LOCUS       NM_016072               3253 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens golgi transport 1B (GOLT1B), mRNA.
ACCESSION   NM_016072
VERSION     NM_016072.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3253)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3253)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   3  (bases 1 to 3253)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3253)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 3253)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   6  (bases 1 to 3253)
  AUTHORS   Bourdon,V., Naef,F., Rao,P.H., Reuter,V., Mok,S.C., Bosl,G.J.,
            Koul,S., Murty,V.V., Kucherlapati,R.S. and Chaganti,R.S.
  TITLE     Genomic and expression analysis of the 12p11-p12 amplicon using EST
            arrays identifies two novel amplified and overexpressed genes
  JOURNAL   Cancer Res 62 (21), 6218-6223 (2002)
   PUBMED   12414650
REFERENCE   7  (bases 1 to 3253)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   8  (bases 1 to 3253)
  AUTHORS   Conchon,S., Cao,X., Barlowe,C. and Pelham,H.R.
  TITLE     Got1p and Sft2p: membrane proteins involved in traffic to the Golgi
            complex
  JOURNAL   EMBO J 18 (14), 3934-3946 (1999)
   PUBMED   10406798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA579356.1, AB097020.1, AC006559.6 and AA910170.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016072.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.86726.1,
                                           SRR1660807.85057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229314.10/ ENSP00000229314.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DA579356.1         25-50
            27-1098             AB097020.1         1-1072
            1099-3104           AC006559.6         147727-149732
            3105-3248           AA910170.1         1-144               c
            3249-3253           AC006559.6         149877-149881
FEATURES             Location/Qualifiers
     source          1..3253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..3253
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /note="golgi transport 1B"
                     /db_xref="GeneID:51026"
                     /db_xref="HGNC:HGNC:20175"
                     /db_xref="MIM:615078"
     exon            1..160
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..552
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /note="hGOT1a; putative NF-kappa-B-activating protein 470;
                     germ cell tumor 2"
                     /codon_start=1
                     /product="vesicle transport protein GOT1B"
                     /protein_id="NP_057156.1"
                     /db_xref="CCDS:CCDS8689.1"
                     /db_xref="GeneID:51026"
                     /db_xref="HGNC:HGNC:20175"
                     /db_xref="MIM:615078"
                     /translation="MISLTDTQKIGMGLTGFGVFFLFFGMILFFDKALLAIGNVLFVA
                     GLAFVIGLERTFRFFFQKHKMKATGFFLGGVFVVLIGWPLIGMIFEIYGFFLLFRGFF
                     PVVVGFIRRVPVLGSLLNLPGIRSFVDKVGESNNMV"
     exon            161..252
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /inference="alignment:Splign:2.1.0"
     exon            253..431
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /inference="alignment:Splign:2.1.0"
     exon            432..513
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /inference="alignment:Splign:2.1.0"
     exon            514..3253
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1027..1032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /note="hexamer: ATTAAA"
     polyA_site      1048
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /note="hexamer: AATAAA"
     polyA_site      3004
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /note="major polyA site"
     regulatory      3212..3217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
                     /note="hexamer: AATAAA"
     polyA_site      3253
                     /gene="GOLT1B"
                     /gene_synonym="CGI-141; GCT2; GOT1; GOT1B; YMR292W"
ORIGIN      
        1 agtgagggtg gctgcgtgtt tccggaagac gtggcggctc tcgcctgggc tgtttcccgg
       61 cttcatttct cccgactcag cttcccaccc tgggctttcc gaggtgctgt cgccgctgtc
      121 cccaccactg cagccatgat ctccttaacg gacacgcaga aaattggaat gggattaaca
      181 ggatttggag tgtttttcct gttctttgga atgattctct tttttgacaa agcactactg
      241 gctattggaa atgttttatt tgtagccggc ttggcttttg taattggttt agaaagaaca
      301 ttcagattct tcttccaaaa acataaaatg aaagctacag gtttttttct gggtggtgta
      361 tttgtagtcc ttattggttg gcctttgata ggcatgatct tcgaaattta tggatttttt
      421 ctcttgttca ggggcttctt tcctgtcgtt gttggcttta ttagaagagt gccagtcctt
      481 ggatccctcc taaatttacc tggaattaga tcatttgtag ataaagttgg agaaagcaac
      541 aatatggtat aacaacaagt gaatttgaag actcatttaa aatattgtgt tatttataaa
      601 gtcatttgaa gaatattcag cacaaaatta aattacatga aatagcttgt aatgttcttt
      661 acaggagttt aaaacgtata gcctacaaag taccagcagc aaattagcaa agaagcagtg
      721 aaaacaggct tctactcaag tgaactaaga agaagtcagc aagcaaactg agagaggtga
      781 aatccatgtt aatgatgctt aagaaactct tgaaggctat ttgtgttgtt tttccacaat
      841 gtgcgaaact cagccatcct tagagaactg tggtgcctgt ttcttttctt tttattttga
      901 aggctcagga gcatccatag gcatttgctt tttagaaatg tccactgcaa tggcaaaaat
      961 atttccagtt gcactgtatc tctggaagtg atgcatgaat tcgattggat tgtgtcattt
     1021 taaagtatta aaaccaagga aaccccaatt ttgatgtatg gattactttt ttttgtaaac
     1081 atggttaaaa taaaactttt gtggttcttc tgaatcttaa tatttcaaag ccaggtgaaa
     1141 atctgaacta gatattcttt gttggaatat gcaaaggtca ttctttacta acttttagtt
     1201 actaaattat agctaagttt tgtcagcagc atactccgga aagtctcata cttcttggga
     1261 gtctgccctc ctaagtatct gtctatatca ttcattacgt gtaagtattt aacaaaaaag
     1321 cattcttgac catgaatgaa gtagtttgtt tcatagcttg tctcattgaa tagtattatt
     1381 gaagatacta aatgatgcaa accaaatgga ttttttccat gtcatgatgt aatttttctt
     1441 tcttctttct tttttttaaa ttttagcagt ggcttattat ttgtttttca taaattaaaa
     1501 taacttttga taatgtttac tttaagacat gtaacatgtt aaaaggttaa acttatggct
     1561 atttttaaag ggctattcat ttaatctgag ttttccctta ttttcagctt tttcctagca
     1621 tataatagtc attaagcatg acatatcctt catatgatca ctcatcttga gttaattaga
     1681 aaatacctga gttcacgtgc taaagtcatt tcactgtaat aaactgactg tggtttctta
     1741 agaacatgac actaaaaaaa aagtgttttt tttccaccgt tgctgattat tagacagtag
     1801 gaaatagctg ttttctttag ttttacaaga tgtgacagct ttagtggtag atgtagggaa
     1861 acatttcaac agccatagta ctatttgttt taccactgat tgcactgttt tgttttttta
     1921 acagttgcaa agctttttaa tgcataaaag tataattgaa atctgtggta tttatttaca
     1981 aacatgtcta caaaaataga ttacagctta ttttattttt agttaaatct cttaatacac
     2041 agagaactcc caatcttgct catctaaata aggaaagact tggtgtatag tgtgatggtt
     2101 tagtcttaag gattaagaca tttttggtac ttgcatttga cttacgatgt atctgtgaaa
     2161 atgggatgat attgacaaat ggagactcct acctcaatag ttaatggaat aataagaggc
     2221 tactgttgtg tctaatgttc ttcaaaaaag taatatcctc acttggagag tgtcaaatac
     2281 atactttgag gattgacttt atataaggtg ccctgtagaa ctctgttaca catatttttg
     2341 acccatatta tttacaatgt cttgataatt ctaccttttt agagcaagaa tagtatctgc
     2401 taatgtaagg gacatctgta tttaactcct ttgtagacat gaatttctat caaaatgttc
     2461 tttgcactgt aacagagatt ccttttttca ataatcttaa ttcaaaagca ttattagact
     2521 tgaaagggtt tgataatctc ccagtcctta gtaaagattg agagaggctg gagcagtttt
     2581 cagttttaaa tgagtctgca gttaatatca aatgtgagtt tgggactgcc tggcaacatt
     2641 tatatttctt attcagaacc cttgatgaga ctatttttaa acatactagt ctgctgatag
     2701 aaagcactat acatcctatt gtttctttct ttccaaaatc agccttctgt ctgtaacaaa
     2761 aatgtacttt atagagatgg aggaaaaggt ctaatactac atagccttaa gtgtttctgt
     2821 cattgttcaa gtgtattttc tgtaacagaa acatatttgg aatgtttttc ttttcccctt
     2881 ataaattgta attcctgaaa tactgctgct ttaaaaagtc ccactgtcag attatattat
     2941 ctaacaattg aatattgtaa atatacttgt cttacctctc aataaaaggg tacttttcta
     3001 ttaattggtg gtcaagtata tctgtgttat gaagttctaa aagctaattt agcattgcaa
     3061 aataacctca tttttaaaaa attagcctta tatgcagtgt tctatttatc aaatgatctt
     3121 cacatctttc atttccaaat tgttgaaatg tactaatgaa tacaaataga cttcaagtaa
     3181 gcaaaaatgt tcttaatttt gaaaactgta aaataaagtc acttaccttg ggcaatatgc
     3241 tattttttaa aaa
//
