF: Studies indicate that platelets from Bernard-Soulier
            syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a
            platelet-specific adhesion-signaling complex, composed of GPIbalpha
            disulfide linked to GPIbbeta, and noncovalently associated with
            GPIX and GPV.
            Review article
REFERENCE   3  (bases 1 to 3493)
  AUTHORS   Sivaraman,B. and Latour,R.A.
  TITLE     Delineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet
            receptors in mediating platelet adhesion to adsorbed fibrinogen and
            albumin
  JOURNAL   Biomaterials 32 (23), 5365-5370 (2011)
   PUBMED   21529934
  REMARK    GeneRIF: GPIIb/IIIa is the primary receptor set involved in
            platelet adhesion to adsorbed fibrinogen and serum albumin
            irrespective of their degree of adsorption-induced unfolding, while
            the GPIb-IX-V receptor complex plays an insignificant role.
REFERENCE   4  (bases 1 to 3493)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 3493)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3493)
  AUTHORS   Hickey,M.J., Hagen,F.S., Yagi,M. and Roth,G.J.
  TITLE     Human platelet glycoprotein V: characterization of the polypeptide
            and the related Ib-V-IX receptor system of adhesive, leucine-rich
            glycoproteins
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8327-8331 (1993)
   PUBMED   7690959
REFERENCE   7  (bases 1 to 3493)
  AUTHORS   Modderman,P.W., Admiraal,L.G., Sonnenberg,A. and von dem Borne,A.E.
  TITLE     Glycoproteins V and Ib-IX form a noncovalent complex in the
            platelet membrane
  JOURNAL   J Biol Chem 267 (1), 364-369 (1992)
   PUBMED   1730602
REFERENCE   8  (bases 1 to 3493)
  AUTHORS   Kroll,M.H., Harris,T.S., Moake,J.L., Handin,R.I. and Schafer,A.I.
  TITLE     von Willebrand factor binding to platelet GpIb initiates signals
            for platelet activation
  JOURNAL   J Clin Invest 88 (5), 1568-1573 (1991)
   PUBMED   1939645
REFERENCE   9  (bases 1 to 3493)
  AUTHORS   Roth,G.J., Church,T.A., McMullen,B.A. and Williams,S.A.
  TITLE     Human platelet glycoprotein V: a surface leucine-rich glycoprotein
            related to adhesion
  JOURNAL   Biochem Biophys Res Commun 170 (1), 153-161 (1990)
   PUBMED   2372284
REFERENCE   10 (bases 1 to 3493)
  AUTHORS   Shimomura,T., Fujimura,K., Maehama,S., Takemoto,M., Oda,K.,
            Fujimoto,T., Oyama,R., Suzuki,M., Ichihara-Tanaka,K., Titani,K. et
            al.
  TITLE     Rapid purification and characterization of human platelet
            glycoprotein V: the amino acid sequence contains leucine-rich
            repetitive modules as in glycoprotein Ib
  JOURNAL   Blood 75 (12), 2349-2356 (1990)
   PUBMED   2350580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125362.6.
            
            On Jul 20, 2006 this sequence version replaced NM_004488.1.
            
            Summary: Human platelet glycoprotein V (GP5) is a part of the
            Ib-V-IX system of surface glycoproteins that constitute the
            receptor for von Willebrand factor (VWF; MIM 613160) and mediate
            the adhesion of platelets to injured vascular surfaces in the
            arterial circulation, a critical initiating event in hemostasis.
            The main portion of the receptor is a heterodimer composed of 2
            polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta
            chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The
            complete receptor complex includes noncovalent association of the
            alpha and beta subunits with platelet glycoprotein IX (GP9; MIM
            173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown
            to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder
            (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM,
            Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: L11238.1, BM145911.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2152798, SAMN03465405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000692618.1/ ENSP00000509337.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC125362.6         63459-63487         c
            30-3493             AC125362.6         59042-62505         c
FEATURES             Location/Qualifiers
     source          1..3493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..3493
                     /gene="GP5"
                     /gene_synonym="CD42d; GPV"
                     /note="glycoprotein V platelet"
                     /db_xref="GeneID:2814"
                     /db_xref="HGNC:HGNC:4443"
                     /db_xref="MIM:173511"
     exon            1..29
                     /gene="GP5"
                     /gene_synonym="CD42d; GPV"
                     /inference="alignment:Splign:2.1.0"
     exon            30..3493
                     /gene="GP5"
                     /gene_synonym="CD42d; GPV"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1714
                     /gene="GP5"
                     /gene_synonym="CD42d; GPV"
                     /note="platelet glycoprotein V; glycoprotein 5"
                     /codon_start=1
                     /product="platelet glycoprotein V precursor"
                     /protein_id="NP_004479.1"
                     /db_xref="CCDS:CCDS3307.1"
                     /db_xref="GeneID:2814"
                     /db_xref="HGNC:HGNC:4443"
                     /db_xref="MIM:173511"
                     /translation="MLRGTLLCAVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARIS
                     ALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKT
                     LRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDF
                     LPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLG
                     ALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFEN
                     PLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGA
                     FQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESV
                     QLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPR
                     CAGPGAHAGLPLWALPGGDAECPGPRGPPPRPAADSSSEAPVHPALAPNSSEPWVWAQ
                     PVTTGKGQDHSPFWGFYFLLLAVQAMITVIIVFAMIKIGQLFRKLIRERALG"
ORIGIN      
        1 agttactttg gagtgcagaa ccatttcaga catgctgagg gggactctac tgtgcgcggt
       61 gctcgggctt ctgcgcgccc agcccttccc ctgtccgcca gcttgcaagt gtgtcttccg
      121 ggacgccgcg cagtgctcgg ggggcgacgt ggcgcgcatc tccgcgctag gcctgcccac
      181 caacctcacg cacatcctgc tcttcggaat gggccgcggc gtcctgcaga gccagagctt
      241 cagcggcatg accgtcctgc agcgcctcat gatctccgac agccacattt ccgccgttgc
      301 ccccggcacc ttcagtgacc tgataaaact gaaaaccctg aggctgtcgc gcaacaaaat
      361 cacgcatctt ccaggtgcgc tgctggataa gatggtgctc ctggagcagt tgtttttgga
      421 ccacaatgcg ctaaggggca ttgaccaaaa catgtttcag aaactggtta acctgcagga
      481 gctcgctctg aaccagaatc agctcgattt ccttcctgcc agtctcttca cgaatctgga
      541 gaacctgaag ttgttggatt tatcgggaaa caacctgacc cacctgccca aggggttgct
      601 tggagcacag gctaagctcg agagacttct gctccactcg aaccgccttg tgtctctgga
      661 ttcggggctg ttgaacagcc tgggcgccct gacggagctg cagttccacc gaaatcacat
      721 ccgttccatc gcacccgggg ccttcgaccg gctcccaaac ctcagttctt tgacgctttc
      781 gagaaaccac cttgcgtttc tcccctctgc gctctttctt cattcgcaca atctgactct
      841 gttgactctg ttcgagaacc cgctggcaga gctcccgggg gtgctcttcg gggagatggg
      901 gggcctgcag gagctgtggc tgaaccgcac ccagctgcgc accctgcccg ccgccgcctt
      961 ccgcaacctg agccgcctgc ggtacttagg ggtgactctg agcccgcggc tgagcgcgct
     1021 tccgcagggc gccttccagg gccttggcga gctccaggtg ctcgccctgc actccaacgg
     1081 cctgaccgcc ctccccgacg gcttgctgcg cggcctcggc aagctgcgcc aggtgtccct
     1141 gcgccgcaac aggctgcgcg ccctgccccg tgccctcttc cgcaatctca gcagcctgga
     1201 gagcgtccag ctcgaccaca accagctgga gaccctgcct ggcgacgtgt ttggggctct
     1261 gccccggctg acggaggtcc tgttggggca caactcctgg cgctgcgact gtggcctggg
     1321 gcccttcctg gggtggctgc ggcagcacct aggcctcgtg ggcggggaag agcccccacg
     1381 gtgcgcaggc cctggggcgc acgccggcct gccgctctgg gccctgccgg ggggtgacgc
     1441 ggagtgcccg ggcccccggg gcccgcctcc ccgccccgct gcggacagct cctcggaagc
     1501 ccctgtccac ccagccttgg ctcccaacag ctcagaaccc tgggtgtggg cccagccggt
     1561 gaccacgggc aaaggtcaag atcatagtcc gttctggggg ttttattttc tgcttttagc
     1621 tgttcaggcc atgatcaccg tgatcatcgt gtttgctatg attaaaattg gccaactctt
     1681 tcgaaaatta atcagagaga gagcccttgg gtaaaccaat gggaaaatct tctaattact
     1741 tagaacctga ccagatgtgg ctcggagggg aatccagacc cgctgctgtc ttgctctccc
     1801 tcccctcccc actcctcctc tcttcttcct cttctctctc actgccacgc cttcctttcc
     1861 ctcctcctcc ccctctccgc tctgtgctct tcattctcac aggcccgcaa cccctcctct
     1921 ctgtgtcccc cgcccgttcc tggaaactga gcttgacgtt tgtaaactgt ggttgcctgc
     1981 cttccccagc tcccacgcgg gtgtgcgctg acactgccgg gggcgctgga ctgtgttgga
     2041 cccatccgtg ctccgctgtg cctggcttgg cgtctggtgg agagaggggc ctcttcagtg
     2101 tctactgagt aaggggacag ctccaggccg gggcctgtct cctgcacaga gtaagccggt
     2161 aaatgtttgt gaaatcaatg cgtggataaa ggaacacatg ccatccaagt gatgatggct
     2221 tttcctggag ggaaaggata ggctgttgct ctatctaatt ttttgttttt gtttttggac
     2281 agtctagctc tgtggcccag gctggcgtgc agtgggccgt ctcagttcac tgcagcctcc
     2341 gcctcccagg ttcaagtgat tctcatgcct cagcgttctg agtagctggg attagaggcg
     2401 tgtgccacta cacccggcta atttttgtac tttttaaagt agagacgggg ctttgccata
     2461 ttggcctggc tgatctcaaa ctcctggtct tgaactcctg gccacaagtg atctgcccgc
     2521 cttggcctcc caaagtgctg ggattacagg cgtaagccac tacacctggc cctcttcatc
     2581 gaattttatt tgagaagtag agctcttgcc attttttccc ttgctccatt tttctcactt
     2641 tatgtctctc tgacctatgg gctacttggg agagcactgg actccattca tgcatgagca
     2701 ttttcaggat aagcgacttc tgtgaggctg agagaggaag aaaacacgga gccttccctc
     2761 caggtgccca gtgtaggtcc agcgtgtttc ctgagcctcc tgtgagtttc cacttgcttt
     2821 acatccatgc aacatgtcat tttgaaactg gattgatttg catttcctgg aactctgcca
     2881 cctcatttca caagcattta tggagcagtt aacatgtgac tggtattcat gaatataatg
     2941 ataagcttga ttctagttca gctgctgtca cagtctcatt tgttcttcca actgaaagcc
     3001 gtaaaacctt tgttgcttta attgaatgtc tgtgcttatg agaggcagtg gttaaaacag
     3061 gggctggcga gttgacaact gtgggttcaa atcccagctc taccacttac taactgcatg
     3121 ggactttggg taagacacct gcttacattc tctaagcctt ggtttcctga accttaaaac
     3181 aggataacat agtacctgct tcgtagagtt tttgtgagaa ttaaaggcaa taaagcatat
     3241 aatgacttag cccagcggcc tgcaggcaat acatgttaat gaatgttagc tattattact
     3301 aaaggatgag caattattat tggcatcatg atttctaaag aagagctttg agttggtatt
     3361 tttctctgtg tataagggta agtccgaact ttctcagact ggaggttaca ttcacatcag
     3421 tctgtcttcc cctgcggatg gcctcagccc tgggtggcca gactctgtgc tcacaatcca
     3481 gagcaatgga tcc
//
