LOCUS       NM_015530               2447 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens golgi reassembly stacking protein 2 (GORASP2),
            transcript variant 1, mRNA.
ACCESSION   NM_015530
VERSION     NM_015530.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2447)
  AUTHORS   Yang,F., Chen,L., Wen,B., Wang,X., Wang,L., Ji,K. and Liu,H.
  TITLE     Golgi Reassembly Stacking Protein 2 Modulates Myometrial
            Contractility during Labor by Affecting ATP Production
  JOURNAL   Int J Mol Sci 24 (12), 10116 (2023)
   PUBMED   37373263
  REMARK    GeneRIF: Golgi Reassembly Stacking Protein 2 Modulates Myometrial
            Contractility during Labor by Affecting ATP Production.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2447)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2447)
  AUTHORS   Ahat,E., Song,Y., Xia,K., Reid,W., Li,J., Bui,S., Zhang,F.,
            Linhardt,R.J. and Wang,Y.
  TITLE     GRASP depletion-mediated Golgi fragmentation impairs
            glycosaminoglycan synthesis, sulfation, and secretion
  JOURNAL   Cell Mol Life Sci 79 (4), 199 (2022)
   PUBMED   35312866
  REMARK    GeneRIF: GRASP depletion-mediated Golgi fragmentation impairs
            glycosaminoglycan synthesis, sulfation, and secretion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2447)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2447)
  AUTHORS   Pothukuchi,P., Agliarulo,I., Pirozzi,M., Rizzo,R., Russo,D.,
            Turacchio,G., Nuchel,J., Yang,J.S., Gehin,C., Capolupo,L.,
            Hernandez-Corbacho,M.J., Biswas,A., Vanacore,G., Dathan,N.,
            Nitta,T., Henklein,P., Thattai,M., Inokuchi,J.I., Hsu,V.W.,
            Plomann,M., Obeid,L.M., Hannun,Y.A., Luini,A., D'Angelo,G. and
            Parashuraman,S.
  TITLE     GRASP55 regulates intra-Golgi localization of glycosylation enzymes
            to control glycosphingolipid biosynthesis
  JOURNAL   EMBO J 40 (20), e107766 (2021)
   PUBMED   34516001
  REMARK    GeneRIF: GRASP55 regulates intra-Golgi localization of
            glycosylation enzymes to control glycosphingolipid biosynthesis.
REFERENCE   6  (bases 1 to 2447)
  AUTHORS   Duran,J.M., Kinseth,M., Bossard,C., Rose,D.W., Polishchuk,R.,
            Wu,C.C., Yates,J., Zimmerman,T. and Malhotra,V.
  TITLE     The role of GRASP55 in Golgi fragmentation and entry of cells into
            mitosis
  JOURNAL   Mol Biol Cell 19 (6), 2579-2587 (2008)
   PUBMED   18385516
REFERENCE   7  (bases 1 to 2447)
  AUTHORS   Lane,J.D., Lucocq,J., Pryde,J., Barr,F.A., Woodman,P.G., Allan,V.J.
            and Lowe,M.
  TITLE     Caspase-mediated cleavage of the stacking protein GRASP65 is
            required for Golgi fragmentation during apoptosis
  JOURNAL   J Cell Biol 156 (3), 495-509 (2002)
   PUBMED   11815631
  REMARK    GeneRIF: GRASP65 is an important structural component required for
            maintenance of Golgi apparatus integrity
REFERENCE   8  (bases 1 to 2447)
  AUTHORS   Short,B., Preisinger,C., Korner,R., Kopajtich,R., Byron,O. and
            Barr,F.A.
  TITLE     A GRASP55-rab2 effector complex linking Golgi structure to membrane
            traffic
  JOURNAL   J Cell Biol 155 (6), 877-883 (2001)
   PUBMED   11739401
  REMARK    GeneRIF: GRASP55 forms an effector complex for the small GTPase
            rab2, together with a conserved coiled-coil protein golgin-45
            (JEM-1).
REFERENCE   9  (bases 1 to 2447)
  AUTHORS   Jesch,S.A., Lewis,T.S., Ahn,N.G. and Linstedt,A.D.
  TITLE     Mitotic phosphorylation of Golgi reassembly stacking protein 55 by
            mitogen-activated protein kinase ERK2
  JOURNAL   Mol Biol Cell 12 (6), 1811-1817 (2001)
   PUBMED   11408587
REFERENCE   10 (bases 1 to 2447)
  AUTHORS   Kuo,A., Zhong,C., Lane,W.S. and Derynck,R.
  TITLE     Transmembrane transforming growth factor-alpha tethers to the PDZ
            domain-containing, Golgi membrane-associated protein p59/GRASP55
  JOURNAL   EMBO J 19 (23), 6427-6439 (2000)
   PUBMED   11101516
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010092.4, BC007770.2 and
            BQ004408.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015530.4.
            
            Summary: This gene encodes a member of the Golgi reassembly
            stacking protein family. These proteins may play a role in the
            stacking of Golgi cisternae and Golgi ribbon formation, as well as
            Golgi fragmentation during apoptosis or mitosis. The encoded
            protein also plays a role in the intracellular transport of
            transforming growth factor alpha and may function as a molecular
            chaperone. A pseudogene of this gene is located on the short arm of
            chromosome 2. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1172575.1, AK023201.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234160.5/ ENSP00000234160.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC010092.4         100137-100175       c
            40-1272             BC007770.2         1-1233
            1273-1273           AC010092.4         63472-63472         c
            1274-2445           BC007770.2         1235-2406
            2446-2447           BQ004408.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..2447
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..2447
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /note="golgi reassembly stacking protein 2"
                     /db_xref="GeneID:26003"
                     /db_xref="HGNC:HGNC:17500"
                     /db_xref="MIM:608693"
     exon            1..151
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1447
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /note="isoform 1 is encoded by transcript variant 1; golgi
                     phosphoprotein 6; golgi reassembly stacking protein 2,
                     55kDa; Golgi reassembly-stacking protein 2"
                     /codon_start=1
                     /product="Golgi reassembly-stacking protein 2 isoform 1"
                     /protein_id="NP_056345.3"
                     /db_xref="CCDS:CCDS33325.1"
                     /db_xref="GeneID:26003"
                     /db_xref="HGNC:HGNC:17500"
                     /db_xref="MIM:608693"
                     /translation="MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSIN
                     GSRLNKDNDTLKDLLKANVEKPVKMLIYSSKTLELRETSVTPSNLWGGQGLLGVSIRF
                     CSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGADTVMNESEDLFSLIETHEAKP
                     LKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEEGKKISLPGQ
                     MAGTPITPLKDGFTEVQLSSVNPPSLSPPGTTGIEQSLTGLSISSTPPAVSSVLSTGV
                     PTVPLLPPQVNQSLTSVPPMNPATTLPGLMPLPAGLPNLPNLNLNLPAPHIMPGVGLP
                     ELVNPGLPPLPSMPPRNLPGIAPLPLPSEFLPSFPLVPESSSAASSGELLSSLPPTSN
                     APSDPATTTAKADAASSLTVDVTPPTAKAPTTVEDRVGDSTPVSEKPVSAAVDANASE
                     SP"
     exon            152..232
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            233..436
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            437..523
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            524..654
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            655..787
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            788..911
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            912..998
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1106
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..2447
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /note="hexamer: AATAAA"
     polyA_site      2233
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /note="major polyA site"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /note="hexamer: ATTAAA"
     polyA_site      2447
                     /gene="GORASP2"
                     /gene_synonym="GOLPH6; GRASP55; GRS2; p59"
                     /note="major polyA site"
ORIGIN      
        1 aagtgctacg cggaggatta gagcaggcgg tgcgctgggg gcgggagcag cgcggagccc
       61 ggctcggcca caccgatcgc ccgccgccat gggctcctcg caaagcgtcg agatcccggg
      121 cgggggcacc gagggctacc acgttctgcg ggtacaagaa aattccccag gacacagagc
      181 tggtttggag cctttctttg attttattgt ttctattaat ggttcaagat taaataaaga
      241 caatgacact cttaaggatc tgctgaaagc aaacgttgaa aagcctgtaa agatgcttat
      301 ctatagcagc aaaacattgg aactgcgaga gacctcagtc acaccaagta acctgtgggg
      361 cggccagggc ttattgggag tgagcattcg tttctgcagc tttgatgggg caaatgaaaa
      421 tgtttggcat gtgctggagg tggaatcaaa ttctcctgca gcactggcag gtcttagacc
      481 acacagtgat tatataattg gagcagatac agtcatgaat gagtctgaag atctattcag
      541 ccttatcgaa acacatgaag caaaaccatt gaaactgtat gtgtacaaca cagacactga
      601 taactgtcga gaagtgatta ttacaccaaa ttctgcatgg ggtggagaag gcagcctagg
      661 atgtggcatt ggatatggtt atttgcatcg aatacctaca cgcccatttg aggaaggaaa
      721 gaaaatttct cttccaggac aaatggctgg tacacctatt acacctctta aagatgggtt
      781 tacagaggtc cagctgtcct cagttaatcc cccgtctttg tcaccaccag gaactacagg
      841 aattgaacag agtctgactg gactttctat tagctcaact ccaccagctg tcagtagtgt
      901 tctcagtaca ggtgtaccaa cagtaccgtt attgccacca caagtaaacc agtccctcac
      961 ttctgtgcca ccaatgaatc cagctactac attaccaggt ctgatgcctt taccagcagg
     1021 actgcccaac ctccccaacc tcaacctcaa cctcccagca ccacacatca tgccaggggt
     1081 tggcttacca gaacttgtaa acccaggtct gccacctctt ccttccatgc ctccccgaaa
     1141 cttacctggc attgcacctc tccccctgcc atccgagttc ctcccgtcat tccccttggt
     1201 tccagagagc tcttctgcag caagctcagg agagctgctg tcttccctcc cgcccaccag
     1261 caacgcaccc tccgaccctg ccacaactac tgcaaaggca gacgctgcct cctcactcac
     1321 tgtggatgtg acgcccccca ctgccaaggc ccccaccacc gttgaggaca gagtcggcga
     1381 ctccacccca gtcagcgaga agcctgtttc tgcggctgtg gatgccaatg cttctgagtc
     1441 accttaactt tgaaccattc tttggaattg gcgtggtata tttaaccacg ggagcgtgtc
     1501 tggaaacgca aactatcatt aatttcatac tagtttgtac cgtatctgta ggcatcctgt
     1561 aaataattcc aaggggaaaa ctaaacgagg acgtgggttg tatcctgcca ggttgagtgg
     1621 ggctcacacg ctagggtgag atgtcagaaa gcgcttgtat tttaaacaac caaaaagaat
     1681 tgtaagggtg gcttgctgcc aggcttgcac tgccgttcct gggggtgtgc atcttcggga
     1741 aaggtggtgg cggggcgtcc actaggtttc ctgtcccctg ctgctccttc cgtaagaaaa
     1801 tgaaatattc tatgcctaat actcacacgc aacatttctt gtactttgta agtcgtttgc
     1861 gagaatgcag accacctcac taaactgtaa acggtaaaga gatttttact tttggtctcc
     1921 gtgagtcgca tctctactaa ggtttacaca ggaattccac ctgaagactt gtgttaaagt
     1981 tctacagcgc gcactgttaa ctgaacgtct ttttcttcag cctatacgcg gatccttgtt
     2041 ttgagctctc agaatcactc agacaacatt ttgtaactgc tgctgttgct ttctacatac
     2101 accttataaa gtgacatttc aaaagaaata aggtgccaca gttttaaacc agaaggtggc
     2161 actctgtggc tccttgtagt attatagcta tactgggaaa gcatagatac agcaataaag
     2221 tacagtaatt ttactttttt tcttgtgtta catctaaatt acaaccctta attgccacgt
     2281 gtgcacttac tactctccag tatgtcttat tactctccag tatgtcacgc atctttaact
     2341 tttcacgtcc tatgtttgct ttctcccatt tttaagagat ggtaagttaa ctggaattga
     2401 tttactgaat gaaattaaat gcagatatcc ctgtttttga aataaga
//
