LOCUS       NM_001007025            5987 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens golgi SNAP receptor complex member 1 (GOSR1),
            transcript variant 2, mRNA.
ACCESSION   NM_001007025
VERSION     NM_001007025.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5987)
  AUTHORS   Li,M., Liu,R., Zhao,Y. and Liu,P.
  TITLE     Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and
            Diseases
  JOURNAL   Curr Protein Pept Sci 24 (4), 288-295 (2023)
   PUBMED   36924089
  REMARK    GeneRIF: Diverse Role of SNARE Protein GS28 in Vesicle Trafficking
            and Diseases.
            Review article
REFERENCE   2  (bases 1 to 5987)
  AUTHORS   Lee,S.H., Yoo,H.J., Rim,D.E., Cui,Y., Lee,A., Jung,E.S., Oh,S.T.,
            Kim,J.G., Kwon,O.J., Kim,S.Y. and Jeong,S.W.
  TITLE     Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts
            Prognosis in Colorectal Cancers
  JOURNAL   Int J Med Sci 14 (6), 515-522 (2017)
   PUBMED   28638266
  REMARK    GeneRIF: these results indicate that GS28 nuclear predominant
            expression could serve as a prognostic marker for colorectal cancer
            (CRC) and may help in identifying aggressive forms of CRC
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5987)
  AUTHORS   Cho,U., Kim,H.M., Park,H.S., Kwon,O.J., Lee,A. and Jeong,S.W.
  TITLE     Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts
            Worse Prognosis in Cervical Cancers
  JOURNAL   PLoS One 11 (9), e0162623 (2016)
   PUBMED   27611086
  REMARK    GeneRIF: High nuclear expression of GS28 is associated with poor
            prognosis in early-stage cervical cancer patients. GS28 might be a
            novel prognostic marker and a potential therapeutic target in
            cervical cancer treatment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5987)
  AUTHORS   Fusella,A., Micaroni,M., Di Giandomenico,D., Mironov,A.A. and
            Beznoussenko,G.V.
  TITLE     Segregation of the Qb-SNAREs GS27 and GS28 into Golgi vesicles
            regulates intra-Golgi transport
  JOURNAL   Traffic 14 (5), 568-584 (2013)
   PUBMED   23387339
  REMARK    GeneRIF: Golgi vesicles, presumably with COPI, serve to inhibit
            intra-Golgi transport by the extraction of GS27 and GS28 from the
            Golgi cisternae, which blocks the formation of inter-cisternal
            connections
REFERENCE   5  (bases 1 to 5987)
  AUTHORS   Sun,N.K., Huang,S.L., Chien,K.Y. and Chao,C.C.
  TITLE     Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming
            GS28-MDM2-p53 complexes and by preventing the ubiquitination and
            degradation of p53
  JOURNAL   Biochem J 444 (2), 303-314 (2012)
   PUBMED   22397410
  REMARK    GeneRIF: GS28 may potentiate cells to DNA-damage-induced apoptosis
            by inhibiting the ubiquitination and degradation of p53.
REFERENCE   6  (bases 1 to 5987)
  AUTHORS   Bui,T.D., Levy,E.R., Subramaniam,V.N., Lowe,S.L. and Hong,W.
  TITLE     cDNA characterization and chromosomal mapping of human golgi SNARE
            GS27 and GS28 to chromosome 17
  JOURNAL   Genomics 57 (2), 285-288 (1999)
   PUBMED   10198168
REFERENCE   7  (bases 1 to 5987)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
REFERENCE   8  (bases 1 to 5987)
  AUTHORS   Tang,B.L., Low,D.Y., Lee,S.S., Tan,A.E. and Hong,W.
  TITLE     Molecular cloning and localization of human syntaxin 16, a member
            of the syntaxin family of SNARE proteins
  JOURNAL   Biochem Biophys Res Commun 242 (3), 673-679 (1998)
   PUBMED   9464276
REFERENCE   9  (bases 1 to 5987)
  AUTHORS   Subramaniam,V.N., Peter,F., Philp,R., Wong,S.H. and Hong,W.
  TITLE     GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi
            transport
  JOURNAL   Science 272 (5265), 1161-1163 (1996)
   PUBMED   8638159
REFERENCE   10 (bases 1 to 5987)
  AUTHORS   Nagahama,M., Orci,L., Ravazzola,M., Amherdt,M., Lacomis,L.,
            Tempst,P., Rothman,J.E. and Sollner,T.H.
  TITLE     A v-SNARE implicated in intra-Golgi transport
  JOURNAL   J Cell Biol 133 (3), 507-516 (1996)
   PUBMED   8636227
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000606.1, BE785872.1,
            BC040471.1, CB054624.1, BC040072.2, AK074298.1 and AC011840.7.
            
            On Jun 2, 2019 this sequence version replaced NM_001007025.1.
            
            Summary: This gene encodes a trafficking membrane protein which
            transports proteins among the endoplasmic reticulum and the Golgi
            and between Golgi compartments. This protein is considered an
            essential component of the Golgi SNAP receptor (SNARE) complex.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) lacks an in-frame small
            segment of 6 nts in the 5' coding region, as compared to variant 1.
            The encoded isoform 2 thus lacks internal 2 aa, as compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.363494.1,
                                           SRR5189667.114343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451249.7/ ENSP00000414441.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AK000606.1         1-38
            39-457              BE785872.1         7-425
            458-815             AK000606.1         464-821
            816-2597            BC040471.1         803-2584
            2598-3003           CB054624.1         223-628
            3004-4906           BC040072.2         781-2683
            4907-4971           AK074298.1         1898-1962
            4972-5209           BC040072.2         2749-2986
            5210-5987           AC011840.7         58567-59344         c
FEATURES             Location/Qualifiers
     source          1..5987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..5987
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /note="golgi SNAP receptor complex member 1"
                     /db_xref="GeneID:9527"
                     /db_xref="HGNC:HGNC:4430"
                     /db_xref="MIM:604026"
     exon            1..57
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..773
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /note="isoform 2 is encoded by transcript variant 2; Golgi
                     SNARE 28 kDa; golgi integral membrane protein 2; 28 kDa
                     cis-Golgi SNARE p28; cis-golgi SNARE; 28 kDa Golgi SNARE
                     protein"
                     /codon_start=1
                     /product="Golgi SNAP receptor complex member 1 isoform 2"
                     /protein_id="NP_001007026.1"
                     /db_xref="CCDS:CCDS45643.1"
                     /db_xref="GeneID:9527"
                     /db_xref="HGNC:HGNC:4430"
                     /db_xref="MIM:604026"
                     /translation="MAAGTSSYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSTRD
                     GRRDSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAAL
                     MHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTEL
                     FLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQ
                     RINLRKRRDSLILGGVIGICTILLLLYAFH"
     exon            58..172
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     exon            173..260
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     exon            261..368
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     exon            369..460
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     exon            461..535
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     exon            536..565
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     exon            566..648
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     exon            649..5987
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4004..4009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /note="hexamer: AATAAA"
     polyA_site      4027
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /note="major polyA site"
     regulatory      5188..5193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /note="hexamer: AATAAA"
     polyA_site      5209
                     /gene="GOSR1"
                     /gene_synonym="GOLIM2; GOS-28; GOS28; GOS28/P28; GS28;
                     P28"
                     /note="major polyA site"
ORIGIN      
        1 atcccggctg acgttggacg acaaagatgg cggcagggac cagcagttac tgggaagatc
       61 tcaggaaaca ggctcgacag ctggaaaatg aacttgacct gaaactagtt tccttcagca
      121 aactatgtac aagttacagt catagcagta cccgagatgg aagacgcgac agttctgata
      181 caacacccct tttaaatgga tcaagccaag acagaatgtt tgagacaatg gcgattgaga
      241 ttgaacaact tttggcaagg cttacagggg taaatgataa aatggcagaa tataccaaca
      301 gtgcaggtgt cccctccttg aatgcagccc tgatgcatac attacagcgg catagagaca
      361 tattgcagga ttatacacat gaattccata aaaccaaagc aaactttatg gcaatacggg
      421 aaagggagaa tcttatggga tcagtacgaa aagatattga gtcatataaa agtgggtctg
      481 gagtaaacaa cagaagaact gagctatttt tgaaagaaca tgaccacctt cgaaactcag
      541 atcgtctgat agaagagaca ataagcattg ctatggcaac aaaagaaaat atgacttcac
      601 agagaggaat gttgaagtca attcacagca aaatgaacac tttggccaat cgttttcctg
      661 ctgtaaacag cctgatccag aggatcaacc tgaggaagcg gcgggactcg ctcatcctag
      721 ggggtgttat tgggatctgt accatcctgt tgctgctgta tgcgttccat tgatgggaca
      781 tcttcaggga ctcttgacag ccaccgcttt cacaccctgg tctggaataa ggaaacatcg
      841 gagggagaag ttgactgtct tgataattag cctgaccagc aggatgaatg caagactgac
      901 agtgatggac tctgtgacat ggtcaggttg agctgaagcc acagtttctc tgtgctgtgt
      961 tttctaacac atttttctgt ttttaattaa aaaaaaaaaa aaaaggtttt cagttgcttt
     1021 tgtctcccta ggaggcaggt aaaccaatca aaaacagagt tttctgtgtt tccatgatag
     1081 tgttgaagcc taatgacaag ccaggtctta cagctgggct cttcagaaaa ccaggtttct
     1141 acatccaaag actgcttttc ttttagctgc cagattggat tgtgaataaa aataattctt
     1201 ccctctccct ctccctctcc ccacggtctc cctctttcca cggtctccct ctgatgccga
     1261 gccgaagctg gactgtactg ctgccatctc ggctcactgc aacctccctg cctgattctc
     1321 ctgcctcagc ctgccgagtg cctgcaattg caggcgagcg ccgccacgcc tgactgcctc
     1381 ggcctcccga ggtgccggga ttgcagacgg agtctcgttc actcagtgct caatggtgcc
     1441 caggctggag tgcagtggcg tgatctcggc tcactacaac ctccacctcc cagccacctg
     1501 ccttggcctc ccaaagtgcc gagattgcag cctctgcccg gccgccaccc cgtctggaaa
     1561 gtgaggagcg cctctgcccg gccgccatcc catctaggaa gtgaggagcg cctcttccca
     1621 gccgccatcc catctaggaa gtgaggagcg tctctgcccg gccgcccatc gtctgagatg
     1681 tggggagcgc ctctgccccg ccgccccgtc tgggatgtga ggagctcctc tgcccggccg
     1741 cgaccccgtc tgggaggtga ggagcgtctc tgtctggcca ccccgtctga gaagtgagga
     1801 gacctccgcc cggcagccgc cctgtctgag aagtgaggag cccctccgcc cggcagccac
     1861 cccatctggg aagtgaggag cgtctacgcc cgggcagctg ccccgtccgg gagggaggtg
     1921 ggggggtcag ccccccgccc ggccagccgc cccgtccggg agggaggtgg gggggatcag
     1981 ccccccgccc ggccagccgc cccgtccggg agggaggtgg ggggcgcctc tgcccggccg
     2041 cccctgcccg gccgccccta ctgggaagtg aggagcccct ctgcctggcc accaccccat
     2101 ctgggaggtg tgcccagcag ctcattgaga acgggccatg atgacaatgg cggttttgtg
     2161 gaatagaaaa ggcggaaagg tggggaaaag attgagaaat tggatggttg ccgtgtctgt
     2221 gtagaaagaa gtagacatgg gagacttttc attttgttct gtactaagaa aaattcttct
     2281 gccttgggat cctgttgatc tatgacctta cccccaacct ggtgctctct gaaacatgtg
     2341 ctgtgtccac tcagggttaa atggattaag ggtggtgcaa gatgtgcttt gttaaacaga
     2401 tgcttgaagg cagcatgctc cttaagagtc atcaccactc cctaatctca agtacccagg
     2461 gacacaaaca ctgcggaagg cggcagggtc ctctgcctag gaaaaccaga gacctttgtt
     2521 cacttgttga tctgctgacc ttccctccac tattgtccta tgaccctgcc aaatccccct
     2581 ctgcgagaaa cacccaagaa tgatcaatta aaaaaaaaat aatataataa taattcttgt
     2641 cctcttattt tacactcata atgagaaatc acaagttctt tcttgatgat ctgtgctata
     2701 gatttctact ctgtctcctc aactctgttg atatttgggg aaaattctgt ttttcataga
     2761 ttctttgaga tgctgatgga ccagcttcag catgtttgag gttgtctgaa atggagatca
     2821 ctgtaaaact gtctttttct tttaaattac aagtacactg gggttaactg tattgctgga
     2881 aaaacatcaa gaatgacagt cttatattta aggcaccagt cattgtttcc attttttttt
     2941 taattcttcc cttggattaa tattttctac tgaaaagaaa tgaaatctca gttccactat
     3001 gataaaagaa acgaatcacc agtgtctgtc agtgccccca ctgctcctcc tcataccagc
     3061 attgacactg gtagctgagg aaggggactg ctcaatttct aatgtgatct attcaagaag
     3121 ccacatataa aaaggcattg agggctcact gtccagagaa ttgcttttgt aaatgctcca
     3181 caacgtatgg gcaaaagttt aaggactact gcctgatgta ccaggaatcc tgagttctgt
     3241 gaaaatctgt tcattccaaa tctgttaagc atttccaaac atccagagaa tggtttcact
     3301 gttgagggtg catgtggcag aatctgtctc tctctgcacc tgtcttctgt taccatccct
     3361 ggacagtgac agattttaag ccagccacca gaattctttt cgagttaacc atttcttagt
     3421 ttctgtaaat tcatgacttg tcttactgaa ctacagcctg gtttgtagac ttccaacatc
     3481 tacactgctg ctcttcacca ttggaattca ctgtggtatt tatagtattg gcttcagtcc
     3541 gagccacagg caataaaagg atatcagctg tagttctcag ctacatcatg gtgtatagat
     3601 gctgttattc aggcgaactt gctcatgggt ggactaacac ctggtttggt acagagactg
     3661 agaagttttt cattctggtg tcaaagtttt gttacattat gggtgtgaag ggcatttgat
     3721 atatttttct taactatggg gtttattttt ctaaatgtgg gttgattgac tgttaattga
     3781 ttcagggtac ccttaaaaga aaagaagttt tcccattgtg aaccttaaat gatcagagaa
     3841 gtaagttcat tgattaaatt ctctgttggg agaacaaaac ttttctccct tgacacttta
     3901 ttatctttga tttttcaaag ggccttgatt ggtggttgtg tctcggttaa aatttatggg
     3961 actttgctat gtagttggca tttataaaat ctgaagtatc ataaataaag ttatttattt
     4021 aattatacta ccagtctttt ttactggtct gattcttttg tgcattcatt aaagctgatt
     4081 gtgtgagagt gaactgggac acaagctagt ctagctcact gcagccaagc aaaccctgtt
     4141 gatggctgat gggcctttcc attagggttt tgcttatgtg aagtaatgga attatgttgg
     4201 ttattttctt tatgaaaata aaccagttct tccaaggaag ttaaaaggct tggtatggat
     4261 gttggtgtca gataggtctg actaacctct ccgtgctgca gcctatacta aggtgaccca
     4321 gggccacatg tagacagcta ggccagtgct ttttcctctt agggtttctt tgcagaaaga
     4381 aacctccagc aagggaagag aggtgtgtgt ccacaggaag gggctccgtg gggatcccat
     4441 gaagggattt gagctctttc agctccatgt catttaactt ttttgtttaa ccaccttggc
     4501 tttctctcct tttttgctgt cctccttacg gaccagttac cagattcaga ggctaacagt
     4561 tagttacttg ttaatgctag tcacagccag gaggtcagaa ggaattttct acttctggat
     4621 ccaaatgtta cctcttaggg gaagttatgc cccctcaact attgtcttat tataatgaat
     4681 ctttcctttt tggtcctttt aagtaaccac tcaaaacttt tcatttcact gaaaaaatat
     4741 gaaaaaccat gacaataggg ctgggtgcag tggctcacgc ctgtaatctt agcactttgg
     4801 gagaccaagg caggcggatc gtttgaggcc aggagtttga gaccagcctg ggcaatgtag
     4861 caagactctg tctctgcaaa aaaaattaaa agatacctga gagctcactt taatatcaag
     4921 gtatttgcat ccattcccac cctgttagct cttaagggag gagggaaatc aattccaacc
     4981 atactttcct gtgatggaag atgtttcctc ttgaaaaaat gccaatacag atttttaaaa
     5041 cctattgttt tccaaatgca ctttgtaagt ttttgctttt aaaatagctt cttggaacca
     5101 attttattgt atttgtactt aatttttgtt ctcatctaaa tgtgcatttt ctgactgtat
     5161 agaagaagct ttggtatgta atttaataat aaattagaaa tctaaatgat tgcatttgta
     5221 attgtttata ttgaaacagt aaccatcaag gtagtttggg gatagagatt atggtatctc
     5281 tggtgttgat aagtgtttct catgatgtcc tgaaacccag gatgaaataa tacaggtgct
     5341 gaaaagctgt cacatgtcat tcagaaacca tcatatgaac agtccactag tattttagcc
     5401 ctagaagtga aggggaatct cttaacatga aacttcagga ggcataatgg gaatctacaa
     5461 ttgtagaatt ggctgggtgc agtggctaac acctgtaatc ccagcagttc gagaggccga
     5521 ggcaggagga ttgcttgaga ccagggattt gagaccagtc tgggcaacac agcaaagacc
     5581 ttgtctctac aaaaactaaa attagccatt catgatggtg tgcacctata gtcccagcta
     5641 ctcggaaggc tgaggtagga ggatcatgag cccaggaggt caaggctgca gtaagcaacg
     5701 attgtgccac tgtactccag cctgggtgac agagaccctg tctcaaaaat aaattaattt
     5761 tttaaaaatc gtgtactgct gggctttagt acattagttg tgcaaccagc cccactgtct
     5821 aattttagag ctttgcaatt aatccagcca gtgatcaatt cctcttctat aaaatggtga
     5881 taaggatggc taccataatt gtgccctgat tatattgtca gggttatgtg aggaaatgct
     5941 cataagcatc tcagcaaagc caggggtaca gggctcacct gacataa
//
