LOCUS       NM_001282860            7745 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens gon-4 like (GON4L), transcript variant 3, mRNA.
ACCESSION   NM_001282860 XM_005245278
VERSION     NM_001282860.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7745)
  AUTHORS   Bucholc,K., Skrajna,A., Adamska,K., Yang,X.C., Krajewski,K.,
            Poznanski,J., Dadlez,M., Dominski,Z. and Zhukov,I.
  TITLE     Structural Analysis of the SANT/Myb Domain of FLASH and YARP
            Proteins and Their Complex with the C-Terminal Fragment of NPAT by
            NMR Spectroscopy and Computer Simulations
  JOURNAL   Int J Mol Sci 21 (15), 5268 (2020)
   PUBMED   32722282
  REMARK    GeneRIF: Structural Analysis of the SANT/Myb Domain of FLASH and
            YARP Proteins and Their Complex with the C-Terminal Fragment of
            NPAT by NMR Spectroscopy and Computer Simulations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7745)
  AUTHORS   Agarwal,N., Dancik,G.M., Goodspeed,A., Costello,J.C., Owens,C.,
            Duex,J.E. and Theodorescu,D.
  TITLE     GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24
            Axis
  JOURNAL   Cancer Res 76 (17), 5175-5185 (2016)
   PUBMED   27312530
  REMARK    GeneRIF: our results define GON4L as a novel driver of cancer
            growth
REFERENCE   3  (bases 1 to 7745)
  AUTHORS   Yang,X.C., Sabath,I., Kunduru,L., van Wijnen,A.J., Marzluff,W.F.
            and Dominski,Z.
  TITLE     A conserved interaction that is essential for the biogenesis of
            histone locus bodies
  JOURNAL   J Biol Chem 289 (49), 33767-33782 (2014)
   PUBMED   25339177
  REMARK    GeneRIF: The conserved C-terminal domain shared by FLASH, YARP, and
            Mute recognizes the C-terminal sequence of NPAT orthologues, thus
            acting as a signal targeting proteins to histone locus bodies.
REFERENCE   4  (bases 1 to 7745)
  AUTHORS   Lu,P., Hankel,I.L., Hostager,B.S., Swartzendruber,J.A.,
            Friedman,A.D., Brenton,J.L., Rothman,P.B. and Colgan,J.D.
  TITLE     The developmental regulator protein Gon4l associates with protein
            YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates
            transcriptional repression
  JOURNAL   J Biol Chem 286 (20), 18311-18319 (2011)
   PUBMED   21454521
  REMARK    GeneRIF: Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that
            Gon4l may function as a platform for the assembly of complexes that
            regulate gene expression.
REFERENCE   5  (bases 1 to 7745)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 7745)
  AUTHORS   Ohtomo,T., Horii,T., Nomizu,M., Suga,T. and Yamada,J.
  TITLE     Cloning and expression analysis of YY1AP-related protein in the rat
            brain
  JOURNAL   Amino Acids 34 (1), 155-161 (2008)
   PUBMED   17285227
REFERENCE   7  (bases 1 to 7745)
  AUTHORS   Ohtomo,T., Horii,T., Nomizu,M., Suga,T. and Yamada,J.
  TITLE     Molecular cloning of a structural homolog of YY1AP, a coactivator
            of the multifunctional transcription factor YY1
  JOURNAL   Amino Acids 33 (4), 645-652 (2007)
   PUBMED   17297563
  REMARK    GeneRIF: study describes the cloning of a novel homolog of YY1AP,
            referred to as YARP; it is proposed that YARP is multifunctional
            and plays not only a role analogous to YY1AP, but also its own
            specific roles in DNA-utilizing processes such as transcription
REFERENCE   8  (bases 1 to 7745)
  AUTHORS   Kuryshev,V.Y., Vorobyov,E., Zink,D., Schmitz,J.,
            Rozhdestvensky,T.S., Munstermann,E., Ernst,U., Wellenreuther,R.,
            Moosmayer,P., Bechtel,S., Schupp,I., Horst,J., Korn,B., Poustka,A.
            and Wiemann,S.
  TITLE     An anthropoid-specific segmental duplication on human chromosome
            1q22
  JOURNAL   Genomics 88 (2), 143-151 (2006)
   PUBMED   16545939
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139128.24 and AL162734.15.
            
            On Oct 4, 2019 this sequence version replaced NM_001282860.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest protein. Variants 3 and 4 encode
            isoform (c).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY335490.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368331.6/ ENSP00000357315.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL139128.24        93660-93727         c
            69-599              AL139128.24        89789-90319         c
            600-791             AL139128.24        63350-63541         c
            792-982             AL139128.24        58799-58989         c
            983-1057            AL139128.24        57987-58061         c
            1058-1108           AL139128.24        57119-57169         c
            1109-1159           AL139128.24        52725-52775         c
            1160-1255           AL139128.24        52318-52413         c
            1256-1375           AL139128.24        50843-50962         c
            1376-1546           AL139128.24        50147-50317         c
            1547-1739           AL139128.24        41462-41654         c
            1740-1841           AL139128.24        31563-31664         c
            1842-1882           AL139128.24        21847-21887         c
            1883-1986           AL139128.24        20499-20602         c
            1987-2185           AL139128.24        14135-14333         c
            2186-2272           AL139128.24        12908-12994         c
            2273-2444           AL139128.24        11515-11686         c
            2445-2589           AL139128.24        9579-9723           c
            2590-2740           AL139128.24        7580-7730           c
            2741-2857           AL139128.24        3938-4054           c
            2858-4567           AL139128.24        1513-3222           c
            4568-4644           AL139128.24        1-77                c
            4645-4820           AL162734.15        105486-105661       c
            4821-5005           AL162734.15        104364-104548       c
            5006-5203           AL162734.15        102618-102815       c
            5204-5347           AL162734.15        100065-100208       c
            5348-5491           AL162734.15        99354-99497         c
            5492-5611           AL162734.15        99132-99251         c
            5612-5725           AL162734.15        96549-96662         c
            5726-5936           AL162734.15        95378-95588         c
            5937-6567           AL162734.15        94134-94764         c
            6568-6670           AL162734.15        93941-94043         c
            6671-7745           AL162734.15        91833-92907         c
FEATURES             Location/Qualifiers
     source          1..7745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..7745
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /note="gon-4 like"
                     /db_xref="GeneID:54856"
                     /db_xref="HGNC:HGNC:25973"
                     /db_xref="MIM:610393"
     exon            1..68
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            69..599
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..6820
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /note="isoform c is encoded by transcript variant 3;
                     2610100B20Rik; YY1AP related protein; YY1AP-related
                     protein1; GON-4-like protein; gon-4 homolog"
                     /codon_start=1
                     /product="GON-4-like protein isoform c"
                     /protein_id="NP_001269789.1"
                     /db_xref="CCDS:CCDS60296.1"
                     /db_xref="GeneID:54856"
                     /db_xref="HGNC:HGNC:25973"
                     /db_xref="MIM:610393"
                     /translation="MLPCKKRRTTVTESLQHKGNQEENNVDLESAVKPESDQVKDLSS
                     VSLSWDPSHGRVAGFEVQSLQDAGNQLGMEDTSLSSGMLTQNTNVPILEGVDVAISQG
                     ITLPSLESFHPLNIHIGKGKLHATGSKRGKKMTLRPGPVTQEDRCDHLTLKEPFSGEP
                     SEEVKEEGGKPQMNSEGEIPSLPSGSQSAKPVSQPRKSTQPDVCASPQEKPLRTLFHQ
                     PEEEIEDGGLFIPMEEQDNEESEKRRKKKKGTKRKRDGRGQEGTLAYDLKLDDMLDRT
                     LEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFEPKMTRSKLKEVV
                     EKGVVIPTWNISPIKKANEIKPPQFVDIHLEEDDSSDEEYQPDDEEEDETAEESLLES
                     DVESTASSPRGAKKSRLRQSSEMTETDEESGILSEAEKVTTPAIRHISAEVVPMGPPP
                     PPKPKQTRDSTFMEKLHAVDEELASSPVCMDSFQPMDDSLIAFRTRSKMPLKDVPLGQ
                     LEAELQAPDITPDMYDPNTADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDLD
                     EPDTEDFRTDRAVRITKKEVNELMEELFETFQDEMGFSNMEDDGPEEEECVAEPRPNF
                     NTPQALRFEEPLANLLNEQHRTVKELFEQLKMKKSSAKQLQEVEKVKPQSEKVHQTLI
                     LDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLNPEATTTRIFLKELGTFAQSSIALH
                     HQYNPKFQTLFQPCNLMGAMQLIEDFSTHVSIDCSPHKTVKKTANEFPCLPKQVAWIL
                     ATSKVFMYPELLPVCSLKAKNPQDKIVFTKAEDNLLALGLKHFEGTEFPNPLISKYLL
                     TCKTAHQLTVRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEIQPHQWKPPIEREEH
                     RLPFWLKASLPSIQEELRHMADGAREVGNMTGTTEINSDRSLEKDNLELGSESRYPLL
                     LPKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQPSPSLQPSFNPGKTPARSTHSEA
                     PPSKMVLRIPHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAVPPEARTSFPLSES
                     QTLLSSAPVPKVMLPSLAPSKFRKPYVRRRPSKRRGVKASPCMKPAPVIHHPASVIFT
                     VPATTVKIVSLGGGCNMIQPVNAAVAQSPQTIPITTLLVNPTSFPCPLNQSLVASSVS
                     PLIVSGNSVNLPIPSTPEDKAHVNVDIACAVADGENAFQGLEPKLEPQELSPLSATVF
                     PKVEHSPGPPLADAECQEGLSENSACRWTVVKTEEGRQALEPLPQGIQESLNNPTPGD
                     LEEIVKMEPEEAREEISGSPERDICDDIKVEHAVELDTGAPSEELSSAGEVTKQTVLQ
                     KEEERSQPTKTPSSSQEPPDEGTSGTDVNKGSSKNALSSMDPEVRLSSPPGKPEDSSS
                     VDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEEDEMSSASEESVLSVPELQETM
                     EKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMESLQKEDEMTDEAVGDS
                     AEKPPTFASPETAPEVETSRTPPGESIKAAGKGRNNHRARNKRGSRARASKDTSKLLL
                     LYDEDILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRRTA
                     VDLYKSLQILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAE
                     NPSHHQKIIKVLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRM
                     GDFEEINWTEEKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKETE
                     WPDGAKDCACSCHEGGPDSKLKKSKRRSCSHCSSKVCDSKSYKSKEPHELVGSSPHRE
                     ASPMPGAKEAGQGKDMMEEEAPEERESTEATQSRTVRTTRKGEMPVSAGLAVGSTLPS
                     PREVTVTERLLLDGPPPHSPETPQFPPTTGAVLYTVKRNQVGPEVRSCPKASPRLQKE
                     REGQKAVSESEALMLVWDASETEKLPGTVEPPASFLSPVSSKTRDAGRRHVSGKPDTQ
                     ERWLPSSRARVKTRDRTCPVHESPSGIDTSETSPKAPRGGLAKDSGTQAKGPEGEQQP
                     KAAEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPQTFNIISQQLGNKTP
                     AEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDHGDLLSEEELDE"
     exon            600..791
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            792..982
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1057
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1108
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1159
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1255
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1375
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1546
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1739
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1841
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1882
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1986
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2185
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2272
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2444
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2589
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2740
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2857
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..4567
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            4568..4820
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            4821..5005
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5006..5203
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5204..5347
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5348..5491
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5492..5611
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5612..5725
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5726..5936
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            5937..6567
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            6568..6670
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     exon            6671..7745
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7721..7726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /note="hexamer: AGTAAA"
     polyA_site      7745
                     /gene="GON4L"
                     /gene_synonym="GON-4; GON4; YARP"
                     /note="major polyA site"
ORIGIN      
        1 gttgttggct gacttccggt ggtgccaaag ccgtttccgt ggaatcaggc cggctggtga
       61 gggtacagaa tggaacaaaa gtgggacttt taaaatgttg ccctgtaaga agagaagaac
      121 tacagtgaca gagtccctac agcataaagg caatcaagag gaaaacaacg tagacctaga
      181 atcagccgtt aaaccagaat ctgaccaggt taaggacttg agttcggtgt cactatcctg
      241 ggatccaagt catggcagag tagctggctt cgaagtacag tctttgcagg atgcaggaaa
      301 tcagcttggt atggaggata catctctgag ctctggaatg ctcacccaga acacaaatgt
      361 accaattcta gaaggtgttg atgtggccat ctctcaggga atcaccctac cttccttgga
      421 gtcttttcac ccccttaata tacacattgg taaaggaaaa ctccacgcta ctggctcaaa
      481 gagagggaaa aaaatgacac tcaggcctgg gccagttacc caagaagaca gatgtgatca
      541 tcttacccta aaggagcctt tttcaggaga gcctagtgaa gaagtcaagg aagaaggagg
      601 gaaacctcaa atgaattctg aaggggagat accttccctg ccatcaggca gccaatctgc
      661 aaaaccagta agccagccca ggaaatcaac ccagccagat gtttgtgcct ctcctcaaga
      721 aaagccactc aggactctgt ttcaccaacc tgaggaagag atagaagatg gtggactctt
      781 cattccaatg gaagaacaag acaatgaaga aagtgagaaa aggagaaaaa agaaaaaggg
      841 taccaagagg aaacgagatg gaaggggtca agaagggacc ttggcatatg acctgaaact
      901 ggatgacatg cttgaccgta ccttggagga tggtgccaag cagcacaatc taacagcagt
      961 caatgtccga aacatccttc atgaagtaat cacaaatgaa cacgtggtag ctatgatgaa
     1021 agcagccatc agtgagacgg aagatatgcc aatgtttgag cctaaaatga cacgctctaa
     1081 actgaaggaa gtagtggaaa aaggagtggt aattccaaca tggaatattt caccaattaa
     1141 gaaggccaat gaaattaagc ctcctcagtt tgtggatatc caccttgaag aagatgattc
     1201 ctcagatgaa gaataccagc cggatgatga agaagaagat gaaactgctg aagagagctt
     1261 attggaaagt gatgttgaaa gcactgcttc atctccacgt ggggcaaaga aatccagatt
     1321 gaggcagtct tctgagatga ctgaaacaga tgaggagagt ggcatattat cagaggctga
     1381 gaaagtcacc acaccagcca tcaggcacat cagtgctgag gtagtgccca tggggccccc
     1441 gccccctcca aagccgaaac agaccagaga tagtactttc atggagaagt tacatgcggt
     1501 agatgaggag ctggcttcca gtccagtctg catggattct ttccagccca tggatgacag
     1561 tctcattgca tttcgaacgc gttctaagat gcccctgaaa gatgttcccc tgggccaatt
     1621 agaggcagag ctccaagctc cagacatcac tccagatatg tatgacccca atacggcaga
     1681 tgatgaggac tggaagatgt ggctgggggg acttatgaat gatgatgtgg ggaatgaaga
     1741 tgaagcagat gatgatgatg atccagaata taatttcctg gaagacctcg atgaaccaga
     1801 cacagaggat ttccggactg accgggcagt gagaatcacc aaaaaggaag taaatgagct
     1861 gatggaagag ctgtttgaaa ctttccaaga tgagatggga ttctccaaca tggaagatga
     1921 tggcccagaa gaggaggagt gtgtagctga gcctcgtcct aactttaaca cccctcaagc
     1981 tctacggttt gaggaaccac tggccaacct gttaaatgaa caacatcgga cagtgaagga
     2041 gctatttgaa cagctgaaga tgaagaaatc ttcagccaaa cagctgcagg aagtagagaa
     2101 ggttaaaccc cagagtgaga aagttcatca gactctgatt ctggacccag cacagaggaa
     2161 gagactccag cagcagatgc agcagcacgt tcagctcttg acccaaatcc accttcttgc
     2221 cacctgcaac cccaacctca atccggaggc cactaccacc aggatatttc ttaaagagct
     2281 gggaaccttt gctcaaagct ccatcgccct tcaccatcag tacaacccca agtttcagac
     2341 cctgttccaa ccctgtaact tgatgggagc tatgcagctg attgaagact tcagcacaca
     2401 tgtcagcatt gactgcagcc ctcataaaac tgtcaagaag actgcgaatg aatttccctg
     2461 tttgccaaag caagtggctt ggattctggc cacaagcaag gttttcatgt atccagagtt
     2521 acttccagtg tgttccctga aggcaaagaa tccccaggat aagatcgtct tcaccaaggc
     2581 tgaggacaat ttgttagctt taggactgaa gcattttgaa ggaactgagt ttcctaatcc
     2641 tctaatcagc aagtaccttc taacctgcaa aactgcccac caactgacag tgagaatcaa
     2701 gaacctcaac atgaacagag ctcctgacaa catcattaaa ttttataaga agaccaaaca
     2761 gctgccagtc ctaggaaaat gctgtgaaga gatccagcca catcagtgga agccacctat
     2821 agagagagaa gaacaccggc tcccattctg gttaaaggcc agtctgccat ccatccagga
     2881 agaactgcgg cacatggctg atggtgctag agaggtagga aatatgactg gaaccactga
     2941 gatcaactca gatcgaagcc tagaaaaaga caatttggag ttggggagtg aatctcggta
     3001 cccactgcta ttgcctaagg gtgtagtcct gaaactgaag ccagttgcca cccgtttccc
     3061 caggaaggct tggagacaga agcgttcatc agtcctgaag cccctcctta tccaacccag
     3121 cccctctctc cagcccagct tcaaccctgg gaaaacacca gcccgatcaa ctcattcaga
     3181 agcccctccg agcaaaatgg tgctccggat tcctcaccca atacagccag ccactgtttt
     3241 acagacagtt ccaggtgtcc ctccactggg ggtcagtgga ggtgagagtt ttgagtctcc
     3301 tgcagcactg cctgctgtgc cccctgaggc caggacaagc ttccctctgt ctgagtccca
     3361 gactttgctc tcttctgccc ctgtgcccaa ggtaatgctg ccctcccttg ccccttctaa
     3421 gtttcgaaag ccatatgtga gacggagacc ctcaaagaga agaggagtca aggcctctcc
     3481 ctgtatgaaa cctgcccctg ttatccacca ccctgcatct gttatcttca ctgttcctgc
     3541 taccactgtg aagattgtga gccttggcgg tggctgtaac atgatccagc ctgtcaatgc
     3601 ggctgtggcc cagagtcccc agactattcc catcactacc ctcttggtta accctacttc
     3661 cttcccctgt ccattgaacc agtcccttgt ggcctcctct gtctcaccct taattgtttc
     3721 tggcaattct gtgaatcttc ctataccatc cacccctgaa gataaggccc acgtgaatgt
     3781 ggacattgct tgtgctgtgg ctgatgggga aaatgccttt cagggcctag aacccaaatt
     3841 agagccccag gaactatctc ctctctctgc tactgttttc ccgaaagtgg aacatagccc
     3901 agggcctcca ctagcagatg cagagtgcca agaaggattg tcagagaata gtgcctgtcg
     3961 ctggaccgtt gtgaaaacag aggaggggag gcaagctctg gagccgctcc ctcagggcat
     4021 ccaggagtct ctaaacaacc ctacccctgg ggatttagag gaaattgtca agatggaacc
     4081 tgaagaagct agagaggaaa tcagtggatc ccctgagcgt gatatttgtg atgacatcaa
     4141 agtggaacat gctgtggaat tggacactgg tgccccaagc gaggagttga gcagtgctgg
     4201 agaagtaacg aaacagacag tcttacagaa ggaagaggag aggagtcagc caactaaaac
     4261 cccttcatct tctcaagagc cccctgatga aggaacctca gggacagatg tgaacaaagg
     4321 atcatcaaag aatgctttgt cctcaatgga tcctgaagtg aggcttagta gccccccagg
     4381 gaagccagaa gattcatcca gtgttgatgg tcagtcagtg gggactccag ttgggccaga
     4441 aactggagga gagaagaatg ggccagaaga agaggaagaa gaggactttg atgacctcac
     4501 ccaagatgag gaagatgaaa tgtcatcagc ttctgaggaa tctgtgcttt ctgtcccaga
     4561 actccaggaa acaatggaga aactgacttg gctggcatct gaaaggcgca tgagtcagga
     4621 gggtgagtct gaagaagaga attctcagga ggagaactct gagccagaag aagaggagga
     4681 agaagaagca gaaggaatgg aaagcctgca gaaagaggat gaaatgacgg atgaagcagt
     4741 tggagactct gctgagaagc ctcctacttt tgcttcacct gagactgctc cagaagtgga
     4801 gaccagcaga actccaccag gagagagcat caaagctgct ggaaaaggcc ggaacaatca
     4861 tcgagctcgc aacaagcggg gaagtcgggc tcgggccagc aaggacacct ccaagctgct
     4921 gttgctgtat gatgaggaca ttctcgagcg agatccactc agggagcaga aggacttggc
     4981 ctttgcccaa gcttatctga ccagggtgcg agaagcccta caacatatcc ctggcaagta
     5041 tgaagacttc cttcaagtca tctatgaatt tgagtcaagt acccagagac ggacggctgt
     5101 agatctctac aaaagcctgc aaattctgct ccaagactgg cctcagctgt tgaaagactt
     5161 tgctgctttc ctgttacctg agcaagctct ggcctgtgga ttatttgagg agcagcaggc
     5221 ttttgagaag agccgcaagt tccttcggca gctggagatt tgctttgcag agaacccctc
     5281 acaccaccag aagattatca aggtcctcca aggctgtgca gactgccttc cccaggagat
     5341 caccgagctc aagacacaga tgtggcagct cctcaagggc cacgaccacc tgcaggatga
     5401 gttttctatc ttctttgacc acttgcgccc agcagctagc cggatgggtg actttgaaga
     5461 gatcaattgg actgaggaaa aggagtatga gtttgatggc tttgaagaag tggccctgcc
     5521 tgatgtggaa gaagaggagg agcctcccaa gatacccaca gcctcaaaga acaagaggaa
     5581 aaaagagatc ggggtccaaa atcatgataa ggagactgaa tggccagatg gggccaagga
     5641 ctgtgcctgc tcctgccatg aaggaggtcc agattccaag ctgaagaaga gcaaaaggcg
     5701 gagctgtagc cactgtagca gcaaggtctg tgacagcaaa tcctacaaga gcaaggagcc
     5761 ccatgagttg gtgggcagca gcccccaccg agaggctagt cctatgcctg gtgctaagga
     5821 agctgggcag ggcaaggata tgatggaaga ggaagcccca gaggagcggg agagcactga
     5881 ggccacccag agcaggactg tcaggaccac cagaaaggga gagatgcctg tttcagcagg
     5941 attggcagtg gggagcactt tgccatcccc tcgagaagtg actgttacag aacggctcct
     6001 cctggatggc ccaccacctc attcaccaga gactcctcaa tttcccccca caactggagc
     6061 tgtactgtac actgttaaga gaaaccaggt tgggcctgag gttcgctcct gccccaaggc
     6121 atcccccaga cttcagaaag agagggaggg ccaaaaggca gtgagtgagt cagaggcttt
     6181 gatgctggtc tgggatgcat cagaaactga gaaattgcct ggtaccgtgg aaccccctgc
     6241 ttccttcctg agtcctgttt cctcaaagac cagagatgca gggagaagac atgtgtccgg
     6301 gaaaccagac actcaagaga gatggctgcc ctcaagcaga gctcgggtga agacaagaga
     6361 caggacgtgc cctgtccatg aatctccatc aggaattgac acctcagaga cttctcccaa
     6421 agcccctaga gggggtttgg ctaaagacag tggaacacag gccaagggtc cagaggggga
     6481 gcagcagcca aaggccgcag aagctacggt gtgtgccaac aacagcaagg tcagctccac
     6541 tggggaaaag gttgtcctgt ggacaaggga agctgaccgt gtgatcctca ccatgtgcca
     6601 ggagcaaggg gcacagccac agaccttcaa catcatctcc cagcagctgg gaaataagac
     6661 ccctgctgag gtttcccacc gttttcgaga actcatgcag ctcttccaca ctgcctgtga
     6721 agccagctct gaggatgagg atgatgcaac cagtaccagc aatgcagacc agctgtctga
     6781 ccatggggac cttctgtctg aagaggagct ggatgaatga gactctggga atcatctaca
     6841 caggaccaaa cccaacaggc gccctggcac cggggagggg gtagttgtac tctgcttgta
     6901 cagtccttga gcccagttta cagatctgga gagcaggagg ccaggacaag gacaaaggct
     6961 ggaggatgga gtaggaccca ggggctctgc catcctaggc atcattcaag gtcttttatg
     7021 aagactttac agatgtcctc tgtaaatagc atcgagagtg gagttcagct cctttctcta
     7081 cttttttttg gtctgatggc acatatttat tgttctgtgg tctaatcaca gtgtttctaa
     7141 atgtaaaaag tgcatatgtt ggtgtagcta gtcccgcgac attgagctcc tctgcatgaa
     7201 gacactgggc tcctgcatcc agctgttttt attgcaaact agctcctttc tcccacactg
     7261 ggaactttag tccacgaggc tgtcaccacc ctggtagcac tgggccaggc tttgtagctc
     7321 ctgcagcagc tctgctacgt catcgtgctc cactccagca tccatgaagc tggcccagcg
     7381 ccgcaagtcg agtttggtga ggtctctggc caaggcttcc agggtctggt gcagggacga
     7441 agaggaacac agtgccccaa acactgggat gctctccact gctgtggagg gagaggaaac
     7501 agagacctgt agatggatga ttattctgcc ctgggactcg ccaaactgat aaggaagtcc
     7561 aaccttagta gacttgattg taaactcaac aaatttggtg tattgtcccc ttagtacacc
     7621 agtactccag aggaagaatg cttttcttgg gagccatagg gtgaataaag gaatgtttaa
     7681 ctgtggactt tttcagcact tttaatccag gaatggagat agtaaaacct ctcccatact
     7741 tgaaa
//
