LOCUS       NM_020399               4597 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens golgi associated PDZ and coiled-coil motif containing
            (GOPC), transcript variant 1, mRNA.
ACCESSION   NM_020399
VERSION     NM_020399.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4597)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4597)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4597)
  AUTHORS   Cushing,P.R., Fellows,A., Villone,D., Boisguerin,P. and Madden,D.R.
  TITLE     The relative binding affinities of PDZ partners for CFTR: a
            biochemical basis for efficient endocytic recycling
  JOURNAL   Biochemistry 47 (38), 10084-10098 (2008)
   PUBMED   18754678
  REMARK    GeneRIF: The cystic fibrosis-associated ligand (CAL) PDZ domain of
            the C-terminus of cystic fibrosis-associated conductance regulator
            (CFTR) is competitively involved with PDZ proteins Na+/H+
            exchanger-3 regulatory factors NHERF1 and NHERF2.
REFERENCE   4  (bases 1 to 4597)
  AUTHORS   Li,X., Zhang,J., Cao,Z., Wu,J. and Shi,Y.
  TITLE     Solution structure of GOPC PDZ domain and its interaction with the
            C-terminal motif of neuroligin
  JOURNAL   Protein Sci 15 (9), 2149-2158 (2006)
   PUBMED   16882988
  REMARK    GeneRIF: Our discoveries provide insight into the specific
            interaction of the GOPC PDZ domain with the C-terminal peptide of
            Nlg and also provide a general insight about the possible binding
            mode of the interaction of Nlg with other PDZ domain-containing
            proteins.
REFERENCE   5  (bases 1 to 4597)
  AUTHORS   Ito,H., Iwamoto,I., Morishita,R., Nozawa,Y., Asano,T. and Nagata,K.
  TITLE     Identification of a PDZ protein, PIST, as a binding partner for Rho
            effector Rhotekin: biochemical and cell-biological characterization
            of Rhotekin-PIST interaction
  JOURNAL   Biochem J 397 (3), 389-398 (2006)
   PUBMED   16646955
REFERENCE   6  (bases 1 to 4597)
  AUTHORS   He,J., Bellini,M., Inuzuka,H., Xu,J., Xiong,Y., Yang,X.,
            Castleberry,A.M. and Hall,R.A.
  TITLE     Proteomic analysis of beta1-adrenergic receptor interactions with
            PDZ scaffold proteins
  JOURNAL   J Biol Chem 281 (5), 2820-2827 (2006)
   PUBMED   16316992
REFERENCE   7  (bases 1 to 4597)
  AUTHORS   Hicks,S.W. and Machamer,C.E.
  TITLE     Isoform-specific interaction of golgin-160 with the
            Golgi-associated protein PIST
  JOURNAL   J Biol Chem 280 (32), 28944-28951 (2005)
   PUBMED   15951434
  REMARK    GeneRIF: golgin-160 assosiates in an isoform-specific manner with
            the Golgi-associated protein PIST
REFERENCE   8  (bases 1 to 4597)
  AUTHORS   Cheng,J., Wang,H. and Guggino,W.B.
  TITLE     Modulation of mature cystic fibrosis transmembrane regulator
            protein by the PDZ domain protein CAL
  JOURNAL   J Biol Chem 279 (3), 1892-1898 (2004)
   PUBMED   14570915
  REMARK    GeneRIF: CAL retains CFTR in the cell and targets CFTR for
            degradation.
REFERENCE   9  (bases 1 to 4597)
  AUTHORS   Yao,R., Maeda,T., Takada,S. and Noda,T.
  TITLE     Identification of a PDZ domain containing Golgi protein, GOPC, as
            an interaction partner of frizzled
  JOURNAL   Biochem Biophys Res Commun 286 (4), 771-778 (2001)
   PUBMED   11520064
REFERENCE   10 (bases 1 to 4597)
  AUTHORS   Neudauer,C.L., Joberty,G. and Macara,I.G.
  TITLE     PIST: a novel PDZ/coiled-coil domain binding partner for the
            rho-family GTPase TC10
  JOURNAL   Biochem Biophys Res Commun 280 (2), 541-547 (2001)
   PUBMED   11162552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA109449.1, BX419592.2, AF287894.1, Z85999.1 and AY033606.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020399.3.
            
            Summary: This gene encodes a Golgi protein with a PDZ domain. The
            PDZ domain is globular and proteins which contain them bind other
            proteins through short motifs near the C-termini. Mice which are
            deficient in the orthologous protein have globozoospermia and are
            infertile. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.83362.1,
                                           SRR1660809.13389.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368498.7/ ENSP00000357484.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                DA109449.1         32-110
            80-697              BX419592.2         46-663
            698-1605            AF287894.1         551-1458
            1606-4542           Z85999.1           72790-75726         c
            4543-4597           AY033606.1         4501-4555
FEATURES             Location/Qualifiers
     source          1..4597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.1"
     gene            1..4597
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /note="golgi associated PDZ and coiled-coil motif
                     containing"
                     /db_xref="GeneID:57120"
                     /db_xref="HGNC:HGNC:17643"
                     /db_xref="MIM:606845"
     exon            1..508
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1612
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /note="isoform a is encoded by transcript variant 1;
                     CFTR-associated ligand; fused in glioblastoma; dJ94G16.2
                     PIST; PDZ/coiled-coil domain binding partner for the
                     rho-family GTPase TC10; PDZ protein interacting
                     specifically with TC10; golgi-associated PDZ and
                     coiled-coil motif containing protein; Golgi-associated PDZ
                     and coiled-coil motif-containing protein"
                     /codon_start=1
                     /product="Golgi-associated PDZ and coiled-coil
                     motif-containing protein isoform a"
                     /protein_id="NP_065132.1"
                     /db_xref="CCDS:CCDS5117.1"
                     /db_xref="GeneID:57120"
                     /db_xref="HGNC:HGNC:17643"
                     /db_xref="MIM:606845"
                     /translation="MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKA
                     FVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLK
                     SELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELER
                     ELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRV
                     QQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDS
                     LKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGD
                     AILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYR
                     LYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKL
                     DDLHTLYHKKSY"
     exon            509..673
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            674..697
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            698..873
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1039
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1135
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1300
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1481
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..4597
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4519..4524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /note="hexamer: AATAAA"
     polyA_site      4546
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /note="major polyA site"
     regulatory      4569..4574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
                     /note="hexamer: AATAAA"
     polyA_site      4597
                     /gene="GOPC"
                     /gene_synonym="CAL; dJ94G16.2; FIG; GOPC1; PIST"
ORIGIN      
        1 gggactgact gagtcttccg tgtgtcgccg ccgttgccgc ctcagcttca gcctcgttac
       61 tcctgcggtt ctgtgactgt gctgctggcg ttaacggcgc gaggtgaagg gaggtgacgg
      121 agtgtgcccg cgcgcgcggg ggtcccctca gtcccagcag ttcccttcgt gcgcgggggg
      181 cggcgagggt cttcagcagt cgggagaggc ccttgacggc gccatgtcgg cgggcggtcc
      241 atgcccagca gcagccggag ggggcccagg gggcgcctcc tgctccgtgg gggcccctgg
      301 cggggtatcc atgttccggt ggctggaggt gctggagaag gagttcgaca aagcttttgt
      361 ggatgtggat ctgctcctgg gagagatcga tccagaccaa gcggacatca cttatgaggg
      421 gcgacagaag atgaccagcc tgagctcctg ctttgcacag ctttgccaca aagcccagtc
      481 tgtgtctcaa atcaaccaca agctggaggc acagttggtg gatctgaaat ctgaactgac
      541 agaaacccaa gcagagaaag ttgttttgga gaaagaagta catgatcagc ttttacagct
      601 gcactctatt cagctgcagc ttcatgctaa aactggtcaa agtgctgact ctggtaccat
      661 taaggcaaaa ttgtctggcc cctctgtgga ggagctggaa agagagcttg aggcaaacaa
      721 aaaagaaaaa atgaaagaag cacaacttga agctgaagtg aaattgttga gaaaagagaa
      781 tgaagccctt cgtagacata tagctgttct ccaggctgaa gtatatgggg cgagactagc
      841 tgccaagtac ttggataagg aactggcagg aagggtccaa cagatacaat tgctaggacg
      901 agatatgaag ggacctgctc atgataagct ttggaaccaa ttagaagctg aaatacattt
      961 gcatcgtcac aaaactgtga tccgagcctg cagaggacgt aatgacttga aacgaccaat
     1021 gcaagcacca ccaggccatg atcaagattc cctaaagaaa agccaaggtg ttggtccaat
     1081 tagaaaagtt ctcctcctta aggaagatca tgaaggcctt ggcatttcaa ttacaggtgg
     1141 gaaagaacat ggtgttccaa tcctcatctc tgagatccat ccggggcaac ctgctgatag
     1201 atgcggaggg ctgcacgttg gggatgctat tttggcagtc aacggagtta acctaaggga
     1261 cacaaagcat aaagaagctg taactattct ttctcagcag agaggagaga ttgaatttga
     1321 agtagtttat gtggctcctg aagtggattc tgatgatgaa aacgtagagt atgaagatga
     1381 gagtggacat cgttaccgtt tgtaccttga tgagttagaa ggaggtggta accctggtgc
     1441 tagttgcaaa gacacaagtg gggaaatcaa agtattacaa ggatttaata agaaggcagt
     1501 aactgacaca catgaaaatg gagacctggg cactgcaagt gaaactccgc tagatgacgg
     1561 tgcttcaaaa ttagatgatc tgcacactct gtatcataaa aaatcttatt aaattgacca
     1621 tatctccaga caagattgtt aatcagacta ttctgaattt ggggcactgg ggaagatggt
     1681 gacaaagact acaaaatcag gggaggctgt ttgttgccta aatgaaaggc gggtacctca
     1741 gggcttcatg tgaacaattc tcaatgcata aaacaccctg ttttctgtgg tagaccataa
     1801 ttagctattg catgtaaagc aattttgatt ttcttgaact tgtaagcacc aaagcatgtg
     1861 tttcccaaag gggtattact gggctcttaa gtaccaaatg aaaccctact gttttacttg
     1921 gttccttttc cctttagtag gaggacagtg ctaactggaa ttttataagg agtacccttt
     1981 aaaatacaga gagtaagtga attcatattt tatattctag aatgttaact gtggtatttc
     2041 agaagacaga gcttgactca atgaattgta gaaatatagg cttgacttaa tttttgtaac
     2101 tgaaaggctt tagacttaaa aaaatttatt gtgcatccta aaatctaaac caattattaa
     2161 tgatcattta ttgtaatgag tttgcatttc agctttattc aatgcagtac aaaatagttt
     2221 tctttaagca gtcttttatc aatcaatgct gcactagaaa tagattctca aaagttacta
     2281 aacattttac tttttttgtt ttttaaaaga aatgcagatg agtgtaaaac atctgttctc
     2341 aattatgttg atctgtgtgc gcagtactgg agcatttacc cattcatgtt gagcctcaaa
     2401 tgcttgtttt ctggggtcca caaaagacag ttttatacat tttgagttgt tcataaagtt
     2461 tgtcttgtga tagtcctggc acttaaagac aaatttttct ggtagtaaaa gttcagattt
     2521 attactatgt catgaaacac agtacattca aatcaaacgg cagttttctt tctaagtaaa
     2581 tgatttccag tcatctaaaa ggtgggcaag atgagataaa gacattttga tacagtaatt
     2641 gttttggttg ggttttcatg tcagtttatg tttgactaaa gctctcttca tatgcaggtt
     2701 tataaatttg ttaggtctgt tgtcccatga ttaaacatgg agtgcctcct ctctgattta
     2761 atattctgca ggtcattgta acctgctagg caaagtcaca acattgcatt aaagaggtga
     2821 tagctttgct aatatcactg ttttaaagga cgtacagtta aaggaatatt aagtgggaga
     2881 aagcctacaa ggcttttaga atattatcag tatcttcatt tctggtattc agatgttatg
     2941 tgataaaaca catttttttt ggctttccca gatacactat atatttgttc aagggtaaat
     3001 ctataaaatg tatatacttt attttgtggt tttgctattt ataaatttaa tgttttaact
     3061 gttgctcatt tatggtttgt tttgggtggt ggtgttcatc tgtatatcac catgttaatt
     3121 tgtaatggaa gtgcacttcg tagtgtatat tgttactgac attaaaatac tttatagcat
     3181 tgtctctgag caaaagctag tatttaattg tacaaatgaa taagcaagtt acatgttatt
     3241 gtttgctctt gacagggtag gcctcttaaa agaaaaaaaa caacttgttt tttctttatg
     3301 aatcccctat gccaaacaca taccttccat gcatgacatg agatctgcaa actggatttt
     3361 agccaccgta tttatttagt caaaaaaatt gtccattgta gcagacccga aaaccttttt
     3421 gctgtgacat gaaaccatgt tattcttatc ttcttaaaac acagcctggg atggaatggc
     3481 catggcattt ttttcagaga acatccttta tctgctatga ctgaatcctt aggaaatgta
     3541 agctataacc ctttgatttt caagaactac cgaataagtg tatgaagagg tggtttttta
     3601 aaacttcaag ttggaatttt tatgaggtca ctgtgtaatt tgaagaattg tgtgagattg
     3661 tcatgatata aattcctttt aaggactgat aaatagaatg aaaagtttcc aggtagttta
     3721 aaactccaca ggtcagtttc cttttcattc ctgcttcact gtggtttata agcctacggg
     3781 agagcaccgt tgctcagatg ctactgtgag cttcctgtcc ggtgttagaa agtaactagt
     3841 taaaagttca ttttagaatg tatggttttt ggggatgaac taagaattag ttattagttc
     3901 caaaggactg agaaccaatt ttaatatttt cacatttata ggaaagaaat tcatatgtcc
     3961 ctgaaacttc taggacaaaa ccaaacaagt aaggagggaa ctgttgcaaa gccatttcat
     4021 cgagaagggg acagaaggag aaatacacac atgtatacac aaacagaatg gttgagaaaa
     4081 cgttttaata aaatgtgagg gttgtatgtg tgcgtgtata tatttacact taacctctaa
     4141 aattctcttc tacagtatct ctgttatgaa tatgatggaa aagcaacatt ttggtggtga
     4201 gactattgtt aaaataaatt tgagaaagac gaaaattttg tgagtcttga taattacaag
     4261 tcaacagcta tcgaaagtta gcacagcttg tctgtggtgc tgtttttttc cccactgcag
     4321 tggacttatg ctgttttcat gtttagaaac aaaaaggttt catgtgattc atgtgtaaga
     4381 tgcacagtat ttgacatcct gattatgtaa tccctattcc atctatccag tcttacactt
     4441 atggttggcc tcaaatctat tgcatttatg ataatgtatt atatctagtt gagtttaata
     4501 tttttttatt agcctgtaaa taaagatggc atcttctaca ttaaaatgat attgatctca
     4561 tttttttaaa taaacatttt gtttccttga cgttaaa
//
