LOCUS       NM_152413               1373 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens glutamic-oxaloacetic transaminase 1 like 1 (GOT1L1),
            mRNA.
ACCESSION   NM_152413
VERSION     NM_152413.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Matsuda,S., Katane,M., Maeda,K., Kaneko,Y., Saitoh,Y., Miyamoto,T.,
            Sekine,M. and Homma,H.
  TITLE     Biosynthesis of D-aspartate in mammals: the rat and human homologs
            of mouse aspartate racemase are not responsible for the
            biosynthesis of D-aspartate
  JOURNAL   Amino Acids 47 (5), 975-985 (2015)
   PUBMED   25646960
  REMARK    GeneRIF: The rat and human homologs of mouse GOT1L1 are not
            involved in D-aspartate biosynthesis.
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Martins-de-Souza,D., Guest,P.C., Mann,D.M., Roeber,S., Rahmoune,H.,
            Bauder,C., Kretzschmar,H., Volk,B., Baborie,A. and Bahn,S.
  TITLE     Proteomic analysis identifies dysfunction in cellular transport,
            energy, and protein metabolism in different brain regions of
            atypical frontotemporal lobar degeneration
  JOURNAL   J Proteome Res 11 (4), 2533-2543 (2012)
   PUBMED   22360420
  REMARK    GeneRIF: A protein encoded by this locus was found to be
            differentially expressed in postmortem brains from patients with
            atypical frontotemporal lobar degeneration.
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Chern,C.J.
  TITLE     Localization of the structural genes for hexokinase-1 and inorganic
            pyrophosphatase on region (pter-->q24) of human chromosome 10
  JOURNAL   Cytogenet Cell Genet 17 (6), 338-342 (1976)
   PUBMED   17494625
  REMARK    GeneRIF: Neither human hexokinase-1 nor human inorganic
            pyrophosphatase expression segregated concordantly with human
            cytoplasmic glutamic-oxaloacetic transaminase expression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC029504.1 and BM559469.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152413.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029504.1, SRR5189664.173989.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148093 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307599.5/ ENSP00000303077.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-762               BC029504.1         7-768
            763-790             BM559469.1         769-796
            791-1373            BC029504.1         797-1379
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..1373
                     /gene="GOT1L1"
                     /note="glutamic-oxaloacetic transaminase 1 like 1"
                     /db_xref="GeneID:137362"
                     /db_xref="HGNC:HGNC:28487"
     exon            1..210
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1361
                     /gene="GOT1L1"
                     /EC_number="2.6.1.1"
                     /note="transaminase A-like protein 1; glutamate
                     oxaloacetate transaminase 1-like protein 1"
                     /codon_start=1
                     /product="putative aspartate aminotransferase, cytoplasmic
                     2"
                     /protein_id="NP_689626.2"
                     /db_xref="CCDS:CCDS47839.1"
                     /db_xref="GeneID:137362"
                     /db_xref="HGNC:HGNC:28487"
                     /translation="MPTLSVFMDVPLAHKLEGSLLKTYKQDDYPNKIFLAYRVCMTNE
                     GHPWVSLVVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFGKHSQAIVENRVGG
                     VHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTVYEYSVWDPKK
                     LCMDPDILLNVVEQIPHGCVLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQG
                     LYTSDLEEDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQQLLCVLS
                     QLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQL
                     LGTPGSWGHITEQSGTHGYLGLNSQQVEYLVRKKHIYIPKNGQINFSCINANNINYIT
                     EGINEAVLLTESSEMCLPKEKKTLIGIKL"
     exon            211..392
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..504
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..614
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..707
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..858
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1024
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1167
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1373
                     /gene="GOT1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOT1L1"
                     /note="hexamer: AATAAA"
     polyA_site      1373
                     /gene="GOT1L1"
                     /note="major polyA site"
ORIGIN      
        1 aggactgccc ggcccagcct tggaggaaga cttctgggca gaagcggaac acaggagcag
       61 agacacatag tcttggctcc agtttcgttt cagttatgcc caccctttca gtgttcatgg
      121 atgtgcccct cgcccacaag ctagagggca gcttgttaaa gacctacaaa caagatgatt
      181 acccgaacaa gatattctta gcctatagag tctgcatgac aaatgaaggc catccctggg
      241 tttctctcgt ggtgcagaag actcgactac agatttcaca ggatccctcc ctgaattatg
      301 agtacttgcc caccatgggc ctgaaatcat tcatccaggc ctctctagca ctcctctttg
      361 gaaagcacag ccaagccatt gtggagaaca gggtaggggg tgtacacact gttggtgaca
      421 gtggtgcctt ccagcttggc gtccagtttc tcagagcttg gcataaggat gctcgtatag
      481 tttacatcat ctcttctcaa aaagaactgc atggactcgt cttccaggac atgggcttta
      541 cagtttatga atactctgtc tgggacccca agaagctatg catggacccc gacatactcc
      601 tcaatgtggt ggagcagatc ccacatggct gtgtccttgt gatggggaac attatcgact
      661 gcaagttgac accaagtggg tgggcaaagt tgatgtccat gataaagagc aagcagatat
      721 tcccattttt tgatattccc tgtcaaggtt tatacaccag tgacttggaa gaagatacta
      781 gaatcttaca atactttgtg tctcaaggct ttgagttctt ctgcagccag tctctgtcca
      841 agaattttgg catttatgat gaaggagtgg ggatgctagt ggtggtggca gtcaacaacc
      901 agcagctgct gtgtgtcctc tcccagctgg aaggattagc ccaggccctg tggctaaacc
      961 cccccaacac gggtgcacgt gtcatcacct ccatcctctg caaccctgct ctgctgggag
     1021 aatggaagca gagtctaaaa gaagttgtag agaacatcat gctaaccaag gaaaaagtga
     1081 aggagaaact ccagctcctg ggaacccctg ggtcctgggg tcacatcacc gagcagagtg
     1141 ggacccacgg ctatcttgga ctcaactccc agcaggtgga atacctggtc aggaagaagc
     1201 acatctatat ccccaagaac ggtcagatta acttcagctg tatcaatgcc aacaacataa
     1261 attacatcac tgagggcatc aatgaggctg tcctcctcac agagagctca gagatgtgtc
     1321 ttccaaagga aaaaaaaaca ctgattggaa taaaacttta gtctttgcaa aaa
//
